Genomes and Genes


Kotb Abdelmohsen


Affiliation: National Institutes of Health
Country: USA


  1. Abdelmohsen K, Panda A, Kang M, Guo R, Kim J, Grammatikakis I, et al. 7SL RNA represses p53 translation by competing with HuR. Nucleic Acids Res. 2014;42:10099-111 pubmed publisher
    ..Our findings suggest that targeting 7SL may be effective in the treatment of cancers with reduced p53 levels. ..
  2. Abdelmohsen K, Srikantan S, Kang M, Gorospe M. Regulation of senescence by microRNA biogenesis factors. Ageing Res Rev. 2012;11:491-500 pubmed publisher
    ..We discuss how miRNA biogenesis proteins promote or inhibit senescence, and thus influence the senescent phenotype that affects normal tissue function and pathology. ..
  3. Kim J, Kim K, Noh J, Yoon J, Abdelmohsen K, Gorospe M. Long noncoding RNAs in diseases of aging. Biochim Biophys Acta. 2016;1859:209-21 pubmed publisher
    ..This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. ..
  4. Panda A, Abdelmohsen K, Gorospe M. RT-qPCR Detection of Senescence-Associated Circular RNAs. Methods Mol Biol. 2017;1534:79-87 pubmed
    ..In this chapter, we describe a method for the detection and measurement of circRNAs in senescent cells using specialized reverse transcription (RT) followed by real-time quantitative (q)PCR analysis. ..
  5. Panda A, Dudekula D, Abdelmohsen K, Gorospe M. Analysis of Circular RNAs Using the Web Tool CircInteractome. Methods Mol Biol. 2018;1724:43-56 pubmed publisher
    ..Here, we review the CircInteractome tool and explain recent updates to the site. The database is freely accessible at . ..
  6. Abdelmohsen K, Gorospe M. RNA-binding protein nucleolin in disease. RNA Biol. 2012;9:799-808 pubmed publisher
    ..Here, we review the RNA-binding activities of nucleolin, its influence on gene expression patterns, and its impact upon diseases. We also discuss the rising interest in targeting nucleolin therapeutically. ..
  7. Panda A, Grammatikakis I, Yoon J, Abdelmohsen K. Posttranscriptional regulation of insulin family ligands and receptors. Int J Mol Sci. 2013;14:19202-29 pubmed publisher
    ..Due to the pathological impacts of insulin system, we also discussed the possibilities of discovering new potential regulators which will improve understanding of insulin system and associated diseases. ..
  8. Panda A, Abdelmohsen K, Gorospe M. SASP regulation by noncoding RNA. Mech Ageing Dev. 2017;168:37-43 pubmed publisher
    ..Here, we review the microRNAs, lncRNAs, and circRNAs that influence the production of SASP factors and discuss the rising interest in SASP-regulatory ncRNAs as diagnostic and therapeutic targets. ..
  9. Munk R, Panda A, Grammatikakis I, Gorospe M, Abdelmohsen K. Senescence-Associated MicroRNAs. Int Rev Cell Mol Biol. 2017;334:177-205 pubmed publisher
    ..Here, we review senescence-associated (SA)-MicroRNAs and discuss their implications in senescence-relevant pathologies. ..