J B Ames

Summary

Affiliation: National Institute of Standards and Technology
Country: USA

Publications

  1. ncbi Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulates sporulation and confers calcium tolerance
    Nobuko Hamasaki-Katagiri
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Biol Chem 279:12744-54. 2004
  2. ncbi Structure and membrane-targeting mechanism of retinal Ca2+-binding proteins, recoverin and GCAP-2
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA
    Adv Exp Med Biol 514:333-48. 2002
  3. ncbi Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases
    J B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 274:19329-37. 1999
  4. ncbi Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae
    J B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biochemistry 39:12149-61. 2000
  5. pmc NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biochemistry 44:6416-23. 2005
  6. ncbi Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biochemistry 41:5776-87. 2002
  7. ncbi Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3
    M Osawa
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 276:41005-13. 2001
  8. ncbi Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 281:37237-45. 2006
  9. pmc Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast
    Nobuko Hamasaki-Katagiri
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 285:4405-14. 2010
  10. pmc Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels
    Jennifer N Wingard
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, 20850, USA
    J Biol Chem 280:37461-70. 2005

Collaborators

Detail Information

Publications23

  1. ncbi Fission yeast homolog of neuronal calcium sensor-1 (Ncs1p) regulates sporulation and confers calcium tolerance
    Nobuko Hamasaki-Katagiri
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    J Biol Chem 279:12744-54. 2004
    ..We propose that Schizosaccharomyces pombe Ncs1p negatively regulates sporulation perhaps by controlling Ca2+-dependent desensitization of Git3p...
  2. ncbi Structure and membrane-targeting mechanism of retinal Ca2+-binding proteins, recoverin and GCAP-2
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA
    Adv Exp Med Biol 514:333-48. 2002
    ..The Ca2+-induced structural changes in these proteins are important for elucidating their membrane-targeting mechanisms and for understanding the molecular mechanism of Ca2+-sensitive regulation of phototransduction...
  3. ncbi Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases
    J B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 274:19329-37. 1999
    ....
  4. ncbi Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae
    J B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biochemistry 39:12149-61. 2000
    ..Subcellular fractionation experiments showed that both the N-myristoyl group and Ca(2+)-binding contribute to the ability of Frq1 to associate with membranes...
  5. pmc NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biochemistry 44:6416-23. 2005
    ..We propose that ligand binding to 2B4 might stabilize the structure of the FG-loop in the ligand complex...
  6. ncbi Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Biochemistry 41:5776-87. 2002
    ..We propose that Ca2+-bound myr-E85Q may represent a stable intermediate state in the kinetic mechanism of the calcium-myristoyl switch...
  7. ncbi Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3
    M Osawa
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 276:41005-13. 2001
    ..The C-terminal fragment is a tetramer in the Ca(2+)-free state and dissociates into dimers at saturating Ca(2+) levels...
  8. ncbi Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin
    James B Ames
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 281:37237-45. 2006
    ..We propose that Ca(2+)-bound recoverin is bound between rhodopsin and RK in a ternary complex on rod outer segment disk membranes, thereby blocking RK interaction with rhodopsin at high Ca(2+)...
  9. pmc Neuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast
    Nobuko Hamasaki-Katagiri
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 285:4405-14. 2010
    ..We propose that Ncs1p promotes Ca(2+) tolerance in fission yeast, in part by cytosolic Ca(2+) buffering and perhaps by negatively regulating the Yam8p Ca(2+) channel...
  10. pmc Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels
    Jennifer N Wingard
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, 20850, USA
    J Biol Chem 280:37461-70. 2005
    ..Both conformational states may serve to modulate the activity of Ca(2+) channel targets...
  11. ncbi Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM
    Masanori Osawa
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 280:18008-14. 2005
    ..We propose that Mg(2+) binding at EF-2 may structurally bridge DREAM to DNA targets and that Ca(2+)-induced protein dimerization disrupts DNA binding...
  12. pmc Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi
    Jennifer N Wingard
    Center for Advanced Research in Biotechnology, University of Maryland, National Institute of Standards and Technology, Rockville, Maryland 20850, USA
    J Biol Chem 283:23388-96. 2008
    ..We propose that exposed acyl groups at the N terminus may anchor FCaBP to the flagellar membrane and that Ca(2+)-induced conformational changes may control its binding to membrane-bound protein targets...
  13. doi NMR structure of DREAM: Implications for Ca(2+)-dependent DNA binding and protein dimerization
    Jacqueline D Lusin
    Department of Chemistry, University of California, Davis, California 95616, USA
    Biochemistry 47:2252-64. 2008
    ....
  14. ncbi Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)
    Thomas Strahl
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720 3202, USA
    J Biol Chem 282:30949-59. 2007
    ..Frq1 may activate Pik1 by facilitating membrane targeting via the exposed N-myristoyl group and by imposing a structural transition that promotes association of the lipid kinase unique motif with the kinase domain...
  15. ncbi Vector geometry mapping. A method to characterize the conformation of helix-loop-helix calcium-binding proteins
    Kyoko L Yap
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 173:317-24. 2002
  16. ncbi Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry
    Peter B Stathopulos
    Division of Signaling Biology and Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto M5G 1L7, Ontario, Canada
    J Biol Chem 281:35855-62. 2006
    ..The low Ca2+ affinity of EF-SAM is reconciled with the confirmed role of STIM1 as an ER Ca2+ sensor...
  17. ncbi Examination of the structure, stability, and catalytic potential in the engineered phosphoryl carrier domain of pyruvate phosphate dikinase
    Ying Lin
    Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Biochemistry 45:1702-11. 2006
    ..These results are interpreted as evidence that the central domain, although solvent-compatible, must be tethered by the flexible linkers to the N-terminal domain for the productive domain-domain docking required for efficient catalysis...
  18. pmc Genetic polymorphism and protein conformational plasticity in the calmodulin superfamily: two ways to promote multifunctionality
    Mitsuhiko Ikura
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Proc Natl Acad Sci U S A 103:1159-64. 2006
    ..In this review, we examine the essence of molecular recognition activities and the mechanisms by which calmodulin superfamily proteins control a wide variety of Ca(2+) signaling processes...
  19. ncbi A flagellum-specific calcium sensor
    Kathryn T Buchanan
    Department of Pathology and Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 280:40104-11. 2005
    ..These findings may have broader implications for the calcium acyl switch mechanism of protein regulation...
  20. ncbi The role of calcium-binding proteins in the control of transcription: structure to function
    Mitsuhiko Ikura
    Division of Molecular and Structural Biology, Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Room 7 707A, Toronto, Ontario, Canada M5G 2M9
    Bioessays 24:625-36. 2002
    ..In light of the structural studies reported to date, this review provides an overview of the structural basis of EF-hand Ca(2+)-binding proteins linked with transcriptional regulation...
  21. ncbi Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1
    Inken G Huttner
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720 3202, USA
    J Biol Chem 278:4862-74. 2003
    ..This study defines the segment of Pik1 required for high affinity binding of Frq1...
  22. ncbi Structure, topology, and dynamics of myristoylated recoverin bound to phospholipid bilayers
    Kathleen G Valentine
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 42:6333-40. 2003
    ..These results demonstrate that membrane binding by recoverin is achieved primarily by insertion of the myristoyl group inside the bilayer with apparently little rearrangement of the protein structure...
  23. ncbi Calcium binding sequences in calmyrin regulates interaction with presenilin-2
    Jingsong Zhu
    Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201, USA
    Exp Cell Res 300:440-54. 2004
    ..Our results suggest that calmyrin functions as a calcium sensor and that calcium binding sequences in calmyrin are important for interaction with the PS2 loop...