Christian C Abnet

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Christian C Abnet
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 172:94-106. 2010
  2. ncbi request reprint Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3034, Bethesda, MD 20892 7232, USA
    J Natl Cancer Inst 98:1445-52. 2006
  3. pmc Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study
    Michael B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:1966-75. 2010
  4. pmc The relationship between serum ghrelin and the risk of gastric and esophagogastric junctional adenocarcinomas
    Gwen Murphy
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 3034, Rockville, MD 20892, USA
    J Natl Cancer Inst 103:1123-9. 2011
  5. pmc Serum ghrelin is inversely associated with risk of subsequent oesophageal squamous cell carcinoma
    Gwen Murphy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20892, USA
    Gut 61:1533-7. 2012
  6. pmc Physical activity and head and neck cancer risk
    Michael F Leitzmann
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Causes Control 19:1391-9. 2008
  7. ncbi request reprint Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland)
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Causes Control 17:117-25. 2006
  8. pmc Prospective study of serum 25-hydroxyvitamin D concentration and mortality in a Chinese population
    Shih Wen Lin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Am J Epidemiol 176:1043-50. 2012
  9. ncbi request reprint Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes
    Mark J Roth
    NIH, NCI, CCR, Cancer Prevention Studies Branch, Bethesda, MD 20892, USA
    Cancer Causes Control 15:1077-83. 2004
  10. pmc Physical activity and esophageal and gastric carcinoma in a large prospective study
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Prev Med 36:112-9. 2009

Detail Information

Publications78

  1. pmc Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Christian C Abnet
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Am J Epidemiol 172:94-106. 2010
    ..31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers...
  2. ncbi request reprint Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3034, Bethesda, MD 20892 7232, USA
    J Natl Cancer Inst 98:1445-52. 2006
    ..pylori strain differences are less clear. We conducted a prospective nested case-control study of H. pylori serology to address these questions...
  3. pmc Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study
    Michael B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:1966-75. 2010
    ..Helicobacter pylori can induce gastric atrophy in humans, which in turn increases gastric cancer risk. Whether H. pylori and gastric atrophy also affect the risk of esophageal squamous cell carcinoma (ESCC), however, remains unresolved...
  4. pmc The relationship between serum ghrelin and the risk of gastric and esophagogastric junctional adenocarcinomas
    Gwen Murphy
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 3034, Rockville, MD 20892, USA
    J Natl Cancer Inst 103:1123-9. 2011
    ..However, the relationship between ghrelin and the risk of gastric and esophagogastric junctional cancers has not been investigated...
  5. pmc Serum ghrelin is inversely associated with risk of subsequent oesophageal squamous cell carcinoma
    Gwen Murphy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rockville, MD 20892, USA
    Gut 61:1533-7. 2012
    ..Ghrelin, a hormone which, is also produced in the gastric fundic glands may be a marker of gastric atrophy, but its association with OSCC is not known...
  6. pmc Physical activity and head and neck cancer risk
    Michael F Leitzmann
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Causes Control 19:1391-9. 2008
    ..To investigate the relation of physical activity to head and neck cancer...
  7. ncbi request reprint Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland)
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Causes Control 17:117-25. 2006
    ..Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals...
  8. pmc Prospective study of serum 25-hydroxyvitamin D concentration and mortality in a Chinese population
    Shih Wen Lin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Am J Epidemiol 176:1043-50. 2012
    ..Results were similar for men and women. This study showed that prediagnostic serum 25(OH)D concentrations were not associated with all-cause or cause-specific mortality rates in this Chinese population who had low levels of vitamin D...
  9. ncbi request reprint Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes
    Mark J Roth
    NIH, NCI, CCR, Cancer Prevention Studies Branch, Bethesda, MD 20892, USA
    Cancer Causes Control 15:1077-83. 2004
    ..To determine if genetic polymorphisms of CYP1A1, GSTM1, GSTP1, or GSTT1 are associated with an increased risk of developing esophageal squamous cell carcinoma (ESCC), gastric cardia cancer (GCC), or either in a high-risk Asian population...
  10. pmc Physical activity and esophageal and gastric carcinoma in a large prospective study
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Am J Prev Med 36:112-9. 2009
    ..Few studies have investigated the relationship of physical activity to esophageal and gastric carcinoma according to histology and anatomic site...
  11. pmc Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma
    Lisa Adams
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Prev Res (Phila) 1:357-61. 2008
    ....
  12. ncbi request reprint Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population
    Sharon A Savage
    Pediatric Oncology Branch, Center for Cancer Research, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 13:1547-9. 2004
  13. pmc The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
    Jay H Lubin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892, USA
    Cancer Epidemiol 36:306-16. 2012
    ..e., the impact on the OR for a fixed total exposure of high exposure rate for short duration compared with low exposure rate for long duration...
  14. pmc Urinary prostaglandin E2 metabolite and gastric cancer risk in the Shanghai women's health study
    Linda M Dong
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 18:3075-8. 2009
    ..pylori status, and for cases diagnosed within 46 months after study enrollment. Our findings suggest that higher levels of urinary PGE-M, a marker of inflammation, may be associated with gastric cancer risk...
  15. pmc Tooth loss and lack of regular oral hygiene are associated with higher risk of esophageal squamous cell carcinoma
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 320, 6120 Executive Boulevard, MSC 7232, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 17:3062-8. 2008
    ..Our results are consistent with several previous analyses in other high-risk populations...
  16. ncbi request reprint Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 122:2330-6. 2008
    ..Results from this large prospective observational study are consistent with previous case-control studies and support the hypothesis that total fruit and vegetable intake is associated with reduced risk of head and neck cancer...
  17. ncbi request reprint Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Scand J Gastroenterol 40:681-7. 2005
    ..pylori seropositivity...
  18. pmc A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 42:764-7. 2010
    ..19 x 10(-15); OR = 1.57), and for those in the noncardia stomach it was absent (P = 0.44; OR = 1.05). Our findings at 10q23 could provide insight into the high incidence of both cancers in China...
  19. ncbi request reprint Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma
    Sharon A Savage
    Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Gaithersburg, MD 20892 4605, USA
    Cancer Epidemiol Biomarkers Prev 13:2251-7. 2004
    ..These variants could confer an altered IL8 expression pattern or interact with environmental factors to increase the risk for inflammation and GCC...
  20. pmc Prospective study of ultraviolet radiation exposure and mortality risk in the United States
    Shih Wen Lin
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, 6E404, MSC9768, Bethesda, MD 20892, USA
    Am J Epidemiol 178:521-33. 2013
    ..Q1 = 1.37, 95% CI: 1.21, 1.55), and stroke (HRQ4 vs. Q1 = 1.16, 95% CI: 1.01, 1.33) but not with deaths due to injury, diabetes, or infectious disease. These results suggest that UVR exposure might not be beneficial for longevity...
  21. pmc Opium: an emerging risk factor for gastric adenocarcinoma
    Ramin Shakeri
    Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Int J Cancer 133:455-61. 2013
    ..We showed, for the first time, an association between opium use and gastric adenocarcinoma. Given that opium use is a traditional practice in many parts of the world, these results are of public health significance...
  22. pmc Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis
    Linda M Liao
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
    Gastroenterology 142:442-452.e5; quiz e22-3. 2012
    ..However, individual studies have been too small to accurately assess the effects of medication type, frequency, or duration of use. We performed a pooled analysis to investigate these associations...
  23. pmc The gastric cardia is not a target for human papillomavirus-induced carcinogenesis
    Jill Koshiol
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7070, Rockville, MD 20852 7248, USA
    Cancer Epidemiol Biomarkers Prev 19:1137-9. 2010
    ..Given the availability of an effective HPV vaccine and its potential to prevent HPV-associated cancer, we decided to evaluate the prevalence of HPV DNA in GCA...
  24. pmc Serum pepsinogens and risk of esophageal squamous dysplasia
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Int J Cancer 124:456-60. 2009
    ..03. Lower serum PGI/II ratio was linearly associated with higher risk of ESD. This result is consistent with recent findings that gastric atrophy may increase the risk of ESCC...
  25. pmc Prospective study of serum cysteine levels and oesophageal and gastric cancers in China
    Gwen Murphy
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Gut 60:618-23. 2011
    ..To examine the relationship between serum cysteine concentration and risk of these cancers we conducted a nested case-cohort study within the General Population Nutrition Intervention Trial in Linxian, China...
  26. ncbi request reprint Fruit and vegetable intake and esophageal cancer in a large prospective cohort study
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 121:2753-60. 2007
    ..A significant inverse association between EAC and Chenopodiaceae (spinach) intake was observed. Results from our study suggest that the relation of fruit and vegetable intake and esophageal cancer risk may vary by histologic type...
  27. ncbi request reprint Zinc concentration in esophageal biopsy specimens measured by x-ray fluorescence and esophageal cancer risk
    Christian C Abnet
    Cancer Prevention Studies Branch, National Cancer Institute, National Institutes of Health, 6116 Executive Blvd, Rm 705, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:301-6. 2005
    ....
  28. ncbi request reprint The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Carcinogenesis 28:112-7. 2007
    ..10; and a model combining both exposure and genotype information had a total r2 of 0.33. Our results suggest that CYP1B1 genotypes are strongly associated with urine 1-OHPG concentrations in this population...
  29. ncbi request reprint Self-reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population-based Chinese cohort
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 119:1508-10. 2006
    ..37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer...
  30. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  31. ncbi request reprint Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China
    Rachael Z Stolzenberg-Solomon
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 12:1222-6. 2003
    ..59; 95% CI, 1.04-2.42). No association was observed for GCA. Our results suggest that the MTHFR C677T and MTRR A66G polymorphisms influence the risk of ESCC and GCA in this population...
  32. ncbi request reprint Lung cancer chemoprevention: a randomized, double-blind trial in Linxian, China
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 3034, Bethesda, MD 10892 7232, USA
    Cancer Epidemiol Biomarkers Prev 15:1562-4. 2006
    ..Supplementation with combinations of vitamins and minerals at nutrient-repletion levels for 5.25 years did not reduce lung cancer mortality in this nutrient-inadequate population in Linxian, China...
  33. ncbi request reprint High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran
    Farin Kamangar
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:425-8. 2005
    ..The northeastern region of Iran has some of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world...
  34. pmc Meat consumption and risk of esophageal and gastric cancer in a large prospective study
    Amanda J Cross
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
    Am J Gastroenterol 106:432-42. 2011
    ..Although there have been multiple studies of meat and colorectal cancer, other gastrointestinal malignancies are understudied...
  35. doi request reprint Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 19:459-67. 2008
    ..Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent...
  36. ncbi request reprint Human papillomavirus serology and the risk of esophageal and gastric cancers: results from a cohort in a high-risk region in China
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 119:579-84. 2006
    ..4). For HPV 73, these figures were 1.3 (0.6-2.5), 1.2 (0.6-2.3) and 0.9 (0.4-2.1). The results of this study do not support a major role for HPV 16, HPV 18 and HPV 73 in the etiology of esophageal and gastric cancers in Linxian, China...
  37. pmc Iron in relation to gastric cancer in the Alpha-tocopherol, Beta-carotene Cancer Prevention Study
    Michael B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS Suite 550 Room 5014, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 21:2033-42. 2012
    ..We used the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study to assess whether iron metrics were associated with gastric cardia cancer (GCC) and gastric noncardia cancer (GNCC)...
  38. pmc Serum thyroglobulin, a biomarker for iodine deficiency, is not associated with increased risk of upper gastrointestinal cancers in a large Chinese cohort
    Shih Wen Lin
    Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 129:2284-9. 2011
    ..Our results do not support the hypothesis that iodine deficiency, as assessed by serum Tg, is associated with an increased risk of UGI cancers...
  39. ncbi request reprint Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China
    Gina D Tran
    Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8314, USA
    Int J Cancer 113:456-63. 2005
    ..General socioeconomic status (SES) is a common denominator in many of these factors and improving SES is a promising approach for reducing the tremendous burden of upper gastrointestinal cancers in Linxian...
  40. pmc Vitamin E intake and risk of esophageal and gastric cancers in the NIH-AARP Diet and Health Study
    Sarah Carman
    NEB DCEG, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Int J Cancer 125:165-70. 2009
    ..An increase of 71 mg/day (half the interquartile range) in supplemental vitamin E had an hazard ratio (95% confidence interval) of 0.92 (0.85-1.00) and the p value for trend in the quartile analysis was 0.015...
  41. ncbi request reprint Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7058, USA
    Cancer Causes Control 14:645-55. 2003
    ....
  42. ncbi request reprint Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7060, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 98:1005-10. 2006
    ..Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear...
  43. pmc Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies
    Christian C Abnet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7236, USA
    Hum Mol Genet 21:2132-41. 2012
    ..Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants...
  44. ncbi request reprint Gene expression differences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population
    Nina Joshi
    Genetics Branch, Center for Cancer Research, National Cancer Institute NIH, EPS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Res 66:6851-60. 2006
    ..These data suggest that local and systemic immune responses may influence the natural history of esophageal squamous dysplasia...
  45. pmc Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran
    Behnoush Abedi-Ardekani
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 3018, Bethesda, MD 20892 7232, USA
    Gut 59:1178-83. 2010
    ....
  46. ncbi request reprint Prospective investigation of the cigarette smoking-head and neck cancer association by sex
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer 110:1593-601. 2007
    ..Very few prospective studies have examined the association between cigarette smoking and cancers of the head and neck in women, even though the rates of smoking in women are increasing rapidly worldwide...
  47. ncbi request reprint Cellular immune response is not associated with incident cancer or total mortality: a prospective follow-up
    Mark J Roth
    NIH, NCI, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, Bethesda, Maryland 20852, USA
    Eur J Cancer Prev 15:548-50. 2006
    ..This implies that immune competence, as measured by these stimulation indices, is not associated with incident cancer or total mortality in this population...
  48. ncbi request reprint Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Epidemiol 34:467-74. 2005
    ..Tooth loss has previously been associated with a higher risk of cancer, heart disease, and stroke, but the role of confounding by smoking remains an issue...
  49. pmc Heme iron from meat and risk of adenocarcinoma of the esophagus and stomach
    Mary H Ward
    Department of Health and Human Services, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Eur J Cancer Prev 21:134-8. 2012
    ..Our results suggest that high intakes of heme and iron from meat may be important dietary risk factors for esophageal and stomach cancer and may partly explain associations with red meat...
  50. ncbi request reprint Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 3034, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 15:1920-8. 2006
    ..The overall associations between IL-1B or IL-1RN proinflammatory polymorphisms and gastric cancer were null but several studies showed an association. The sources of this variation are unclear...
  51. ncbi request reprint Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers
    Mehdi Nouraie
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 14:2087-92. 2005
    ..Tocopherols were associated with higher risk of GCC, whereas dietary intake of fruits, vitamin C, tocopherols, and lycopene seemed protective for GNCC...
  52. pmc Association between smoking and risk of bladder cancer among men and women
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20852, USA
    JAMA 306:737-45. 2011
    ..2 per 100,000 person-years) and women (32.5 per 100,000 person-years to 33.2 per 100,000 person-years); however, changing smoking prevalence and cigarette composition warrant revisiting risk estimates for smoking and bladder cancer...
  53. ncbi request reprint Poor oral health as a risk factor for esophageal squamous dysplasia in northeastern Iran
    Alireza Sepehr
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:543-6. 2005
    ..The reasons for observing such high rates of ESCC in this area are not fully clear. The current study evaluates the association between some potential risk factors and squamous dysplasia, a precursor lesion of ESCC, in northeastern Iran...
  54. pmc Aryl hydrocarbon receptor expression is associated with a family history of upper gastrointestinal tract cancer in a high-risk population exposed to aromatic hydrocarbons
    Mark J Roth
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7232, USA
    Cancer Epidemiol Biomarkers Prev 18:2391-6. 2009
    ....
  55. pmc Serum vitamin D concentration and prostate cancer risk: a nested case-control study
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 100:796-804. 2008
    ....
  56. ncbi request reprint p16, MGMT, RARbeta2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesions
    Mark J Roth
    National Cancer Institute, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20892, USA
    Oncol Rep 15:1591-7. 2006
    ..Balloon cytology may be able to screen the length of the esophagus effectively for a subset of cells with abnormal methylation, and may be useful in a primary screening test for ESCC and its precursor lesions...
  57. pmc Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population
    Wen Qing Li
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Bethesda, MD 20852, USA
    Carcinogenesis 34:1536-42. 2013
    ..05). We provide evidence for an association between specific genes in the DNA repair pathways and the risk of ESCC and GC. Further studies are warranted to validate these associations and to investigate underlying mechanisms...
  58. pmc A multi-day environmental study of polycyclic aromatic hydrocarbon exposure in a high-risk region for esophageal cancer in China
    Nicole C Deziel
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Expo Sci Environ Epidemiol 23:52-9. 2013
    ..Further evaluation of the role of PAH exposure from air and food in the elevated rates of esophageal cancer in this region is warranted...
  59. pmc Association of coffee drinking with total and cause-specific mortality
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    N Engl J Med 366:1891-904. 2012
    ..Coffee is one of the most widely consumed beverages, but the association between coffee consumption and the risk of death remains unclear...
  60. ncbi request reprint A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Epidemiol 165:1424-33. 2007
    ..93, 95% CI: 2.69, 9.03) but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma...
  61. pmc Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer
    Neal D Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA
    Carcinogenesis 30:71-7. 2009
    ..These findings should be interpreted cautiously until replicated in other studies...
  62. pmc Prospective study of physical activity and lung cancer by histologic type in current, former, and never smokers
    Michael F Leitzmann
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA
    Am J Epidemiol 169:542-53. 2009
    ..The inverse findings among former and current smokers in combination with the null results for physical activity among never smokers may point toward residual confounding by cigarette smoking as an explanation for the relations observed...
  63. pmc Genetic variants in fas signaling pathway genes and risk of gastric cancer
    Paula L Hyland
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD, USA Cancer Prevention Fellowship Program, Division of Cancer Prevention, NCI, NIH, Bethesda, MD, USA
    Int J Cancer 134:822-31. 2014
    ..As one of the first attempts to investigate a pathway-level association, our results suggest that these genes and the Fas signaling pathway warrant further evaluation in relation to GC risk in other populations. ..
  64. pmc Esophageal cancer in young people: a case series of 109 cases and review of the literature
    Sonja P Dawsey
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    PLoS ONE 5:e14080. 2010
    ..In summary, this case series describes the largest number of young EC patients reported to date, and it highlights the uniqueness of the EC experience in western Kenya...
  65. pmc Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium
    Michael B Cook
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
    J Natl Cancer Inst 102:1344-53. 2010
    ....
  66. pmc Prospective study of ultraviolet radiation exposure and risk of cancer in the United States
    Shih Wen Lin
    Cancer Prevention Fellowship Program, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Cancer 131:E1015-23. 2012
    ..81-0.96) cancers (all p-trend < 0.05). We also found nonlinear associations for some cancer sites, including the thyroid and pancreas. Our results add to mounting evidence for the influential role of UVR exposure on cancer...
  67. pmc Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    BMC Cancer 4:30. 2004
    ..We wished to examine the prevalence of mtDNA mutation and polymorphism in subjects from this high risk area of China...
  68. ncbi request reprint Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison
    Alireza Sepehr
    The US National Cancer Institute, Bethesda, MD, USA
    Cancer Lett 213:195-202. 2004
    ..We conclude that it is unlikely that variations in these polymorphic genes are major contributors to the high incidence of EC among Turkomans in Iran...
  69. pmc No role for human papillomavirus in esophageal squamous cell carcinoma in China
    Jill Koshiol
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852 7248, USA
    Int J Cancer 127:93-100. 2010
    ..HPV DNA contamination cannot be ruled out as an explanation for high HPV prevalence in ESCC tissue studies with less stringent tissue procurement and processing protocols...
  70. ncbi request reprint Prospective study of serum vitamin E levels and esophageal and gastric cancers
    Philip R Taylor
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 8314, USA
    J Natl Cancer Inst 95:1414-6. 2003
    ..89 to 4.75) for GNCC. Serum gamma-tocopherol level was not associated with the incidence of any of these cancers. Our findings provide support for the role of alpha-tocopherol in the etiology of upper gastrointestinal cancers...
  71. doi request reprint High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:1262-8. 2008
    ..We conducted this study to determine whether drinking mate could lead to substantial exposure to polycyclic aromatic hydrocarbons (PAH), including known carcinogens, such as benzo[a]pyrene...
  72. pmc Serum 25-hydroxyvitamin D and cancer mortality in the NHANES III study (1988-2006)
    D Michal Freedman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7238, USA
    Cancer Res 70:8587-97. 2010
    ..These findings argue for caution before increasing 25(OH)D levels to prevent cancer...
  73. pmc Environmental causes of esophageal cancer
    Farin Kamangar
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Blvd, Bethesda, MD 20892 7232, USA
    Gastroenterol Clin North Am 38:27-57, vii. 2009
    ..Results of studies investigating other factors are also discussed...
  74. pmc Prospective study of self-reported diabetes and risk of upper gastrointestinal cancers
    Shih Wen Lin
    Cancer Prevention Fellowship Program, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 20:954-61. 2011
    ..Obesity increases the risks of GCA and EADC, and the associations may be partially mediated by insulin resistance. A few case-control studies have shown an association between diabetes and an increased risk of EADC...
  75. pmc Menstrual and reproductive factors and gastric cancer risk in a large prospective study of women
    Neal D Freedman
    Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Gut 56:1671-7. 2007
    ..Gastric cancer incidence rates are consistently lower in women than men in both high and low-risk regions worldwide. Sex hormones, such as progesterone and estrogen, may protect women against gastric cancer...
  76. pmc Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer
    Arthur Schatzkin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Cancer Prev Res (Phila) 2:104-13. 2009
    ..We conclude that Mendelian randomization is not universally applicable, but, under the right conditions, can complement evidence for causal associations from conventional epidemiologic studies...
  77. ncbi request reprint Reliability and validity of opiate use self-report in a population at high risk for esophageal cancer in Golestan, Iran
    Christian C Abnet
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 13:1068-70. 2004
    ..To assess the reliability and validity of self-reported opium use in a rural Iranian population at high risk for esophageal cancer in preparation for a large cohort study...
  78. pmc Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C
    Neal D Freedman
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Hepatology 50:1360-9. 2009
    ..47 (0.27-0.85) for 3 or more cups/day (P-trend = 0.0003) versus not drinking. Risk estimates did not vary by treatment assignment or cirrhosis status at baseline. Tea intake was not associated with outcomes...