S Balzar

Summary

Affiliation: National Jewish Medical and Research Center
Country: USA

Publications

  1. ncbi Transbronchial biopsy as a tool to evaluate small airways in asthma
    S Balzar
    National Jewish Medical and Research Centre, Denver, CO 80206, USA
    Eur Respir J 20:254-9. 2002
  2. ncbi Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptoms
    Silvana Balzar
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int Arch Allergy Immunol 140:96-102. 2006
  3. ncbi Increased TGF-beta2 in severe asthma with eosinophilia
    Silvana Balzar
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 115:110-7. 2005
  4. ncbi Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    Silvana Balzar
    Department of Medicine and Division of Biostatistics, National Jewish Medical and Research Center, 1400 Jackson St, J 226, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:431-9. 2005
  5. ncbi Persistent wheezing in very young children is associated with lower respiratory inflammation
    M E Krawiec
    Department of Pediatrics and Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 163:1338-43. 2001
  6. ncbi Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition
    H W Chu
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D104, Denver 80206, Colorado, USA
    Clin Exp Allergy 32:1558-65. 2002
  7. ncbi Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
    Am J Pathol 165:1097-106. 2004
  8. ncbi Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:1345-52. 2003
  9. ncbi Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation
    Christina Miranda
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 113:101-8. 2004
  10. ncbi Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma
    Philip E Silkoff
    National Jewish Medical and Research Center, Narbeth, PA 19072, USA
    J Allergy Clin Immunol 116:1249-55. 2005

Collaborators

Detail Information

Publications18

  1. ncbi Transbronchial biopsy as a tool to evaluate small airways in asthma
    S Balzar
    National Jewish Medical and Research Centre, Denver, CO 80206, USA
    Eur Respir J 20:254-9. 2002
    ..This study suggests that small airway may be identified and analysed in transbronchial biopsy tissue samples and therefore transbronchial biopsy tissue samples could expand the analysis of inflammation and tissue remodelling in asthma...
  2. ncbi Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptoms
    Silvana Balzar
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int Arch Allergy Immunol 140:96-102. 2006
    ....
  3. ncbi Increased TGF-beta2 in severe asthma with eosinophilia
    Silvana Balzar
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 115:110-7. 2005
    ..However, little is known regarding the expression of specific TGF-beta isoforms (TGF-beta1, TGF-beta2, and TGF-beta3) in asthma, despite recent evidence suggesting that isoforms may have differing biologic activities...
  4. ncbi Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    Silvana Balzar
    Department of Medicine and Division of Biostatistics, National Jewish Medical and Research Center, 1400 Jackson St, J 226, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:431-9. 2005
    ..89; p </= 0.001 for all correlations). These data suggest that induction of chymase-positive mast cells, particularly in the small airway outer wall/alveolar attachments region, may be protective for lung function in severe asthma...
  5. ncbi Persistent wheezing in very young children is associated with lower respiratory inflammation
    M E Krawiec
    Department of Pediatrics and Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 163:1338-43. 2001
    ..05) were also increased in WC compared with NC, whereas PGD(2) and beta-tryptase were not. This study confirms that inflammation is present in the airways of very young WC and may differ from patterns seen in adults with asthma...
  6. ncbi Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition
    H W Chu
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D104, Denver 80206, Colorado, USA
    Clin Exp Allergy 32:1558-65. 2002
    ..Although 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a product of 15-lipoxygenase (15-LO), may be involved in mild to moderate asthma, little is known about its potential roles in severe asthma...
  7. ncbi Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
    Am J Pathol 165:1097-106. 2004
    ..These data suggest that TGF-beta2 production by asthmatic bronchial epithelial cells may increase airway mucin expression. IL-13-induced mucin expression may occur in part through TGF-beta2 up-regulation...
  8. ncbi Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:1345-52. 2003
    ..Although MMP-9 is increased in lavage fluid and sputum in patients with asthma, controversy exists as to the role of tissue MMP-9...
  9. ncbi Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation
    Christina Miranda
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 113:101-8. 2004
    ..CONCLUSIONS: Differentiating severe asthma by age at onset and presence or absence of eosinophils identifies phenotypes of asthma, which could benefit subsequent genetic and therapeutic studies...
  10. ncbi Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma
    Philip E Silkoff
    National Jewish Medical and Research Center, Narbeth, PA 19072, USA
    J Allergy Clin Immunol 116:1249-55. 2005
    ..The fractional concentration of exhaled nitric oxide (FENO) is increased in asthma, correlates with eosinophilic inflammation, and decreases after steroid therapy...
  11. ncbi Role of insulin-like growth factor binding protein-3 in allergic airway remodeling
    Kristen L Veraldi
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 180:611-7. 2009
    ....
  12. ncbi Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 179:782-90. 2009
    ..IL-13 is known to induce 15LO1 and MUC5AC in human airway epithelial cells in vitro. Whether 15LO1 and/or its product 15-HETE modulate MUC5AC expression is unknown...
  13. ncbi Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways
    Weimin Liu
    Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:893-902.e2. 2008
    ..Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown...
  14. ncbi Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function
    Weimin Liu
    Division of Allergy and Immunology, Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Mol Cell Biol 30:1783-99. 2010
    ..Thus, we have developed a cellular model of sustained ERK1/2 activation, which may provide a mechanistic understanding of self-sustained biological processes in chronic illnesses such as asthma...
  15. ncbi Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts
    XiuXia Zhou
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:1388-97. 2007
    ..Although these interactions have implications for remodeling in asthma, little is understood regarding the mechanisms controlling TIMP-1 product...
  16. ncbi IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes
    Silvana Balzar
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, UPMC Montefiore, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:855-62. 2007
    ..IgE-mediated responses contribute to allergy and asthma. Little is understood regarding the relationship of tissue IgE to systemic IgE, inflammation or clinical outcomes...
  17. ncbi IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  18. ncbi Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle?
    Sally E Wenzel
    Am J Respir Crit Care Med 174:364-5. 2006