Genomes and Genes
Affiliation: National Institutes of Health
- Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancerJohn I Risinger
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 63:6-11. 2003..These data provide the basis for investigation of previously unrecognized novel pathways involved in the development of endometrial cancers...
- Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motilityO Aprelikova
Cancer and Cell Biology Branch, Bethesda, MD, USA
Oncogene 32:3246-53. 2013..In contrast to the effect of miR-148a, WNT10B stimulated migration of endometrial cancer cell lines. Our findings have defined a molecular mechanism in the tumor microenvironment that is a novel target for cancer therapy. ..
- miRNA signature associated with outcome of gastric cancer patients following chemotherapyChang Hee Kim
Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
BMC Med Genomics 4:79. 2011..In order to identify miRNA signatures for gastric cancer and for predicting clinical resistance to cisplatin/fluorouracil (CF) chemotherapy, a comprehensive miRNA microarray analysis was performed using endoscopic biopsy samples...
- Universal Reference RNA as a standard for microarray experimentsNatalia Novoradovskaya
Stratagene, 11011 N, Torrey Pines Road, La Jolla, CA 92037, USA
BMC Genomics 5:20. 2004..Measuring signal at each spot as the ratio of experimental RNA to reference RNA targets, rather than relying on absolute signal intensity, decreases variability by normalizing signal output in any two-color hybridization experiment...
- MicroRNA regulation in cancer-associated fibroblastsOlga Aprelikova
Laboratory of Cancer Biology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
Cancer Immunol Immunother 61:231-7. 2012..The microRNA signature of CAFs is discussed with respect to their functional relevance to tumor cells as well as other cell types involved in tumor homeostasis...
- The role of miR-31 and its target gene SATB2 in cancer-associated fibroblastsOlga Aprelikova
Laboratory of Tumor and Stem Cell Biology, National Cancer Institute, Bethesda, MD, USA
Cell Cycle 9:4387-98. 2010..These findings provide new insights into tumor-stroma interaction and document that miR-31 and its target gene SATB2, are involved in regulation of tumor cell motility...
- Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic responseOlga Aprelikova
Laboratory of Tumor and Stem Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 69:616-24. 2009....
- Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selectionOlga Aprelikova
Laboratory of Biosystems and Cancer, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 66:5641-7. 2006..These data suggest that the choice of the target genes by HIF-1 or HIF-2 depends on availability and cooperation of HIFs with other factors recognizing their cognate elements in the promoters...
- BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cellsO Aprelikova
Section of Molecular Signaling and Oncogenesis, Division of Clinical Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 276:25647-50. 2001..We find that BRCA1 induction of 14-3-3 sigma requires the presence of wild type p53 and can be regulated by a minimal p53 response element...
- Regulation of HIF prolyl hydroxylases by hypoxia-inducible factorsOlga Aprelikova
Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
J Cell Biochem 92:491-501. 2004..These data further advance our understanding of the differential role of HIF factors and putative feedback loop in HIF regulation...
- Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancersAmir A Jazaeri
Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
Clin Cancer Res 11:6300-10. 2005..The goal of this study was to determine whether distinct gene expression profiles are associated with intrinsic and/or acquired chemoresistance in epithelial ovarian carcinoma...
- Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expressionJohn Ian Risinger
Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Clin Cancer Res 13:1713-9. 2007..The purpose of this study was to identify those CT genes with the greatest incidence of expression in uterine cancers...
- Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient miceXiaoling Xu
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Development 130:2001-12. 2003..Thus, our study revealed an essential role of Brca1 in DNA-damage repair and crossing-over of homologous chromosomes during spermatogenesis...
- Gene expression profiling of microsatellite unstable and microsatellite stable endometrial cancers indicates distinct pathways of aberrant signalingJohn I Risinger
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, USA
Cancer Res 65:5031-7. 2005..These data classify histologically similar endometrioid endometrial cancers into two distinct groupings with implications affecting therapy and prevention...
- Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinomaJoseph Riss
Laboratory of Biosystems and Cancer, Comparative Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 66:7216-24. 2006..The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia...
- Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control systemKurt W Kohn
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Biol Cell 15:3042-52. 2004..The studies disclosed the mechanism responsible for the sharp transitions. We show how parameter sets giving switch-like behavior can be found and how this type of behavior provides a foundation for quantitative studies in cells...
- BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivationJames M A Turner
Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Curr Biol 14:2135-42. 2004..These observations highlight an important role for BRCA1 in recruiting the kinase ATR to XY chromatin at the onset of MSCI and provide compelling evidence that it is ATR that phosphorylates H2AX and triggers MSCI...
- Regulation of hypoxia-inducible genes by ETS1 transcription factorKonstantin Salnikow
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Carcinogenesis 29:1493-9. 2008..Collectively, our data indicate the involvement of ETS1 along with HIF-1 in regulating hypoxia-inducible genes...
- BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer diseaseTeresa A Evans
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Int J Med Sci 4:140-5. 2007....