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Genomes and GenesSpecies | Subash BabuSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Immunopathogenesis of lymphatic filarial diseaseSubash Babu
NIRT ICER, Chennai, India
Semin Immunopathol 34:847-61. 2012....- Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-κB-dependent regulation of angiogenic growth factors in filarial lymphatic pathologySubash Babu
National Institutes of Health International Center for Excellence in Research, Chennai, India
Infect Immun 80:2509-18. 2012..Our data therefore strongly suggest an important association between TLR signaling and lymphangiogenesis in the development of pathology in human lymphatic filariasis... - Glucose challenge increases circulating progenitor cells in Asian Indian male subjects with normal glucose tolerance which is compromised in subjects with pre-diabetes: A pilot studyAbel A Nathan
Laboratory of Vascular Biology, Department of Biotechnology, Indian Institute of Technology Madras IIT Madras, Chennai, India
BMC Endocr Disord 11:2. 2011..abstract:.. - Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapySubash Babu
National Institutes of Health International Center for Excellence in Research, Chennai, India
PLoS Negl Trop Dis 3:e489. 2009.... - Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test resultsSubash Babu
National Institutes of Health International Center for Excellence in Research, India
J Infect Dis 201:20-31. 2010..The factors governing latency in tuberculosis are not well understood but appear to involve both the pathogen and the host. We have used tuberculin skin test (TST) positivity as a tool to study cytokine responses in latent tuberculosis... - Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1Subash Babu
National Institutes of Health International Center for Excellence in Research, India
J Infect Dis 200:288-98. 2009.... - Alternatively activated and immunoregulatory monocytes in human filarial infectionsSubash Babu
National Institutes of Health International Center for Excellence in Research, Chennai, India
J Infect Dis 199:1827-37. 2009..Monocytes/macrophages from filaria-infected animals exhibit an alternatively activated phenotype; however, very little is known about the alternative activation phenotype of monocytes in human filarial infection... - Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cellsSubash Babu
National Institutes of Health International Center for Excellence in Research, Chennai, India
PLoS Negl Trop Dis 3:e420. 2009..Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients... - Filarial lymphatic pathology reflects augmented toll-like receptor-mediated, mitogen-activated protein kinase-mediated proinflammatory cytokine productionSubash Babu
International Center for Excellence in Research, National Institutes of Health, Chennai, India
Infect Immun 79:4600-8. 2011..Our data, therefore, strongly suggest an important role for TLR2- and TLR9-mediated proinflammatory cytokine induction and activation of both the MAPK and NF-κB pathways in the development of pathology in human lymphatic filariasis... - Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121)Vivekanandhan Aravindhan
Laboratory of Molecular Immunology, AU KBC Research Centre, Anna University, Chennai, India
Am J Trop Med Hyg 86:828-33. 2012..In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population... - Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial diseaseR Anuradha
National Institutes of Health, International Center for Excellence in Research, Chennai, India
PLoS Pathog 8:e1002749. 2012.... - Decreased prevalence of lymphatic filariasis among diabetic subjects associated with a diminished pro-inflammatory cytokine response (CURES 83)Vivekanandhan Aravindhan
Madras Diabetes Research Foundation, Chennai, India
PLoS Negl Trop Dis 4:e707. 2010.... 
IL-10 dependent suppression of type 1, type 2 and type 17 cytokines in active pulmonary tuberculosisNathella Pavan Kumar
National Institutes of Health International Center for Excellence in Research, Chennai, India National Institute for Research in Tuberculosis, Chennai, India
PLoS ONE 8:e59572. 2013....- Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial diseaseRajamanickam Anuradha
National Institutes of Health International Center for Excellence in Research, Chennai, India
PLoS Negl Trop Dis 6:e1681. 2012..Homeostatic as well as inflammation-induced balance between MMPs and TIMPs is considered critical in mediating tissue pathology... - Increased levels of both Th1 and Th2 cytokines in subjects with metabolic syndrome (CURES-103)Jayagopi Surendar
Madras Diabetes Research Foundation, Chennai, India
Diabetes Technol Ther 13:477-82. 2011..The aim of the study was to look at the T-helper (Th) 1 (interleukin [IL]-12, IL-2, and interferon-γ [IFN-γ]) and Th2 (IL-4, IL-5, and IL-13) cytokines in MS in the high-risk Asian Indian population... - Suppressed type 1, type 2, and type 17 cytokine responses in active tuberculosis in childrenN Pavan Kumar
NIH ICER, Chetpet, Chennai 600031, India
Clin Vaccine Immunol 18:1856-64. 2011.... - Immune complexes isolated from patients with pulmonary tuberculosis modulate the activation and function of normal granulocytesP Senbagavalli
National Institutes of Health International Center for Excellence in Research, Chennai, India
Clin Vaccine Immunol 19:1965-71. 2012..Thus, ICs from patients with TB exhibit a profound effect on granulocyte function with activation of certain effector mechanisms and dampening of others... - Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patientsSwetha Sundararajan
Dept of Immunology, National Institute for Research in Tuberculosis, Chennai, India
Hum Immunol 73:985-91. 2012..A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-γ in NTB PF was observed. This study implicates the possible usage of MMPs as bio-markers aiding diagnosis in TB pleuritis... - Increased levels of serum granulocyte-macrophage colony-stimulating factor is associated with activated peripheral dendritic cells in type 2 diabetes subjects (CURES-99)Jayagopi Surendar
Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialties Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, International Diabetes Federation Centre for Education, Chennai, India
Diabetes Technol Ther 14:344-9. 2012..In the present study, serum GM-CSF levels and the activation status of DCs were studied in type 2 diabetes mellitus (T2DM) subjects... 
Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulationSubash Babu
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892, USA
J Immunol 175:1170-6. 2005..The diminished expression and function of TLR is thus a likely consequence of chronic Ag stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in filariasis...- Chemokine receptors of T cells and of B cells in lymphatic filarial infection: a role for CCR9 in pathogenesisSubash Babu
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 191:1018-26. 2005..These results suggest that chemokine receptors (particularly CCR9) are involved in the pathogenesis of lymphatic filarial disease and that trafficking of particular cellular subsets may influence clinical outcome... - Filarial parasites induce NK cell activation, type 1 and type 2 cytokine secretion, and subsequent apoptotic cell deathSubash Babu
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:2445-56. 2007.... - Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infectionSubash Babu
Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 176:3885-9. 2006..Thus, diminished expression and function of T cell TLR is a novel mechanism underlying T cell immune tolerance in lymphatic filariasis... - Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistenceSubash Babu
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 176:3248-56. 2006..Hence, we conclude that a profound impairment of live parasite-specific Th1 and Th2 immune responses occurs in lymphatic filariasis that is governed at the transcriptional level by a complex interplay of inhibitory mediators... - Transcriptional control of impaired Th1 responses in patent lymphatic filariasis by T-box expressed in T cells and suppressor of cytokine signaling genesSubash Babu
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, 4 Center Drive, Room 4 B1 05, Bethesda, MD 20892 0425, USA
Infect Immun 73:3394-401. 2005..Our data therefore indicate that the impaired Th1 responses observed in patent lymphatic filariasis are associated with decreased expression of T-bet, SOCS-1, SOCS-5, and SOCS-7 and increased expression of SOCS-3 in T cells... - Circulating biomarkers of pulmonary and extrapulmonary tuberculosis in childrenNathella Pavan Kumar
National Institutes of Health International Center for Excellence in Research, Chennai, India
Clin Vaccine Immunol 20:704-11. 2013..Thus, pediatric TB is characterized by elevated levels of a variety of biomarkers at homeostasis, suggesting that these responses may play a crucial role in disease pathogenesis... - Evidence of microbial translocation associated with perturbations in T cell and antigen-presenting cell homeostasis in hookworm infectionsPalakkal Jovvian George
National Institutes of Health, International Center for Excellence in Research, Chennai, India
PLoS Negl Trop Dis 6:e1830. 2012..MT is a common cause of systemic immune activation in HIV infection and is associated with reduced frequencies of CD4(+) T cells; no data exist, however, on the role of MT in intestinal helminth infections... - Recombinant Brugia malayi pepsin inhibitor (rBm33) induced monocyte function and absence of apoptotic cell death: an in vitro studyKirthika Sreenivas
Centre for Biotechnology, Anna University, S P Road, Guindy, Chennai, Tamil Nadu 600025, India
Microb Pathog 53:19-27. 2012..These observations suggest that rBm33 stimulates macrophages to induce Th1 response and does not promote apoptosis... - Expansion of pathogen-specific mono- and multifunctional Th1 and Th17 cells in multi-focal tuberculous lymphadenitisNathella Pavan Kumar
National Institutes of Health International Center for Excellence in Research, Chennai, India
PLoS ONE 8:e57123. 2013..Th1 and Th17 responses are known to play an important role in immunity to pulmonary tuberculosis (PTB), although little is known about their role in extrapulmonary forms of tuberculosis (TB)... - Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasisPrakash Senbagavalli
National Institutes of Health International Center for Excellence in Research, Chennai, India
Am J Trop Med Hyg 85:89-96. 2011..Thus, CIC-mediated enhanced granulocyte activation and modulation of complement function are important features of filarial infection and disease... - Decreased prevalence of lymphatic filariasis among subjects with type-1 diabetesVivekanandhan Aravindhan
Laboratory of Molecular Immunology, Anna University K B Chandrashekar Research Centre, Chennai, India
Am J Trop Med Hyg 83:1336-9. 2010..001). Thus, there appears to be a striking inverse relationship between the prevalence of LF and T1DM in southern India...