Madson Q Almeida

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice KennedyShriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1387-98. 2010
  2. pmc Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:E687-93. 2012
  3. pmc Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors
    Madson Q Almeida
    PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 20:165-75. 2011
  4. pmc Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions
    Madson Q Almeida
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E728-38. 2011
  5. pmc Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours
    Anya Rothenbuhler
    Section on Endocrinology and Genetics and Pediatric Endocrinology Training Program, both at Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Clin Endocrinol (Oxf) 77:195-9. 2012
  6. pmc Cyclic AMP and c-KIT Signaling in Familial Testicular Germ Cell Tumor Predisposition
    Monalisa F Azevedo
    MD, D med Sci, Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 98:E1393-400. 2013
  7. pmc Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone
    Kit Man Tsang
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics and Pediatric Endocrinology Inter institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:8683-8. 2010
  8. pmc Carney complex and other conditions associated with micronodular adrenal hyperplasias
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Best Pract Res Clin Endocrinol Metab 24:907-14. 2010
  9. pmc Solid tumors associated with multiple endocrine neoplasias
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room I 3330, 10 Center Dr, MSC 1103, Bethesda, MD 20892, USA
    Cancer Genet Cytogenet 203:30-6. 2010
  10. pmc How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
    Mol Cell Endocrinol 336:162-8. 2011

Collaborators

Detail Information

Publications11

  1. pmc Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice KennedyShriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1387-98. 2010
    ....
  2. pmc Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 97:E687-93. 2012
    ....
  3. pmc Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors
    Madson Q Almeida
    PDEGEN, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 20:165-75. 2011
    ....
  4. pmc Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions
    Madson Q Almeida
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E728-38. 2011
    ..Massive macronodular adrenocortical disease or ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a clinically and genetically heterogeneous disorder...
  5. pmc Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours
    Anya Rothenbuhler
    Section on Endocrinology and Genetics and Pediatric Endocrinology Training Program, both at Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1103, USA
    Clin Endocrinol (Oxf) 77:195-9. 2012
    ..Genetic aberrations in various components of cAMP signalling pathway predispose to endocrine tumours. Mutations in the phosphodiesterases (PDEs) are involved in the predisposition to adrenocortical neoplastic conditions...
  6. pmc Cyclic AMP and c-KIT Signaling in Familial Testicular Germ Cell Tumor Predisposition
    Monalisa F Azevedo
    MD, D med Sci, Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1 3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 98:E1393-400. 2013
    ..Conclusions: Patients with FTGCT and PDE11A defects also carry KITLG risk alleles more frequently. There may be an interaction between cAMP and c-KIT signaling in predisposition to testicular germ cell tumors. ..
  7. pmc Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone
    Kit Man Tsang
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics and Pediatric Endocrinology Inter institute Training Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:8683-8. 2010
    ....
  8. pmc Carney complex and other conditions associated with micronodular adrenal hyperplasias
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Best Pract Res Clin Endocrinol Metab 24:907-14. 2010
    ..Recent evidences demonstrated that dysregulation of cAMP/PKA pathway can modulate other signaling pathways and contributes to adrenocortical tumorigenesis...
  9. pmc Solid tumors associated with multiple endocrine neoplasias
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room I 3330, 10 Center Dr, MSC 1103, Bethesda, MD 20892, USA
    Cancer Genet Cytogenet 203:30-6. 2010
    ..The Carney complex is yet another form of MEN that is characterized by skin tumors and pigmented lesions, myxomas, schwannomas, and various endocrine neoplasias...
  10. pmc How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
    Madson Q Almeida
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
    Mol Cell Endocrinol 336:162-8. 2011
    ..In this review, we summarize all recent data from ours and other laboratories, supporting the view that Wnt-signaling acts as an important mediator of tumorigenicity induced by abnormal PRKAR1A function and aberrant cAMP signaling...
  11. pmc Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer
    Fabio Rueda Faucz
    Section of Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 96:E135-40. 2011
    ..In addition, the combined cancer genome expression metaanalysis datasets included PDE11A among the top 1% down-regulated genes in PCa...