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Genomes and Genes | Lucy M AndersonSummaryAffiliation: National Cancer Institute Country: USA Publications
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Publications
Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal modelsL M Anderson
Laboratory of Comparative Carcinogenesis, National Cancer Institute, FCRDC, Frederick, Maryland, USA
Environ Health Perspect 108:573-94. 2000..Usefulness for human risk estimation would be strengthened by the study of these factors in more than one species, and by a focus on specific human risk issues...
Preconceptional fasting of fathers alters serum glucose in offspring of miceLucy M Anderson
Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Maryland, USA
Nutrition 22:327-31. 2006..Maternal nutrition has long-term effects on offspring characteristics. Similar effects mediated through fathers have not been tested...- Predictive values of traditional animal bioassay studies for human perinatal carcinogenesis risk determinationLucy M Anderson
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Toxicol Appl Pharmacol 199:162-74. 2004.... - Introduction and overview. Perinatal carcinogenesis: growing a node for epidemiology, risk management, and animal studiesLucy M Anderson
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Toxicol Appl Pharmacol 199:85-90. 2004.... - Environmental genotoxicants/carcinogens and childhood cancer: bridgeable gaps in scientific knowledgeLucy M Anderson
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Mutat Res 608:136-56. 2006..Investigations of interactions between factors may be key to understanding risk. Finally, fathers and newborn infants should receive more attention as especially sensitive targets... - DNA damage, superoxide, and mutant K-ras in human lung adenocarcinoma cellsMalgorzata Romanowska
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538 206, Fort Detrick, Frederick, MD 21702, USA
Free Radic Biol Med 43:1145-55. 2007..These results suggest that persistent DNA damage in some lung adenocarcinoma cells may be caused by superoxide resulting from mutant K-ras activity, and that OGG1 is important for prevention of this damage... - Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugsAnna E Maciag
SAIC Frederick, Inc, National Cancer Institute, Frederick, Maryland 21702, United States
J Med Chem 54:7751-8. 2011..The data suggest that rate of reactivity with glutathione and activation of JNK/ATF3 are determinants of cancer cell killing by these prodrugs... - Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1Gunamani Sithanandam
Basic Research Program, SAIC Frederick, Frederick, Maryland 21702, USA
Am J Respir Cell Mol Biol 33:490-9. 2005..Complexes of EGFR/Grb2/Gab1/Shp2 after TGF-alpha stimulation were prominent only in E10 and C10 cells. Thus, alternate pathways downstream of EGFR regulate mitosis in these paired malignant versus nontransformed lung cell lines... 
Molecular and organismal changes in offspring of male mice treated with chemical stressorsYih Horng Shiao
Laboratory of Comparative Carcinogenesis, Frederick National Laboratory for Cancer Research, Frederick, MD, USA
Environ Mol Mutagen 53:392-407. 2012....- Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugsRahul S Nandurdikar
Drug Design Section, Chemical Biology Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Bioorg Med Chem 20:3094-9. 2012..We show that nitro-to-cyano substitution increases the half-life of the prodrug in the presence of GSH without compromising the compound's in vivo antitumor activity... - Gene expression dose-response changes in microarrays after exposure of human peripheral lung epithelial cells to nickel(II)Robert Y S Cheng
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Bldg 538, Ft Detrick, Frederick, MD 21702, USA
Toxicol Appl Pharmacol 191:22-39. 2003..Overall, most of the genes impacted by nontoxic concentrations of nickel(II) acetate related to gene transcription, protein synthesis and stability, cytoskeleton, signaling, metabolism, cell membrane, and extracellular matrix... - Epigenetic and gene expression changes related to transgenerational carcinogenesisRobert Y-S Cheng
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Mol Carcinog 40:1-11. 2004..These results also support the hypothesis of an epigenetic and/or gene expression-based mechanism for transgenerational carcinogenesis. Published 2004 Wiley-Liss, Inc... - Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathwayGunamani Sithanandam
Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Building 538, Ft Detrick, Frederick, MD 21702 1201, USA
Carcinogenesis 24:1581-92. 2003..It could be a useful therapeutic target... - Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell linesMalgorzata Romanowska
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538, Ft Detrick, Frederick, MD 21702, USA
Lung Cancer 55:35-42. 2007..Characterization of individual tumors with regard to GPX1 and GPX4 levels and regulation might be useful for interpretation of clinical studies on effects of selenium in lung cancer risk... - Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549Gunamani Sithanandam
Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
Oncogene 24:1847-59. 2005..All three Akt isoforms are to varying degrees involved in these cell behaviors, with Akt2 especially implicated in migration and invasion. ErbB3 and the Akts are promising targets for therapy, and siRNAs may be useful for this purpose... - Anti-tumor efficacy of naked siRNAs for ERBB3 or AKT2 against lung adenocarcinoma cell xenograftsGunamani Sithanandam
Basic Science Program, SAIC Frederick, Inc, Frederick, MD, USA
Int J Cancer 130:251-8. 2012..There were no significant changes in serum cytokines. These results show that naked siRNAs to ERBB3 or AKT2 may have potential for lung cancer therapy... - Increased serum corticosterone and glucose in offspring of chromium(III)-treated male miceRobert Y S Cheng
Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
Environ Health Perspect 110:801-4. 2002..Risk of neoplasia may be influenced by these changes... - Protease inhibitor-induced stabilization of p21(waf1/cip1) and cell-cycle arrest in chemical carcinogen-exposed mammary and lung cellsQasim A Khan
Cellular Pathogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland, USA
Mol Carcinog 33:1-8. 2002..The results suggest that failure of cell-cycle arrest in carcinogen-treated mammary and lung cells is related to increased protease-mediated degradation of p21(waf1/cip1) and/or related regulatory proteins... - Ontogeny-driven rDNA rearrangement, methylation, and transcription, and paternal influenceYih Horng Shiao
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
PLoS ONE 6:e22266. 2011..Thus, the genome is also dynamic during mammalian ontogeny and its rearrangement may trigger epigenetic changes and subsequent transcriptional controls, that are further influenced by paternal exposures... - Allele-specific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposureYih Horng Shiao
Laboratory of Comparative Carcinogenesis, West 7th Street, Building 538, Room 205, National Cancer Institute, Frederick, MD 21702, USA
Toxicol Appl Pharmacol 205:290-6. 2005..0001). Thus, one allele of the 45S rRNA spacer promoter is hypomethylated in sperm germ cells after Cr(III) exposure. This epimutation may lead to increase of tumor risk in the offspring... - An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cellsYih Horng Shiao
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland, USA
PLoS ONE 4:e7505. 2009..We investigated whether a similar nc-rRNA might be expressed in human cancer epithelial cells, and related to any genomic characteristics... - Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesisAnna Maciag
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Exp Lung Res 31:83-104. 2005..Literature is reviewed regarding generation of reactive oxygen and cyclooxygenase-2 induction by ras, cyclooxygenase-2 release of DNA-damaging reactive oxygen, and involvement of cyclooxygenase-2 and reactive oxygen in lung cancer.. - Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumorsYih-Horng Shiao
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD, USA
Cancer Lett 187:207-14. 2002..No VHL mutations were observed in three chromophilic tumors. KBrO(3)-induced rat renal tumors are morphologically similar to their human counterpart but the genetic basis of tumorigenesis is different... - Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cellsAnna Maciag
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Inc, Frederick, MD 21702, USA
Carcinogenesis 25:2231-7. 2004..Our data suggest that up-regulation of COX-2, with a consequent increase in peroxides and DNA damage, contributes to the dominant oncogenicity of mutant K-ras... - Cancer biology and hormesis: comments on Calabrese (2005)Lucy M Anderson
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Ft Detrick, Maryland 21702, USA
Crit Rev Toxicol 35:583-6. 2005..Further investigations are warranted, especially for therapeutic drugs, phytochemicals, and environmental toxicants... - The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen speciesAnna E Maciag
SAIC Frederick, Inc, National Cancer Institute, Frederick, MD 21702, USA
J Pharmacol Exp Ther 336:313-20. 2011..PRX1 and OGG1 proteins, which can be easily measured, could function as biomarkers for identifying tumors sensitive to the therapy... - Robustness of the Chen-Dougherty-Bittner procedure against non-normality and heterogeneity in the coefficient of variationDouglas A Powell
National Cancer Institute at Frederick, Data Management Services, Frederick, Maryland 21702-1201, USA
J Biomed Opt 7:650-60. 2002..This effect mitigated the inflation in the size of the ratio as a result of increasing CV heterogeneity. These findings suggest that the Chen-Dougherty-Bittner procedure may be used even if underlying assumptions do not hold... - Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumorsYih Horng Shiao
Laboratory of Comparative Carcinogenesis, Building 538, Room 205, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Cancer Lett 179:33-8. 2002..Immunoblotting of normal kidney detected two VHL proteins of 20 and 22kDa in a 16-day-old fetal rat but only 20kDa protein in an adult rat. This is the first demonstration of VHL alteration at the protein level... - Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxinGayatri Ramakrishna
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Toxicol Appl Pharmacol 179:21-34. 2002..TCDD may promote tumors by contributing to downregulation of K-ras and stimulation of raf-1... - Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung--importance of mouse strainRichard J Calvert
Division of Research and Applied Technology, Office of Nutritional Products, Labeling, and Dietary Supplements, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA
Biochem Pharmacol 72:1749-55. 2006..KM feeding and PF treatment had no significant effects on K-ras activity. These data are consistent with the concept that K-ras in lung has an oncogenic function when mutated, but may act as a tumor suppressor when wild-type... - Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in femalesRichard J Calvert
Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA
Biochem Pharmacol 66:393-403. 2003..In the light of these data, both sexes should be included in future animal and human chemoprevention trials... - Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependentRichard J Calvert
Division of Research and Applied Technology, Office of Nutritional Products, Labeling and Dietary Supplements, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, Washington, DC, USA
Biochem Pharmacol 64:41-8. 2002..A difference in response among the mouse strains suggests that individual genetic differences may alter the effect of hypocholesterolemic agents on K-ras membrane localization, and potentially the risk of ras-dependent cancer... - Challenges and opportunities in research on early-life events/exposures and cancer development later in lifeSomdat Mahabir
Modifiable Risk Factors Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd, Bethesda, MD 20892, USA
Cancer Causes Control 23:983-90. 2012..This in turn has the potential to transform cancer prevention strategies through interventions in early-life rather than later in life, as is the current practice, where it is perhaps less effective... - Gestation stage-specific oxidative deoxyribonucleic acid damage from sidestream smoke in pregnant rats and their fetusesAnna Maciag
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Arch Environ Health 58:238-44. 2003..These gestational stage- and tissue-specific increases of 1.2- to 1.4-fold are similar to the putative relative increases in risk of human cancers related to ETS... - Marked liver tumorigenesis by Helicobacter hepaticus requires perinatal exposureBhalchandra A Diwan
Basic Research Program, SAIC Frederick, Inc, Frederick, Maryland, USA
Environ Health Perspect 116:1352-6. 2008..Although severe hepatitis and liver tumors occur in a high percentage of A/J male mice naturally infected with Helicobacter hepaticus, these effects have not been observed after injection of adult mice with the bacteria... - Increased K-ras protein and activity in mouse and human lung epithelial cells at confluenceWafa Kammouni
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Cell Growth Differ 13:441-8. 2002..In sum, increased protein expression and activity of K-ras p21 are associated with growth arrest, not with proliferation, in mouse and human lung cell lines... - VHL down-regulation and differential localization as mechanisms in tumorigenesisYih Horng Shiao
Laboratory of Comparative Carcinogenesis, National Cancer Institute Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
Kidney Int 64:1671-4. 2003..Early studies in animal tumors suggest that changes in VHL protein level and localization may be also important in tumorigenesis. In this study, we determined the role of VHL protein in human renal cell carcinomas... - Microarray analysis of altered gene expression in the TM4 Sertoli-like cell line exposed to chromium(III) chlorideRobert Y S Cheng
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, National Institutes of Health, Box B, Building 538, Fort Detrick, Frederick, MD 21702, USA
Reprod Toxicol 16:223-36. 2002..The largest average increase was observed for the transcription factor Bach2, and this increase was confirmed by RT-PCR. The results show that Cr(III) has significant effects on gene expression in a Sertoli-like cell line... - The biology of tobacco and nicotine: bench to bedsidePhillip A Dennis
Cancer Therapeutics Branch, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20889, USA
Cancer Epidemiol Biomarkers Prev 14:764-7. 2005..Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized... - Susceptibility to postnatal growth retardation induced by 5-AZA-2'-deoxycytidine in utero: gender specificity and correlation with reduced insulin-like growth factor 1Francisco Javier Cisneros
North Carolina State University, Environmental and Molecular Toxicology Department, 850 Main Campus Dr, Raleigh, NC 27695, USA
Life Sci 72:2887-94. 2003..Our data suggest that the decreased levels of IGF-1 associated with the treatment could be the cause of the observed growth retardation in the in utero-exposed mice. A gender dimorphic effect, where males are more affected, is evident... - Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylationIvana Vucenik
Department of Medical and Research Technology, University of Maryland School of Medicine, 100 Penn Street, Baltimore, MD 21201, USA
Breast Cancer Res Treat 91:35-45. 2005..Our data suggest potential usefulness of IP6 as a novel therapeutic modulator of PKC delta and p27Kip1, an important prognostic factor in human breast cancers... - DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesisVassilis L Souliotis
National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
Mutat Res 500:75-87. 2002..These results suggest that, in addition to the accumulation of DNA damage, alterations in hepatocyte DNA replication during the chronic NDMA exposure may influence the dose-dependence of its carcinogenic efficacy... - Intra- and intercellular variations in the repair efficiency of O6-methylguanine, and their contribution to kinetic complexityVassilis L Souliotis
National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou Ave, Athens 11635, Greece
Mutat Res 568:155-70. 2004..The additional cellular factors involved appear not to be related to the transcriptional state of the sequences being repaired, but may reflect different states of chromatin condensation...