Sunita K Agarwal
Affiliation: National Institutes of Health
Iyer S, Agarwal S. Epigenetic regulation in the tumorigenesis of MEN1-associated endocrine cell types. J Mol Endocrinol. 2018;61:R13-R24 pubmed publisher
..This review presents epigenetic control mechanisms relevant to the interactions and targets of menin, and the contribution of epigenetics in the tumorigenesis of endocrine cell types from menin loss. ..
Parekh V, Modali S, Welch J, SIMONDS W, WEINSTEIN L, Kebebew E, et al
. Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas. Endocr Relat Cancer. 2018;: pubmed publisher
..2017). Another study from India did not find this YY1 mutation in their insulinoma samples (Irshad, et al. 2017). To determine the frequency and consequence of the recurrent YY1 mutation we analyzed a cohort of 23 sporadic insulinomas. ..
Desai S, Kharade S, Parekh V, Iyer S, Agarwal S. Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b). J Biol Chem. 2015;290:25595-608 pubmed publisher
..Our data also implicate the use of pro-oncogenic activities of phospho-HLXB9 in Î²-cell expansion strategies to alleviate Î²-cell loss in diabetes. ..
Guan B, Welch J, Sapp J, Ling H, Li Y, Johnston J, et al
. GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism. Am J Hum Genet. 2016;99:1034-1044 pubmed publisher
..Our results demonstrate that germline-activating mutations affecting the CCID of GCM2 can cause FIHP. ..
Iyer S, Modali S, Agarwal S. Long Noncoding RNA MEG3 Is an Epigenetic Determinant of Oncogenic Signaling in Functional Pancreatic Neuroendocrine Tumor Cells. Mol Cell Biol. 2017;37: pubmed publisher
..These findings have clinical relevance for targeting c-MET in PNETs. There is also the potential for pancreatic islet Î²-cell expansion through c-MET regulation to ameliorate Î²-cell loss in diabetes. ..
Agarwal S, Impey S, McWeeney S, Scacheri P, Collins F, Goodman R, et al
. Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia. 2007;9:101-7 pubmed
..These unbiased data also suggest that menin could play a broad role in transcriptional regulation. ..
Agarwal S, Simonds W, Marx S. The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3. Mol Cancer. 2008;7:65 pubmed publisher
..These data also suggest that actinins (and actin) participate in sequestering parafibromin in the cytoplasmic compartment. ..
Agarwal S, Mateo C, Marx S. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. J Clin Endocrinol Metab. 2009;94:1826-34 pubmed publisher
..Rare germline mutation in any among four (p15, p18, p21, and p27) of the seven CDKIs is a probable cause of MEN1 or of some related states. ..
Agarwal S, Jothi R. Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors. PLoS ONE. 2012;7:e37952 pubmed publisher