Christian C Abnet

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories
    Craig B Borkowf
    National Cancer Institute, Center for Cancer Research, Cancer Prevention Studies Branch, 6116 Executive Blvd, Suite 705, MSC 8314, Bethesda, MD 20892 8314, USA
    Stat Med 22:1477-93. 2003
  2. pmc Serum 25-hydroxyvitamin D and risk of oropharynx and larynx cancers in Finnish men
    Hannah Arem
    Yale School of Public Health, Department ofChronic Disease Epidemiology, New Haven, Connecticut, USA
    Cancer Epidemiol Biomarkers Prev 20:1178-84. 2011
  3. pmc Prospective study of self-reported diabetes and risk of upper gastrointestinal cancers
    Shih Wen Lin
    Cancer Prevention Fellowship Program, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 20:954-61. 2011
  4. pmc Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Christian C Abnet
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 172:94-106. 2010
  5. pmc Aryl hydrocarbon receptor expression is associated with a family history of upper gastrointestinal tract cancer in a high-risk population exposed to aromatic hydrocarbons
    Mark J Roth
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 18:2391-6. 2009
  6. pmc Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers
    W Chen
    Department of Epidemiology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
    Br J Cancer 97:123-8. 2007
  7. pmc A prospective study of vitamin and mineral supplement use and the risk of upper gastrointestinal cancers
    Sonja P Dawsey
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 9:e88774. 2014
  8. pmc Esophageal cancer in young people: a case series of 109 cases and review of the literature
    Sonja P Dawsey
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    PLoS ONE 5:e14080. 2010
  9. pmc Association of tooth loss and oral hygiene with risk of gastric adenocarcinoma
    Ramin Shakeri
    Digestive Disease Research Centre, Tehran University of Medical Sciences, Shariati Hospital, 1411713135, Tehran, Iran
    Cancer Prev Res (Phila) 6:477-82. 2013
  10. pmc Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Hum Mol Genet 21:2132-41. 2012

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories
    Craig B Borkowf
    National Cancer Institute, Center for Cancer Research, Cancer Prevention Studies Branch, 6116 Executive Blvd, Suite 705, MSC 8314, Bethesda, MD 20892 8314, USA
    Stat Med 22:1477-93. 2003
    ..Conversely, using appropriate lowess methods to adjust the data tends to give nearly unbiased parameter estimates, near nominal significance levels, and improved power...
  2. pmc Serum 25-hydroxyvitamin D and risk of oropharynx and larynx cancers in Finnish men
    Hannah Arem
    Yale School of Public Health, Department ofChronic Disease Epidemiology, New Haven, Connecticut, USA
    Cancer Epidemiol Biomarkers Prev 20:1178-84. 2011
    ..Prolonged darker months in Finland are associated with lower levels of ultraviolet B radiation, raising concerns about low vitamin D levels...
  3. pmc Prospective study of self-reported diabetes and risk of upper gastrointestinal cancers
    Shih Wen Lin
    Cancer Prevention Fellowship Program, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 20:954-61. 2011
    ..Obesity increases the risks of GCA and EADC, and the associations may be partially mediated by insulin resistance. A few case-control studies have shown an association between diabetes and an increased risk of EADC...
  4. pmc Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Christian C Abnet
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 172:94-106. 2010
    ..31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers...
  5. pmc Aryl hydrocarbon receptor expression is associated with a family history of upper gastrointestinal tract cancer in a high-risk population exposed to aromatic hydrocarbons
    Mark J Roth
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 18:2391-6. 2009
    ....
  6. pmc Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers
    W Chen
    Department of Epidemiology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
    Br J Cancer 97:123-8. 2007
    ..Further refinements of the analysis did not suggest any factors, which could explain this unexpected result...
  7. pmc A prospective study of vitamin and mineral supplement use and the risk of upper gastrointestinal cancers
    Sonja P Dawsey
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America
    PLoS ONE 9:e88774. 2014
    ..03 to 1.56) cancers. We saw no evidence that multivitamin use was associated with reduced risk of four highly fatal upper gastrointestinal cancers, but there were some differences in risk with reported use of individual supplements. ..
  8. pmc Esophageal cancer in young people: a case series of 109 cases and review of the literature
    Sonja P Dawsey
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    PLoS ONE 5:e14080. 2010
    ..In summary, this case series describes the largest number of young EC patients reported to date, and it highlights the uniqueness of the EC experience in western Kenya...
  9. pmc Association of tooth loss and oral hygiene with risk of gastric adenocarcinoma
    Ramin Shakeri
    Digestive Disease Research Centre, Tehran University of Medical Sciences, Shariati Hospital, 1411713135, Tehran, Iran
    Cancer Prev Res (Phila) 6:477-82. 2013
    ....
  10. pmc Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Hum Mol Genet 21:2132-41. 2012
    ..Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants...
  11. pmc Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil
    Renato B Fagundes
    Universidade Federal de Santa Maria, Departamento de Clinica Medica, Centro de Ciencias da Saude, Santa Maria, RS, Brazil
    BMC Cancer 6:139. 2006
    ..The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil...
  12. ncbi request reprint A cross-sectional study of human serum sphingolipids, diet and physiologic parameters
    C C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Nutr 131:2748-52. 2001
    ..This study represents the largest report of human serum sphingolipid concentrations to date and provides insight into potential explanatory variables that can be incorporated into future studies...
  13. pmc Carcinogenic food contaminants
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, Maryland 20852, USA
    Cancer Invest 25:189-96. 2007
    ..This review presents a summary of the evidence for the carcinogenicity of these and other agents and the ranks provided by two important assessment programs...
  14. ncbi request reprint Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Epidemiol 34:467-74. 2005
    ..Tooth loss has previously been associated with a higher risk of cancer, heart disease, and stroke, but the role of confounding by smoking remains an issue...
  15. ncbi request reprint Zinc concentration in esophageal biopsy specimens measured by x-ray fluorescence and esophageal cancer risk
    Christian C Abnet
    Cancer Prevention Studies Branch, National Cancer Institute, National Institutes of Health, 6116 Executive Blvd, Rm 705, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:301-6. 2005
    ....
  16. ncbi request reprint Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population-based Chinese cohort
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 119:1508-10. 2006
    ..37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer...
  17. ncbi request reprint Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Scand J Gastroenterol 40:681-7. 2005
    ..pylori seropositivity...
  18. ncbi request reprint The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Carcinogenesis 28:112-7. 2007
    ..10; and a model combining both exposure and genotype information had a total r2 of 0.33. Our results suggest that CYP1B1 genotypes are strongly associated with urine 1-OHPG concentrations in this population...
  19. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    ..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China...
  20. pmc Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort
    C C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 320, 6120 Executive Boulevard, MSC 7232, Rockville, MD 20852, USA
    Br J Cancer 104:1511-6. 2011
    ..We tested the association between gastric cancer and plasma pepsinogens and antibodies against Helicobacter pylori in a case-control study nested in a prospective cohort...
  21. ncbi request reprint Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 14:645-55. 2003
    ....
  22. pmc Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 320, 6120 Executive Boulevard, MSC 7232, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 17:3062-8. 2008
    ..Our results are consistent with several previous analyses in other high-risk populations...
  23. ncbi request reprint Prospective study of tooth loss and incident esophageal and gastric cancers in China
    C C Abnet
    Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 12:847-54. 2001
    ..To determine the association between tooth loss and the risk of developing esophageal squamous cell carcinoma, gastric cardia adenocarcinoma, or gastric non-cardia adenocarcinoma in a prospective study...
  24. ncbi request reprint Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china
    C C Abnet
    National Cancer Institute, Center for Cancer Research, Cancer Prevention Studies Branch, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 12:821-8. 2001
    ..We conducted a prospective nested case-control study to examine the relationship between serum sphingolipids and ESCC incidence...
  25. ncbi request reprint Reliability and validity of opiate use self-report in a population at high risk for esophageal cancer in Golestan, Iran
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 13:1068-70. 2004
    ..To assess the reliability and validity of self-reported opium use in a rural Iranian population at high risk for esophageal cancer in preparation for a large cohort study...
  26. pmc Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 4:30. 2004
    ..We wished to examine the prevalence of mtDNA mutation and polymorphism in subjects from this high risk area of China...
  27. pmc Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis
    C C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Br J Cancer 100:551-7. 2009
    ..64 (0.52-0.80), 0.82 (0.65-1.04), and 0.64 (0.52-0.79), respectively. The corresponding numbers for other NSAIDs were 0.68 (0.57-0.81), 0.80 (0.67-0.95), and 0.65 (0.50-0.85), respectively...
  28. pmc A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, United States
    Eur J Cancer 44:465-71. 2008
    ..84 (0.50-1.42). Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI. Increased adiposity was associated with higher risk of EADC even within the normal weight range...
  29. pmc Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:1889-93. 2007
    ..Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer...
  30. ncbi request reprint Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3034, Bethesda, MD 20892 7232, USA
    J Natl Cancer Inst 98:1445-52. 2006
    ..pylori strain differences are less clear. We conducted a prospective nested case-control study of H. pylori serology to address these questions...
  31. pmc Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study
    Michael B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:1966-75. 2010
    ..Helicobacter pylori can induce gastric atrophy in humans, which in turn increases gastric cancer risk. Whether H. pylori and gastric atrophy also affect the risk of esophageal squamous cell carcinoma (ESCC), however, remains unresolved...
  32. pmc Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial
    You Lin Qiao
    Cancer Institute, Chinese Academy of Medical Sciences, Beijing, Peoples Republic of China
    J Natl Cancer Inst 101:507-18. 2009
    ..Here, we present 10-year follow-up after the end of active intervention...
  33. ncbi request reprint Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes
    Mark J Roth
    NIH, NCI, CCR, Cancer Prevention Studies Branch, Bethesda, MD 20892, USA
    Cancer Causes Control 15:1077-83. 2004
    ..To determine if genetic polymorphisms of CYP1A1, GSTM1, GSTP1, or GSTT1 are associated with an increased risk of developing esophageal squamous cell carcinoma (ESCC), gastric cardia cancer (GCC), or either in a high-risk Asian population...
  34. ncbi request reprint Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland)
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Causes Control 17:117-25. 2006
    ..Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals...
  35. pmc Physical activity and head and neck cancer risk
    Michael F Leitzmann
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Causes Control 19:1391-9. 2008
    ..To investigate the relation of physical activity to head and neck cancer...
  36. pmc The relationship between serum ghrelin and the risk of gastric and esophagogastric junctional adenocarcinomas
    Gwen Murphy
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 3034, Rockville, MD 20892, USA
    J Natl Cancer Inst 103:1123-9. 2011
    ..However, the relationship between ghrelin and the risk of gastric and esophagogastric junctional cancers has not been investigated...
  37. ncbi request reprint Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death
    Wen Qiang Wei
    Department of Epidemiology, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Am J Clin Nutr 79:80-5. 2004
    ....
  38. pmc Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma
    Lisa Adams
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 1:357-61. 2008
    ....
  39. pmc Serum ghrelin is inversely associated with risk of subsequent oesophageal squamous cell carcinoma
    Gwen Murphy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20892, USA
    Gut 61:1533-7. 2012
    ..Ghrelin, a hormone which, is also produced in the gastric fundic glands may be a marker of gastric atrophy, but its association with OSCC is not known...
  40. ncbi request reprint Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population
    Sharon A Savage
    Pediatric Oncology Branch, Center for Cancer Research, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 13:1547-9. 2004
  41. pmc The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
    Jay H Lubin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892, USA
    Cancer Epidemiol 36:306-16. 2012
    ..e., the impact on the OR for a fixed total exposure of high exposure rate for short duration compared with low exposure rate for long duration...
  42. pmc Prospective study of serum 25-hydroxyvitamin D concentration and mortality in a Chinese population
    Shih Wen Lin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Am J Epidemiol 176:1043-50. 2012
    ..Results were similar for men and women. This study showed that prediagnostic serum 25(OH)D concentrations were not associated with all-cause or cause-specific mortality rates in this Chinese population who had low levels of vitamin D...
  43. pmc Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort
    Neal D Freedman
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Rockville, MD 20852, USA
    J Natl Cancer Inst 102:1354-65. 2010
    ..Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations...
  44. pmc Serum pepsinogens and risk of esophageal squamous dysplasia
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Int J Cancer 124:456-60. 2009
    ..03. Lower serum PGI/II ratio was linearly associated with higher risk of ESD. This result is consistent with recent findings that gastric atrophy may increase the risk of ESCC...
  45. ncbi request reprint High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran
    Farin Kamangar
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:425-8. 2005
    ..The northeastern region of Iran has some of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world...
  46. pmc Urinary prostaglandin E2 metabolite and gastric cancer risk in the Shanghai women's health study
    Linda M Dong
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 18:3075-8. 2009
    ..pylori status, and for cases diagnosed within 46 months after study enrollment. Our findings suggest that higher levels of urinary PGE-M, a marker of inflammation, may be associated with gastric cancer risk...
  47. pmc Is opium a real risk factor for esophageal cancer or just a methodological artifact? Hospital and neighborhood controls in case-control studies
    Ramin Shakeri
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    PLoS ONE 7:e32711. 2012
    ..Control selection is a major challenge in epidemiologic case-control studies. The aim of our study was to evaluate using hospital versus neighborhood control groups in studying risk factors of esophageal squamous cell carcinoma (ESCC)...
  48. pmc Patterns of food and nutrient consumption in northern Iran, a high-risk area for esophageal cancer
    Farhad Islami
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Nutr Cancer 61:475-83. 2009
    ....
  49. pmc Physical activity and esophageal and gastric carcinoma in a large prospective study
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Prev Med 36:112-9. 2009
    ..Few studies have investigated the relationship of physical activity to esophageal and gastric carcinoma according to histology and anatomic site...
  50. ncbi request reprint Prospective study of serum vitamin E levels and esophageal and gastric cancers
    Philip R Taylor
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8314, USA
    J Natl Cancer Inst 95:1414-6. 2003
    ..89 to 4.75) for GNCC. Serum gamma-tocopherol level was not associated with the incidence of any of these cancers. Our findings provide support for the role of alpha-tocopherol in the etiology of upper gastrointestinal cancers...
  51. ncbi request reprint Human papillomavirus serology and the risk of esophageal and gastric cancers: results from a cohort in a high-risk region in China
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 119:579-84. 2006
    ..4). For HPV 73, these figures were 1.3 (0.6-2.5), 1.2 (0.6-2.3) and 0.9 (0.4-2.1). The results of this study do not support a major role for HPV 16, HPV 18 and HPV 73 in the etiology of esophageal and gastric cancers in Linxian, China...
  52. pmc Genetic variants in fas signaling pathway genes and risk of gastric cancer
    Paula L Hyland
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA Cancer Prevention Fellowship Program, Division of Cancer Prevention, NCI, NIH, Bethesda, MD, USA
    Int J Cancer 134:822-31. 2014
    ..As one of the first attempts to investigate a pathway-level association, our results suggest that these genes and the Fas signaling pathway warrant further evaluation in relation to GC risk in other populations. ..
  53. ncbi request reprint Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 12:1222-6. 2003
    ..59; 95% CI, 1.04-2.42). No association was observed for GCA. Our results suggest that the MTHFR C677T and MTRR A66G polymorphisms influence the risk of ESCC and GCA in this population...
  54. ncbi request reprint Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 122:2330-6. 2008
    ..Results from this large prospective observational study are consistent with previous case-control studies and support the hypothesis that total fruit and vegetable intake is associated with reduced risk of head and neck cancer...
  55. ncbi request reprint Fruit and vegetable intake and esophageal cancer in a large prospective cohort study
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 121:2753-60. 2007
    ..A significant inverse association between EAC and Chenopodiaceae (spinach) intake was observed. Results from our study suggest that the relation of fruit and vegetable intake and esophageal cancer risk may vary by histologic type...
  56. pmc Meat consumption and risk of esophageal and gastric cancer in a large prospective study
    Amanda J Cross
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Am J Gastroenterol 106:432-42. 2011
    ..Although there have been multiple studies of meat and colorectal cancer, other gastrointestinal malignancies are understudied...
  57. ncbi request reprint Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population
    Nina Joshi
    Genetics Branch, Center for Cancer Research, National Cancer Institute NIH, EPS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Res 66:6851-60. 2006
    ..These data suggest that local and systemic immune responses may influence the natural history of esophageal squamous dysplasia...
  58. pmc Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population
    Wen Qing Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e68999. 2013
    ..05). Our data suggest an association between specific genes in the EGFR signaling pathway and risk of GC and ESCC. Further studies are warranted to validate these associations and to investigate underlying mechanisms. ..
  59. pmc Prospective study of ultraviolet radiation exposure and mortality risk in the United States
    Shih Wen Lin
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, 6E404, MSC9768, Bethesda, MD 20892, USA
    Am J Epidemiol 178:521-33. 2013
    ..Q1 = 1.37, 95% CI: 1.21, 1.55), and stroke (HRQ4 vs. Q1 = 1.16, 95% CI: 1.01, 1.33) but not with deaths due to injury, diabetes, or infectious disease. These results suggest that UVR exposure might not be beneficial for longevity...
  60. ncbi request reprint Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma
    Sharon A Savage
    Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Gaithersburg, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 13:2251-7. 2004
    ..These variants could confer an altered IL8 expression pattern or interact with environmental factors to increase the risk for inflammation and GCC...
  61. pmc Opium: an emerging risk factor for gastric adenocarcinoma
    Ramin Shakeri
    Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Int J Cancer 133:455-61. 2013
    ..We showed, for the first time, an association between opium use and gastric adenocarcinoma. Given that opium use is a traditional practice in many parts of the world, these results are of public health significance...
  62. pmc Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study
    Farhad Islami
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, 14117 Tehran, Iran
    BMJ 338:b929. 2009
    ..To investigate the association between tea drinking habits in Golestan province, northern Iran, and risk of oesophageal squamous cell carcinoma...
  63. pmc Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis
    Linda M Liao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Gastroenterology 142:442-452.e5; quiz e22-3. 2012
    ..However, individual studies have been too small to accurately assess the effects of medication type, frequency, or duration of use. We performed a pooled analysis to investigate these associations...
  64. pmc The gastric cardia is not a target for human papillomavirus-induced carcinogenesis
    Jill Koshiol
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7070, Rockville, MD 20852 7248, USA
    Cancer Epidemiol Biomarkers Prev 19:1137-9. 2010
    ..Given the availability of an effective HPV vaccine and its potential to prevent HPV-associated cancer, we decided to evaluate the prevalence of HPV DNA in GCA...
  65. pmc Prospective study of serum cysteine levels and oesophageal and gastric cancers in China
    Gwen Murphy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Gut 60:618-23. 2011
    ..To examine the relationship between serum cysteine concentration and risk of these cancers we conducted a nested case-cohort study within the General Population Nutrition Intervention Trial in Linxian, China...
  66. pmc The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Cancer 116:1572-81. 2010
    ..Established risk factors do not appear to explain these differences, suggesting a possible role for sex hormones...
  67. ncbi request reprint Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China
    Gina D Tran
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8314, USA
    Int J Cancer 113:456-63. 2005
    ..General socioeconomic status (SES) is a common denominator in many of these factors and improving SES is a promising approach for reducing the tremendous burden of upper gastrointestinal cancers in Linxian...
  68. pmc Index-based dietary patterns and risk of head and neck cancer in a large prospective study
    Wen Qing Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD W QL, YP, JWW, AMG, PRT, NDF, and CCA, and AARP, Washington, DC ARH
    Am J Clin Nutr 99:559-66. 2014
    ..Studies of dietary patterns that examine overall diets may provide broader insight than studies of individual foods. Little is known about the association between dietary patterns and risk of HNC...
  69. ncbi request reprint Serum markers as predictors of esophageal squamous dysplasia and early cancer
    Wen Chen
    Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China
    Anticancer Res 24:3245-9. 2004
    ..Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma (ESCC). A primary screening test for ESCC which identified this lesion could lead to a reduction in disease-specific mortality...
  70. pmc Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population
    Tram Kim Lam
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Genetic Epidemiology Branch TKL and PRT, Nutritional Epidemiology Branch NDF, SMD, and CCA, and the Division of Cancer Control and Population Sciences, Epidemiology and Genomics Research Program TKL, Rockville, MD and the Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China J HF and Y LQ
    Am J Clin Nutr 98:1289-97. 2013
    ..Prospective studies suggested that vitamin C may reduce risks; however, associations are unclear because of limited sample size...
  71. ncbi request reprint Chemoprevention of primary liver cancer: a randomized, double-blind trial in Linxian, China
    Chen Xu Qu
    Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China
    J Natl Cancer Inst 99:1240-7. 2007
    ..We examined the effects of supplementation with four different combinations of vitamins and minerals on primary liver cancer mortality among 29450 initially healthy adults from Linxian, China...
  72. ncbi request reprint Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison
    Alireza Sepehr
    The US National Cancer Institute, Bethesda, MD, USA
    Cancer Lett 213:195-202. 2004
    ..We conclude that it is unlikely that variations in these polymorphic genes are major contributors to the high incidence of EC among Turkomans in Iran...
  73. pmc Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran
    Behnoush Abedi-Ardekani
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 3018, Bethesda, MD 20892 7232, USA
    Gut 59:1178-83. 2010
    ....
  74. pmc Socio-economic status and oesophageal cancer: results from a population-based case-control study in a high-risk area
    Farhad Islami
    Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Int J Epidemiol 38:978-88. 2009
    ..We examined a wide range of SES indicators to investigate the association between different SES components and risk of OSCC in the region...
  75. doi request reprint Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 19:459-67. 2008
    ..Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent...
  76. ncbi request reprint Lung cancer chemoprevention: a randomized, double-blind trial in Linxian, China
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 3034, Bethesda, MD 10892 7232, USA
    Cancer Epidemiol Biomarkers Prev 15:1562-4. 2006
    ..Supplementation with combinations of vitamins and minerals at nutrient-repletion levels for 5.25 years did not reduce lung cancer mortality in this nutrient-inadequate population in Linxian, China...
  77. ncbi request reprint Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7060, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 98:1005-10. 2006
    ..Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear...
  78. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  79. pmc Iron in relation to gastric cancer in the Alpha-tocopherol, Beta-carotene Cancer Prevention Study
    Michael B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS Suite 550 Room 5014, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 21:2033-42. 2012
    ..We used the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study to assess whether iron metrics were associated with gastric cardia cancer (GCC) and gastric noncardia cancer (GNCC)...
  80. pmc Opium use and mortality in Golestan Cohort Study: prospective cohort study of 50,000 adults in Iran
    Hooman Khademi
    Digestive Disease Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    BMJ 344:e2502. 2012
    ..To investigate the association between opium use and subsequent risk of death...
  81. ncbi request reprint Ecologic study of serum selenium and upper gastrointestinal cancers in Iran
    Mehdi Nouarie
    Digestive Disease Research Center, Tehran University of Medical Sciences, Iran
    World J Gastroenterol 10:2544-6. 2004
    ..The aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency...
  82. pmc Serum thyroglobulin, a biomarker for iodine deficiency, is not associated with increased risk of upper gastrointestinal cancers in a large Chinese cohort
    Shih Wen Lin
    Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 129:2284-9. 2011
    ..Our results do not support the hypothesis that iodine deficiency, as assessed by serum Tg, is associated with an increased risk of UGI cancers...
  83. ncbi request reprint A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Epidemiol 165:1424-33. 2007
    ..93, 95% CI: 2.69, 9.03) but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma...
  84. pmc Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium
    Neal D Freedman
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, MD 20852, USA
    Gut 60:1029-37. 2011
    ..Therefore, the association of alcohol intake with OSCC, OA, and OGJA was determined in nine case-control studies and two cohort studies of the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium (BEACON)...
  85. pmc Cigarette smoking and subsequent risk of lung cancer in men and women: analysis of a prospective cohort study
    Neal D Freedman
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 ExecutiveBoulevard, MSC 7232, Rockville, MD 20852, USA
    Lancet Oncol 9:649-56. 2008
    ..To address this question, we aimed to compare incidence rates of lung cancer by stratum of smoking use in men and women of the National Institutes of Health (NIH)-AARP cohort...
  86. ncbi request reprint Prospective investigation of the cigarette smoking-head and neck cancer association by sex
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer 110:1593-601. 2007
    ..Very few prospective studies have examined the association between cigarette smoking and cancers of the head and neck in women, even though the rates of smoking in women are increasing rapidly worldwide...
  87. pmc Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study
    Sarah Carman
    NEB DCEG, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Int J Cancer 125:165-70. 2009
    ..An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an hazard ratio (95% confidence interval) of 0.92 (0.85-1.00) and the p value for trend in the quartile analysis was 0.015...
  88. ncbi request reprint Poor oral health as a risk factor for esophageal squamous dysplasia in northeastern Iran
    Alireza Sepehr
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:543-6. 2005
    ..The reasons for observing such high rates of ESCC in this area are not fully clear. The current study evaluates the association between some potential risk factors and squamous dysplasia, a precursor lesion of ESCC, in northeastern Iran...
  89. ncbi request reprint Cellular immune response is not associated with incident cancer or total mortality: a prospective follow-up
    Mark J Roth
    NIH, NCI, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, Bethesda, Maryland 20852, USA
    Eur J Cancer Prev 15:548-50. 2006
    ..This implies that immune competence, as measured by these stimulation indices, is not associated with incident cancer or total mortality in this population...
  90. ncbi request reprint Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers
    Mehdi Nouraie
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 14:2087-92. 2005
    ..Tocopherols were associated with higher risk of GCC, whereas dietary intake of fruits, vitamin C, tocopherols, and lycopene seemed protective for GNCC...
  91. ncbi request reprint Real-time telomerase assay of less-invasively collected esophageal cell samples
    Brenna M McGruder
    Biochemical Science Division, National Institute of Standards and Technology, 100 Bureau Drive, MS 8311, 20899, Gaithersburg, MD, USA
    Cancer Lett 244:91-100. 2006
    ..These findings demonstrate the feasibility of using the RTTRAP assay in EBC samples and suggest that individuals from high-risk populations can be screened for telomerase activity...
  92. pmc Association between smoking and risk of bladder cancer among men and women
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
    JAMA 306:737-45. 2011
    ..2 per 100,000 person-years) and women (32.5 per 100,000 person-years to 33.2 per 100,000 person-years); however, changing smoking prevalence and cigarette composition warrant revisiting risk estimates for smoking and bladder cancer...
  93. ncbi request reprint Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 3034, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 15:1920-8. 2006
    ..The overall associations between IL-1B or IL-1RN proinflammatory polymorphisms and gastric cancer were null but several studies showed an association. The sources of this variation are unclear...
  94. pmc Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Carcinogenesis 30:71-7. 2009
    ..These findings should be interpreted cautiously until replicated in other studies...
  95. pmc Prospective study of physical activity and lung cancer by histologic type in current, former, and never smokers
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Am J Epidemiol 169:542-53. 2009
    ..The inverse findings among former and current smokers in combination with the null results for physical activity among never smokers may point toward residual confounding by cigarette smoking as an explanation for the relations observed...
  96. pmc No role for human papillomavirus in esophageal squamous cell carcinoma in China
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852 7248, USA
    Int J Cancer 127:93-100. 2010
    ..HPV DNA contamination cannot be ruled out as an explanation for high HPV prevalence in ESCC tissue studies with less stringent tissue procurement and processing protocols...
  97. pmc Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer
    Arthur Schatzkin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Cancer Prev Res (Phila) 2:104-13. 2009
    ..We conclude that Mendelian randomization is not universally applicable, but, under the right conditions, can complement evidence for causal associations from conventional epidemiologic studies...
  98. ncbi request reprint p16, MGMT, RARbeta2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesions
    Mark J Roth
    National Cancer Institute, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20892, USA
    Oncol Rep 15:1591-7. 2006
    ..Balloon cytology may be able to screen the length of the esophagus effectively for a subset of cells with abnormal methylation, and may be useful in a primary screening test for ESCC and its precursor lesions...
  99. pmc Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C
    Neal D Freedman
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Hepatology 50:1360-9. 2009
    ..47 (0.27-0.85) for 3 or more cups/day (P-trend = 0.0003) versus not drinking. Risk estimates did not vary by treatment assignment or cirrhosis status at baseline. Tea intake was not associated with outcomes...
  100. pmc Serum 25-hydroxyvitamin D and cancer mortality in the NHANES III study (1988-2006)
    D Michal Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7238, USA
    Cancer Res 70:8587-97. 2010
    ..These findings argue for caution before increasing 25(OH)D levels to prevent cancer...
  101. pmc Menstrual and reproductive factors and gastric cancer risk in a large prospective study of women
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Gut 56:1671-7. 2007
    ..Gastric cancer incidence rates are consistently lower in women than men in both high and low-risk regions worldwide. Sex hormones, such as progesterone and estrogen, may protect women against gastric cancer...