Robert S Balaban

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Role of calcium in metabolic signaling between cardiac sarcoplasmic reticulum and mitochondria in vitro
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1061, USA
    Am J Physiol Cell Physiol 284:C285-93. 2003
  2. pmc Domestication of the cardiac mitochondrion for energy conversion
    Robert S Balaban
    Laboratory of Cardiac Energetic, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    J Mol Cell Cardiol 46:832-41. 2009
  3. pmc The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1787:1334-41. 2009
  4. pmc The mitochondrial proteome: a dynamic functional program in tissues and disease states
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Department of Health and Human Services, Bethesda, Maryland, USA
    Environ Mol Mutagen 51:352-9. 2010
  5. ncbi request reprint Tissue heterogeneity of the mammalian mitochondrial proteome
    D Thor Johnson
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Rm B1D416, Bethesda, MD 20892 1061, USA
    Am J Physiol Cell Physiol 292:C689-97. 2007
  6. ncbi request reprint Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institute of Health, 9000 Rockville Pike, Bethesda MD 20892, USA
    Ann N Y Acad Sci 1080:140-53. 2006
  7. ncbi request reprint Modeling mitochondrial function
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Am J Physiol Cell Physiol 291:C1107-13. 2006
  8. pmc Use of (32)P to study dynamics of the mitochondrial phosphoproteome
    Angel M Aponte
    Laboratory of Cardiac Energetics and Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    J Proteome Res 8:2679-95. 2009
  9. pmc Regulation of oxidative phosphorylation complex activity: effects of tissue-specific metabolic stress within an allometric series and acute changes in workload
    Darci Phillips
    Laboratory of Cardiac Energetics, NHLBI, NIH, Bethesda, MD 20892 1061, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1034-48. 2012
  10. pmc Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation
    Emily S Boja
    Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    J Proteome Res 8:4665-75. 2009

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Role of calcium in metabolic signaling between cardiac sarcoplasmic reticulum and mitochondria in vitro
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1061, USA
    Am J Physiol Cell Physiol 284:C285-93. 2003
    ..It is suggested that this balanced activation by cytosolic Ca(2+) is partially responsible for the minimal alteration in energy metabolism intermediates that occurs with changes in cardiac workload in vivo...
  2. pmc Domestication of the cardiac mitochondrion for energy conversion
    Robert S Balaban
    Laboratory of Cardiac Energetic, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    J Mol Cell Cardiol 46:832-41. 2009
    ....
  3. pmc The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1787:1334-41. 2009
    ..This balanced activation extends the energy homeostasis observed in the cytosol into the mitochondria matrix in the never resting heart...
  4. pmc The mitochondrial proteome: a dynamic functional program in tissues and disease states
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Department of Health and Human Services, Bethesda, Maryland, USA
    Environ Mol Mutagen 51:352-9. 2010
    ..Screening methods are being introduced to detect the active or dynamic posttranslational sites to focus attention on sites that might provide insight into regulatory mechanisms...
  5. ncbi request reprint Tissue heterogeneity of the mammalian mitochondrial proteome
    D Thor Johnson
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Rm B1D416, Bethesda, MD 20892 1061, USA
    Am J Physiol Cell Physiol 292:C689-97. 2007
    ..These data confirm the notion that mitochondria are tuned by the nucleus for specific functions in different tissues...
  6. ncbi request reprint Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institute of Health, 9000 Rockville Pike, Bethesda MD 20892, USA
    Ann N Y Acad Sci 1080:140-53. 2006
    ..In addition, complex I is far from equilibrium and may play an important role in regulating the rate of reducing equivalent delivery to the cytochromes...
  7. ncbi request reprint Modeling mitochondrial function
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA
    Am J Physiol Cell Physiol 291:C1107-13. 2006
    ....
  8. pmc Use of (32)P to study dynamics of the mitochondrial phosphoproteome
    Angel M Aponte
    Laboratory of Cardiac Energetics and Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    J Proteome Res 8:2679-95. 2009
    ..These results demonstrate that a dynamic and extensive mitochondrial matrix phosphoproteome exists in heart and liver...
  9. pmc Regulation of oxidative phosphorylation complex activity: effects of tissue-specific metabolic stress within an allometric series and acute changes in workload
    Darci Phillips
    Laboratory of Cardiac Energetics, NHLBI, NIH, Bethesda, MD 20892 1061, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1034-48. 2012
    ..These data are consistent with the notion that metabolic stress modulates MOPCs activity in the heart...
  10. pmc Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation
    Emily S Boja
    Proteomics Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    J Proteome Res 8:4665-75. 2009
    ..This screening validated the iTRAQ/HCD technology as a method for functional quantitation of mitochondrial protein phosphorylation as well as providing insight into the regulation of mitochondria via phosphorylation...
  11. ncbi request reprint The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
    Stefan M Schieke
    Cardiology Branch, Laboratory of Cardiac Energetics, Flow Cytometry Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:27643-52. 2006
    ..These results may provide insight into recent observations linking the TOR pathway to life span regulation of lower organisms...
  12. pmc Proteomic changes associated with diabetes in the BB-DP rat
    D Thor Johnson
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Am J Physiol Endocrinol Metab 296:E422-32. 2009
    ....
  13. ncbi request reprint The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism
    Shino Nemoto
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg 10 6N 240, 10 Center Drive, Bethesda, MD 20892 1622, USA
    J Biol Chem 281:10555-60. 2006
    ..These results demonstrate that p66(shc) regulates mitochondrial oxidative capacity and suggest that p66(shc) may extend life span by repartitioning metabolic energy conversion away from oxidative and toward glycolytic pathways...
  14. pmc 32P labeling of protein phosphorylation and metabolite association in the mitochondria matrix
    Angel M Aponte
    Proteomics Core Facility, National Heart Lung and Blood Institute, DHHS, Bethesda, Maryland, USA
    Methods Enzymol 457:63-80. 2009
    ..The use of this, in situ, labeling approach is extremely valuable in confirming protein phosphorylation sites as well as examining the dynamics of these processes under near physiological conditions...
  15. pmc Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism
    Darci Phillips
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    Biochemistry 48:7140-9. 2009
    ....
  16. pmc Stoichiometry of STAT3 and mitochondrial proteins: Implications for the regulation of oxidative phosphorylation by protein-protein interactions
    Darci Phillips
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 285:23532-6. 2010
    ..Thus, STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways that warrant further investigation...
  17. doi request reprint Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria
    Brian Glancy
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States
    Biochemistry 52:2793-809. 2013
    ....
  18. pmc Homogenous protein programming in the mammalian left and right ventricle free walls
    Darci Phillips
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 1061, USA
    Physiol Genomics 43:1198-206. 2011
    ..The constant myocyte composition in the LV and RV implies that the ratio of energy metabolism and contractile elements may be optimal for the sustained cardiac contractile activity in the mammalian heart...
  19. pmc p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content
    Joon Young Park
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 105:705-12, 11 p following 712. 2009
    ..Understanding the biology of how p53 improves exercise capacity may provide useful insights for improving both cardiovascular as well as general health...
  20. ncbi request reprint Distribution of mitochondrial NADH fluorescence lifetimes: steady-state kinetics of matrix NADH interactions
    Ksenia Blinova
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biochemistry 44:2585-94. 2005
    ....
  21. ncbi request reprint Metabolic network control of oxidative phosphorylation: multiple roles of inorganic phosphate
    Salil Bose
    Laboratory of Cardiac Energetics, NHLBI, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Biol Chem 278:39155-65. 2003
    ....
  22. pmc Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium
    Rachel K Hopper
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    Biochemistry 45:2524-36. 2006
    ..These data demonstrate the use of a phosphoproteome screen in determining mitochondrial signaling pathways and reveal new pathways for Ca(2+) modification of mitochondrial function at the level of MnSOD...
  23. ncbi request reprint Functional consequences of mitochondrial proteome heterogeneity
    D Thor Johnson
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Dr, Rm B1D416, Bethesda, MD 20892 1061, USA
    Am J Physiol Cell Physiol 292:C698-707. 2007
    ..These studies demonstrate the existence of mitochondrial biochemical functions that at present are poorly defined...
  24. pmc Continuous monitoring of enzymatic activity within native electrophoresis gels: application to mitochondrial oxidative phosphorylation complexes
    Raul Covian
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Anal Biochem 431:30-9. 2012
    ..The utility of monitoring the entire kinetic behavior of these reactions in native gels, as well as the general application of this approach, is discussed...
  25. pmc Intrinsic protein kinase activity in mitochondrial oxidative phosphorylation complexes
    Darci Phillips
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, United States
    Biochemistry 50:2515-29. 2011
    ..Collectively, this study proposes that many of the mitochondrial complexes contain an autophosphorylation mechanism, which may play a functional role in the regulation of these multiprotein units...
  26. pmc Short communication: Subcellular motion compensation for minimally invasive microscopy, in vivo: evidence for oxygen gradients in resting muscle
    James L Schroeder
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Circ Res 106:1129-33. 2010
    ..A primary limitation of optical microscopy in vivo is tissue motion, which prevents physiological time course observations or image averaging...
  27. pmc Cardiac mitochondrial matrix and respiratory complex protein phosphorylation
    Raul Covian
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Bethesda, Maryland 20817, USA
    Am J Physiol Heart Circ Physiol 303:H940-66. 2012
    ....
  28. pmc Role of mitochondrial Ca2+ in the regulation of cellular energetics
    Brian Glancy
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20817, USA
    Biochemistry 51:2959-73. 2012
    ..Though most specific molecular mechanisms have yet to be elucidated, it is clear that Ca(2+) provides a balanced activation of mitochondrial energy metabolism that exceeds the alteration of dehydrogenases alone...
  29. pmc Mitochondrial NADH fluorescence is enhanced by complex I binding
    Ksenia Blinova
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Biochemistry 47:9636-45. 2008
    ....
  30. ncbi request reprint Stunned, infarcted, and normal myocardium in dogs: simultaneous differentiation by using gadolinium-enhanced cine MR imaging with magnetization transfer contrast
    Clifford R Weiss
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Bldg 10, Rm B1D416, MSC 1061, Bethesda, MD 20892 1061, USA
    Radiology 226:723-30. 2003
    ..To simultaneously differentiate stunned, infarcted, and normal myocardial regions by using gadolinium-enhanced cine magnetic resonance (MR) imaging with magnetization transfer contrast...
  31. ncbi request reprint Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging
    Timothy F Christian
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B1D416, MSC 1061, 10 Center Dr, Bethesda, MD 20892 1061, USA
    Radiology 232:677-84. 2004
    ..To compare fluorescent microsphere measurements of myocardial blood flow (MBF) with qualitative, semiquantitative, and fully quantitative measurements of first-pass perfusion at magnetic resonance (MR) imaging...
  32. pmc The visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle
    Paul D Jobsis
    National Heart, Lung, and Blood Institute, National Institutes of Health, MSC 1061, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 293:H3379-87. 2007
    ..Alterations in this layer may occur in various disease states that effect diastolic function...
  33. pmc Measurement of skeletal muscle perfusion during postischemic reactive hyperemia using contrast-enhanced MRI with a step-input function
    Richard B Thompson
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 54:289-98. 2005
    ..4% from tissue relaxometry studies. Bulk blood flow studies in the same volunteers using phase-contrast velocimetry (popliteal artery) yielded significantly lower flow values, but with a correlation coefficient R2 = 0.62 and P = 0.004...
  34. ncbi request reprint NAD(P)H fluorescence imaging of mitochondrial metabolism in contracting Xenopus skeletal muscle fibers: effect of oxygen availability
    Michael C Hogan
    NHLBI Light Microscopy Facility, National Institutes of Health, 9000 Rockville Pike, Bldg 10 Room B1D 416, Bethesda, MD 20892 1061, USA
    J Appl Physiol 98:1420-6. 2005
    ..These results also demonstrate that although oxygen availability influences the rate of NAD(P)H oxidation, it does not prevent NAD(P)H from being oxidized through the process of oxidative phosphorylation at the onset of contractions...
  35. ncbi request reprint Cardiac energy metabolism homeostasis: role of cytosolic calcium
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute NIH, Building 10, Room B1 D161, Bethesda, MD 20892, USA
    J Mol Cell Cardiol 34:1259-71. 2002
    ..A model of the cardiac energy metabolism control network is proposed that includes a Ca(2+) parallel activation component together with more classical elements including metabolite feedback and cytosolic compartmentation...
  36. pmc NADH enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP): applications to enzyme and mitochondrial reaction kinetics, in vitro
    Frederic Joubert
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1061, USA
    Biophys J 86:629-45. 2004
    ..Initial data support the notion that the NADH regeneration process is far from equilibrium in mitochondria and is potentially controlled by NADH levels as well as several other matrix factors...
  37. doi request reprint Increased oxidative metabolism in the Li-Fraumeni syndrome
    Ping Yuan Wang
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 368:1027-32. 2013
    ..These results suggest that p53 regulates bioenergetic homeostasis in humans. (Funded by the National Heart, Lung, and Blood Institute and the National Institutes of Health; ClinicalTrials.gov number, NCT00406445.)...
  38. pmc The renal artery ostium flow diverter: structure and potential role in atherosclerosis
    Edward B Neufeld
    Laboratory of Cardiac Energetics, NHLBI, NIH, Bethesda, MD 20892, United States
    Atherosclerosis 211:153-8. 2010
    ..We propose that the rigid macromolecular structure of the renal artery ostium diverter is required for its vascular function and contributes to the initiation of renal atherosclerosis by the retention of LDL...
  39. ncbi request reprint Enzyme-dependent fluorescence recovery after photobleaching of NADH: in vivo and in vitro applications to the study of enzyme kinetics
    Christian A Combs
    Light Microscopy Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Enzymol 385:257-86. 2004
  40. pmc In vivo study of microcirculation in canine myocardium using the IVIM method
    Virginie Callot
    Laboratory of Cardiac Energetics, NHLBI, NIH, Bethesda, Maryland 20892, USA
    Magn Reson Med 50:531-40. 2003
    ..With vasodilatation by adenosine infusion, a 25% increase in the VVF and a 7% increase in the mean microflow velocity were observed, while no change in the ADC was detected. A 28.5% decrease of the ADC was observed postmortem...
  41. ncbi request reprint Contribution of mitochondria to cardiac muscle water/macromolecule proton magnetization transfer
    Kathleen Ward
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20817, USA
    Magn Reson Med 50:1312-6. 2003
    ..The current data indicate that mitochondria macromolecules contribute significantly to MT in the intact heart...
  42. pmc Multi-photon excitation microscopy in intact animals
    Emily C Rothstein
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Human Health Services, Bethesda, MD 20892, USA
    J Microsc 222:58-64. 2006
    ..The remaining most significant issue for physiological studies using this approach is motion on the micrometre scale. Several strategies for motion compensation are described and discussed...
  43. pmc Skeletal muscle NAD(P)H two-photon fluorescence microscopy in vivo: topology and optical inner filters
    Emily C Rothstein
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Human Health Services, Bldg 10, Rm B1D416, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Biophys J 88:2165-76. 2005
    ..These data demonstrate the feasibility, and highlight the complexity, of using NAD(P)H TPEFM in skeletal muscle to characterize the topology and metabolic function of mitochondria within the living mouse...
  44. pmc Limited utility of acetoxymethyl (AM)-based intracellular delivery systems, in vivo: interference by extracellular esterases
    Paul D Jobsis
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Bethesda, Maryland 20892, USA
    J Microsc 226:74-81. 2007
    ..Different approaches to trapping exogenous probes will need to be explored for physiological studies using intravital microscopy...
  45. pmc Optical spectroscopy in turbid media using an integrating sphere: Mitochondrial chromophore analysis during metabolic transitions
    David J Chess
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA Electronic address
    Anal Biochem 439:161-72. 2013
    ..Surprisingly, I/R resulted in an inhibition of all measured MOPC conductances, suggesting a coordinated down-regulation of mitochondrial activity with this well-established cardiac perturbation. ..
  46. ncbi request reprint Automatic assessment of dynamic contrast-enhanced MRI in an ischemic rat hindlimb model: an exploratory study of transplanted multipotent progenitor cells
    Li Yueh Hsu
    National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    NMR Biomed 21:111-9. 2008
    ..The differences were primarily determined by late contrast enhancement of PBS-treated limbs. These computerized methods appear promising for assessing perfusion and late enhancement in dynamic contrast-enhanced MRI...
  47. pmc Protein composition and function of red and white skeletal muscle mitochondria
    Brian Glancy
    National Heart, Lung, and Blood Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Am J Physiol Cell Physiol 300:C1280-90. 2011
    ..These data suggest that metabolic demand differences between red and white muscle fibers are primarily matched by the number of mitochondria and not by significant alterations in the mitochondria themselves...
  48. ncbi request reprint A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in Type 2 diabetes mellitus
    Ines Pagel-Langenickel
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1454, USA
    Am J Physiol Heart Circ Physiol 293:H2659-66. 2007
    ..It remains to be determined whether longer-term insulin sensitization therapy with rosiglitazone will augment skeletal muscle mitochondrial bioenergetics in those diabetic subjects with relatively preserved basal aerobic capacity...
  49. ncbi request reprint Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
    ..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging...
  50. ncbi request reprint Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells
    Kathleen A Hinds
    Hematology Branch, Laboratory of Molecular Biology, Laboratory National Heart, Lung, and Blood Institute NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:867-72. 2003
    ..MRI studies could detect labeled CD34+ cells and mesenchymal stem cells (MSCs) at single cell resolution. This appears to be a promising tool for serial noninvasive monitoring of in vivo cell homing and localization using MRI...
  51. ncbi request reprint Does binding of Gd-DTPA to myocardial tissue contribute to late enhancement in a model of acute myocardial infarction?
    Ulrich K M Decking
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 49:168-71. 2003
    ..The data from this acute myocardial infarction model do not support the notion that Gd-DTPA binding in the early stages of myocardial damage contributes to delayed enhancement...
  52. pmc A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos
    Yong Ou Kim
    Laboratory Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:159-64. 2004
    ..Together, these studies not only identify key regulators but also reveal mechanisms underlying heart development...
  53. ncbi request reprint Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging
    Raymond Y Kwong
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 107:531-7. 2003
    ..Managing chest pain in the emergency department remains a challenge with current diagnostic strategies. We hypothesized that cardiac MRI could accurately identify patients with possible or probable acute coronary syndrome...
  54. ncbi request reprint Multislice first-pass cardiac perfusion MRI: validation in a model of myocardial infarction
    Frederick H Epstein
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Magn Reson Med 47:482-91. 2002
    ..Additionally, analysis of myocardial time-intensity curves (TICs) indicated that 15.8 +/- 6 sectors, corresponding to 260 microl of endocardium, can be analyzed (R(2) > 0.95)...
  55. ncbi request reprint Fluorescence absorbance inner-filter decomposition: the role of emission shape on estimates of free Ca(2+) using Rhod-2
    Paul R Territo
    Lilly Center for Molecular and Anatomical Imaging, Lilly Research Laboratories, Eli Lilly and Company, 2001 West Main Street, B220 GL54, Greenfield, Indiana 46140, USA
    Appl Spectrosc 61:138-47. 2007
    ..These data demonstrate that secondary inner-filter correction can significantly improve spectral decomposition of complex emission spectra, which are used in a variety of biological applications...
  56. ncbi request reprint High-resolution imaging reveals a limit in spatial resolution of blood flow measurements by microspheres
    Ulrich K M Decking
    Department of Cardiovascular Physiology, Heinrich Heine University, 40225 Dusseldorf, Germany
    Am J Physiol Heart Circ Physiol 287:H1132-40. 2004
    ..We propose that at high spatial resolution (<2 microl) structural aspects of the vascular network dominate microsphere distribution, resulting in the organized patterns observed...
  57. ncbi request reprint Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice
    Pradeep P A Mammen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8573, USA
    Am J Physiol Heart Circ Physiol 285:H2132-41. 2003
    ..These new data establish that myoglobin is an important cytoplasmic cardiac hemoprotein that functions in regulating NO homeostasis within cardiomyocytes...
  58. pmc Contribution of macromolecular structure to the retention of low-density lipoprotein at arterial branch points
    Gina P Kwon
    Hughes Medical Institute, Chevy Chase, MD, USA
    Circulation 117:2919-27. 2008
    ..In this study, we characterized the submicron microstructure of arterial wall collagen and elastin to evaluate its potential role in regional LDL deposition...