Research Topics
| A H AletrasSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
T2* measurement during first-pass contrast-enhanced cardiac perfusion imagingPeter Kellman
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1061, USA
Magn Reson Med 56:1132-4. 2006..For single-dose Gd-DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T(2) (*) had a mean value of 9 ms (N = 10) at peak enhancement. Distortion of the AIF due to T(2) (*) signal intensity loss will be less than 10% using TE = 0.6 ms...
AIR-SPAMM: alternative inversion recovery spatial modulation of magnetization for myocardial taggingAnthony H Aletras
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room B1D416, MSC 1061, Bethesda, MD 20892 1061, USA
J Magn Reson 166:236-45. 2004..AIR-SPAMM can be used either for imaging systole as demonstrated by initial in vivo results or potentially for imaging the entire cardiac cycle in a slice-interleaved manner...- Mixed echo train acquisition displacement encoding with stimulated echoes: an optimized DENSE method for in vivo functional imaging of the human heartA H Aletras
Laboratory of Cardiac Energetics, NHLBI, NIH, Bethesda, Maryland 20892 1061, USA
Magn Reson Med 46:523-34. 2001..Data processing requires minimal user intervention and provides a rapid quantitative feedback on the MRI scanner for evaluating cardiac function. Published 2001 Wiley-Liss, Inc... - MRI of the human eye using magnetization transfer contrast enhancementM J Lizak
Laboratory of Ocular Therapeutics, Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
Invest Ophthalmol Vis Sci 41:3878-81. 2000..To determine the feasibility of using magnetization transfer contrast-enhanced magnetic resonance imaging (MRI) to track cataractous lens changes... - The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylationJ S Davis
Molecular Physiology Section, Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cell 107:631-41. 2001..To demonstrate the importance of cardiac light chain phosphorylation, we cloned a myosin light chain kinase from a human heart and have identified a gain-in-function mutation in two individuals with cardiac hypertrophy... - Effect of muscle action and metabolic strain on oxidative metabolic responses in human skeletal muscleC A Combs
Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Appl Physiol 87:1768-75. 1999..Pooled data were found to more closely conform to previous biochemical measurements when a term for increasing oxidative capacity with metabolic strain was added to models of respiratory control... 
ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heartAnthony H Aletras
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
Magn Reson Med 59:229-35. 2008..Imperfect blood suppression, present in all animals on some TSE images, was a problem eliminated by TSE-SSFP and T2-prepared SSFP...- Quantitative myocardial infarction on delayed enhancement MRI. Part I: Animal validation of an automated feature analysis and combined thresholding infarct sizing algorithmLi-Yueh Hsu
Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health/DHHS, 10 Center Drive, Bethesda, MD 20892, USA
J Magn Reson Imaging 23:298-308. 2006..007). CONCLUSION: The FACT algorithm accurately measured MI size on delayed enhancement MR imaging in vivo and ex vivo. The FACT algorithm was also more accurate than human manual contouring and simple intensity thresholding approaches... - Quantitative myocardial infarction on delayed enhancement MRI. Part II: Clinical application of an automated feature analysis and combined thresholding infarct sizing algorithmLi-Yueh Hsu
Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health/DHHS, 10 Center Drive, Bethesda, MD 20892, USA
J Magn Reson Imaging 23:309-14. 2006..002 and P < 0.001). CONCLUSION: Clinically relevant overestimation of MI can occur in visual interpretation and in human manual contouring, particularly with respect to extent of infarction on a regional basis... - Quantitative myocardial perfusion analysis with a dual-bolus contrast-enhanced first-pass MRI technique in humansLi-Yueh Hsu
Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health/DHHS, 10 Center Drive, Bethesda, MD 20892, USA
J Magn Reson Imaging 23:315-22. 2006..CONCLUSION: Rest and stress MBF (mL/min/g) and MPR estimated by dual-bolus perfusion MRI fit within published ranges. Semiquantitative methods (SLP and CER) significantly underestimated MPR... - Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validationsAnthony H Aletras
National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-1061, USA
Circulation 113:1865-70. 2006..The persistence of postischemic edema allows T2-weighted CMR to delineate the area at risk 2 days after reperfused myocardial infarction... - T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echoPeter Kellman
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
Magn Reson Med 57:891-7. 2007..Free-breathing T2 prepared SSFP provides T2-weighted images of acute MI with fewer artifacts and better diagnostic accuracy than conventional dark-blood TSE... - Estimation of absolute myocardial blood flow during first-pass MR perfusion imaging using a dual-bolus injection technique: comparison to single-bolus injection methodTimothy F Christian
Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05495, USA
J Magn Reson Imaging 27:1271-7. 2008..To compare the dual-bolus to single-bolus quantitative first-pass magnetic resonance myocardial perfusion imaging for estimation of absolute myocardial blood flow (MBF)... - Age-related vascular stiffness and left ventricular size after myocardial infarctionGlenn A Hirsch
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Am J Geriatr Cardiol 16:222-8. 2007..02) were significant predictors of end-systolic volume index. Older patients have increased LV size after MI compared with younger patients, possibly related to age-related decreases in aortic distensibility affecting LV remodeling... - In vivo T2-weighted magnetic resonance imaging can accurately determine the ischemic area at risk for 2-day-old nonreperfused myocardial infarctionGauri S Tilak
National Heart, Lung and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 1061, USA
Invest Radiol 43:7-15. 2008..AAR was defined as the size of the perfusion defect on day 0. MI and the residual ischemic viable border zone comprise the AAR... - Myocardial strain decreases with increasing transmurality of infarction: a Doppler echocardiographic and magnetic resonance correlation studyVandana Sachdev
Echocardiography Laboratory, Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Am Soc Echocardiogr 19:34-9. 2006..We studied longitudinal strain measurements in patients with evidence of myocardial infarction by cardiac magnetic resonance imaging to determine whether end-systolic strain could identify the severity of the infarction... - Determining canine myocardial area at risk with manganese-enhanced MR imagingAlex Natanzon
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Dr, MSC 1061, Bldg 10, Room B1D-416, Bethesda, MD 20892-1061, USA
Radiology 236:859-66. 2005..CONCLUSION: Manganese-enhanced MR imaging can depict the area at risk during LAD artery occlusion and at least 2 hours after reperfusion without hemodynamic compromise... - Manganese enhanced magnetic resonance imaging of normal and ischemic canine heartTom C-C Hu
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1061, USA
Magn Reson Med 54:196-200. 2005..03). In conclusion, the intracellular contrast agent MnCl2 enhances the canine heart and shows promise in detecting ischemia at doses that do not cause adverse cardiac effects... - Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancementPeter Kellman
Laboratory of Cardiac Energetics, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892-1061, USA
Magn Reson Med 47:372-83. 2002..Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection... - Multishot EPI-SSFP in the heartDaniel A Herzka
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 20892 1061, USA
Magn Reson Med 47:655-64. 2002..The increased TR of multishot EPI-SSFP led to a reduced specific absorption rate (SAR) for a fixed RF flip angle, and allowed the use of a larger flip angle without increasing the SAR above the FDA-approved limits... - Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imagingRaymond Y Kwong
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1061, USA
Circulation 107:531-7. 2003..Performed urgently to evaluate chest pain, MRI accurately detected a high fraction of patients with acute coronary syndrome, including patients with enzyme-negative unstable angina... - Stunned, infarcted, and normal myocardium in dogs: simultaneous differentiation by using gadolinium-enhanced cine MR imaging with magnetization transfer contrastClifford R Weiss
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, 10 Center Dr, Bldg 10, Rm B1D416, MSC 1061, Bethesda, MD 20892-1061, USA
Radiology 226:723-30. 2003..CONCLUSION: One day after myocardial ischemia, MTET during one MR imaging examination enabled simultaneous differentiation of infarcted, stunned, and normal myocardial regions on the basis of gadolinium enhancement and regional function... - Artifact suppression in imaging of myocardial infarction using B1-weighted phased-array combined phase-sensitive inversion recoveryPeter Kellman
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892 1061, USA
Magn Reson Med 51:408-12. 2004..Example images are shown that illustrate the suppression of CSF ghost artifacts by the use of B1-weighted phased-array combining of multiple receiver coils... - Gadolinium delayed enhancement cardiovascular magnetic resonance correlates with clinical measures of myocardial infarctionW Patricia Ingkanisorn
National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1061, USA
J Am Coll Cardiol 43:2253-9. 2004..003). CONCLUSION: In humans imaged shortly after acute MI, gadolinium delayed enhancement acute CMR infarct size correlates with acute and chronic indices of infarct size but will appear to diminish in size on follow-up... - meta-DENSE complex acquisition for reduced intravoxel dephasingAnthony H Aletras
Laboratory of Cardiac Energetics, US Department of Health and Human Services, National Heart, Lung and Blood Institute, National Institutes of Heath, Bethesda, MD, USA
J Magn Reson 169:246-9. 2004.... - Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imagingTimothy F Christian
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bldg 10, Rm B1D416, MSC 1061, 10 Center Dr, Bethesda, MD 20892-1061, USA
Radiology 232:677-84. 2004..0 mL/min/g). Use of qualitative MR imaging measures such as the contrast enhancement ratio led to substantially underestimated hyperemic blood flow measurements... - Wash-in kinetics for gadolinium-enhanced magnetic resonance imaging of carotid atheromaBruce A Wasserman
Russell H Morgan Department of Radiology and Radiological Sciences, Baltimore, Maryland, USA
J Magn Reson Imaging 21:91-5. 2005..To determine the wash-in kinetics of intravenous gadolinium into the fibrous cap and lipid core of carotid atheroma, and identify the time following gadolinium administration that maximizes contrast between the cap and core... - DENSE with SENSEAnthony H Aletras
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Magn Reson 176:99-106. 2005..Images from phantoms, normal volunteers, and a patient are provided to demonstrate the SENSE-DENSE combination of methods. The overall breath-hold time is halved while preserving strain map quality... - Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarctionFelix M Gonzalez
Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
Circulation 117:2986-94. 2008....