Affiliation: National Institutes of Health
- Catechol-O-methyltransferase genotype and dopamine regulation in the human brainMayada Akil
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 23:2008-13. 2003..This indicates that COMT genotype is a heritable aspect of dopamine regulation and it further explicates the mechanism by which the COMT valine allele increases susceptibility for psychosis...
- Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophreniaSubroto Ghose
Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA
Int J Neurosci 118:1609-27. 2008..The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia...
- Postmortem investigations of the pathophysiology of schizophrenia: the role of susceptibility genesWilliam R Perlman
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1384, USA
J Psychiatry Neurosci 29:287-93. 2004....
- Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
- Reliability of psychiatric diagnosis in postmortem researchAmy Deep-Soboslay
Section on Neuropathology, Clinical Brain Disorders Branch, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
Biol Psychiatry 57:96-101. 2005..Finding reliable methods for assessing lifetime psychiatric diagnoses in subjects after death is extremely challenging...