Vladimir K Bakalov

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency
    Vladimir K Bakalov
    Section on Epigenetics and Development, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, 10 Center Dr CRC 1 3330 Bethesda, MD 20892 1103, USA
    J Autoimmun 38:315-21. 2012
  2. ncbi request reprint Selective reduction in cortical bone mineral density in turner syndrome independent of ovarian hormone deficiency
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:5717-22. 2003
  3. pmc X-chromosome gene dosage and the risk of diabetes in Turner syndrome
    Vladimir K Bakalov
    National Institute of Child Health and Human Development, Clinical Research Center, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:3289-96. 2009
  4. pmc Uterine development in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Pediatr 151:528-31, 531.e1. 2007
  5. ncbi request reprint Growth hormone therapy and bone mineral density in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:4886-9. 2004
  6. pmc Growth hormone treatment and left ventricular dimensions in Turner syndrome
    Lea Ann Matura
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Pediatr 150:587-91. 2007
  7. pmc Bicuspid aortic valve and aortic coarctation are linked to deletion of the X chromosome short arm in Turner syndrome
    Carolyn Bondy
    Section on Epigenetics and Development, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Med Genet 50:662-5. 2013
  8. ncbi request reprint Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women
    Emily C Corrigan
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Menopause 13:911-6. 2006
  9. ncbi request reprint Bone mineral density and fractures in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health, Bethesda, Maryland 20892, USA
    Am J Med 115:259-64. 2003
  10. pmc Reduced abdominal adiposity and improved glucose tolerance in growth hormone-treated girls with Turner syndrome
    Nicole Wooten
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:2109-14. 2008

Collaborators

Detail Information

Publications35

  1. pmc Autoimmune disorders in women with turner syndrome and women with karyotypically normal primary ovarian insufficiency
    Vladimir K Bakalov
    Section on Epigenetics and Development, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, 10 Center Dr CRC 1 3330 Bethesda, MD 20892 1103, USA
    J Autoimmun 38:315-21. 2012
    ..The absence of a normal second X-chromosome further contributes to increased autoimmunity in TS...
  2. ncbi request reprint Selective reduction in cortical bone mineral density in turner syndrome independent of ovarian hormone deficiency
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:5717-22. 2003
    ..We conclude that there is a selective deficiency in forearm cortical bone in TS that appears independent of ovarian hormone exposure and is probably related to X-chromosome gene(s) haploinsufficiency...
  3. pmc X-chromosome gene dosage and the risk of diabetes in Turner syndrome
    Vladimir K Bakalov
    National Institute of Child Health and Human Development, Clinical Research Center, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 94:3289-96. 2009
    ..Turner syndrome (TS) is caused by the absence or fragmentation of the second sex chromosome. An increased risk of diabetes mellitus (DM) has consistently been noted, but the specific phenotype and genetic etiology of this trait are unknown...
  4. pmc Uterine development in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    J Pediatr 151:528-31, 531.e1. 2007
    ..To evaluate uterine development of women with Turner syndrome (TS) receiving conventional medical care...
  5. ncbi request reprint Growth hormone therapy and bone mineral density in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:4886-9. 2004
    ..Furthermore, regression analysis in a linear model including independent variables of age, age at diagnosis, body mass index, presence of spontaneous puberty, and GH use confirmed that GH use did not contribute to variation in BMD...
  6. pmc Growth hormone treatment and left ventricular dimensions in Turner syndrome
    Lea Ann Matura
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Pediatr 150:587-91. 2007
    ..To determine whether cardiac dimensions were different in girls with Turner syndrome (TS) who received growth hormone (GH) compared with those who did not receive GH...
  7. pmc Bicuspid aortic valve and aortic coarctation are linked to deletion of the X chromosome short arm in Turner syndrome
    Carolyn Bondy
    Section on Epigenetics and Development, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    J Med Genet 50:662-5. 2013
    ..Haploinsufficiency for gene(s) located on Xp have been implicated in the short stature characteristic of the syndrome, but the chromosomal region related to the CHD phenotype has not been established...
  8. ncbi request reprint Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women
    Emily C Corrigan
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Menopause 13:911-6. 2006
    ..It remains unclear whether these changes are due primarily to ovarian failure or aging. The aim of this study was to clarify the impact of ovarian failure on body composition and insulin sensitivity in young women...
  9. ncbi request reprint Bone mineral density and fractures in Turner syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health, Bethesda, Maryland 20892, USA
    Am J Med 115:259-64. 2003
    ..To determine whether women with Turner syndrome who were treated with estrogen were more likely to have osteoporosis and fractures...
  10. pmc Reduced abdominal adiposity and improved glucose tolerance in growth hormone-treated girls with Turner syndrome
    Nicole Wooten
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:2109-14. 2008
    ..Individuals with Turner syndrome (TS) are at increased risk for impaired glucose tolerance and diabetes mellitus. It is unknown whether pharmacological GH treatment commonly used to treat short stature in TS alters this risk...
  11. ncbi request reprint Prolongation of the cardiac QTc interval in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Medicine (Baltimore) 85:75-81. 2006
    ....
  12. ncbi request reprint Prolonged rate-corrected QT interval and other electrocardiogram abnormalities in girls with Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Building 10 CRC, Room 1 3330, Bethesda, MD 20892 1103, USA
    Pediatrics 118:e1220-5. 2006
    ..We recently reported that electrocardiographic abnormalities are common in adults with monosomy X (Turner syndrome), but this issue has not been investigated in girls with Turner syndrome...
  13. ncbi request reprint The effects of growth hormone treatment on bone mineral density and body composition in girls with turner syndrome
    Mim Ari
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20892, USA
    J Clin Endocrinol Metab 91:4302-5. 2006
    ..Many girls with Turner syndrome (TS) are treated with GH to increase adult height. In addition to promoting longitudinal bone growth, GH has effects on bone and body composition...
  14. ncbi request reprint Testosterone deficiency in young women with 46,XX spontaneous premature ovarian failure
    Sophia N Kalantaridou
    Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 86:1475-82. 2006
    ..To determine whether women with 46,XX spontaneous premature ovarian failure have lower serum free-T levels than do control women...
  15. ncbi request reprint Growth hormone treatment and aortic dimensions in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 91:1785-8. 2006
    ..In recent years many girls with Turner syndrome (TS) have been treated with supraphysiological doses of GH to increase adult height. In addition to promoting statural growth, GH may have direct effects on the cardiovascular system...
  16. ncbi request reprint Impaired insulin secretion in the Turner metabolic syndrome
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10 10N262, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 89:3516-20. 2004
    ....
  17. ncbi request reprint Perturbation of the transforming growth factor β system in Turner syndrome
    Jian Zhou
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Beijing Da Xue Xue Bao 44:720-4. 2012
    ..To measure components of the circulating transforming growth factor β (TGFβ) system in patients with Turner syndrome (TS) compared to relevant controls and to ascertain correlation with endocrine and cardiovascular parameters...
  18. ncbi request reprint Trends in GH use in a Turner syndrome natural history study
    Liat Gutin
    Section on Epigenetics and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    Pediatr Endocrinol Rev 9:725-7. 2012
    ..Further studies on the socioeconomic factors implicated in patterns of GH use and non-use for girls with TS are needed to illuminate this important issue...
  19. ncbi request reprint Investigation of cardiac status and bone mineral density in Turner syndrome
    Carolyn A Bondy
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, CRC 1 3330, 10 Center Dr, National Institutes of Health, Bethesda, MD 20892, USA
    Growth Horm IGF Res 16:S103-8. 2006
    ..Therefore, judicious management of estrogen therapy to prevent osteoporosis while minimizing estrogen-associated adverse events is a challenging aspect of care for girls and women with TS...
  20. pmc Otolaryngologic markers for the early diagnosis of Turner syndrome
    Tomoko Makishima
    Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850 3320, USA
    Int J Pediatr Otorhinolaryngol 73:1564-7. 2009
    ..To identify and characterize otolaryngologic markers for the early diagnosis of Turner syndrome (TS)...
  21. ncbi request reprint Analysis of auditory phenotype and karyotype in 200 females with Turner syndrome
    Kelly A King
    Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ear Hear 28:831-41. 2007
    ..The purpose of this study was to describe the auditory phenotype in a large group of individuals with Turner Syndrome, with analysis focusing on hearing loss and age, as well as the phenotypic relationship to karyotype variation...
  22. pmc N-terminal pro-brain natriuretic peptide levels and aortic diameters
    Liat S Gutin
    Section on Epigenetics and Development, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Am Heart J 164:419-24. 2012
    ..To better understand the pathology and develop tools to monitor the risk of aortic disease, we investigated N-terminal pro-brain natriuretic peptide (BNP) (NT-proBNP) levels in women with TS and healthy female controls...
  23. ncbi request reprint Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure
    Vladimir K Bakalov
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Fertil Steril 84:958-65. 2005
    ..To assess the association between serum adrenal cortex autoantibodies and histologically confirmed autoimmune lymphocytic oophoritis...
  24. ncbi request reprint Monosomy for the X-chromosome is associated with an atherogenic lipid profile
    Phillip L Van
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 91:2867-70. 2006
    ..To determine whether X-chromosomal gene dosage affects lipid metabolism independent of sex steroid effects, we compared lipid profiles in age- and body mass-matched young women with ovarian failure, differing only in X-chromosome dosage...
  25. ncbi request reprint Major vascular anomalies in Turner syndrome: prevalence and magnetic resonance angiographic features
    Vincent B Ho
    Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Circulation 110:1694-700. 2004
    ..To better understand the prevalence and pathogenesis of cardiovascular defects in TS, we prospectively evaluated a group of asymptomatic adult volunteers with TS using magnetic resonance (MR) angiography...
  26. doi request reprint Fracture risk and bone mineral density in Turner syndrome
    Vladimir K Bakalov
    National Institute of Child Health and Human Development, Bethesda, MD, USA
    Rev Endocr Metab Disord 9:145-51. 2008
    ..In addition, other measures to prevent fall and trauma should be considered, including optimizing hearing and vision, avoiding contact sports and exercise to improve coordination...
  27. ncbi request reprint The physical phenotype of girls and women with Turner syndrome is not X-imprinted
    Carolyn A Bondy
    Chief Developmental Endocrinology Branch, National Institute of Child Health, NIH, Bethesda, MD 20982, USA
    Hum Genet 121:469-74. 2007
    ..We did demonstrate a selective maternal effect on final stature that was independent of X-chromosome origin, suggesting potential autosomal imprinting effects on growth revealed by X monosomy...
  28. pmc High levels of education and employment among women with Turner syndrome
    Harley N Gould
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Womens Health (Larchmt) 22:230-5. 2013
    ..In this study we evaluated the influence of adult height and parental origin of the single X chromosome on education, employment, and marital outcomes among women with TS...
  29. ncbi request reprint Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans?
    Ilia J Elenkov
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1737-45. 2008
    ....
  30. ncbi request reprint Mechanisms of follicular dysfunction in 46,XX spontaneous premature ovarian failure
    Lawrence M Nelson
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10N262, Bethesda, MD 20892 1862, USA
    Endocrinol Metab Clin North Am 32:613-37. 2003
    ..With appropriate medical management and emotional support provided by a sensitive clinician, most young women with 46,XX spontaneous premature ovarian failure will lead happy, healthy, and fulfilling lives...
  31. ncbi request reprint Deficient medical care for adults with the Turner syndrome
    Carolyn Bondy
    Ann Intern Med 145:866-7. 2006
  32. ncbi request reprint The prevalence of diabetes mellitus in the parents of women with Turner's syndrome
    Vladimir K Bakalov
    Clin Endocrinol (Oxf) 60:272. 2004
  33. ncbi request reprint Declining estrogen use in young women with Turner syndrome
    Carolyn A Bondy
    Arch Intern Med 166:1322. 2006
  34. ncbi request reprint Maternal X chromosome, visceral adiposity, and lipid profile
    Phillip L Van
    JAMA 295:1373-4. 2006
  35. ncbi request reprint Association between fetal lymphedema and congenital cardiovascular defects in Turner syndrome
    Melissa L Loscalzo
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 115:732-5. 2005
    ..The objective of this study was to determine whether there is a specific association between a history of fetal lymphedema and CCVDs in monosomy X, or TS, independent of karyotype or general severity of the phenotype...