Research Topics
| Nader AyubSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Dendrimer-induced leukocyte procoagulant activity depends on particle size and surface chargeMarina A Dobrovolskaia
Nanotechnology Characterization Lab SAIC Frederick Inc, NCI Frederick 1050 Boyles St, Bldg 469 Frederick, MD 21702, USA
Nanomedicine (Lond) 7:245-56. 2012..The purpose of this study was to investigate the effects of nanoparticle physicochemical properties on leukocyte PCA, and to get insight into the mechanism of PCA induction...
Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistributionMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Mol Pharm 5:487-95. 2008..We will also provide an overview of in vitro methods useful in identifying interactions with components of the immune system and the potential effects of such interaction on particle distribution to tissues...
Method for analysis of nanoparticle hemolytic properties in vitroMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
Nano Lett 8:2180-7. 2008..We propose alternative methods to avoid misleading results from nanoparticles and discuss the potential relevance of nanoparticle in vitro hemolytic properties to in vivo systems...
Immunological properties of engineered nanomaterialsMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, NCI Frederick, 1050 Boyles St, Bldg 469, Frederick, Maryland 21702, USA
Nat Nanotechnol 2:469-78. 2007..Modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery...
Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profilesMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
Nanomedicine 5:106-17. 2009..The difference in size measurements obtained from dynamic light scattering, electron microscopy, and scanning probe microscopy are also discussed...
Evaluation of nanoparticle immunotoxicityMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
Nat Nanotechnol 4:411-4. 2009..This article outlines practical strategies for identifying and controlling interferences in common evaluation methods and the implications for regulation...
Ambiguities in applying traditional Limulus amebocyte lysate tests to quantify endotoxin in nanoparticle formulationsMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Nanomedicine (Lond) 5:555-62. 2010..Here we report that nanoparticles often interfere with these traditional endotoxin detection tests and suggest approaches to detect and overcome such interferences...
