Anthony H Aletras

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart
    Anthony H Aletras
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Magn Reson Med 59:229-35. 2008
  2. ncbi request reprint DENSE with SENSE
    Anthony H Aletras
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Magn Reson 176:99-106. 2005
  3. ncbi request reprint meta-DENSE complex acquisition for reduced intravoxel dephasing
    Anthony H Aletras
    Laboratory of Cardiac Energetics, US Department of Health and Human Services, National Heart, Lung and Blood Institute, National Institutes of Heath, Bethesda, MD, USA
    J Magn Reson 169:246-9. 2004
  4. pmc Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction
    Colin Berry
    Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:527-35. 2010
  5. pmc Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    JACC Cardiovasc Imaging 5:596-603. 2012
  6. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012
  7. pmc Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart
    Erik B Schelbert
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:743-52. 2010
  8. pmc A quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans
    Li Yueh Hsu
    Advanced Cardiovascular Imaging Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    JACC Cardiovasc Imaging 5:154-66. 2012
  9. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:309-14. 2006
  10. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:298-308. 2006

Detail Information

Publications35

  1. doi request reprint ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart
    Anthony H Aletras
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Magn Reson Med 59:229-35. 2008
    ..Imperfect blood suppression, present in all animals on some TSE images, was a problem eliminated by TSE-SSFP and T2-prepared SSFP...
  2. ncbi request reprint DENSE with SENSE
    Anthony H Aletras
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    J Magn Reson 176:99-106. 2005
    ..Images from phantoms, normal volunteers, and a patient are provided to demonstrate the SENSE-DENSE combination of methods. The overall breath-hold time is halved while preserving strain map quality...
  3. ncbi request reprint meta-DENSE complex acquisition for reduced intravoxel dephasing
    Anthony H Aletras
    Laboratory of Cardiac Energetics, US Department of Health and Human Services, National Heart, Lung and Blood Institute, National Institutes of Heath, Bethesda, MD, USA
    J Magn Reson 169:246-9. 2004
    ....
  4. pmc Magnetic resonance imaging delineates the ischemic area at risk and myocardial salvage in patients with acute myocardial infarction
    Colin Berry
    Department of Health and Human Services, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:527-35. 2010
    ..The area at risk (AAR) is a key determinant of myocardial infarction (MI) size. We investigated whether magnetic resonance imaging (MRI) measurement of AAR would be correlated with an angiographic AAR risk score in patients with acute MI...
  5. pmc Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    JACC Cardiovasc Imaging 5:596-603. 2012
    ..The aim of this study was to determine whether cardiac magnetic resonance (CMR) in vivo T1 mapping can measure myocardial area at risk (AAR) compared with microspheres or T2 mapping CMR...
  6. pmc Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892 1061, USA
    Eur Heart J 33:1268-78. 2012
    ....
  7. pmc Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart
    Erik B Schelbert
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 3:743-52. 2010
    ....
  8. pmc A quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans
    Li Yueh Hsu
    Advanced Cardiovascular Imaging Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    JACC Cardiovasc Imaging 5:154-66. 2012
    ..The aim of this study was to evaluate fully quantitative myocardial blood flow (MBF) at a pixel level based on contrast-enhanced first-pass cardiac magnetic resonance (CMR) imaging in dogs and in patients...
  9. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:309-14. 2006
    ....
  10. ncbi request reprint Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithm
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:298-308. 2006
    ..To develop a computer algorithm to measure myocardial infarct size in gadolinium-enhanced magnetic resonance (MR) imaging and to validate this method using a canine histopathological reference...
  11. pmc T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo
    Peter Kellman
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 57:891-7. 2007
    ..Free-breathing T2 prepared SSFP provides T2-weighted images of acute MI with fewer artifacts and better diagnostic accuracy than conventional dark-blood TSE...
  12. pmc T2* measurement during first-pass contrast-enhanced cardiac perfusion imaging
    Peter Kellman
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 56:1132-4. 2006
    ..For single-dose Gd-DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T(2) (*) had a mean value of 9 ms (N = 10) at peak enhancement. Distortion of the AIF due to T(2) (*) signal intensity loss will be less than 10% using TE = 0.6 ms...
  13. ncbi request reprint Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations
    Anthony H Aletras
    National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circulation 113:1865-70. 2006
    ....
  14. ncbi request reprint Gadolinium delayed enhancement cardiovascular magnetic resonance correlates with clinical measures of myocardial infarction
    W Patricia Ingkanisorn
    National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    J Am Coll Cardiol 43:2253-9. 2004
    ..Acute infarct mass by cardiac magnetic resonance (CMR) was compared with peak troponin I, acute and chronic left ventricular (LV) systolic function, and chronic infarct mass in patients imaged after recent acute MI...
  15. ncbi request reprint Stunned, infarcted, and normal myocardium in dogs: simultaneous differentiation by using gadolinium-enhanced cine MR imaging with magnetization transfer contrast
    Clifford R Weiss
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Bldg 10, Rm B1D416, MSC 1061, Bethesda, MD 20892 1061, USA
    Radiology 226:723-30. 2003
    ..To simultaneously differentiate stunned, infarcted, and normal myocardial regions by using gadolinium-enhanced cine magnetic resonance (MR) imaging with magnetization transfer contrast...
  16. pmc Artifact suppression in imaging of myocardial infarction using B1-weighted phased-array combined phase-sensitive inversion recovery
    Peter Kellman
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 51:408-12. 2004
    ..Example images are shown that illustrate the suppression of CSF ghost artifacts by the use of B1-weighted phased-array combining of multiple receiver coils...
  17. ncbi request reprint Age-related vascular stiffness and left ventricular size after myocardial infarction
    Glenn A Hirsch
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Geriatr Cardiol 16:222-8. 2007
    ..02) were significant predictors of end-systolic volume index. Older patients have increased LV size after MI compared with younger patients, possibly related to age-related decreases in aortic distensibility affecting LV remodeling...
  18. pmc Heterogeneity of intramural function in hypertrophic cardiomyopathy: mechanistic insights from MRI late gadolinium enhancement and high-resolution displacement encoding with stimulated echoes strain maps
    Anthony H Aletras
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 4:425-34. 2011
    ..The aim of this study was to determine whether excess collagen or myocardial scarring, as determined by LGE MRI, are the primary mechanisms leading to heterogeneous regional contractile function in patients with HCM...
  19. ncbi request reprint In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarction
    Gauri S Tilak
    National Heart, Lung and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    Invest Radiol 43:7-15. 2008
    ..AAR was defined as the size of the perfusion defect on day 0. MI and the residual ischemic viable border zone comprise the AAR...
  20. ncbi request reprint Quantitative myocardial perfusion analysis with a dual-bolus contrast-enhanced first-pass MRI technique in humans
    Li Yueh Hsu
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 23:315-22. 2006
    ..To compare fully quantitative and semiquantitative analysis of rest and stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) using a dual-bolus first-pass perfusion MRI method in humans...
  21. pmc Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction
    Felix M Gonzalez
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 117:2986-94. 2008
    ....
  22. doi request reprint Bright-blood T(2)-weighted MRI has high diagnostic accuracy for myocardial hemorrhage in myocardial infarction: a preclinical validation study in swine
    Alexander R Payne
    National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, MD 20892 1061, USA
    Circ Cardiovasc Imaging 4:738-45. 2011
    ..Myocardial hemorrhage after myocardial infarction (MI) usually goes undetected. We investigated the diagnostic accuracy of bright-blood T(2)-weighted cardiac MRI for myocardial hemorrhage in experimental MI...
  23. pmc Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement
    Peter Kellman
    Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 47:372-83. 2002
    ..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection...
  24. ncbi request reprint Prognosis of negative adenosine stress magnetic resonance in patients presenting to an emergency department with chest pain
    W Patricia Ingkanisorn
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, and Suburban Hospital, Bethesda, Maryland 20892 1061, USA
    J Am Coll Cardiol 47:1427-32. 2006
    ..This study was designed to determine the diagnostic value of adenosine cardiac magnetic resonance (CMR) in troponin-negative patients with chest pain...
  25. ncbi request reprint Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart
    Tom C C Hu
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
    Magn Reson Med 54:196-200. 2005
    ..03). In conclusion, the intracellular contrast agent MnCl2 enhances the canine heart and shows promise in detecting ischemia at doses that do not cause adverse cardiac effects...
  26. ncbi request reprint AIR-SPAMM: alternative inversion recovery spatial modulation of magnetization for myocardial tagging
    Anthony H Aletras
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D416, MSC 1061, Bethesda, MD 20892 1061, USA
    J Magn Reson 166:236-45. 2004
    ..AIR-SPAMM can be used either for imaging systole as demonstrated by initial in vivo results or potentially for imaging the entire cardiac cycle in a slice-interleaved manner...
  27. ncbi request reprint Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging
    Timothy F Christian
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B1D416, MSC 1061, 10 Center Dr, Bethesda, MD 20892 1061, USA
    Radiology 232:677-84. 2004
    ..To compare fluorescent microsphere measurements of myocardial blood flow (MBF) with qualitative, semiquantitative, and fully quantitative measurements of first-pass perfusion at magnetic resonance (MR) imaging...
  28. ncbi request reprint Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults
    Erik B Schelbert
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 308:890-6. 2012
    ..Unrecognized myocardial infarction (MI) is prognostically important. Electrocardiography (ECG) has limited sensitivity for detecting unrecognized MI (UMI)...
  29. ncbi request reprint Determining canine myocardial area at risk with manganese-enhanced MR imaging
    Alex Natanzon
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, 10 Center Dr, MSC 1061, Bldg 10, Room B1D 416, Bethesda, MD 20892 1061, USA
    Radiology 236:859-66. 2005
    ..To test whether manganese-enhanced magnetic resonance (MR) imaging can safely depict the myocardial area at risk both during coronary artery occlusion and for at least 2 hours after reperfusion in dogs...
  30. doi request reprint Diagnostic accuracy of stress perfusion CMR in comparison with quantitative coronary angiography: fully quantitative, semiquantitative, and qualitative assessment
    Federico E Mordini
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland Department of Cardiology, Veterans Affairs Medical Center, Washington, DC
    JACC Cardiovasc Imaging 7:14-22. 2014
    ....
  31. pmc Multishot EPI-SSFP in the heart
    Daniel A Herzka
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 20892 1061, USA
    Magn Reson Med 47:655-64. 2002
    ..The increased TR of multishot EPI-SSFP led to a reduced specific absorption rate (SAR) for a fixed RF flip angle, and allowed the use of a larger flip angle without increasing the SAR above the FDA-approved limits...
  32. ncbi request reprint Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation study
    Vandana Sachdev
    Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Soc Echocardiogr 19:34-9. 2006
    ..We studied longitudinal strain measurements in patients with evidence of myocardial infarction by cardiac magnetic resonance imaging to determine whether end-systolic strain could identify the severity of the infarction...
  33. ncbi request reprint Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging
    Raymond Y Kwong
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 107:531-7. 2003
    ..Managing chest pain in the emergency department remains a challenge with current diagnostic strategies. We hypothesized that cardiac MRI could accurately identify patients with possible or probable acute coronary syndrome...
  34. ncbi request reprint Wash-in kinetics for gadolinium-enhanced magnetic resonance imaging of carotid atheroma
    Bruce A Wasserman
    Russell H Morgan Department of Radiology and Radiological Sciences, Baltimore, Maryland, USA
    J Magn Reson Imaging 21:91-5. 2005
    ..To determine the wash-in kinetics of intravenous gadolinium into the fibrous cap and lipid core of carotid atheroma, and identify the time following gadolinium administration that maximizes contrast between the cap and core...
  35. doi request reprint Estimation of absolute myocardial blood flow during first-pass MR perfusion imaging using a dual-bolus injection technique: comparison to single-bolus injection method
    Timothy F Christian
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05495, USA
    J Magn Reson Imaging 27:1271-7. 2008
    ..To compare the dual-bolus to single-bolus quantitative first-pass magnetic resonance myocardial perfusion imaging for estimation of absolute myocardial blood flow (MBF)...