Salvatore Alesci

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 148:3900-7. 2007
  2. ncbi request reprint Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
  3. ncbi request reprint L-Carnitine is a modulator of the glucocorticoid receptor alpha
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Ann N Y Acad Sci 1024:147-52. 2004
  4. ncbi request reprint Glucocorticoid-induced osteoporosis: from basic mechanisms to clinical aspects
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Neuroimmunomodulation 12:1-19. 2005
  5. ncbi request reprint Development of a human mitochondria-focused cDNA microarray (hMitChip) and validation in skeletal muscle cells: implications for pharmaco- and mitogenomics
    S Alesci
    Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD 20892 1284, USA
    Pharmacogenomics J 6:333-42. 2006
  6. pmc Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature
    Lucia Martiniova
    Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Clin Exp Metastasis 26:239-50. 2009
  7. pmc Mitochondrial localization of human recombinant adenovirus: from evolution to gene therapy
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimmunomodulation 14:221-3. 2007
  8. ncbi request reprint Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism
    Massimo U De Martino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:72-85. 2004
  9. ncbi request reprint Modulatory effects of L-carnitine on glucocorticoid receptor activity
    Irini Manoli
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1033:147-57. 2004
  10. ncbi request reprint Intramuscular administration of ACTH1-24 vs. 24-hour blood sampling in the assessment of adrenocortical function
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Hormones (Athens) 4:96-100. 2005

Collaborators

Detail Information

Publications31

  1. pmc Adenoviral gene transfer in bovine adrenomedullary and murine pheochromocytoma cells: potential clinical and therapeutic relevance
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 148:3900-7. 2007
    ..At the same time, in light of their ability to effectively deliver and express genes in pheochromocytoma cells, they may be applicable to the gene therapy of adrenomedullary tumors...
  2. ncbi request reprint Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
    ..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...
  3. ncbi request reprint L-Carnitine is a modulator of the glucocorticoid receptor alpha
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Ann N Y Acad Sci 1024:147-52. 2004
    ..We conclude that pharmacologic doses of LC can activate GRalpha and, via this mechanism, regulate glucocorticoid-responsive genes, potentially sharing some of the biological and therapeutic properties of glucocorticoids...
  4. ncbi request reprint Glucocorticoid-induced osteoporosis: from basic mechanisms to clinical aspects
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Neuroimmunomodulation 12:1-19. 2005
    ....
  5. ncbi request reprint Development of a human mitochondria-focused cDNA microarray (hMitChip) and validation in skeletal muscle cells: implications for pharmaco- and mitogenomics
    S Alesci
    Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD 20892 1284, USA
    Pharmacogenomics J 6:333-42. 2006
    ..We suggest that hMitChip is a reliable and novel tool that will prove useful for systematically studying the contribution of mitochondrial genomics to human health and disease...
  6. pmc Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature
    Lucia Martiniova
    Section on Medical Neuroendocrinology, Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Clin Exp Metastasis 26:239-50. 2009
    ..Microarray gene expression comparison and quantitative real-time PCR of these more aggressive cells to the MPC-parental cell line identified genes that may be important for the metastatic process...
  7. pmc Mitochondrial localization of human recombinant adenovirus: from evolution to gene therapy
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD, USA
    Neuroimmunomodulation 14:221-3. 2007
    ..This finding, while opening new perspectives in viral gene therapy, may provide new insights into the pathogenesis, prevention and treatment of viral diseases. In addition, it may advance the current understanding of cell evolution...
  8. ncbi request reprint Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism
    Massimo U De Martino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:72-85. 2004
    ..It appears that glucocorticoids exert their intermediary effects partly via physical interaction with COUP-TFII...
  9. ncbi request reprint Modulatory effects of L-carnitine on glucocorticoid receptor activity
    Irini Manoli
    Endocrine Section, Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1033:147-57. 2004
    ..The clinical and therapeutic implications of these findings, as well as a better understanding of their mechanisms, warrant further research...
  10. ncbi request reprint Intramuscular administration of ACTH1-24 vs. 24-hour blood sampling in the assessment of adrenocortical function
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Hormones (Athens) 4:96-100. 2005
    ..In conclusion, we confirmed that i.m. administration of ACTH1-24, followed by a single blood sampling at 60 min for cortisol measurement represents a valid, convenient and cost- effective screening test of adrenal function...
  11. doi request reprint Increased uptake of [¹²³I]meta-iodobenzylguanidine, [¹⁸F]fluorodopamine, and [³H]norepinephrine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitors
    Lucia Martiniova
    Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 1E 3140, 10 Center Drive MSC 1109, Bethesda, Maryland 20892 1109, USA
    Endocr Relat Cancer 18:143-57. 2011
    ..HDAC inhibitors may enhance the therapeutic efficacy of [(131)I]MIBG treatment in patients with advanced malignant pheochromocytoma and paraganglioma...
  12. ncbi request reprint Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells
    Irini Manoli
    Endocrine Section, Laboratory of Clinical Investigation, NCCAM, NIH, Bethesda, Maryland 20892, USA
    FASEB J 19:1359-61. 2005
    ..We suggest that MAO-A-mediated oxidative stress can lead to cell damage, representing a novel pathogenetic mechanism for glucocorticoid-induced myopathy and a potential target for therapeutic intervention...
  13. ncbi request reprint L-carnitine: A nutritional modulator of glucocorticoid receptor functions
    Salvatore Alesci
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    FASEB J 17:1553-5. 2003
    ....
  14. pmc Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage
    Rosilla F Bachmann
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Neuropsychopharmacol 12:805-22. 2009
    ..These agents may have potential clinical utility in the treatment of other diseases associated with impaired mitochondrial function, such as neurodegenerative diseases and schizophrenia...
  15. ncbi request reprint Intracrine modulation of gene expression by intracellular generation of active glucocorticoids
    Oren Fruchter
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Steroids 71:1001-6. 2006
    ..The intracrine mechanism is an under-appreciated aspect of GC activity that could be a potential target for future therapies aimed at modulating GC effects at the cellular level...
  16. pmc Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia
    Philip W Gold
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
    Proc Natl Acad Sci U S A 102:8303-8. 2005
    ..Even mildly-to-moderately depressed melancholic patients had clinically relevant increases in the arterial NE-appearance rate. These findings will not apply to all clinical subtypes of major depression...
  17. ncbi request reprint The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism
    Massimo U De Martino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Mail Stop Code 1583, Building 10, Room 9D42, Bethesda, MD 20892 1583, USA
    Mol Endocrinol 18:820-33. 2004
    ..These interactions influence the transcription of both COUP-TFII- and GRalpha-responsive target genes, seem to be promoter specific, and can be in either a positive or negative direction...
  18. ncbi request reprint Mitochondria as key components of the stress response
    Irini Manoli
    Human Biochemical Genetics Section, MGB, NHGRI, NIH, Bethesda, MD 20892, USA
    Trends Endocrinol Metab 18:190-8. 2007
    ..Understanding the often reciprocal interplay between stress mediators and mitochondrial function is likely to help identify potential therapeutic targets for many stress and mitochondria-related pathologies...
  19. ncbi request reprint The human glucocorticoid receptor (GR) isoform {beta} differentially suppresses GR{alpha}-induced transactivation stimulated by synthetic glucocorticoids
    Oren Fruchter
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 90:3505-9. 2005
    ..These results may provide helpful information concerning the selection of synthetic glucocorticoids for treatment of pathological conditions in which hGRbeta modulates the sensitivity of tissues to glucocorticoids...
  20. ncbi request reprint Changes of noradrenergic activity and lipolysis in the subcutaneous abdominal adipose tissue of hypo- and hyperthyroid patients: an in vivo microdialysis study
    Jara Nedvidkova
    Dr Sc, Building 10, Room 9D42, NICHD, NIH, 10 Center Drive, MSC 1583, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1018:541-9. 2004
    ..We suggest that thyroid hormones regulate lipolysis primarily by affecting local NE concentration and/or adrenergic postreceptor signaling...
  21. ncbi request reprint Genomic medicine: exploring the basis of a new approach to endocrine hypertension
    Salvatore Alesci
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:177-92. 2002
    ..Research in this field is only in its infancy, but with the ever-increasing advances in DNA technologies, genomic therapies for endocrine hypertension may become available within the next few decades...
  22. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  23. pmc Biomarkers in the age of omics: time for a systems biology approach
    Mones S Abu-Asab
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    OMICS 15:105-12. 2011
    ....
  24. ncbi request reprint Animal models of pheochromocytoma including NIH initial experience
    Shoichiro Ohta
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E 3141, 10 Center Drive MSC 1109, Bethesda, MD 20892 1109, USA
    Ann N Y Acad Sci 1073:300-5. 2006
    ..This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma...
  25. ncbi request reprint The genomics of mood disorders
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Prog Brain Res 158:129-39. 2006
  26. pmc Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy
    Salvatore Alesci
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Proc Natl Acad Sci U S A 99:7484-9. 2002
    ..At the same time, the high level of transfection in adrenocortical cells might make appropriately modified adenoviral vectors suitable for gene therapy of adrenocortical carcinomas with poor prognosis...
  27. ncbi request reprint Third-generation human mitochondria-focused cDNA microarray and its bioinformatic tools for analysis of gene expression
    Xueyan Bai
    The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
    Biotechniques 42:365-75. 2007
    ..Thus, hMitChip3 and its bioinformatics software provide an integrated tool for profiling mitochondria-focused gene expression...
  28. ncbi request reprint Depression and osteoporosis in men: association or casual link?
    Ioannis Ilias
    Department of Pharmacology, Patras University Medical School, Rion Patras, Greece
    Hormones (Athens) 5:9-16. 2006
    ..We suggest that similar neurohormonal changes may cause osteoporosis in men...
  29. ncbi request reprint Effects of hypo- and hyperthyroidism on noradrenergic activity and glycerol concentrations in human subcutaneous abdominal adipose tissue assessed with microdialysis
    Martin Haluzik
    Third Department of Medicine, First Faculty of Medicine, Prague, Czech Republic
    J Clin Endocrinol Metab 88:5605-8. 2003
    ..05), 503 +/- 113% (P < 0.01), and 267 +/- 17.2 (P < 0.01). In summary, by affecting local NE levels and adrenergic postreceptor signaling, thyroid hormones may influence the lipolysis rate in the abdominal sc adipose tissue...
  30. ncbi request reprint Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa
    Jara Nedvidkova
    Institute of Endocrinology, Charles University, Prague, Czech Republic
    J Clin Endocrinol Metab 88:1678-82. 2003
    ..This abnormality may be part of a chronic adaptation to prolonged food restriction, which attempts to restore a normal feeding conduct by maintaining the drive to eat...
  31. ncbi request reprint High-density lipoprotein-facilitated entry of thyroid hormones into cells: a mechanism different from the low-density lipoprotein-facilitated entry
    Salvatore Benvenga
    Sezione di Endocrinologia, Dipartimento Clinico Sperimentale di Medicina e Farmacologia, University of Messina School of Medicine, Policlinico Universitario, Messina, Italy
    Thyroid 12:547-56. 2002
    ..This effect of HDL represents facilitated diffusion of TH through the cell membrane...