Research Topics
Genomes and Genes | Paul S AlbertSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Summer activity patterns among teenage girls: harmonic shape invariant modeling to estimate circadian cyclesSemhar Ogbagaber
Biostatistics and Bioinformatics Branch, Division of Epidemiology Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Bethesda, MD, 20892, USA
J Circadian Rhythms 10:2. 2012..abstract:..- Simultaneous integrated boost of biopsy proven, MRI defined dominant intra-prostatic lesions to 95 Gray with IMRT: early results of a phase I NCI studyAnurag K Singh
Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, USA
Radiat Oncol 2:36. 2007..To assess the feasibility and early toxicity of selective, IMRT-based dose escalation (simultaneous integrated boost) to biopsy proven dominant intra-prostatic lesions visible on MRI... 
Imputation approaches for estimating diagnostic accuracy for multiple tests from partially verified designsPaul S Albert
Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda Maryland 20892, USA
Biometrics 63:947-57. 2007..I apply imputation to a study designed to estimate the diagnostic accuracy of digital radiography for gastric cancer. The feasibility and robustness of imputation is illustrated with analysis, asymptotic results, and simulations...- Modeling longitudinal biomarker data from multiple assays that have different known detection limitsPaul S Albert
Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
Biometrics 64:527-37. 2008..The methodology is illustrated with a recent study examining the use of a vaccine in treating macaques with simian immunodeficiency virus... - Random effects modeling approaches for estimating ROC curves from repeated ordinal tests without a gold standardPaul S Albert
Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Biometrics 63:593-602. 2007..These modeling approaches, along with the importance of accounting for the dependence between tests, are illustrated by analyzing the uterine cancer pathology data analyzed by Zhou et al. (2005)... - Random effects and latent processes approaches for analyzing binary longitudinal data with missingness: a comparison of approaches using opiate clinical trial dataPaul S Albert
Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, USA
Stat Methods Med Res 16:417-39. 2007..We also compare these random effect and latent process approaches with other methods for accounting for non-ignorable missingness using this data set... - Use of multiple assays subject to detection limits with regression modeling in assessing the relationship between exposure and outcomePaul S Albert
Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD 20906, USA
Epidemiology 21:S35-43. 2010..Often various assays can be used to measure a particular environmental exposure, with some assays being more invasive or expensive than others... 
A linear mixed model for predicting a binary event from longitudinal data under random effects misspecificationPaul S Albert
Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Stat Med 31:143-54. 2012..However, under some circumstances, estimates of individual risk may be sensitive to severe random effects misspecification. We illustrate the methodology with data from a longitudinal fetal growth study...- On estimating the relationship between longitudinal measurements and time-to-event data using a simple two-stage procedurePaul S Albert
Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Biometrics 66:983-7; discussion 987-91. 2010..2008), an advantage of our proposed approach over joint modeling is that it can be implemented with standard statistical software and does not require complex estimation techniques... - Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trialGerd Bobe
Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Prev Res (Phila) 3:764-75. 2010..Our results suggest that serum IL-6 may serve as a risk indicator and as a response indicator to dietary flavonols for colorectal cancer prevention... - Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC scoreNicole L Simone
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Int J Radiat Oncol Biol Phys 70:90-5. 2008..To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score... - Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention TrialGwen Murphy
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, MD 20892, USA
Int J Cancer 124:2148-51. 2009..Increased risk of adenoma recurrence as conferred by DRD2 genotypes may be related to difference in alcohol and fat intake across genotypes... - Postpolypectomy colonoscopy surveillance guidelines: predictive accuracy for advanced adenoma at 4 yearsAdeyinka O Laiyemo
Cancer Prevention Fellowship Program, Biometry Research Group, Divisionof Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Ann Intern Med 148:419-26. 2008..Lack of confidence in postpolypectomy surveillance guidelines may be a factor in the observed low adherence rates among providers... - Improved efficacy of alpha-particle-targeted radiation therapy: dual targeting of human epidermal growth factor receptor-2 and tumor-associated glycoprotein 72Diane E Milenic
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer 116:1059-66. 2010..A next logical step to improve therapeutic benefit would be to target tumors with both molecules simultaneously... - Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention TrialGerd Bobe
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute NCI, NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 19:1441-52. 2010..Serum adiponectin, leptin, C-peptide, and homocysteine are indicators for obesity, hyperinsulinemia, and chronic inflammation, which have all been associated with colorectal cancer... - Potentiation of high-LET radiation by gemcitabine: targeting HER2 with trastuzumab to treat disseminated peritoneal diseaseDiane E Milenic
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch and Biometric Research Branch, National Cancer Institute, Bethesda, MD 20892, USA
Clin Cancer Res 13:1926-35. 2007..The objective of the studies presented here was improvement of the efficacy of alpha-particle radioimmunotherapy using a chemotherapeutic agent... - Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention TrialGerd Bobe
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Frederick, MD, USA
Int J Cancer 130:1649-59. 2012..04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women... - Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancerDeborah Citrin
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Radiat Oncol Biol Phys 74:1040-6. 2009..To report the long-term outcomes and toxicity of a regimen of infusion paclitaxel delivered concurrently with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck... - Multimodality therapy: potentiation of high linear energy transfer radiation with paclitaxel for the treatment of disseminated peritoneal diseaseDiane E Milenic
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
Clin Cancer Res 14:5108-15. 2008..Studies herein explore paclitaxel enhancement of the therapeutic efficacy of alpha-particle-targeted radiation therapy... - A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomasTeri N Kreisl
Neuro Oncology Branch, National Cancer Institute, NIH, 9030 Old Georgetown Road, Bloch Bldg 82, Room 225, Bethesda, MD 20892, USA
Neuro Oncol 12:181-9. 2010..Enzastaurin has anti-glioma activity in patients with recurrent high-grade glioma, but does not appear to have enough single-agent activity to be useful as monotherapy... - Hyperplastic polyps and the risk of adenoma recurrence in the polyp prevention trialAdeyinka O Laiyemo
Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA
Clin Gastroenterol Hepatol 7:192-7. 2009..Prospective information on the risk of adenoma recurrence associated with hyperplastic polyps is limited. We sought to investigate whether the coexistence of hyperplastic polyps with adenomas increases the risk of adenoma recurrence... - The effect of strict adherence to a high-fiber, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrenceLeah B Sansbury
Division of Cancer Control and Population Sciences, 6130 Executive Boulevard, Room 5106, Mail Stop Code 7324, Bethesda, MD 20892, USA
Am J Epidemiol 170:576-84. 2009..65, 95% confidence interval: 0.47, 0.92). Findings suggest that high compliance with a low-fat, high-fiber diet is associated with reduced risk of adenoma recurrence... - The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomizationElaine Lanza
Laboratory for Cancer Prevention, Centre for Cancer Research, National Cancer Institute, 6116 Executive Boulevard, Room 7206, Bethesda, MD 20892 8325, USA
Cancer Epidemiol Biomarkers Prev 16:1745-52. 2007..04 (0.98-1.09). This study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up. (Cancer Epidemiol Biomarkers Prev 2007;16(9):1745-52)... - Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols?Gerd Bobe
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Eur J Cancer Prev 20:86-95. 2011..In conclusion, our results suggest that IL SNPs, in combination with a flavonol-rich diet or decreased serum IL, may lower the risk of adenoma recurrence... - Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot studyAnurag K Singh
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Int J Radiat Oncol Biol Phys 65:1008-13. 2006..1 g amifostine suspension. Further studies should be conducted in populations at higher risk for developing symptomatic acute and late proctitis... - Alpha-particle radioimmunotherapy of disseminated peritoneal disease using a (212)Pb-labeled radioimmunoconjugate targeting HER2Diane E Milenic
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC 1088, Building 10, Bethesda, MD 20892, USA
Cancer Biother Radiopharm 20:557-68. 2005..98). No improvement in median survival was noted with a similar regimen in the Shaw xenograft model... - The utility of menstrual cycle length as an indicator of cumulative hormonal exposureSunni L Mumford
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, 7B03, Rockville, Maryland 20852, USA
J Clin Endocrinol Metab 97:E1871-9. 2012..Associations between menstrual cycle length and chronic diseases are hypothesized to be due to differences in underlying hormonal patterns... - Latent class models for joint analysis of disease prevalence and high-dimensional semicontinuous biomarker dataBo Zhang
Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Biostatistics 13:74-88. 2012.... - Prostate cancer: value of multiparametric MR imaging at 3 T for detection--histopathologic correlationBaris Turkbey
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Bldg 10, Room 1B40, Bethesda, MD 20892 1088, USA
Radiology 255:89-99. 2010.... - Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomasFabio M Iwamoto
Neuro Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Cancer 116:1776-82. 2010..Talampanel is an oral AMPA receptor inhibitor with excellent central nervous system penetration and good tolerability in clinical trials for epilepsy and other neurologic disorders... - Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal womenJackie A Lavigne
National Cancer Institute, Bethesda, MD 20892 4264, USA
Am J Clin Nutr 81:503-7. 2005..Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I or IGFBP-3 have not been conducted... - Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastomaTeri N Kreisl
Neuro Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8200, USA
J Clin Oncol 27:740-5. 2009..To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma... - High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trialElaine Lanza
Nutritional Epidemiology Branch, Division of Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Nutr 136:1896-903. 2006..001). The median in the highest quartile of change in dry bean intake was 370% higher than the baseline intake. The PPT trial-based cohort provides evidence that dry beans may be inversely associated with advanced adenoma recurrence... - Quantitative RT-PCR gene expression analysis of laser microdissected tissue samplesHeidi S Erickson
Pathogenetics Unit, Laboratory of Pathology and Urologic Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
Nat Protoc 4:902-22. 2009..The entire protocol from tissue microdissection through qRT-PCR analysis requires approximately 16 h... - Patient selection determines the prostate cancer yield of dynamic contrast-enhanced magnetic resonance imaging-guided transrectal biopsies in a closed 3-Tesla scannerAnurag K Singh
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1642, USA
BJU Int 101:181-5. 2008.... - Estimating diagnostic accuracy of multiple binary tests with an imperfect reference standardPaul S Albert
Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, U S A
Stat Med 28:780-97. 2009..The methodology is demonstrated with a study examining the diagnostic accuracy of various HIV-antibody tests for HIV... - A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinomaColleen H Druzgal
Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg. 10 CRC, Rm 4-2732, 10 Center Drive, Bethesda, MD 20892, USA
Head Neck 27:771-84. 2005..HGF, IL-6, IL-8, and VEGF merit investigation as markers of response, survival, and recurrence in larger prospective studies... - High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese populationNan Hu
Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 7236, USA
Genes Chromosomes Cancer 39:205-16. 2004..Only one alteration was observed in CDKN2B, G171A in the 5' untranslated region. Both mutation and intragenic allelic loss in CDKN2A appear to play a role in the development of ESCC... - Analysis of progression-free survival data using a discrete time survival model that incorporates measurements with and without diagnostic errorSally Hunsberger
National Cancer Institute, Biostatistics Research Branch, Rockville, MD, USA
Clin Trials 7:634-42. 2010..The second method is considered to be the reference standard but is expensive, time consuming, and logistically difficult. The first method has measurement error associated with it, but, it is less expensive and easier to obtain... - Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention TrialGwen Murphy
Cancer Prevention Fellowship Program, Office of Preventive Oncology, Bethesda, MD, USA
Cancer Causes Control 19:751-8. 2008..A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk... - Identification of EpCAM as a molecular target of prostate cancer stromaSumana Mukherjee
Pathogenetics Unit, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
Am J Pathol 175:2277-87. 2009..Since the stromal compartment may be particularly accessible to vascular-delivered agents, epithelial cell adhesion activating molecule could become a valuable molecular target for imaging or treatment of prostate cancer... - Adherence to the polyp prevention trial dietary intervention is associated with a behavioral pattern of adherence to nondietary trial requirements and general health recommendationsKay L Wanke
Epidemiology Research Branch, Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, Bethesda, MD 20892, USA
J Nutr 137:391-8. 2007..These individuals also were more likely to adhere to social norms for healthy lifestyles and demonstrated greater adherence to other aspects of trial participation... - Targeting of HER2 antigen for the treatment of disseminated peritoneal diseaseDiane E Milenic
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, and Biometric Research Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Clin Cancer Res 10:7834-41. 2004..The results of this study were not as dramatic as with the former model, and higher doses were required to obtain an increase in survival of the mice (P = 0.001)... - Candidate measures of whole plant food intake are related to biomarkers of nutrition and health in the US population (National Health and Nutrition Examination Survey 1999-2002)Leah M Lipsky
Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20852, USA
Nutr Res 32:251-9. 2012..Whole plant food measures are interpretable indicators of dietary intake that are significantly related to nutrition and health biomarkers and may be of public health use... - Pooling designs for outcomes under a Gaussian random effects modelYaakov Malinovsky
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Biometrics 68:45-52. 2012..The design methodology is illustrated with a longitudinal study of premenopausal women focusing on assessing the reproducibility of F2-isoprostane, a biomarker of oxidative stress, over the menstrual cycle... - Do elevated gravitational-force events while driving predict crashes and near crashes?Bruce G Simons-Morton
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 7B13M, Bethesda, MD 20892 7510, USA
Am J Epidemiol 175:1075-9. 2012..76. The authors conclude that elevated gravitational-force event rates can be used to assess risk and to show high predictive accuracy of a near-future crash... - Binary regression analysis with pooled exposure measurements: a regression calibration approachZhiwei Zhang
Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Biometrics 67:636-45. 2011..The methods are illustrated using data from the Collaborative Perinatal Project... - Common leptin receptor polymorphisms do not modify the effect of alcohol ingestion on serum leptin levels in a controlled feeding and alcohol ingestion studyMark J Roth
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 705, MSC 8314, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 14:1576-8. 2005..No significant effects were found between common leptin receptor polymorphisms and serum leptin levels (P > or = 0.26)... - Urine analysis and protein networking identify met as a marker of metastatic prostate cancerAndrea L Russo
Radiation Oncology Branch, National Cancer Institute, H Lee Moffitt Cancer Center, Tampa, Florida, USA
Clin Cancer Res 15:4292-8. 2009..Metastatic prostate cancer is a major cause of death of men in the United States. Expression of met, a receptor tyrosine kinase, has been associated with progression of prostate cancer... - A phase I trial of enzastaurin in patients with recurrent gliomasTeri N Kreisl
Neuro Oncology Branch and Biometric Research Branch, National Cancer Institute, National Institute of Neurological Disorder and Stroke, NIH, Bethesda, MD 20892, USA
Clin Cancer Res 15:3617-23. 2009..Prior phase I studies did not show increased drug exposures with escalating once daily administration. Limits from gastrointestinal absorption may be overcome by twice daily dosing, potentially improving antitumor effects... - A finite mixture survival model to characterize risk groups of neuroblastomaSally Hunsberger
Biometric Research Branch, National Cancer Institute, 6130 Executive Boulevard, Rm 8120, Rockville, MD 20852, USA
Stat Med 28:1301-14. 2009..The robustness of the model and the prediction method is examined via simulation by looking at misclassification rates under misspecified models... - Assessing surrogates as trial endpoints using mixed modelsEdward L Korn
Biometric Research Branch, EPN 8128, National Cancer Institute, Bethesda, MD 20892, USA
Stat Med 24:163-82. 2005..Graphical displays are also suggested. Two sets of trial results previously analysed for trial-level surrogacy are used as examples... - Identifying multiple changepoints in heterogeneous binary data with an application to molecular geneticsPaul S Albert
Biometric Research Branch, National Cancer Institute, 6130 Executive Blvd, Room 8136, Bethesda, MD 20892, USA
Biostatistics 5:515-29. 2004..Using simulations, we show that our approach works well and that it is robust to departures from some key modeling assumptions... - A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinomaMichael W Brown
Radiation Oncology Branch, CCR, National Institutes of Health, Bethesda, MD 20892-1002, USA
Int J Radiat Oncol Biol Phys 65:274-83. 2006..IMRTi allowed dose escalation to 64.8 Gy with acceptable normal tissue doses and superior dosimetry compared with 3D-CRT and IMRTs... - Polycyclic aromatic hydrocarbon-DNA adducts determined by semiquantitative immunohistochemistry in human esophageal biopsies taken in 1985Hilde E van Gijssel
Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NIH, 37 Convent Dr, MSC-4255, Bethesda, MD 20892-4255, USA
Mutat Res 547:55-62. 2004.... - Dietary fiber intake: assessing the degree of agreement between food frequency questionnaires and 4-day food recordsTamaro S Hudson
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-8329, USA
J Am Coll Nutr 25:370-81. 2006.... - A latent autoregressive model for longitudinal binary data subject to informative missingnessPaul S Albert
Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Biometrics 58:631-42. 2002..We illustrate our new methodology using the opiate clinical trial data... - Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinomaClint Allen
Tumor Biology Section, Head and Neck Surgery Branch, National Institute of Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 13:3182-90. 2007..Longitudinal changes in these serum factors could be early biomarkers of treatment response and survival... - Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapyLinda W Chan
Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room B3/B69, Bethesda, MD, 20892-1002, USA
J Clin Oncol 22:499-506. 2004..02). CONCLUSION: This small exploratory study suggests that the angiogenic urinary trends of VEGF and MMPs may be useful predictive markers for progression-free survival in cancer patients after the completion of radiotherapy... - Imaging localized prostate cancer: current approaches and new developmentsBaris Turkbey
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1088, USA
AJR Am J Roentgenol 192:1471-80. 2009..Recent developments in imaging technologies, particularly MRI and PET, may lead to significant improvements in lesion detection and staging... - A cautionary note on the robustness of latent class models for estimating diagnostic error without a gold standardPaul S Albert
Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA
Biometrics 60:427-35. 2004..Further, data analysis and simulations demonstrate the practical implications of model misspecification. Finally, we present some guidelines about the use of these models for practitioners... - No association between fatty acid intake and adenomatous polyp recurrence in the polyp prevention trialMarie M Cantwell
Center Cancer Research, National Cancer Institute, NIH, 6116 Executive Boulevard, Suite 702, Room 7218, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:2059-60. 2005 - On analyzing circadian rhythms data using nonlinear mixed models with harmonic termsPaul S Albert
Biometric Research Branch, National Cancer Institute, Executive Plaza North, Bethesda, Maryland 20892 7434, USA
Biometrics 61:1115-20; discussion 1120-2. 2005..The proposed parametric approach provides an alternative to Wang et al.'s semiparametric approach and has the added advantage of being easy to implement in most statistical software packages... - Relationship between serum leptin levels and alcohol consumption in a controlled feeding and alcohol ingestion studyMark J Roth
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
J Natl Cancer Inst 95:1722-5. 2003.... - Induction of autoantibodies to CCR5 in macaques and subsequent effects upon challenge with an R5-tropic simian/human immunodeficiency virusBryce Chackerian
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 78:4037-47. 2004.... - Use of complementary/alternative therapies by women with advanced-stage breast cancerJoannie Shen
Laboratory of Clinical Sciences, National Institute of Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD, USA
BMC Complement Altern Med 2:8. 2002.... - Modeling tumor growth with random onsetPaul S Albert
Biometric Research Branch, National Cancer Institute, Executive Plaza North, Room 8136, Bethesda, Maryland 20892 7434, USA
Biometrics 59:897-906. 2003..We illustrate this methodology with an application examining the effect of different mutations on tumorigenesis... - Modeling familial association of ages at onset of disease in the presence of competing riskJoanna H Shih
Biometric Research Branch, National Cancer Institute, Rockville, Maryland 20852, USA
Biometrics 66:1012-23. 2010..2006, Journal of the American Statistical Association 101, 65-77). The proposed method is illustrated using the kinship data from the Washington Ashkenazi Study... - Effects of alcohol and menstrual cycle on insulin-like growth factor-I and insulin-like growth factor binding protein-3Jackie A Lavigne
Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 37, Room 5046, Bethesda, MD 20892 4264, USA
Cancer Epidemiol Biomarkers Prev 13:2264-7. 2004..This is the first controlled diet study to show that alcohol decreases serum IGF-I in premenopausal women and that IGF-I significantly increases over the course of the menstrual cycle whether or not alcohol is present... - Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categoriesCraig B Borkowf
National Cancer Institute, Center for Cancer Research, Cancer Prevention Studies Branch, 6116 Executive Blvd, Suite 705, MSC 8314, Bethesda, MD 20892 8314, USA
Stat Med 22:1477-93. 2003..Conversely, using appropriate lowess methods to adjust the data tends to give nearly unbiased parameter estimates, near nominal significance levels, and improved power... - Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob miceRoycelynn A Mentor-Marcel
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
Cancer Prev Res (Phila) 2:60-9. 2009..Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis... - Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention TrialGerd Bobe
Laboratory of Cancer Prevention, National Cancer Institute Frederick, Room 110, Building 576, Frederick, MD 21702 1201, USA
Cancer Epidemiol Biomarkers Prev 17:1344-53. 2008..Our data suggest that a flavonol-rich diet may decrease the risk of advanced adenoma recurrence... - Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob miceGerd Bobe
Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
Nutr Cancer 60:373-81. 2008..04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans... - Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States)Joseph A Tangrea
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7058, USA
Cancer Causes Control 14:403-11. 2003.... - A joint modeling approach to data with informative cluster size: robustness to the cluster size modelZhen Chen
Biostatistics and Bioinformatics Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, U S A
Stat Med 30:1825-36. 2011..We also found that there is little efficiency loss under this model misspecification. A developmental toxicity study was used to motivate the research and to demonstrate the findings... - Design of a binary biomarker study from the results of a pilot studyPaul S Albert
Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892 7434, USA
Biometrics 58:576-85. 2002..We illustrate the methodology with data from a study assessing the reproducibility of p53 immunohistochemistry in bladder tumors... - Dynamic contrast-enhanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parametersIclal Ocak
Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
AJR Am J Roentgenol 189:849. 2007.... - A phase I trial of lenalidomide in patients with recurrent primary central nervous system tumorsHoward A Fine
Neuro Oncology Branch and Medical Oncology Branch, National Cancer Institute, The National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
Clin Cancer Res 13:7101-6. 2007.... - Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopyEmilie A Steffen-Smith
Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health NIH, Bethesda, MD 20892, USA
Childs Nerv Syst 24:807-13. 2008.... - Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapyThierry M Muanza
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Radiat Oncol Biol Phys 62:1316-21. 2005..Endoscopic examination of the rectal mucosa at the end and immediate follow-up of a course of therapy does not seem to be informative or reproducible between observers in the acute setting... - EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignanciesDeirdre O'Mahony
Metabolism Branch, Center for Cancer Research, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland and MedImmune, Inc, Gaithersburg, Maryland, USA
Clin Cancer Res 15:2514-22. 2009..The development of EBV-LPD has been associated with the use of immunosuppressive agents used in solid organ, bone marrow, and stem cell transplantation and in certain congenital immunodeficiencies... - Efficacy of CD34+ stem cell dose in patients undergoing allogeneic peripheral blood stem cell transplantation after total body irradiationAnurag K Singh
Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Biol Blood Marrow Transplant 13:339-44. 2007..A method for assessing risk of mortality by CD34(+) dose as a continuous variable is presented. Risk of mortality decreased with CD34(+) doses between 4-8 x 10(6) cells/kg and then began to increase... - The effects of payment method on clinical decision-making: physician responses to clinical scenariosJoannie Shen
Laboratory of Clinical Studies, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20814 1610, USA
Med Care 42:297-302. 2004..The influence of payment mechanisms on physician decisions is not well understood... - Assessment of normalization strategies for quantitative RT-PCR using microdissected tissue samplesHeidi S Erickson
Pathogenetics Unit, Laboratory of Pathology and Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Lab Invest 87:951-62. 2007..Taken together, these results suggest that precise gene expression measurements can be made from MD samples if the appropriate normalization strategy is employed... - Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrenceAlfredo Velasco
Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 1501, USA
Cancer 94:690-9. 2002.... - Does nonsteroidal anti-inflammatory drug use modify the effect of a low-fat, high-fiber diet on recurrence of colorectal adenomas?Terryl J Hartman
Department of Nutritional Sciences, The Pennsylvania State University, 5A Henderson Building, University Park, PA 16802, USA
Cancer Epidemiol Biomarkers Prev 14:2359-65. 2005..Nevertheless, our results suggest that adopting a low-fat, high-fiber diet rich in fruits and vegetables may lower the risk of colorectal adenoma recurrence among individuals who do not regularly use NSAIDs... - The association between cigarette smoking and colorectal polyp recurrence (United States)Electra D Paskett
Division of Population Sciences, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210 1240, USA
Cancer Causes Control 16:1021-33. 2005..This association was investigated prospectively with data from the Polyp Prevention Trial... - Carotenoids, vitamin A and risk of adenomatous polyp recurrence in the polyp prevention trialSusan Steck-Scott
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 57299, USA
Int J Cancer 112:295-305. 2004..Thus, alpha-carotene and vitamin A may protect against recurrence in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk... - Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunizationAgneta S von Gegerfelt
Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Building 535, Room 210, Frederick, MD 21702 1201, USA
J Virol 81:1972-9. 2007..Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy... - Efficient estimation of the risk of a disease by quantile-categories of a key predictor variable using generalized additive modelsCraig B Borkowf
Mathematical Statistician, Centers for Disease Control and Prevention CDC, National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Influenza Branch, Epidemiology Section, Atlanta, GA 30333, USA
Stat Med 24:623-45. 2005..An example from nutritional epidemiology illustrates the use of these methods... - The association of calcium and vitamin D with risk of colorectal adenomasTerryl J Hartman
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
J Nutr 135:252-9. 2005..14) on risk for adenoma recurrence. This trial cohort provides some evidence that calcium and vitamin D may be inversely associated with adenoma recurrence... - Comment on Lu, et. al. 2004: Analyzing excessive no changes in clinical trials with clustered dataPaul S Albert
Biometrics 61:879-80; author reply 880-1. 2005 - Long-term salvage radiotherapy outcome after radical prostatectomy and relapse predictorsJoseph P Brooks
Section of Radiation Oncology, Department of Urology, Walter Reed Army Medical Center, Washington, D. C, USA
J Urol 174:2204-8, discussion 2208. 2005..It is well tolerated with few severe late effects. Increasing Gleason score, lymphovascular invasion and lack of a complete response to SRT are significant risks for disease progression requiring additional management... - Lymphovascular invasion in prostate cancer: prognostic significance in patients treated with radiotherapy after radical prostatectomyJoseph P Brooks
Division of Radiation Oncology, Walter Reed Army Medical Center, Washington, DC, USA
Cancer 106:1521-6. 2006..4; P < .001). CONCLUSIONS: LVI was useful as a pathologic marker for reduced efficacy of P-XRT after RP in terms of increased risk of BCR and DM. Future studies will be needed to validate these findings... - Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogeneLaura S Schmidt
Basic Research Program, SAIC Frederick, Inc, Frederick, Maryland, USA
J Urol 172:1256-61. 2004..In the current study we evaluated the clinical phenotype and germline MET mutation of 3 new HPRC families. We describe the early onset clinical features of HPRC... - Inter-observer variability in the measurement of diffuse intrinsic pontine gliomasRobert M Hayward
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10 CRC, Rm 1 3940, Bethesda, MD 20892, USA
J Neurooncol 90:57-61. 2008..Endpoints for clinical trials determining efficacy in this population should also include more objective measures, such as survival, and additional endpoints need to be investigated...