Subash Babu

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Immunopathogenesis of lymphatic filarial disease
    Subash Babu
    NIRT ICER, Chennai, India
    Semin Immunopathol 34:847-61. 2012
  2. pmc Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-κB-dependent regulation of angiogenic growth factors in filarial lymphatic pathology
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    Infect Immun 80:2509-18. 2012
  3. pmc Glucose challenge increases circulating progenitor cells in Asian Indian male subjects with normal glucose tolerance which is compromised in subjects with pre-diabetes: A pilot study
    Abel A Nathan
    Laboratory of Vascular Biology, Department of Biotechnology, Indian Institute of Technology Madras IIT Madras, Chennai, India
    BMC Endocr Disord 11:2. 2011
  4. pmc Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test results
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, India
    J Infect Dis 201:20-31. 2010
  5. pmc Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapy
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    PLoS Negl Trop Dis 3:e489. 2009
  6. pmc Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, India
    J Infect Dis 200:288-98. 2009
  7. pmc Alternatively activated and immunoregulatory monocytes in human filarial infections
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    J Infect Dis 199:1827-37. 2009
  8. pmc Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    PLoS Negl Trop Dis 3:e420. 2009
  9. pmc Filarial lymphatic pathology reflects augmented toll-like receptor-mediated, mitogen-activated protein kinase-mediated proinflammatory cytokine production
    Subash Babu
    International Center for Excellence in Research, National Institutes of Health, Chennai, India
    Infect Immun 79:4600-8. 2011
  10. pmc Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121)
    Vivekanandhan Aravindhan
    Laboratory of Molecular Immunology, AU KBC Research Centre, Anna University, Chennai, India
    Am J Trop Med Hyg 86:828-33. 2012

Collaborators

  • Vivekanandhan Aravindhan
  • T B Nutman
  • Viswanathan Mohan
  • Sulochana D Das
  • Michael P Fay
  • Nathella Pavan Kumar
  • Rajamanickam Anuradha
  • R Anuradha
  • V Kumaraswami
  • Jayagopi Surendar
  • Parakkal Jovvian George
  • Vasanthapuram Kumaraswami
  • N Pavan Kumar
  • Luke E Hanna
  • Mohideen S Jawahar
  • Rathinam Sridhar
  • Vaithilingam V Banurekha
  • Vedachalam Chandrasekaran
  • Palakkal Jovvian George
  • R Ganesh
  • Swetha Sundararajan
  • Nathella Pavankumar
  • Kirthika Sreenivas
  • Janani Shankar
  • P Senbagavalli
  • Abel A Nathan
  • Prakash Senbagavalli
  • Dina Nair
  • N Suresh
  • Bruno B Andrade
  • Paramasivam Paul Kumaran
  • Paul Kumaran
  • Venugopal Gopinath
  • P Jovvian George
  • Rangarajan Badri Narayanan
  • V D Ramanathan
  • Kamalakannan Vijayan
  • Jovvian P George
  • J Nancy Hilda
  • R Suresh
  • Maradana Muralidhara Rao
  • Vadakkuppattu D Ramanathan
  • Soumi Bairagi
  • Madhulika Dixit

Detail Information

Publications33

  1. pmc Immunopathogenesis of lymphatic filarial disease
    Subash Babu
    NIRT ICER, Chennai, India
    Semin Immunopathol 34:847-61. 2012
    ....
  2. pmc Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-κB-dependent regulation of angiogenic growth factors in filarial lymphatic pathology
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    Infect Immun 80:2509-18. 2012
    ..Our data therefore strongly suggest an important association between TLR signaling and lymphangiogenesis in the development of pathology in human lymphatic filariasis...
  3. pmc Glucose challenge increases circulating progenitor cells in Asian Indian male subjects with normal glucose tolerance which is compromised in subjects with pre-diabetes: A pilot study
    Abel A Nathan
    Laboratory of Vascular Biology, Department of Biotechnology, Indian Institute of Technology Madras IIT Madras, Chennai, India
    BMC Endocr Disord 11:2. 2011
    ..abstract:..
  4. pmc Regulatory T cells modulate Th17 responses in patients with positive tuberculin skin test results
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, India
    J Infect Dis 201:20-31. 2010
    ..The factors governing latency in tuberculosis are not well understood but appear to involve both the pathogen and the host. We have used tuberculin skin test (TST) positivity as a tool to study cytokine responses in latent tuberculosis...
  5. pmc Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapy
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    PLoS Negl Trop Dis 3:e489. 2009
    ....
  6. pmc Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, India
    J Infect Dis 200:288-98. 2009
    ....
  7. pmc Alternatively activated and immunoregulatory monocytes in human filarial infections
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    J Infect Dis 199:1827-37. 2009
    ..Monocytes/macrophages from filaria-infected animals exhibit an alternatively activated phenotype; however, very little is known about the alternative activation phenotype of monocytes in human filarial infection...
  8. pmc Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    PLoS Negl Trop Dis 3:e420. 2009
    ..Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients...
  9. pmc Filarial lymphatic pathology reflects augmented toll-like receptor-mediated, mitogen-activated protein kinase-mediated proinflammatory cytokine production
    Subash Babu
    International Center for Excellence in Research, National Institutes of Health, Chennai, India
    Infect Immun 79:4600-8. 2011
    ..Our data, therefore, strongly suggest an important role for TLR2- and TLR9-mediated proinflammatory cytokine induction and activation of both the MAPK and NF-κB pathways in the development of pathology in human lymphatic filariasis...
  10. pmc Effect of filarial infection on serum inflammatory and atherogenic biomarkers in coronary artery disease (CURES-121)
    Vivekanandhan Aravindhan
    Laboratory of Molecular Immunology, AU KBC Research Centre, Anna University, Chennai, India
    Am J Trop Med Hyg 86:828-33. 2012
    ..In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population...
  11. pmc Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease
    R Anuradha
    National Institutes of Health, International Center for Excellence in Research, Chennai, India
    PLoS Pathog 8:e1002749. 2012
    ....
  12. pmc IL-4-, TGF-β-, and IL-1-Dependent Expansion of Parasite Antigen-Specific Th9 Cells Is Associated with Clinical Pathology in Human Lymphatic Filariasis
    Rajamanickam Anuradha
    National Institutes of Health International Center for Excellence in Research, Chennai 600031, India
    J Immunol 191:2466-73. 2013
    ....
  13. pmc Modulation of mycobacterial-specific Th1 and th17 cells in latent tuberculosis by coincident hookworm infection
    Parakkal Jovvian George
    National Institutes of Health International Center for Excellence in Research, Chennai 600031, India
    J Immunol 190:5161-8. 2013
    ..Thus, coincident hookworm infection exerts a profound inhibitory effect on protective Th1 and Th17 responses in LTB and may predispose toward the development of active tuberculosis in humans...
  14. pmc Decreased prevalence of lymphatic filariasis among diabetic subjects associated with a diminished pro-inflammatory cytokine response (CURES 83)
    Vivekanandhan Aravindhan
    Madras Diabetes Research Foundation, Chennai, India
    PLoS Negl Trop Dis 4:e707. 2010
    ....
  15. pmc IL-10 dependent suppression of type 1, type 2 and type 17 cytokines in active pulmonary tuberculosis
    Nathella Pavan Kumar
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    PLoS ONE 8:e59572. 2013
    ....
  16. pmc Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease
    Rajamanickam Anuradha
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    PLoS Negl Trop Dis 6:e1681. 2012
    ..Homeostatic as well as inflammation-induced balance between MMPs and TIMPs is considered critical in mediating tissue pathology...
  17. doi request reprint Increased levels of both Th1 and Th2 cytokines in subjects with metabolic syndrome (CURES-103)
    Jayagopi Surendar
    Madras Diabetes Research Foundation, Chennai, India
    Diabetes Technol Ther 13:477-82. 2011
    ..The aim of the study was to look at the T-helper (Th) 1 (interleukin [IL]-12, IL-2, and interferon-γ [IFN-γ]) and Th2 (IL-4, IL-5, and IL-13) cytokines in MS in the high-risk Asian Indian population...
  18. pmc Suppressed type 1, type 2, and type 17 cytokine responses in active tuberculosis in children
    N Pavan Kumar
    NIH ICER, Chetpet, Chennai 600031, India
    Clin Vaccine Immunol 18:1856-64. 2011
    ....
  19. pmc Immune complexes isolated from patients with pulmonary tuberculosis modulate the activation and function of normal granulocytes
    P Senbagavalli
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    Clin Vaccine Immunol 19:1965-71. 2012
    ..Thus, ICs from patients with TB exhibit a profound effect on granulocyte function with activation of certain effector mechanisms and dampening of others...
  20. pmc Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients
    Swetha Sundararajan
    Dept of Immunology, National Institute for Research in Tuberculosis, Chennai, India
    Hum Immunol 73:985-91. 2012
    ..A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-γ in NTB PF was observed. This study implicates the possible usage of MMPs as bio-markers aiding diagnosis in TB pleuritis...
  21. doi request reprint Increased levels of serum granulocyte-macrophage colony-stimulating factor is associated with activated peripheral dendritic cells in type 2 diabetes subjects (CURES-99)
    Jayagopi Surendar
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialties Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, International Diabetes Federation Centre for Education, Chennai, India
    Diabetes Technol Ther 14:344-9. 2012
    ..In the present study, serum GM-CSF levels and the activation status of DCs were studied in type 2 diabetes mellitus (T2DM) subjects...
  22. pmc Transcriptional control of impaired Th1 responses in patent lymphatic filariasis by T-box expressed in T cells and suppressor of cytokine signaling genes
    Subash Babu
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, 4 Center Drive, Room 4 B1 05, Bethesda, MD 20892 0425, USA
    Infect Immun 73:3394-401. 2005
    ..Our data therefore indicate that the impaired Th1 responses observed in patent lymphatic filariasis are associated with decreased expression of T-bet, SOCS-1, SOCS-5, and SOCS-7 and increased expression of SOCS-3 in T cells...
  23. ncbi request reprint Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation
    Subash Babu
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892, USA
    J Immunol 175:1170-6. 2005
    ..The diminished expression and function of TLR is thus a likely consequence of chronic Ag stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in filariasis...
  24. ncbi request reprint Chemokine receptors of T cells and of B cells in lymphatic filarial infection: a role for CCR9 in pathogenesis
    Subash Babu
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 191:1018-26. 2005
    ..These results suggest that chemokine receptors (particularly CCR9) are involved in the pathogenesis of lymphatic filarial disease and that trafficking of particular cellular subsets may influence clinical outcome...
  25. ncbi request reprint Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence
    Subash Babu
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:3248-56. 2006
    ..Hence, we conclude that a profound impairment of live parasite-specific Th1 and Th2 immune responses occurs in lymphatic filariasis that is governed at the transcriptional level by a complex interplay of inhibitory mediators...
  26. ncbi request reprint Cutting edge: diminished T cell TLR expression and function modulates the immune response in human filarial infection
    Subash Babu
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 176:3885-9. 2006
    ..Thus, diminished expression and function of T cell TLR is a novel mechanism underlying T cell immune tolerance in lymphatic filariasis...
  27. ncbi request reprint Filarial parasites induce NK cell activation, type 1 and type 2 cytokine secretion, and subsequent apoptotic cell death
    Subash Babu
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:2445-56. 2007
    ....
  28. pmc Circulating biomarkers of pulmonary and extrapulmonary tuberculosis in children
    Nathella Pavan Kumar
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    Clin Vaccine Immunol 20:704-11. 2013
    ..Thus, pediatric TB is characterized by elevated levels of a variety of biomarkers at homeostasis, suggesting that these responses may play a crucial role in disease pathogenesis...
  29. pmc Evidence of microbial translocation associated with perturbations in T cell and antigen-presenting cell homeostasis in hookworm infections
    Palakkal Jovvian George
    National Institutes of Health, International Center for Excellence in Research, Chennai, India
    PLoS Negl Trop Dis 6:e1830. 2012
    ..MT is a common cause of systemic immune activation in HIV infection and is associated with reduced frequencies of CD4(+) T cells; no data exist, however, on the role of MT in intestinal helminth infections...
  30. pmc Recombinant Brugia malayi pepsin inhibitor (rBm33) induced monocyte function and absence of apoptotic cell death: an in vitro study
    Kirthika Sreenivas
    Centre for Biotechnology, Anna University, S P Road, Guindy, Chennai, Tamil Nadu 600025, India
    Microb Pathog 53:19-27. 2012
    ..These observations suggest that rBm33 stimulates macrophages to induce Th1 response and does not promote apoptosis...
  31. pmc Expansion of pathogen-specific mono- and multifunctional Th1 and Th17 cells in multi-focal tuberculous lymphadenitis
    Nathella Pavan Kumar
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    PLoS ONE 8:e57123. 2013
    ..Th1 and Th17 responses are known to play an important role in immunity to pulmonary tuberculosis (PTB), although little is known about their role in extrapulmonary forms of tuberculosis (TB)...
  32. pmc Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasis
    Prakash Senbagavalli
    National Institutes of Health International Center for Excellence in Research, Chennai, India
    Am J Trop Med Hyg 85:89-96. 2011
    ..Thus, CIC-mediated enhanced granulocyte activation and modulation of complement function are important features of filarial infection and disease...
  33. pmc Decreased prevalence of lymphatic filariasis among subjects with type-1 diabetes
    Vivekanandhan Aravindhan
    Laboratory of Molecular Immunology, Anna University K B Chandrashekar Research Centre, Chennai, India
    Am J Trop Med Hyg 83:1336-9. 2010
    ..001). Thus, there appears to be a striking inverse relationship between the prevalence of LF and T1DM in southern India...