Research Topics
Species | Salvatore AlesciSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevanceSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 148:3900-7. 2007..At the same time, in light of their ability to effectively deliver and express genes in pheochromocytoma cells, they may be applicable to the gene therapy of adrenomedullary tumors...- Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implicationsSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
J Clin Endocrinol Metab 90:2522-30. 2005..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels... - L-Carnitine is a modulator of the glucocorticoid receptor alphaSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
Ann N Y Acad Sci 1024:147-52. 2004..We conclude that pharmacologic doses of LC can activate GRalpha and, via this mechanism, regulate glucocorticoid-responsive genes, potentially sharing some of the biological and therapeutic properties of glucocorticoids... - Glucocorticoid-induced osteoporosis: from basic mechanisms to clinical aspectsSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
Neuroimmunomodulation 12:1-19. 2005.... - Development of a human mitochondria-focused cDNA microarray (hMitChip) and validation in skeletal muscle cells: implications for pharmaco- and mitogenomicsS Alesci
Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD 20892 1284, USA
Pharmacogenomics J 6:333-42. 2006..We suggest that hMitChip is a reliable and novel tool that will prove useful for systematically studying the contribution of mitochondrial genomics to human health and disease... - Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signatureLucia Martiniova
Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
Clin Exp Metastasis 26:239-50. 2009..Microarray gene expression comparison and quantitative real-time PCR of these more aggressive cells to the MPC-parental cell line identified genes that may be important for the metastatic process... - Mitochondrial localization of human recombinant adenovirus: from evolution to gene therapySalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD, USA
Neuroimmunomodulation 14:221-3. 2007..This finding, while opening new perspectives in viral gene therapy, may provide new insights into the pathogenesis, prevention and treatment of viral diseases. In addition, it may advance the current understanding of cell evolution... - Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolismMassimo U De Martino
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
Ann N Y Acad Sci 1024:72-85. 2004..It appears that glucocorticoids exert their intermediary effects partly via physical interaction with COUP-TFII... - Modulatory effects of L-carnitine on glucocorticoid receptor activityIrini Manoli
Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
Ann N Y Acad Sci 1033:147-57. 2004..The clinical and therapeutic implications of these findings, as well as a better understanding of their mechanisms, warrant further research... - Intramuscular administration of ACTH1-24 vs. 24-hour blood sampling in the assessment of adrenocortical functionSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA
Hormones (Athens) 4:96-100. 2005..In conclusion, we confirmed that i.m. administration of ACTH1-24, followed by a single blood sampling at 60 min for cortisol measurement represents a valid, convenient and cost- effective screening test of adrenal function... - Increased uptake of [¹²³I]meta-iodobenzylguanidine, [¹?F]fluorodopamine, and [³H]norepinephrine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitorsLucia Martiniova
Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 1E 3140, 10 Center Drive MSC 1109, Bethesda, Maryland 20892 1109, USA
Endocr Relat Cancer 18:143-57. 2011..HDAC inhibitors may enhance the therapeutic efficacy of [(131)I]MIBG treatment in patients with advanced malignant pheochromocytoma and paraganglioma... - Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cellsIrini Manoli
Endocrine Section, Laboratory of Clinical Investigation, NCCAM, NIH, Bethesda, Maryland 20892, USA
FASEB J 19:1359-61. 2005..We suggest that MAO-A-mediated oxidative stress can lead to cell damage, representing a novel pathogenetic mechanism for glucocorticoid-induced myopathy and a potential target for therapeutic intervention... - L-carnitine: A nutritional modulator of glucocorticoid receptor functionsSalvatore Alesci
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
FASEB J 17:1553-5. 2003.... - Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damageRosilla F Bachmann
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Int J Neuropsychopharmacol 12:805-22. 2009..These agents may have potential clinical utility in the treatment of other diseases associated with impaired mitochondrial function, such as neurodegenerative diseases and schizophrenia... - Intracrine modulation of gene expression by intracellular generation of active glucocorticoidsOren Fruchter
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Steroids 71:1001-6. 2006..The intracrine mechanism is an under-appreciated aspect of GC activity that could be a potential target for future therapies aimed at modulating GC effects at the cellular level... - Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholiaPhilip W Gold
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
Proc Natl Acad Sci U S A 102:8303-8. 2005..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression... - The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolismMassimo U De Martino
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Mail Stop Code 1583, Building 10, Room 9D42, Bethesda, MD 20892 1583, USA
Mol Endocrinol 18:820-33. 2004..These interactions influence the transcription of both COUP-TFII- and GRalpha-responsive target genes, seem to be promoter specific, and can be in either a positive or negative direction... - Mitochondria as key components of the stress responseIrini Manoli
Human Biochemical Genetics Section, MGB, NHGRI, NIH, Bethesda, MD 20892, USA
Trends Endocrinol Metab 18:190-8. 2007..Understanding the often reciprocal interplay between stress mediators and mitochondrial function is likely to help identify potential therapeutic targets for many stress and mitochondria-related pathologies... - The human glucocorticoid receptor (GR) isoform {beta} differentially suppresses GR{alpha}-induced transactivation stimulated by synthetic glucocorticoidsOren Fruchter
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 90:3505-9. 2005..These results may provide helpful information concerning the selection of synthetic glucocorticoids for treatment of pathological conditions in which hGRbeta modulates the sensitivity of tissues to glucocorticoids... - Changes of noradrenergic activity and lipolysis in the subcutaneous abdominal adipose tissue of hypo- and hyperthyroid patients: an in vivo microdialysis studyJara Nedvidkova
Dr Sc, Building 10, Room 9D42, NICHD, NIH, 10 Center Drive, MSC 1583, Bethesda, MD 20892 1583, USA
Ann N Y Acad Sci 1018:541-9. 2004..We suggest that thyroid hormones regulate lipolysis primarily by affecting local NE concentration and/or adrenergic postreceptor signaling... - Genomic medicine: exploring the basis of a new approach to endocrine hypertensionSalvatore Alesci
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
Ann N Y Acad Sci 970:177-92. 2002..Research in this field is only in its infancy, but with the ever-increasing advances in DNA technologies, genomic therapies for endocrine hypertension may become available within the next few decades... - Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid AMitchel A Kling
Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
Biol Psychiatry 62:309-13. 2007..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients... - Biomarkers in the age of omics: time for a systems biology approachMones S Abu-Asab
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
OMICS 15:105-12. 2011.... - Animal models of pheochromocytoma including NIH initial experienceShoichiro Ohta
Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E-3141, 10 Center Drive MSC-1109, Bethesda, MD 20892-1109, USA
Ann N Y Acad Sci 1073:300-5. 2006..This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma... - The genomics of mood disordersSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Prog Brain Res 158:129-39. 2006 - Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapySalvatore Alesci
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
Proc Natl Acad Sci U S A 99:7484-9. 2002..At the same time, the high level of transfection in adrenocortical cells might make appropriately modified adenoviral vectors suitable for gene therapy of adrenocortical carcinomas with poor prognosis... - Third-generation human mitochondria-focused cDNA microarray and its bioinformatic tools for analysis of gene expressionXueyan Bai
The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
Biotechniques 42:365-75. 2007..Thus, hMitChip3 and its bioinformatics software provide an integrated tool for profiling mitochondria-focused gene expression... - Depression and osteoporosis in men: association or casual link?Ioannis Ilias
Department of Pharmacology, Patras University Medical School, Rion Patras, Greece
Hormones (Athens) 5:9-16. 2006..We suggest that similar neurohormonal changes may cause osteoporosis in men... - Effects of hypo- and hyperthyroidism on noradrenergic activity and glycerol concentrations in human subcutaneous abdominal adipose tissue assessed with microdialysisMartin Haluzik
Third Department of Medicine, First Faculty of Medicine, Prague, Czech Republic
J Clin Endocrinol Metab 88:5605-8. 2003..05), 503 +/- 113% (P < 0.01), and 267 +/- 17.2 (P < 0.01). In summary, by affecting local NE levels and adrenergic postreceptor signaling, thyroid hormones may influence the lipolysis rate in the abdominal sc adipose tissue... - Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosaJara Nedvidkova
Institute of Endocrinology, Charles University, Prague, Czech Republic
J Clin Endocrinol Metab 88:1678-82. 2003..This abnormality may be part of a chronic adaptation to prolonged food restriction, which attempts to restore a normal feeding conduct by maintaining the drive to eat... - High-density lipoprotein-facilitated entry of thyroid hormones into cells: a mechanism different from the low-density lipoprotein-facilitated entrySalvatore Benvenga
Sezione di Endocrinologia, Dipartimento Clinico Sperimentale di Medicina e Farmacologia, University of Messina School of Medicine, Policlinico Universitario, Messina, Italy
Thyroid 12:547-56. 2002..This effect of HDL represents facilitated diffusion of TH through the cell membrane...