Affiliation: National Jewish Medical and Research Center
- Transbronchial biopsy as a tool to evaluate small airways in asthmaS Balzar
National Jewish Medical and Research Centre, Denver, CO 80206, USA
Eur Respir J 20:254-9. 2002..This study suggests that small airway may be identified and analysed in transbronchial biopsy tissue samples and therefore transbronchial biopsy tissue samples could expand the analysis of inflammation and tissue remodelling in asthma...
- Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptomsSilvana Balzar
National Jewish Medical and Research Center, Denver, CO 80206, USA
Int Arch Allergy Immunol 140:96-102. 2006....
- Increased TGF-beta2 in severe asthma with eosinophiliaSilvana Balzar
Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver 80206, USA
J Allergy Clin Immunol 115:110-7. 2005..However, little is known regarding the expression of specific TGF-beta isoforms (TGF-beta1, TGF-beta2, and TGF-beta3) in asthma, despite recent evidence suggesting that isoforms may have differing biologic activities...
- Relationship of small airway chymase-positive mast cells and lung function in severe asthmaSilvana Balzar
Department of Medicine and Division of Biostatistics, National Jewish Medical and Research Center, 1400 Jackson St, J 226, Denver, CO 80206, USA
Am J Respir Crit Care Med 171:431-9. 2005..89; p </= 0.001 for all correlations). These data suggest that induction of chymase-positive mast cells, particularly in the small airway outer wall/alveolar attachments region, may be protective for lung function in severe asthma...
- Persistent wheezing in very young children is associated with lower respiratory inflammationM E Krawiec
Department of Pediatrics and Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA
Am J Respir Crit Care Med 163:1338-43. 2001..05) were also increased in WC compared with NC, whereas PGD(2) and beta-tryptase were not. This study confirms that inflammation is present in the airways of very young WC and may differ from patterns seen in adults with asthma...
- Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen depositionH W Chu
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D104, Denver 80206, Colorado, USA
Clin Exp Allergy 32:1558-65. 2002..Although 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), a product of 15-lipoxygenase (15-LO), may be involved in mild to moderate asthma, little is known about its potential roles in severe asthma...
- Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthmaHong Wei Chu
Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
Am J Pathol 165:1097-106. 2004..These data suggest that TGF-beta2 production by asthmatic bronchial epithelial cells may increase airway mucin expression. IL-13-induced mucin expression may occur in part through TGF-beta2 up-regulation...
- Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repairSally E Wenzel
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 111:1345-52. 2003..Although MMP-9 is increased in lavage fluid and sputum in patients with asthma, controversy exists as to the role of tissue MMP-9...
- Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammationChristina Miranda
National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
J Allergy Clin Immunol 113:101-8. 2004..CONCLUSIONS: Differentiating severe asthma by age at onset and presence or absence of eosinophils identifies phenotypes of asthma, which could benefit subsequent genetic and therapeutic studies...
- Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthmaPhilip E Silkoff
National Jewish Medical and Research Center, Narbeth, PA 19072, USA
J Allergy Clin Immunol 116:1249-55. 2005..The fractional concentration of exhaled nitric oxide (FENO) is increased in asthma, correlates with eosinophilic inflammation, and decreases after steroid therapy...
- Role of insulin-like growth factor binding protein-3 in allergic airway remodelingKristen L Veraldi
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Respir Crit Care Med 180:611-7. 2009....
- Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cellsJinming Zhao
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 179:782-90. 2009..IL-13 is known to induce 15LO1 and MUC5AC in human airway epithelial cells in vitro. Whether 15LO1 and/or its product 15-HETE modulate MUC5AC expression is unknown...
- Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airwaysWeimin Liu
Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 121:893-902.e2. 2008..Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown...
- Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial functionWeimin Liu
Division of Allergy and Immunology, Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
Mol Cell Biol 30:1783-99. 2010..Thus, we have developed a cellular model of sustained ERK1/2 activation, which may provide a mechanistic understanding of self-sustained biological processes in chronic illnesses such as asthma...
- Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblastsXiuXia Zhou
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Allergy Clin Immunol 119:1388-97. 2007..Although these interactions have implications for remodeling in asthma, little is understood regarding the mechanisms controlling TIMP-1 product...
- IgE expression pattern in lung: relation to systemic IgE and asthma phenotypesSilvana Balzar
Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, UPMC Montefiore, Pittsburgh, PA 15213, USA
J Allergy Clin Immunol 119:855-62. 2007..IgE-mediated responses contribute to allergy and asthma. Little is understood regarding the relationship of tissue IgE to systemic IgE, inflammation or clinical outcomes...
- IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expressionSally E Wenzel
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Respir Crit Care Med 175:570-6. 2007..However, an effect on exacerbations and tissue inflammation has not been shown...
- Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle?Sally E Wenzel
Am J Respir Crit Care Med 174:364-5. 2006