M C Alavanja

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Cancer incidence among pesticide applicators exposed to cyanazine in the agricultural health study
    Shannon M Lynch
    Clinical and Genetic Epidemiology Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20892, USA
    Environ Health Perspect 114:1248-52. 2006
  2. pmc Phorate exposure and incidence of cancer in the agricultural health study
    Rajeev Mahajan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Environ Health Perspect 114:1205-9. 2006
  3. pmc Fonofos exposure and cancer incidence in the agricultural health study
    Rajeev Mahajan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Environ Health Perspect 114:1838-42. 2006
  4. pmc Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health study
    Claudine Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Environ Health Perspect 114:1521-6. 2006
  5. pmc Lifetime pesticide use and telomere shortening among male pesticide applicators in the Agricultural Health Study
    Lifang Hou
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Environ Health Perspect 121:919-24. 2013
  6. pmc Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS)
    Carol H Christensen
    Toxicology and Epidemiology Branch, Health Effects Division, Office of Pesticide Programs, U S Environmental Protection Agency, Washington, DC, USA
    Environ Health Perspect 118:92-6. 2010
  7. pmc Association study of xenobiotic detoxication and repair genes with malignant brain tumors in children
    L E Salnikova
    Vavilov Institute of General Genetics, Russian Academy of Sciences
    Acta Naturae 2:58-65. 2010
  8. doi request reprint Increased cancer burden among pesticide applicators and others due to pesticide exposure
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, North Bethesda, MD 20892, USA
    CA Cancer J Clin 63:120-42. 2013
  9. doi request reprint Occupational pesticide exposures and cancer risk: a review
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, North Bethesda, Maryland 20892, USA
    J Toxicol Environ Health B Crit Rev 15:238-63. 2012
  10. ncbi request reprint Pesticides and lung cancer risk in the agricultural health study cohort
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Am J Epidemiol 160:876-85. 2004

Collaborators

Detail Information

Publications83

  1. pmc Cancer incidence among pesticide applicators exposed to cyanazine in the agricultural health study
    Shannon M Lynch
    Clinical and Genetic Epidemiology Research Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20892, USA
    Environ Health Perspect 114:1248-52. 2006
    ..We evaluated cancer incidence in cyanazine-exposed pesticide applicators among the 57,311 licensed pesticide applicators in the Agricultural Health Study (AHS)...
  2. pmc Phorate exposure and incidence of cancer in the agricultural health study
    Rajeev Mahajan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Environ Health Perspect 114:1205-9. 2006
    ..We recently reported a link between use of the organophosphate pesticide phorate and risk of prostate cancer among applicators with a family history of prostate cancer in the Agricultural Health Study (AHS)...
  3. pmc Fonofos exposure and cancer incidence in the agricultural health study
    Rajeev Mahajan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Environ Health Perspect 114:1838-42. 2006
    ..A previous investigation in this cohort linked exposure to the organophosphate fonofos with incident prostate cancer in subjects with family history of prostate cancer...
  4. pmc Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health study
    Claudine Samanic
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Environ Health Perspect 114:1521-6. 2006
    ..We evaluated cancer incidence among pesticide applicators exposed to dicamba in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in North Carolina and Iowa...
  5. pmc Lifetime pesticide use and telomere shortening among male pesticide applicators in the Agricultural Health Study
    Lifang Hou
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Environ Health Perspect 121:919-24. 2013
    ..Telomere length (TL) in surrogate tissues may be influenced by environmental exposures...
  6. pmc Coumaphos exposure and incident cancer among male participants in the Agricultural Health Study (AHS)
    Carol H Christensen
    Toxicology and Epidemiology Branch, Health Effects Division, Office of Pesticide Programs, U S Environmental Protection Agency, Washington, DC, USA
    Environ Health Perspect 118:92-6. 2010
    ..Coumaphos is an organophosphate livestock insecticide. Previous research in the Agricultural Health Study (AHS) cohort observed a positive association between coumaphos and prostate cancer in men with a family history of prostate cancer...
  7. pmc Association study of xenobiotic detoxication and repair genes with malignant brain tumors in children
    L E Salnikova
    Vavilov Institute of General Genetics, Russian Academy of Sciences
    Acta Naturae 2:58-65. 2010
    ..017, OR = 2.42). The obtained results are discussed in reference to literary data on the risk of malignant brain tumor formation in children and adults...
  8. doi request reprint Increased cancer burden among pesticide applicators and others due to pesticide exposure
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, North Bethesda, MD 20892, USA
    CA Cancer J Clin 63:120-42. 2013
    ....
  9. doi request reprint Occupational pesticide exposures and cancer risk: a review
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, North Bethesda, Maryland 20892, USA
    J Toxicol Environ Health B Crit Rev 15:238-63. 2012
    ..Nonetheless, it is reasonable and timely for the scientific community to provide a multidisciplinary expert review and evaluation of these pesticides and their potential to produce cancer in occupational settings...
  10. ncbi request reprint Pesticides and lung cancer risk in the agricultural health study cohort
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Am J Epidemiol 160:876-85. 2004
    ..The usage levels in this cohort are considerably higher than those typically experienced by the general population. An excess risk among spouses directly exposed to pesticides could not be evaluated at this time...
  11. ncbi request reprint Cancer incidence in the agricultural health study
    Michael C R Alavanja
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
    Scand J Work Environ Health 31:39-45; discussion 5-7. 2005
    ..This large, prospective cohort study of private applicators, commercial applicators, and spouses of farmer applicators was undertaken to ascertain the etiology of cancers elevated in agriculture...
  12. ncbi request reprint Pesticides and human cancers
    Michael C R Alavanja
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    Cancer Invest 23:700-11. 2005
    ..Collaborations on molecular epidemiology investigations offers such opportunities to both toxicologists and epidemiologists that were not possible even a decade ago...
  13. ncbi request reprint Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Am J Epidemiol 157:800-14. 2003
    ..Important family history-pesticide interactions were observed...
  14. ncbi request reprint Carcinogenicity of agricultural pesticides in adults and children
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    J Agromedicine 12:39-56. 2007
    ..The role of pesticide exposures in the etiology of human cancer is outlined by anatomical site and recent development in exposure assessment and molecular epidemiology are summarized and evaluated...
  15. ncbi request reprint Health effects of chronic pesticide exposure: cancer and neurotoxicity
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, Maryland 20892, USA
    Annu Rev Public Health 25:155-97. 2004
    ..Improving epidemiology studies and integrating this information with toxicology data will allow the human health risks of pesticide exposure to be more accurately judged by public health policy makers...
  16. ncbi request reprint Lung cancer risk and red meat consumption among Iowa women
    M C Alavanja
    Division of Cancer Epidemiology and Genetics, NCI, National Institutes of Health, 6120 Executive Boulevard EPS, Room 8000, Bethesda, MD 20892, USA
    Lung Cancer 34:37-46. 2001
    ..In Iowa, we had the opportunity to investigate concurrently the role of meat intake and macronutrients in lung cancer etiology...
  17. ncbi request reprint Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 8000, Rockville, Maryland, MD 20892, USA
    Oncogene 21:7365-75. 2002
    ..In this article we review both laboratory and epidemiologic data that gives insight into the biologic damage done to the lung from these exposures...
  18. ncbi request reprint Nested case-control analysis of high pesticide exposure events from the Agricultural Health Study
    M C Alavanja
    Division of Cancer Epidemiology and Genetics, NCI, 6120 Executive Blvd EPS, Rm 8000, Rockville, MD, USA
    Am J Ind Med 39:557-63. 2001
    ..A nested case-control analysis of high pesticide exposure events (HPEEs) was conducted using the Iowa farmers enrolled in the Agricultural Health Study (AHS)...
  19. ncbi request reprint Cancer incidence among pesticide applicators exposed to metolachlor in the Agricultural Health Study
    Jennifer A Rusiecki
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    Int J Cancer 118:3118-23. 2006
    ....
  20. ncbi request reprint Characteristics of pesticide use in a pesticide applicator cohort: the Agricultural Health Study
    M C Alavanja
    Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, Maryland, 20892
    Environ Res 80:172-9. 1999
    ..This heterogeneity in potential exposures to pesticides between states should be useful for subsequent epidemiologic analyses using internal comparison groups...
  21. ncbi request reprint High pesticide exposure events among farmers and spouses enrolled in the Agricultural Health Study
    E M Bell
    Occupational and Environmental Epidemiology Branch, National Cancer Institute, USA
    J Agric Saf Health 12:101-16. 2006
    ..Further, only 13% of applicators and 22% of spouses with symptoms resulting from HPEE sought medical care, suggesting that pesticide poisoning surveillance data may seriously underreport the frequency of such events...
  22. ncbi request reprint Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon
    Laura E Beane Freeman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
    Am J Epidemiol 162:1070-9. 2005
    ..Because these results were based on small numbers, additional analyses are necessary as more cases accrue to clarify whether diazinon is associated with cancer risk in humans...
  23. ncbi request reprint Factors affecting use of CR-39 surface monitor technology to estimate past exposure to indoor radon
    J A Mahaffey
    Pacific Northwest National Laboratory, Richland, Washington, USA
    J Expo Anal Environ Epidemiol 6:425-37. 1996
    ..Ceramic materials sometimes provided excessively high radon estimates, probably due to glazes that contained significant uranium or thorium. Due to small sample sizes, investigations of other factors were inconclusive...
  24. ncbi request reprint Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study
    Won Jin Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
    J Natl Cancer Inst 96:1781-9. 2004
    ..We evaluated the incidence of cancer among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina...
  25. ncbi request reprint Malathion exposure and the incidence of cancer in the agricultural health study
    Matthew R Bonner
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Epidemiol 166:1023-34. 2007
    ..Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance...
  26. ncbi request reprint Cancer incidence among pesticide applicators exposed to alachlor in the Agricultural Health Study
    Won Jin Lee
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Am J Epidemiol 159:373-80. 2004
    ..Our findings suggest a possible association between alachlor application and incidence of lymphohematopoietic cancers among applicators in the Agricultural Health Study...
  27. ncbi request reprint Carbaryl exposure and incident cancer in the Agricultural Health Study
    Rajeev Mahajan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Int J Cancer 121:1799-805. 2007
    ..No associations were observed with other examined cancer sites. Because the observed results were not hypothesized a priori and because of limited study of their biological plausibility, they should be interpreted with caution...
  28. ncbi request reprint Dietary heterocyclic amines and the risk of lung cancer among Missouri women
    R Sinha
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 60:3753-6. 2000
    ..Neither DiMeIQx nor PhIP showed an association with smoking categories or lung cancer histology. In conclusion, MeIQx may be associated with lung cancer risk, but DiMeIQx and PhIP are probably not associated with lung cancer risk...
  29. pmc Effects of self-reported health conditions and pesticide exposures on probability of follow-up in a prospective cohort study
    Martha P Montgomery
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 53:486-96. 2010
    ..We investigated the potential for selection bias due to non-participation in the follow-up of a large prospective cohort study...
  30. ncbi request reprint Cancer incidence among pesticide applicators exposed to atrazine in the Agricultural Health Study
    Jennifer A Rusiecki
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892 7240, USA
    J Natl Cancer Inst 96:1375-82. 2004
    ..We evaluated cancer incidence in atrazine-exposed pesticide applicators among 53,943 participants in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina...
  31. doi request reprint Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study
    David L Greenburg
    Department of Medicine EDP, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Cancer Causes Control 19:1401-7. 2008
    ..Captan is a widely used antifungal pesticide whose potential to cause cancer in humans is uncertain...
  32. ncbi request reprint Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women
    Matthew R Bonner
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, MD, USA
    Int J Cancer 119:1462-7. 2006
    ..Additionally, these findings support the hypothesis that radon and SHS promote neoplasia through shared elements of a common pathway...
  33. pmc Cancer incidence among pesticide applicators exposed to permethrin in the Agricultural Health Study
    Jennifer A Rusiecki
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Environ Health Perspect 117:581-6. 2009
    ..Permethrin is a synthetic pyrethroid insecticide widely used in agriculture, in public health, and in many U.S. homes and gardens...
  34. pmc Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS)
    Shannon M Lynch
    Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Environ Res 109:860-8. 2009
    ..27, 95% CI=1.18-4.37; NHL: RR(LD)=3.44, 95% CI=1.29-9.21). Our analysis did not find meaningful associations for other cancers analyzed. Further study is warranted for AL, NHL and prostate cancers...
  35. pmc S-ethyl-N,N-dipropylthiocarbamate exposure and cancer incidence among male pesticide applicators in the agricultural health study: a prospective cohort
    Dana M Van Bemmel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Environ Health Perspect 116:1541-6. 2008
    ..The U.S. Environmental Protection Agency reports that EPTC is most likely not a human carcinogen; however, the previous epidemiologic data on EPTC exposure and cancer risk were limited...
  36. pmc Pendimethalin exposure and cancer incidence among pesticide applicators
    Lifang Hou
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Epidemiology 17:302-7. 2006
    ..We evaluated the incidence of cancer in relation to reported pendimethelin use among pesticide applicators in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina...
  37. ncbi request reprint A quantitative approach for estimating exposure to pesticides in the Agricultural Health Study
    Mustafa Dosemeci
    National Cancer Institute, NIH, Bethesda, MD, USA
    Ann Occup Hyg 46:245-60. 2002
    ....
  38. ncbi request reprint A study on immunological responses to exposures encountered in corn farming
    R Vermeulen
    Division of Cancer Epidemiology and Genetics, NCI, Rockville, MD 20892, USA
    J Biochem Mol Toxicol 19:172. 2005
  39. ncbi request reprint Exposure opportunities of families of farmer pesticide applicators
    B C Gladen
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 34:581-7. 1998
    ..Families of farmer pesticide applicators have unusual opportunities for exposure, directly or indirectly, to pesticides. These exposures are not well characterized...
  40. ncbi request reprint Retinal degeneration in licensed pesticide applicators
    F Kamel
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Ind Med 37:618-28. 2000
    ..Retinal degeneration is the leading cause of visual impairment in older adults, but little is known about its relationship to neurotoxic exposures...
  41. ncbi request reprint Cigarette smoking and lung cancer: modeling effect modification of total exposure and intensity
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Epidemiology 18:639-48. 2007
    ..Above 20 cigarettes per day, there is an "inverse-exposure-rate" effect, ie, the excess odds ratio per pack-year for higher intensity smokers is smaller than for lower-intensity smokers...
  42. pmc Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study
    Jane A Hoppin
    NIEHS Epidemiology Branch, MD A3 05, P O Box 12233, Research Triangle Park, NC 27709 2233, USA
    Am J Respir Crit Care Med 177:11-8. 2008
    ..Risk factors for asthma among farm women are understudied...
  43. pmc Pesticide use and chronic bronchitis among farmers in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709 2233, USA
    Am J Ind Med 50:969-79. 2007
    ..Farmers have increased risk for chronic bronchitis. Few investigators have considered pesticides...
  44. pmc Chlorothalonil exposure and cancer incidence among pesticide applicator participants in the agricultural health study
    Alicia M Mozzachio
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Environ Res 108:400-3. 2008
    ..We explored cancer incidence with chlorothalonil exposure using data from the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina...
  45. pmc Exposure to atrazine and selected non-persistent pesticides among corn farmers during a growing season
    Berit Bakke
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852 7240, USA
    J Expo Sci Environ Epidemiol 19:544-54. 2009
    ..Elevated background levels of non-persistent pesticides, especially 2,4-D, indicate importance in epidemiologic studies of capturing pesticide exposures that might not be directly related to the actual application...
  46. pmc Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study
    Stella Koutros
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20852, USA
    Cancer Causes Control 19:59-65. 2008
    ..We evaluated cancer risk from DDVP (2,2-Dichloroethenyl dimethylphosphate) exposure among pesticide applicators enrolled in the Agricultural Health Study (AHS) cohort...
  47. pmc Heterocyclic aromatic amine pesticide use and human cancer risk: results from the U.S. Agricultural Health Study
    Stella Koutros
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Int J Cancer 124:1206-12. 2009
    ..The use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans...
  48. pmc Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Cancer 124:2495-500. 2009
    ..Organochlorines were not associated with an excess risk of pancreatic cancer in this study. These findings suggest that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer...
  49. pmc Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer Res 69:1877-84. 2009
    ..The observed effect provides evidence to support the hypothesis that HCAs may act as promoters of malignant transformation by altering mitogenic signaling...
  50. ncbi request reprint The Agricultural Health Study biomarker workshop on cancer etiology. Introduction: overview of study design, results, and goals of workshop
    Matthew R Bonner
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7240, USA
    J Biochem Mol Toxicol 19:169-71. 2005
  51. pmc Pesticide exposure and hypertensive disorders during pregnancy
    Tina M Saldana
    Social and Scientific Systems, Inc, 1009 Slater Road, Durham, NC 27703, USA
    Environ Health Perspect 117:1393-6. 2009
    ..Hypertensive disorders of pregnancy, including pregnancy-induced hypertension (PIH) and preeclampsia (PE), complicate 2-8% of pregnancies. Few studies have examined environmental risk factors in relation to these conditions...
  52. ncbi request reprint Reliability of reporting on life-style and agricultural factors by a sample of participants in the Agricultural Health Study from Iowa
    Aaron Blair
    Division of Cancer Epidemiology and Gentics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Epidemiology 13:94-9. 2002
    ....
  53. pmc Meat and meat mutagens and risk of prostate cancer in the Agricultural Health Study
    Stella Koutros
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8111, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 17:80-7. 2008
    ..96-1.59) and 1.20 (95% CI, 0.93-1.55), respectively] when the highest quintile was compared with the lowest. In conclusion, well and very well done meat was associated with an increased risk for prostate cancer in this cohort...
  54. pmc Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer
    Stella Koutros
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Cancer Res 70:9224-33. 2010
    ..This is the first report of effect modification between 8q24 and an environmental exposure on prostate cancer risk...
  55. ncbi request reprint Cigarette smoking and cancer risk: modeling total exposure and intensity
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Am J Epidemiol 166:479-89. 2007
    ..The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites...
  56. ncbi request reprint Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch and Biostatistics Branch, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709 2233, USA
    Am J Respir Crit Care Med 165:683-9. 2002
    ..5 (95% CI 1.2,1.9). Inclusion of crops and animals into these models did not significantly alter the observed OR. These associations, though small, suggest an independent role for specific pesticides in respiratory symptoms of farmers...
  57. ncbi request reprint Pesticides and adult respiratory outcomes in the agricultural health study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Healh Science, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
    Ann N Y Acad Sci 1076:343-54. 2006
    ..00-2.19) for farmers and 1.96 (95% CI = 1.05-3.66) for commercial applicators. Our wheeze results are consistent with recent animal models that support a role for organophosphates and respiratory outcomes...
  58. pmc Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Int J Cancer 120:642-9. 2007
    ....
  59. ncbi request reprint Factor analysis of pesticide use patterns among pesticide applicators in the Agricultural Health Study
    Claudine Samanic
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA
    J Expo Anal Environ Epidemiol 15:225-33. 2005
    ..This heterogeneity in exposure patterns may be used to guide etiologic studies of health effects of farmers and other groups exposed to pesticides...
  60. pmc Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 8121, 6120 Executive Blvd, Bethesda, MD 20892 7240, USA
    Thorax 62:51-6. 2007
    ..To deal with this question further, data from a large (n = 176 997) cohort of male Swedish construction workers, for whom spirometry measurements before follow-up were available, were analysed...
  61. pmc Occupational exposure to carbofuran and the incidence of cancer in the Agricultural Health Study
    Matthew R Bonner
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Environ Health Perspect 113:285-9. 2005
    ..Although carbamate pesticides are suspected human carcinogens, these results should be interpreted cautiously because there was no a priori hypothesis specifically linking carbofuran to lung cancer...
  62. ncbi request reprint Mortality among participants in the agricultural health study
    Aaron Blair
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Ann Epidemiol 15:279-85. 2005
    ..This analysis of the Agricultural Health Study cohort assesses the mortality experience of licensed pesticide applicators and their spouses...
  63. ncbi request reprint Discussion and conclusions
    Michael C R Alavanja
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    J Biochem Mol Toxicol 19:192-3. 2005
  64. ncbi request reprint Pesticides associated with wheeze among commercial pesticide applicators in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
    Am J Epidemiol 163:1129-37. 2006
    ..40, 95% CI: 1.24, 4.65). These results add to the emerging literature linking organophosphate insecticides and respiratory health and suggest a role for chlorimuron-ethyl...
  65. pmc Neurologic symptoms in licensed private pesticide applicators in the agricultural health study
    Freya Kamel
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 113:877-82. 2005
    ....
  66. pmc Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study
    Jane A Hoppin
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 2233, USA
    Occup Environ Med 64:334-41. 2007
    ..Farmer's lung, or hypersensitivity pneumonitis, is an important contributor to respiratory morbidity among farmers...
  67. ncbi request reprint Diesel exhaust, solvents, and other occupational exposures as risk factors for wheeze among farmers
    Jane A Hoppin
    Epidemiology Branch and Biostatistics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709 2233, USA
    Am J Respir Crit Care Med 169:1308-13. 2004
    ..89, 3.73), an indication of daily solvent exposure. These results add to the growing body of evidence of adverse respiratory effects of diesel exposure on the lung and suggest exposure to solvents may contribute as well...
  68. ncbi request reprint Pesticide exposure and self-reported gestational diabetes mellitus in the Agricultural Health Study
    Tina M Saldana
    Epidemiology Branch, National Institute of Environmental Health Sciences, P O Box 12233, MD A3 05, Research Triangle Park, NC 27709, USA
    Diabetes Care 30:529-34. 2007
    ..To examine the association between pesticide use during pregnancy and gestational diabetes mellitus (GDM) among wives of licensed pesticide applicators...
  69. ncbi request reprint Pesticide use by persons who reported a high pesticide exposure event in the agricultural health study
    S A Keim
    Occupational Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Environ Res 85:256-9. 2001
    ..This analysis suggests that current practices directed at minimizing pesticide exposures may not be sufficient for acutely toxic or irritating chemicals...
  70. pmc Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts
    Li Jiao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 21:1305-14. 2010
    ..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes...
  71. pmc Mortality from multiple sclerosis and exposure to residential and occupational solar radiation: a case-control study based on death certificates
    D M Freedman
    Radiation Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA
    Occup Environ Med 57:418-21. 2000
    ..To explore whether mortality from multiple sclerosis is negatively associated with exposure to sunlight...
  72. pmc Chronic bronchitis among nonsmoking farm women in the agricultural health study
    Martin Valcin
    Epidemiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709 2233, USA
    J Occup Environ Med 49:574-83. 2007
    ..The purpose of this study was to examine agricultural risk factors for chronic bronchitis among nonsmoking farm women...
  73. ncbi request reprint Risk factors for falls among Iowa farmers: a case-control study nested in the Agricultural Health Study
    Nancy L Sprince
    Department of Occupational and Environmental Health, The University of Iowa College of Public Health, 100 Oakdale Campus, Iowa City, IA 52242 5000, USA
    Am J Ind Med 44:265-72. 2003
    ..Little is known about risk factors for non-fatal falls on the farm. This case-control study, nested within the Agricultural Health Study, aimed to assess risk factors for work-related falls among Iowa farmers...
  74. pmc Mortality among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study
    Won Jin Lee
    Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
    Environ Health Perspect 115:528-34. 2007
    ..Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited...
  75. ncbi request reprint Comparison of farmers in the agricultural health study to the 1992 and the 1997 censuses of agriculture
    Charles F Lynch
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
    J Agromedicine 10:13-22. 2005
    ....
  76. pmc Pesticide use and colorectal cancer risk in the Agricultural Health Study
    Won Jin Lee
    Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
    Int J Cancer 121:339-46. 2007
    ..Nonetheless the possibility of an association between exposure to certain pesticides and incidence of colorectal cancer among pesticide applicators deserves further evaluation...
  77. ncbi request reprint Pesticide use and pesticide-related symptoms among black farmers in the Agricultural Health Study
    Stephen A Martin
    National Institute of Environmental Health Sciences, NIH, Epidemiology Branch, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 41:202-9. 2002
    ..Health effects of pesticides have not been well studied in black farmers. We describe agricultural practices and pesticide-related symptoms in North Carolina black and white farmers participating in the Agricultural Health Study...
  78. ncbi request reprint Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri women's health study (United States)
    Margaret E Wright
    Department of Epidemiology, and Public Health, Yale University School of Medicine, New Haven, CT 05620 8034, USA
    Cancer Causes Control 14:85-96. 2003
    ..To examine the effect of specific dietary carotenoids and their primary plant food sources on lung cancer risk in a population-based case-control study of women...
  79. pmc Depression and pesticide exposures in female spouses of licensed pesticide applicators in the agricultural health study cohort
    Cheryl Beseler
    Colorado Injury Control Research Center, Department of Psychology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Occup Environ Med 48:1005-13. 2006
    ..This nested case-control study evaluated the association between depression and pesticide exposure among women...
  80. pmc Cutaneous melanoma and obesity in the Agricultural Health Study
    Leslie K Dennis
    Department of Epidemiology, College of Public Health, University of Iowa, 200 Hawkins Dr, C21H GH, Iowa City, IA 52242, USA
    Ann Epidemiol 18:214-21. 2008
    ..To describe the risk of cutaneous melanoma in the Agricultural Health Study (AHS), a cohort of pesticide applicators and their spouses, according to baseline characteristics related to obesity along with sun exposure and sun sensitivity...
  81. ncbi request reprint Risk factors for animal-related injury among Iowa large-livestock farmers: a case-control study nested in the Agricultural Health Study
    Nancy L Sprince
    Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City 52242 5000, USA
    J Rural Health 19:165-73. 2003
    ..Although farmers are at risk for injuries from contact with large livestock, few previous studies have examined risk factors for animal-related injuries...
  82. doi request reprint Captan exposure and evaluation of a pesticide exposure algorithm among orchard pesticide applicators in the Agricultural Health Study
    Cynthia J Hines
    National Institute for Occupational Safety and Health, 4676 Columbia Parkway R 14, Cincinnati, OH 45226, USA
    Ann Occup Hyg 52:153-66. 2008
    ..Some modification of the algorithm is suggested by these results...
  83. ncbi request reprint Risk factors for machinery-related injury among Iowa farmers: a case-control study nested in the Agricultural Health Study
    Nancy L Sprince
    Department of Occupational and Environmental Health, University of Iowa College of Public Health, Iowa City 52242 5000, USA
    Int J Occup Environ Health 8:332-8. 2002
    ..These findings may be useful for future interventions to decrease injuries related to farm machinery...