Research Topics
Genomes and Genes
| James ArthosSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cellsJames Arthos
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 9:301-9. 2008..On CD4+ T cells, engagement of alpha4beta7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1...
The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1Claudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:20877-82. 2009..The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission...- R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cellsClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:3746-51. 2006..Additionally, signaling by R5 gp120 may facilitate the transmission of R5 viruses by inducing a permissive environment for HIV replication... 
Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremiaShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 46:151-9. 2007..In addition, these NK cells, particularly the CD56(dim) CD16(bright) subset, undergo enhanced cell turnover in vivo, as demonstrated by intracellular Ki67 expression...- Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120Lei Chen
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Science 326:1123-7. 2009..This incompatibility, the consequence of slight differences in CD4BS recognition, renders HIV-1 resistant to all but the most accurately targeted antibodies... - HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIVClaudia Cicala
Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Transl Med 9:S2. 2011.... - The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmissionFatima Nawaz
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 7:e1001301. 2011..Understanding the structural features that characterize early-transmitting gp120s may aid in the design of an effective gp120-based subunit vaccine... - Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acidsZhongcheng Zou
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
PLoS ONE 6:e24559. 2011..This glycan-mediated viral adhesion underscores the importance of viral sialic acids in HIV infection and pathogenesis, and suggests a novel class of antiviral compounds targeting Siglec receptors... - HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replicationClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:9380-5. 2002..These observations provide evidence that envelope-mediated signaling contributes to the productive infection of HIV in suboptimally activated T cells... - IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosaRaffaello Cimbro
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 120:2610-9. 2012.... - HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cellsElena Martinelli
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 104:3396-401. 2007.... - Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Jason S McLellan
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 480:336-43. 2011..In addition to structurally defining V1/V2, the results thus identify a paradigm of antibody recognition for highly glycosylated antigens, which-with PG9-involves a site of vulnerability comprising just two glycans and a strand... - Structural definition of a conserved neutralization epitope on HIV-1 gp120Tongqing Zhou
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 445:732-7. 2007..A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1... - HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cellsClaudia Cicala
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1876, USA
Virology 345:105-14. 2006..These observations provide insight into a potential mechanism by which HIV is able to establish infection in resting cells, which may have implications for both transmission of HIV and the persistence of viral reservoirs... - The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cellsJames Arthos
Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland 20892, USA
Virology 292:98-106. 2002..However, envelope--coreceptor interactions, and in particular, envelope--CXCR4 interactions, can contribute to this process... - Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactionsShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 176:1107-14. 2006..Identification of specific surface receptors on NK cells that interact with HIV envelope proteins might explain how HIV is capable of circumventing innate immune defense mechanisms and establishing infection in susceptible individuals... - Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individualsSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 205:1797-805. 2008..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals... - Cryoelectron tomographic analysis of an HIV-neutralizing protein and its complex with native viral gp120Adam Bennett
Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 282:27754-9. 2007.... - HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesPeter D Kwong
Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 420:678-82. 2002..Because this solution is available for cell-surface receptors but not for most antibodies, conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization... - Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapyNeil Gupta
Laboratory of Immunoregulation, NIAID, NIH Bldg. #10 6A08, 9000 Rockville Pike, Bethesda MD 20892, USA
Virology 332:491-7. 2005..NK cells pre-armed in this manner retain the capacity to kill targets over an extended period of time. This strategy may have application to other disease states including various viral infections and cancers... - HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosisAudrey L Kinter
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:2449-55. 2003.... - Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategiesJames Arthos
Laboratory of Immunoregulation, NIAID, and the Molecular Interactions Resource Division of Bioengineering and Physical Science, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:11456-64. 2002..This protein does not enhance viral replication at suboptimal concentrations. These observations may aid in the design of new therapeutics and vaccines... - Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processingPeter C Chien
Department of Pathology, New York University School of Medicine and Veterans Affairs, New York Harbor Healthcare System, New York, NY 10010, USA
J Virol 78:7645-52. 2004..Antibodies to other gp120 regions do not confer this effect. Thus, HIV may evade anti-viral T-helper responses by inducing and exploiting antibodies that conceal the virus envelope antigens from T cells... - HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signalingMilan Fiala
Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA 90095 1760, USA
Cardiovasc Toxicol 4:97-107. 2004.... - HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosisMilan Fiala
Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA, USA
Cardiovasc Toxicol 4:327-37. 2004..In conclusion, HIV-1 and gp120 induce toxicity through induction of cardiomyocyte and endothelial cell apoptosis. HAART drugs disrupt endothelial cell junctions and mitochondria and could cause vascular damage... - Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteersShixia Wang
Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Vaccine 26:3947-57. 2008.... - Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteersShixia Wang
Laboratory of Nucleic Acid Vaccines, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Vaccine 26:1098-110. 2008.... - Structural basis for the interaction between focal adhesion kinase and CD4Marie Line Garron
INSERM, UMR554, 34090 Montpellier, France
J Mol Biol 375:1320-8. 2008..In infected cells, HIV-1 Nef may displace FAK from CD4 to protect the cells from apoptosis... - Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1Shixia Wang
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605-2397, USA
J Virol 79:7933-7. 2005.... - Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cellsMilan Fiala
Department of Medicine, West Los Angeles VA Medical Center and UCLA School of Medicine, Los Angeles, CA 90095, USA
J Neurovirol 11:281-91. 2005..The toxicity of cocaine for the blood-brain barrier may lead to increased virus neuroinvasion and neurovascular complications of cocaine abuse... - Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitorSimon Cocklin
Drexel University College of Medicine, 11313 New College Building, 245 N 15th St, Philadelphia, PA 19102, USA
J Virol 81:3645-8. 2007..The combined results suggest that the HNG-105 molecule may be effective across the HIV-1 subtypes, and they highlight its potential as a lead for developing therapeutic and microbicidal agents to help combat the spread of AIDS...