Damien Arnoult

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
    Damien Arnoult
    EMI U 9922 Institut National de la Santé et de la Recherche Medicale INSERM Université Paris 7, IFR02, AP HP, CHU Bichat, 75018 Paris, France
    J Cell Biol 159:923-9. 2002
  2. ncbi Productive HIV-1 infection of primary CD4+ T cells induces mitochondrial membrane permeabilization leading to a caspase-independent cell death
    Frederic Petit
    INSERM EMI U 9922, CHU Bichat, Universite Paris 7, 16 rue Henri Huchard, 75018 Paris, France
    J Biol Chem 277:1477-87. 2002
  3. ncbi Mitochondria in HIV-1-induced apoptosis
    Damien Arnoult
    , IFR02, AP-HP, , Paris, France
    Biochem Biophys Res Commun 304:561-74. 2003
  4. ncbi A suppressive effect of the adenovirus 5 protein E1B 55K on apoptosis induced by IL-3 deprivation and gamma-irradiation
    Kamal Eddine BenJilani
    EMI U 9922 INSERM Université de PARIS 7 IFR02, AP HP, Faculté de Médecine Xavier Bichat Claude Bernard, 16 rue Henri Huchard, 75018 Paris, France
    Biol Cell 94:77-89. 2002
  5. ncbi CED-9 and EGL-1: a duo also regulating mitochondrial network morphology
    Jerome Estaquier
    Unité de Physiopathologie des Infections Lentivirales, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell 21:730-2. 2006
  6. ncbi Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation
    Damien Arnoult
    Cellular Neurology Unit, Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:35742-50. 2005
  7. ncbi Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria
    Damien Arnoult
    National Institute of Neurological Disorders and Stroke Biochemistry Section, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:7988-93. 2004
  8. ncbi Leishmania major-mediated prevention of programmed cell death induction in infected macrophages is associated with the repression of mitochondrial release of cytochrome c
    Khadija Akarid
    , , 16, rue Henri Huchard, 75870 Paris Cedex 18, France
    J Leukoc Biol 76:95-103. 2004
  9. ncbi Control of mitochondrial permeability by Bcl-2 family members
    Juanita C Sharpe
    Biochemistry Section, Surgical Neurology Branch, NINDS, NIH, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1644:107-13. 2004
  10. ncbi Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
    Mariusz Karbowski
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 164:493-9. 2004

Collaborators

Detail Information

Publications20

  1. ncbi Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
    Damien Arnoult
    EMI U 9922 Institut National de la Santé et de la Recherche Medicale INSERM Université Paris 7, IFR02, AP HP, CHU Bichat, 75018 Paris, France
    J Cell Biol 159:923-9. 2002
    ..These results provide a paradigm for mitochondria-dependent death pathways in which AIF cannot substitute for caspase executioners because its intracytosolic release occurs downstream of that of cytochrome c...
  2. ncbi Productive HIV-1 infection of primary CD4+ T cells induces mitochondrial membrane permeabilization leading to a caspase-independent cell death
    Frederic Petit
    INSERM EMI U 9922, CHU Bichat, Universite Paris 7, 16 rue Henri Huchard, 75018 Paris, France
    J Biol Chem 277:1477-87. 2002
    ..Our findings suggest a major role of the mitochondria in the process of CD4 T cell death induced by HIV, in which targeting of Bax to the mitochondria may be involved...
  3. ncbi Mitochondria in HIV-1-induced apoptosis
    Damien Arnoult
    , IFR02, AP-HP, , Paris, France
    Biochem Biophys Res Commun 304:561-74. 2003
    ..This review summarizes our knowledge of the influence of mitochondrial control on T cell death during HIV and SIV infections...
  4. ncbi A suppressive effect of the adenovirus 5 protein E1B 55K on apoptosis induced by IL-3 deprivation and gamma-irradiation
    Kamal Eddine BenJilani
    EMI U 9922 INSERM Université de PARIS 7 IFR02, AP HP, Faculté de Médecine Xavier Bichat Claude Bernard, 16 rue Henri Huchard, 75018 Paris, France
    Biol Cell 94:77-89. 2002
    ....
  5. ncbi CED-9 and EGL-1: a duo also regulating mitochondrial network morphology
    Jerome Estaquier
    Unité de Physiopathologie des Infections Lentivirales, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell 21:730-2. 2006
    ..In this issue of Molecular Cell, a paper by Delivani et al. (2006) sheds light on a new role of Bcl-2 family members as regulators of mitochondrial network morphology...
  6. ncbi Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation
    Damien Arnoult
    Cellular Neurology Unit, Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:35742-50. 2005
    ..Moreover, our findings indicate that the resulting OPA1 depletion causes a block in mitochondrial fusion, providing a compelling mechanism for the prominent increase in mitochondrial fragmentation seen during apoptosis...
  7. ncbi Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria
    Damien Arnoult
    National Institute of Neurological Disorders and Stroke Biochemistry Section, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:7988-93. 2004
    ....
  8. ncbi Leishmania major-mediated prevention of programmed cell death induction in infected macrophages is associated with the repression of mitochondrial release of cytochrome c
    Khadija Akarid
    , , 16, rue Henri Huchard, 75870 Paris Cedex 18, France
    J Leukoc Biol 76:95-103. 2004
    ..The capacity of L. major to delay PCD induction in the infected macrophages may have implications for Leishmania pathogenesis by favoring the invasion of its host and the persistence of the parasite in the infected cells...
  9. ncbi Control of mitochondrial permeability by Bcl-2 family members
    Juanita C Sharpe
    Biochemistry Section, Surgical Neurology Branch, NINDS, NIH, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1644:107-13. 2004
    ..The molecular mechanisms of the different models for the permeabilization of membranes by the Bcl-2 family members and the regulation of Bcl-2 family member subcellular localizations are discussed...
  10. ncbi Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis
    Mariusz Karbowski
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 164:493-9. 2004
    ..The block in mitochondrial fusion occurs within the same time range as Bax coalescence on the mitochondria and outer mitochondrial membrane permeabilization, and it may be a consequence of Bax/Bak activation during apoptosis...
  11. ncbi Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization
    Damien Arnoult
    Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 22:4385-99. 2003
    ..Thus EndoG and AIF seem to define a 'caspase-dependent' mitochondria-initiated apoptotic DNA degradation pathway that is conserved between mammals and nematodes...
  12. ncbi NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production
    Ivan Tattoli
    Department of Laboratory Medicine and Pathobiology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    EMBO Rep 9:293-300. 2008
    ..Together, these results identify NLRX1 as a NLR that contributes to the link between ROS generation at the mitochondria and innate immune responses...
  13. ncbi Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential
    Olwenn Guillery
    INSERM U582, 75651 Paris Cedex 13, France
    Biol Cell 100:315-25. 2008
    ..In the present paper, we focus on protease processing of OPA1...
  14. ncbi Mitochondrial fragmentation in apoptosis
    Damien Arnoult
    Unité de Physiopathologie des Infections Lentivirales, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, Cedex 15, France
    Trends Cell Biol 17:6-12. 2007
    ..Here, I discuss the apparently conflicting data and conclude that mitochondrial fragmentation is probably not a prerequisite for MOMP and cytochrome c release...
  15. ncbi Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice
    Vincent O Mallet
    Department of Genetics, Development and Molecular Pathology, Cochin Institute, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Nat Biotechnol 20:1234-9. 2002
    ..Moreover, because apoptosis has been described in numerous pathological circumstances, this system is useful for generating mouse models of human disorders as well as for studying the recovery or regeneration of tissues after cell loss...
  16. ncbi Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death
    Damien Arnoult
    Cellular Neurology Unit, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 15:2112-8. 2005
    ....
  17. ncbi Differential modulation of interleukin-2-and interleukin-4-mediated early activation of normal human B lymphocytes by the caspase inhibitor zVAD-fmk
    Shahul Mouhamad
    INSERM U.542, , , 14 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Eur Cytokine Netw 13:439-45. 2002
    ....
  18. ncbi The density of coreceptors at the surface of CD4+ T cells contributes to the extent of human immunodeficiency virus type 1 viral replication-mediated T cell death
    Jean Daniel Lelievre
    INSERM U421, Faculte de Medecine Henri Mondor, Creteil, France
    AIDS Res Hum Retroviruses 20:1230-43. 2004
    ..Our data indicate that the density of chemokine receptors expressed on CD4(+) T cells may be a critical parameters for the cytopathic effect of HIV strains and may have major impact on CD4 T cell depletion during HAART...
  19. ncbi Intrinsic and extrinsic pathways signaling during HIV-1 mediated cell death
    Frederic Petit
    Unité de Physiopathologie des Infections Lentivirales, Institut Pasteur, 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    Biochimie 85:795-811. 2003
    ..In this review, we summarized our current knowledge of the different pathways involved in the death of T cells in the course of HIV infection...
  20. ncbi The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization
    Damien Arnoult
    INSERM U542, Hopital Paul Brousse, Universite Paris Sud, 14 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Apoptosis 13:1100-10. 2008
    ....