Karen Adelman

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
    Karen Adelman
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Nat Rev Genet 13:720-31. 2012
  2. pmc Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling
    Karen Adelman
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 106:18207-12. 2009
  3. pmc Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell 143:540-51. 2010
  4. pmc Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila
    Sergei Nechaev
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Science 327:335-8. 2010
  5. pmc RNA polymerase is poised for activation across the genome
    Ginger W Muse
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Nat Genet 39:1507-11. 2007
  6. pmc NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genes Dev 22:1921-33. 2008
  7. pmc Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genes Dev 26:933-44. 2012
  8. pmc Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II
    Ramendra N Saha
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nat Neurosci 14:848-56. 2011
  9. pmc Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1819:700-6. 2012
  10. pmc Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation
    Sergei Nechaev
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1809:34-45. 2011

Collaborators

Detail Information

Publications13

  1. pmc Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
    Karen Adelman
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Nat Rev Genet 13:720-31. 2012
    ..Here the evidence for pausing of Pol II from recent high-throughput studies will be discussed, as well as the potential interconnected functions of promoter-proximally paused Pol II...
  2. pmc Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling
    Karen Adelman
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 106:18207-12. 2009
    ..We propose that polymerase stalling ensures the coordinated, timely activation the inflammatory gene expression program from Drosophila to mammals...
  3. pmc Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell 143:540-51. 2010
    ....
  4. pmc Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila
    Sergei Nechaev
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Science 327:335-8. 2010
    ..These results indicate that the intrinsic efficiency of early elongation can greatly affect gene expression...
  5. pmc RNA polymerase is poised for activation across the genome
    Ginger W Muse
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Nat Genet 39:1507-11. 2007
    ..This finding indicates a role for regulation of polymerase elongation in the transcriptional responses to dynamic environmental and developmental cues...
  6. pmc NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genes Dev 22:1921-33. 2008
    ..These findings identify a novel, positive role for stalled Pol II in regulating gene expression and suggest that there is a dynamic interplay between stalled Pol II and chromatin structure...
  7. pmc Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genes Dev 26:933-44. 2012
    ..We conclude that the role of pausing goes well beyond poising-inducible genes for activation and propose that the primary function of paused Pol II is to establish basal activity of signal-responsive networks...
  8. pmc Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II
    Ramendra N Saha
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA
    Nat Neurosci 14:848-56. 2011
    ..Together, our data strongly indicate that the rapid induction of neuronal IEGs requires poised Pol II and suggest a role for this mechanism in a wide variety of transcription-dependent processes, including learning and memory...
  9. pmc Coupling polymerase pausing and chromatin landscapes for precise regulation of transcription
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1819:700-6. 2012
    ..This article is part of a Special Issue entitled: Chromatin in time and space...
  10. pmc Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation
    Sergei Nechaev
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochim Biophys Acta 1809:34-45. 2011
    ..We also discuss the interplay between factors that affect early transcript elongation and the potential physiological consequences for genes that are regulated through transcriptional pausing...
  11. ncbi request reprint Promoter-proximal Pol II: when stalling speeds things up
    Sergei Nechaev
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Cell Cycle 7:1539-44. 2008
    ..Here we briefly summarize the current data on promoter-proximal Pol II stalling and discuss implications of this newly appreciated regulatory strategy...
  12. pmc Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Methods 48:398-408. 2009
    ....
  13. doi request reprint Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors
    George Fromm
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell 37:449-50. 2010
    ....