Paul S Albert

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Use of complementary/alternative therapies by women with advanced-stage breast cancer
    Joannie Shen
    Laboratory of Clinical Sciences, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD, USA
    BMC Complement Altern Med 2:8. 2002
  2. ncbi A transitional model for longitudinal binary data subject to nonignorable missing data
    P S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
    Biometrics 56:602-8. 2000
  3. ncbi A cautionary note on the robustness of latent class models for estimating diagnostic error without a gold standard
    Paul S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biometrics 60:427-35. 2004
  4. ncbi Estimating diagnostic accuracy of multiple binary tests with an imperfect reference standard
    Paul S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, U S A
    Stat Med 28:780-97. 2009
  5. ncbi Modeling tumor growth with random onset
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, Executive Plaza North, Room 8136, Bethesda, Maryland 20892 7434, USA
    Biometrics 59:897-906. 2003
  6. ncbi On analyzing circadian rhythms data using nonlinear mixed models with harmonic terms
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, Executive Plaza North, Bethesda, Maryland 20892 7434, USA
    Biometrics 61:1115-20; discussion 1120-2. 2005
  7. ncbi A latent autoregressive model for longitudinal binary data subject to informative missingness
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biometrics 58:631-42. 2002
  8. ncbi Design of a binary biomarker study from the results of a pilot study
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
    Biometrics 58:576-85. 2002
  9. ncbi Limitations of the case-only design for identifying gene-environment interactions
    P S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Am J Epidemiol 154:687-93. 2001
  10. ncbi Latent class modeling approaches for assessing diagnostic error without a gold standard: with applications to p53 immunohistochemical assays in bladder tumors
    P S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
    Biometrics 57:610-9. 2001

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi Use of complementary/alternative therapies by women with advanced-stage breast cancer
    Joannie Shen
    Laboratory of Clinical Sciences, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD, USA
    BMC Complement Altern Med 2:8. 2002
    ....
  2. ncbi A transitional model for longitudinal binary data subject to nonignorable missing data
    P S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
    Biometrics 56:602-8. 2000
    ..Through analyses and simulations, we show the importance of properly accounting for the missing data mechanism when assessing the treatment effect in our example...
  3. ncbi A cautionary note on the robustness of latent class models for estimating diagnostic error without a gold standard
    Paul S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biometrics 60:427-35. 2004
    ..Further, data analysis and simulations demonstrate the practical implications of model misspecification. Finally, we present some guidelines about the use of these models for practitioners...
  4. ncbi Estimating diagnostic accuracy of multiple binary tests with an imperfect reference standard
    Paul S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, U S A
    Stat Med 28:780-97. 2009
    ..The methodology is demonstrated with a study examining the diagnostic accuracy of various HIV-antibody tests for HIV...
  5. ncbi Modeling tumor growth with random onset
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, Executive Plaza North, Room 8136, Bethesda, Maryland 20892 7434, USA
    Biometrics 59:897-906. 2003
    ..We illustrate this methodology with an application examining the effect of different mutations on tumorigenesis...
  6. ncbi On analyzing circadian rhythms data using nonlinear mixed models with harmonic terms
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, Executive Plaza North, Bethesda, Maryland 20892 7434, USA
    Biometrics 61:1115-20; discussion 1120-2. 2005
    ..The proposed parametric approach provides an alternative to Wang et al.'s semiparametric approach and has the added advantage of being easy to implement in most statistical software packages...
  7. ncbi A latent autoregressive model for longitudinal binary data subject to informative missingness
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biometrics 58:631-42. 2002
    ..We illustrate our new methodology using the opiate clinical trial data...
  8. ncbi Design of a binary biomarker study from the results of a pilot study
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
    Biometrics 58:576-85. 2002
    ..We illustrate the methodology with data from a study assessing the reproducibility of p53 immunohistochemistry in bladder tumors...
  9. ncbi Limitations of the case-only design for identifying gene-environment interactions
    P S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Am J Epidemiol 154:687-93. 2001
    ..Investigators should be aware that the increased efficiency of the case-only design is a consequence of a strong assumption and that this design can perform poorly if the assumption is violated...
  10. ncbi Latent class modeling approaches for assessing diagnostic error without a gold standard: with applications to p53 immunohistochemical assays in bladder tumors
    P S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
    Biometrics 57:610-9. 2001
    ..These mixture models are shown to offer an improvement over other methods in a variety of settings, but we caution that, in general, care must be taken in applying latent class models...
  11. ncbi Modeling repeated count data subject to informative dropout
    P S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7438, USA
    Biometrics 56:667-77. 2000
    ..A simulation study is also conducted to compare the various approaches. Through analyses and simulations, we demonstrate the flexibility of the likelihood-based conditional model for analyzing data from the epilepsy trial...
  12. ncbi Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial
    Gerd Bobe
    Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 3:764-75. 2010
    ..Our results suggest that serum IL-6 may serve as a risk indicator and as a response indicator to dietary flavonols for colorectal cancer prevention...
  13. ncbi Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score
    Nicole L Simone
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 70:90-5. 2008
    ..To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score...
  14. ncbi Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial
    Gwen Murphy
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 124:2148-51. 2009
    ..Increased risk of adenoma recurrence as conferred by DRD2 genotypes may be related to difference in alcohol and fat intake across genotypes...
  15. ncbi Postpolypectomy colonoscopy surveillance guidelines: predictive accuracy for advanced adenoma at 4 years
    Adeyinka O Laiyemo
    Cancer Prevention Fellowship Program, Biometry Research Group, Divisionof Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Intern Med 148:419-26. 2008
    ..Lack of confidence in postpolypectomy surveillance guidelines may be a factor in the observed low adherence rates among providers...
  16. ncbi Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women
    Jackie A Lavigne
    National Cancer Institute, Bethesda, MD 20892 4264, USA
    Am J Clin Nutr 81:503-7. 2005
    ..Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted...
  17. ncbi Potentiation of high-LET radiation by gemcitabine: targeting HER2 with trastuzumab to treat disseminated peritoneal disease
    Diane E Milenic
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch and Biometric Research Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Clin Cancer Res 13:1926-35. 2007
    ..The objective of the studies presented here was improvement of the efficacy of alpha-particle radioimmunotherapy using a chemotherapeutic agent...
  18. ncbi Improved efficacy of alpha-particle-targeted radiation therapy: dual targeting of human epidermal growth factor receptor-2 and tumor-associated glycoprotein 72
    Diane E Milenic
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer 116:1059-66. 2010
    ..A next logical step to improve therapeutic benefit would be to target tumors with both molecules simultaneously...
  19. ncbi Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial
    Gerd Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute NCI, NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 19:1441-52. 2010
    ..Serum adiponectin, leptin, C-peptide, and homocysteine are indicators for obesity, hyperinsulinemia, and chronic inflammation, which have all been associated with colorectal cancer...
  20. ncbi A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas
    Teri N Kreisl
    Neuro Oncology Branch, National Cancer Institute, NIH, 9030 Old Georgetown Road, Bloch Bldg 82, Room 225, Bethesda, MD 20892, USA
    Neuro Oncol 12:181-9. 2010
    ..Enzastaurin has anti-glioma activity in patients with recurrent high-grade glioma, but does not appear to have enough single-agent activity to be useful as monotherapy...
  21. ncbi Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial
    Gerd Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Frederick, MD, USA
    Int J Cancer 130:1649-59. 2012
    ..04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women...
  22. ncbi Hyperplastic polyps and the risk of adenoma recurrence in the polyp prevention trial
    Adeyinka O Laiyemo
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Gastroenterol Hepatol 7:192-7. 2009
    ..Prospective information on the risk of adenoma recurrence associated with hyperplastic polyps is limited. We sought to investigate whether the coexistence of hyperplastic polyps with adenomas increases the risk of adenoma recurrence...
  23. ncbi Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer
    Deborah Citrin
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 74:1040-6. 2009
    ..To report the long-term outcomes and toxicity of a regimen of infusion paclitaxel delivered concurrently with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck...
  24. ncbi The effect of strict adherence to a high-fiber, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrence
    Leah B Sansbury
    Division of Cancer Control and Population Sciences, 6130 Executive Boulevard, Room 5106, Mail Stop Code 7324, Bethesda, MD 20892, USA
    Am J Epidemiol 170:576-84. 2009
    ..65, 95% confidence interval: 0.47, 0.92). Findings suggest that high compliance with a low-fat, high-fiber diet is associated with reduced risk of adenoma recurrence...
  25. ncbi Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 65:1008-13. 2006
    ..1 g amifostine suspension. Further studies should be conducted in populations at higher risk for developing symptomatic acute and late proctitis...
  26. ncbi Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?
    Gerd Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Eur J Cancer Prev 20:86-95. 2011
    ..In conclusion, our results suggest that IL SNPs, in combination with a flavonol-rich diet or decreased serum IL, may lower the risk of adenoma recurrence...
  27. ncbi The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization
    Elaine Lanza
    Laboratory for Cancer Prevention, Centre for Cancer Research, National Cancer Institute, 6116 Executive Boulevard, Room 7206, Bethesda, MD 20892 8325, USA
    Cancer Epidemiol Biomarkers Prev 16:1745-52. 2007
    ..04 (0.98-1.09). This study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up. (Cancer Epidemiol Biomarkers Prev 2007;16(9):1745-52)...
  28. ncbi Multimodality therapy: potentiation of high linear energy transfer radiation with paclitaxel for the treatment of disseminated peritoneal disease
    Diane E Milenic
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 14:5108-15. 2008
    ..Studies herein explore paclitaxel enhancement of the therapeutic efficacy of alpha-particle-targeted radiation therapy...
  29. ncbi Alpha-particle radioimmunotherapy of disseminated peritoneal disease using a (212)Pb-labeled radioimmunoconjugate targeting HER2
    Diane E Milenic
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC 1088, Building 10, Bethesda, MD 20892, USA
    Cancer Biother Radiopharm 20:557-68. 2005
    ..98). No improvement in median survival was noted with a similar regimen in the Shaw xenograft model...
  30. ncbi Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    Teri N Kreisl
    Neuro Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8200, USA
    J Clin Oncol 27:740-5. 2009
    ..To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma...
  31. ncbi Prostate cancer: value of multiparametric MR imaging at 3 T for detection--histopathologic correlation
    Baris Turkbey
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Bldg 10, Room 1B40, Bethesda, MD 20892 1088, USA
    Radiology 255:89-99. 2010
    ....
  32. ncbi High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial
    Elaine Lanza
    Nutritional Epidemiology Branch, Division of Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Nutr 136:1896-903. 2006
    ..001). The median in the highest quartile of change in dry bean intake was 370% higher than the baseline intake. The PPT trial-based cohort provides evidence that dry beans may be inversely associated with advanced adenoma recurrence...
  33. ncbi Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas
    Fabio M Iwamoto
    Neuro Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Cancer 116:1776-82. 2010
    ..Talampanel is an oral AMPA receptor inhibitor with excellent central nervous system penetration and good tolerability in clinical trials for epilepsy and other neurologic disorders...
  34. ncbi High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population
    Nan Hu
    Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 7236, USA
    Genes Chromosomes Cancer 39:205-16. 2004
    ..Only one alteration was observed in CDKN2B, G171A in the 5' untranslated region. Both mutation and intragenic allelic loss in CDKN2A appear to play a role in the development of ESCC...
  35. ncbi Patient selection determines the prostate cancer yield of dynamic contrast-enhanced magnetic resonance imaging-guided transrectal biopsies in a closed 3-Tesla scanner
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1642, USA
    BJU Int 101:181-5. 2008
    ....
  36. ncbi Quantitative RT-PCR gene expression analysis of laser microdissected tissue samples
    Heidi S Erickson
    Pathogenetics Unit, Laboratory of Pathology and Urologic Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
    Nat Protoc 4:902-22. 2009
    ..The entire protocol from tissue microdissection through qRT-PCR analysis requires approximately 16 h...
  37. ncbi A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma
    Colleen H Druzgal
    Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg. 10 CRC, Rm 4-2732, 10 Center Drive, Bethesda, MD 20892, USA
    Head Neck 27:771-84. 2005
    ..HGF, IL-6, IL-8, and VEGF merit investigation as markers of response, survival, and recurrence in larger prospective studies...
  38. ncbi Candidate measures of whole plant food intake are related to biomarkers of nutrition and health in the US population (National Health and Nutrition Examination Survey 1999-2002)
    Leah M Lipsky
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20852, USA
    Nutr Res 32:251-9. 2012
    ..Whole plant food measures are interpretable indicators of dietary intake that are significantly related to nutrition and health biomarkers and may be of public health use...
  39. ncbi Latent class models for joint analysis of disease prevalence and high-dimensional semicontinuous biomarker data
    Bo Zhang
    Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Biostatistics 13:74-88. 2012
    ....
  40. ncbi Analysis of progression-free survival data using a discrete time survival model that incorporates measurements with and without diagnostic error
    Sally Hunsberger
    National Cancer Institute, Biostatistics Research Branch, Rockville, MD, USA
    Clin Trials 7:634-42. 2010
    ..The second method is considered to be the reference standard but is expensive, time consuming, and logistically difficult. The first method has measurement error associated with it, but, it is less expensive and easier to obtain...
  41. ncbi Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial
    Gwen Murphy
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, Bethesda, MD, USA
    Cancer Causes Control 19:751-8. 2008
    ..A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk...
  42. ncbi Identification of EpCAM as a molecular target of prostate cancer stroma
    Sumana Mukherjee
    Pathogenetics Unit, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
    Am J Pathol 175:2277-87. 2009
    ..Since the stromal compartment may be particularly accessible to vascular-delivered agents, epithelial cell adhesion activating molecule could become a valuable molecular target for imaging or treatment of prostate cancer...
  43. ncbi Common leptin receptor polymorphisms do not modify the effect of alcohol ingestion on serum leptin levels in a controlled feeding and alcohol ingestion study
    Mark J Roth
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 705, MSC 8314, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:1576-8. 2005
    ..No significant effects were found between common leptin receptor polymorphisms and serum leptin levels (P > or = 0.26)...
  44. ncbi Urine analysis and protein networking identify met as a marker of metastatic prostate cancer
    Andrea L Russo
    Radiation Oncology Branch, National Cancer Institute, H Lee Moffitt Cancer Center, Tampa, Florida, USA
    Clin Cancer Res 15:4292-8. 2009
    ..Metastatic prostate cancer is a major cause of death of men in the United States. Expression of met, a receptor tyrosine kinase, has been associated with progression of prostate cancer...
  45. ncbi Adherence to the polyp prevention trial dietary intervention is associated with a behavioral pattern of adherence to nondietary trial requirements and general health recommendations
    Kay L Wanke
    Epidemiology Research Branch, Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, Bethesda, MD 20892, USA
    J Nutr 137:391-8. 2007
    ..These individuals also were more likely to adhere to social norms for healthy lifestyles and demonstrated greater adherence to other aspects of trial participation...
  46. ncbi Targeting of HER2 antigen for the treatment of disseminated peritoneal disease
    Diane E Milenic
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, and Biometric Research Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Clin Cancer Res 10:7834-41. 2004
    ..The results of this study were not as dramatic as with the former model, and higher doses were required to obtain an increase in survival of the mice (P = 0.001)...
  47. ncbi Do elevated gravitational-force events while driving predict crashes and near crashes?
    Bruce G Simons-Morton
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 7B13M, Bethesda, MD 20892 7510, USA
    Am J Epidemiol 175:1075-9. 2012
    ..76. The authors conclude that elevated gravitational-force event rates can be used to assess risk and to show high predictive accuracy of a near-future crash...
  48. ncbi A linear mixed model for predicting a binary event from longitudinal data under random effects misspecification
    Paul S Albert
    Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Stat Med 31:143-54. 2012
    ..However, under some circumstances, estimates of individual risk may be sensitive to severe random effects misspecification. We illustrate the methodology with data from a longitudinal fetal growth study...
  49. ncbi Polycyclic aromatic hydrocarbon-DNA adducts determined by semiquantitative immunohistochemistry in human esophageal biopsies taken in 1985
    Hilde E van Gijssel
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NIH, 37 Convent Dr, MSC-4255, Bethesda, MD 20892-4255, USA
    Mutat Res 547:55-62. 2004
    ....
  50. ncbi A phase I trial of enzastaurin in patients with recurrent gliomas
    Teri N Kreisl
    Neuro Oncology Branch and Biometric Research Branch, National Cancer Institute, National Institute of Neurological Disorder and Stroke, NIH, Bethesda, MD 20892, USA
    Clin Cancer Res 15:3617-23. 2009
    ..Prior phase I studies did not show increased drug exposures with escalating once daily administration. Limits from gastrointestinal absorption may be overcome by twice daily dosing, potentially improving antitumor effects...
  51. ncbi Assessing surrogates as trial endpoints using mixed models
    Edward L Korn
    Biometric Research Branch, EPN 8128, National Cancer Institute, Bethesda, MD 20892, USA
    Stat Med 24:163-82. 2005
    ..Graphical displays are also suggested. Two sets of trial results previously analysed for trial-level surrogacy are used as examples...
  52. ncbi A finite mixture survival model to characterize risk groups of neuroblastoma
    Sally Hunsberger
    Biometric Research Branch, National Cancer Institute, 6130 Executive Boulevard, Rm 8120, Rockville, MD 20852, USA
    Stat Med 28:1301-14. 2009
    ..The robustness of the model and the prediction method is examined via simulation by looking at misclassification rates under misspecified models...
  53. ncbi Pooling designs for outcomes under a Gaussian random effects model
    Yaakov Malinovsky
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Biometrics 68:45-52. 2012
    ..The design methodology is illustrated with a longitudinal study of premenopausal women focusing on assessing the reproducibility of F2-isoprostane, a biomarker of oxidative stress, over the menstrual cycle...
  54. ncbi Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma
    Clint Allen
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 13:3182-90. 2007
    ..Longitudinal changes in these serum factors could be early biomarkers of treatment response and survival...
  55. ncbi Dietary fiber intake: assessing the degree of agreement between food frequency questionnaires and 4-day food records
    Tamaro S Hudson
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-8329, USA
    J Am Coll Nutr 25:370-81. 2006
    ....
  56. ncbi On estimating the relationship between longitudinal measurements and time-to-event data using a simple two-stage procedure
    Paul S Albert
    Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Biometrics 66:983-7; discussion 987-91. 2010
    ..2008), an advantage of our proposed approach over joint modeling is that it can be implemented with standard statistical software and does not require complex estimation techniques...
  57. ncbi A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma
    Michael W Brown
    Radiation Oncology Branch, CCR, National Institutes of Health, Bethesda, MD 20892-1002, USA
    Int J Radiat Oncol Biol Phys 65:274-83. 2006
    ..IMRTi allowed dose escalation to 64.8 Gy with acceptable normal tissue doses and superior dosimetry compared with 3D-CRT and IMRTs...
  58. ncbi Binary regression analysis with pooled exposure measurements: a regression calibration approach
    Zhiwei Zhang
    Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Biometrics 67:636-45. 2011
    ..The methods are illustrated using data from the Collaborative Perinatal Project...
  59. ncbi Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy
    Linda W Chan
    Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B3/B69, Bethesda, MD, 20892-1002, USA
    J Clin Oncol 22:499-506. 2004
    ..02). CONCLUSION: This small exploratory study suggests that the angiogenic urinary trends of VEGF and MMPs may be useful predictive markers for progression-free survival in cancer patients after the completion of radiotherapy...
  60. ncbi Identifying multiple changepoints in heterogeneous binary data with an application to molecular genetics
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, 6130 Executive Blvd, Room 8136, Bethesda, MD 20892, USA
    Biostatistics 5:515-29. 2004
    ..Using simulations, we show that our approach works well and that it is robust to departures from some key modeling assumptions...
  61. ncbi A mover-stayer model for longitudinal marker data
    P S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
    Biometrics 55:1252-7. 1999
    ..A simulation study is conducted in order to demonstrate the importance of accounting for measurement error in estimating prevalence and incidence for this example...
  62. ncbi Imaging localized prostate cancer: current approaches and new developments
    Baris Turkbey
    Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1088, USA
    AJR Am J Roentgenol 192:1471-80. 2009
    ..Recent developments in imaging technologies, particularly MRI and PET, may lead to significant improvements in lesion detection and staging...
  63. ncbi Modeling longitudinal biomarker data from multiple assays that have different known detection limits
    Paul S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biometrics 64:527-37. 2008
    ..The methodology is illustrated with a recent study examining the use of a vaccine in treating macaques with simian immunodeficiency virus...
  64. ncbi Effects of alcohol and menstrual cycle on insulin-like growth factor-I and insulin-like growth factor binding protein-3
    Jackie A Lavigne
    Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 37, Room 5046, Bethesda, MD 20892 4264, USA
    Cancer Epidemiol Biomarkers Prev 13:2264-7. 2004
    ..This is the first controlled diet study to show that alcohol decreases serum IGF-I in premenopausal women and that IGF-I significantly increases over the course of the menstrual cycle whether or not alcohol is present...
  65. ncbi No association between fatty acid intake and adenomatous polyp recurrence in the polyp prevention trial
    Marie M Cantwell
    Center Cancer Research, National Cancer Institute, NIH, 6116 Executive Boulevard, Suite 702, Room 7218, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 14:2059-60. 2005
  66. ncbi Random effects and latent processes approaches for analyzing binary longitudinal data with missingness: a comparison of approaches using opiate clinical trial data
    Paul S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, USA
    Stat Methods Med Res 16:417-39. 2007
    ..We also compare these random effect and latent process approaches with other methods for accounting for non-ignorable missingness using this data set...
  67. ncbi Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice
    Gerd Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Nutr Cancer 60:373-81. 2008
    ..04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans...
  68. ncbi Induction of autoantibodies to CCR5 in macaques and subsequent effects upon challenge with an R5-tropic simian/human immunodeficiency virus
    Bryce Chackerian
    Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:4037-47. 2004
    ....
  69. ncbi Use of multiple assays subject to detection limits with regression modeling in assessing the relationship between exposure and outcome
    Paul S Albert
    Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20906, USA
    Epidemiology 21:S35-43. 2010
    ..Often various assays can be used to measure a particular environmental exposure, with some assays being more invasive or expensive than others...
  70. ncbi Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States)
    Joseph A Tangrea
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 14:403-11. 2003
    ....
  71. ncbi Relationship between serum leptin levels and alcohol consumption in a controlled feeding and alcohol ingestion study
    Mark J Roth
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Natl Cancer Inst 95:1722-5. 2003
    ....
  72. ncbi The effects of payment method on clinical decision-making: physician responses to clinical scenarios
    Joannie Shen
    Laboratory of Clinical Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20814 1610, USA
    Med Care 42:297-302. 2004
    ..The influence of payment mechanisms on physician decisions is not well understood...
  73. ncbi Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice
    Roycelynn A Mentor-Marcel
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
    Cancer Prev Res (Phila) 2:60-9. 2009
    ..Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis...
  74. ncbi Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories
    Craig B Borkowf
    National Cancer Institute, Center for Cancer Research, Cancer Prevention Studies Branch, 6116 Executive Blvd, Suite 705, MSC 8314, Bethesda, MD 20892 8314, USA
    Stat Med 22:1477-93. 2003
    ..Conversely, using appropriate lowess methods to adjust the data tends to give nearly unbiased parameter estimates, near nominal significance levels, and improved power...
  75. ncbi Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial
    Gerd Bobe
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, Room 110, Building 576, Frederick, MD 21702 1201, USA
    Cancer Epidemiol Biomarkers Prev 17:1344-53. 2008
    ..Our data suggest that a flavonol-rich diet may decrease the risk of advanced adenoma recurrence...
  76. ncbi A joint modeling approach to data with informative cluster size: robustness to the cluster size model
    Zhen Chen
    Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, U S A
    Stat Med 30:1825-36. 2011
    ..We also found that there is little efficiency loss under this model misspecification. A developmental toxicity study was used to motivate the research and to demonstrate the findings...
  77. ncbi Latent model for correlated binary data with diagnostic error
    J H Shih
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7938, USA
    Biometrics 55:1232-5. 1999
    ..The methodology is illustrated with data from a study that assessed the probability of corneal arcus in patients with familial hypercholesterolemia...
  78. ncbi Hormone replacement therapy and colorectal adenoma recurrence among women in the Polyp Prevention Trial
    K Woodson
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute NIH, 6006 Executive Blvd, MSC 7058, Bethesda, MD 20892 7058, USA
    J Natl Cancer Inst 93:1799-805. 2001
    ....
  79. ncbi Repeated probit regression when covariates are measured with error
    D A Follmann
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7938, USA
    Biometrics 55:403-9. 1999
    ..The approach is demonstrated using nutrient safety data from the Diet Intervention of School Age Children (DISC) study...
  80. ncbi Bayesian monitoring of event rates with censored data
    D A Follmann
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 7938, USA
    Biometrics 55:603-7. 1999
    ..Practical issues involved in implementing the procedure are discussed and illustrated with a simulation of the single arm Cord Blood Transplantation Study where 6-month survival is monitored...
  81. ncbi Comparison of one-, two-, and three-dimensional measurements of childhood brain tumors
    K E Warren
    Neuro Oncology Branch, National Cancer Institute NCI and National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1928, USA
    J Natl Cancer Inst 93:1401-5. 2001
    ..Because software to estimate three-dimensional (3D) tumor volume from digitized MRI images is available, we compared all three methods of tumor measurement for childhood brain tumors and clinical outcome...
  82. ncbi A cross-sectional study of human serum sphingolipids, diet and physiologic parameters
    C C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Nutr 131:2748-52. 2001
    ..This study represents the largest report of human serum sphingolipid concentrations to date and provides insight into potential explanatory variables that can be incorporated into future studies...
  83. ncbi Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china
    C C Abnet
    National Cancer Institute, Center for Cancer Research, Cancer Prevention Studies Branch, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 12:821-8. 2001
    ..We conducted a prospective nested case-control study to examine the relationship between serum sphingolipids and ESCC incidence...
  84. ncbi Adjusting for drop-out in clinical trials with repeated measures: design and analysis issues
    M C Wu
    Office of Biostatistics Research, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda, MD 20892-7938, USA
    Stat Med 20:93-108. 2001
    ..The results are highlighted with applications to both a hypertensive and a respiratory disease clinical trial, where multiple measurements of the primary response were made for all participants at each visit...
  85. ncbi Imputation approaches for estimating diagnostic accuracy for multiple tests from partially verified designs
    Paul S Albert
    Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda Maryland 20892, USA
    Biometrics 63:947-57. 2007
    ..I apply imputation to a study designed to estimate the diagnostic accuracy of digital radiography for gastric cancer. The feasibility and robustness of imputation is illustrated with analysis, asymptotic results, and simulations...
  86. ncbi Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy
    Thierry M Muanza
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Radiat Oncol Biol Phys 62:1316-21. 2005
    ..Endoscopic examination of the rectal mucosa at the end and immediate follow-up of a course of therapy does not seem to be informative or reproducible between observers in the acute setting...
  87. ncbi Dynamic contrast-enhanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parameters
    Iclal Ocak
    Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    AJR Am J Roentgenol 189:849. 2007
    ....
  88. ncbi Random effects modeling approaches for estimating ROC curves from repeated ordinal tests without a gold standard
    Paul S Albert
    Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biometrics 63:593-602. 2007
    ..These modeling approaches, along with the importance of accounting for the dependence between tests, are illustrated by analyzing the uterine cancer pathology data analyzed by Zhou et al. (2005)...
  89. ncbi Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy
    Emilie A Steffen-Smith
    Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Childs Nerv Syst 24:807-13. 2008
    ....
  90. ncbi EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignancies
    Deirdre O'Mahony
    Metabolism Branch, Center for Cancer Research, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland and MedImmune, Inc, Gaithersburg, Maryland, USA
    Clin Cancer Res 15:2514-22. 2009
    ..The development of EBV-LPD has been associated with the use of immunosuppressive agents used in solid organ, bone marrow, and stem cell transplantation and in certain congenital immunodeficiencies...
  91. ncbi Efficacy of CD34+ stem cell dose in patients undergoing allogeneic peripheral blood stem cell transplantation after total body irradiation
    Anurag K Singh
    Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 13:339-44. 2007
    ..A method for assessing risk of mortality by CD34(+) dose as a continuous variable is presented. Risk of mortality decreased with CD34(+) doses between 4-8 x 10(6) cells/kg and then began to increase...
  92. ncbi A phase I trial of lenalidomide in patients with recurrent primary central nervous system tumors
    Howard A Fine
    Neuro Oncology Branch and Medical Oncology Branch, National Cancer Institute, The National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Clin Cancer Res 13:7101-6. 2007
    ....
  93. ncbi Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial
    G Bobe
    Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Building 576, Room 101, 1050 Boyles Street, Frederick, MD 21702, USA
    Br J Cancer 103:1453-61. 2010
    ..Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation...
  94. ncbi Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China
    Nan Hu
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute NCI, 6116 Executive Blvd, Room 705, Bethesda, MD 20892, USA
    Cancer Detect Prev 27:132-8. 2003
    ..22 versus 0.36 in high risk group (P=0.047), and 0.22 versus 0.40 in low risk group (P=0.010)), consistent with a disease association. These data suggest that the 203G>A polymorphism in BRCA2 may be associated with risk of ESCC...
  95. ncbi Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrence
    Alfredo Velasco
    Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 1501, USA
    Cancer 94:690-9. 2002
    ....
  96. ncbi Concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer
    J B Sunwoo
    Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Oncol 19:800-11. 2001
    ..CONCLUSION: Paclitaxel administered as a 120-hour continuous infusion in combination with radiotherapy is a feasible and promising treatment for patients with advanced HNSCC...
  97. ncbi Components of variation in serum carotenoid concentrations: the Polyp Prevention Trial
    M R Forman
    Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Eur J Clin Nutr 63:763-70. 2009
    ..The intra- and interindividual variations and season and center effects were estimated from a series of serum carotenoid concentrations in the Polyp Prevention Trial (PPT) participants...
  98. ncbi The association of calcium and vitamin D with risk of colorectal adenomas
    Terryl J Hartman
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 135:252-9. 2005
    ..14) on risk for adenoma recurrence. This trial cohort provides some evidence that calcium and vitamin D may be inversely associated with adenoma recurrence...
  99. ncbi Efficient estimation of the risk of a disease by quantile-categories of a key predictor variable using generalized additive models
    Craig B Borkowf
    Mathematical Statistician, Centers for Disease Control and Prevention CDC, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Influenza Branch, Epidemiology Section, Atlanta, GA 30333, USA
    Stat Med 24:623-45. 2005
    ..An example from nutritional epidemiology illustrates the use of these methods...
  100. ncbi Carotenoids, vitamin A and risk of adenomatous polyp recurrence in the polyp prevention trial
    Susan Steck-Scott
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 57299, USA
    Int J Cancer 112:295-305. 2004
    ..Thus, alpha-carotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk...
  101. ncbi The association between cigarette smoking and colorectal polyp recurrence (United States)
    Electra D Paskett
    Division of Population Sciences, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210 1240, USA
    Cancer Causes Control 16:1021-33. 2005
    ..This association was investigated prospectively with data from the Polyp Prevention Trial...