Kotb Abdelmohsen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Growth inhibition by miR-519 via multiple p21-inducing pathways
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, Research Resources Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA
    Mol Cell Biol 32:2530-48. 2012
  2. pmc miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 105:20297-302. 2008
  3. pmc Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Nucleic Acids Res 39:8513-30. 2011
  4. pmc miR-519 suppresses tumor growth by reducing HuR levels
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, NIA IRP, National Institutes of Health Bethesda, MD, USA
    Cell Cycle 9:1354-9. 2010
  5. pmc Ubiquitin-mediated proteolysis of HuR by heat shock
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, NIA IRP, NIH, Baltimore, MD 21224, USA
    EMBO J 28:1271-82. 2009
  6. pmc miR-375 inhibits differentiation of neurites by lowering HuD levels
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Mol Cell Biol 30:4197-210. 2010
  7. pmc RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
    Stefanie Galban
    LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Cell Biol 28:93-107. 2008
  8. pmc MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90
    Yuki Kuwano
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21228, USA
    Mol Cell Biol 28:4562-75. 2008
  9. pmc Translational control of TOP2A influences doxorubicin efficacy
    Subramanya Srikantan
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, Baltimore, Maryland 21224, USA
    Mol Cell Biol 31:3790-801. 2011
  10. pmc Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs
    Rudolf Pullmann
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21228, USA
    Mol Cell Biol 27:6265-78. 2007

Collaborators

Detail Information

Publications46

  1. pmc Growth inhibition by miR-519 via multiple p21-inducing pathways
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, Research Resources Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA
    Mol Cell Biol 32:2530-48. 2012
    ..Our results indicate that miR-519 promotes DNA damage, alters Ca(2+) homeostasis, and enhances energy production; together, these processes elevate the expression level of p21, promoting growth inhibition and cell survival...
  2. pmc miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 105:20297-302. 2008
    ..In sum, miR-519 represses HuR translation, in turn reducing HuR-regulated gene expression and cell division...
  3. pmc Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Nucleic Acids Res 39:8513-30. 2011
    ..In summary, nucleolin binds G-rich sequences in the CR and UTRs of target mRNAs, many of which encode cancer proteins, and enhances their translation...
  4. pmc miR-519 suppresses tumor growth by reducing HuR levels
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, NIA IRP, National Institutes of Health Bethesda, MD, USA
    Cell Cycle 9:1354-9. 2010
    ..Together, our data reveal that miR-519 inhibits tumorigenesis in large part by repressing HuR expression...
  5. pmc Ubiquitin-mediated proteolysis of HuR by heat shock
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, NIA IRP, NIH, Baltimore, MD 21224, USA
    EMBO J 28:1271-82. 2009
    ..Our findings reveal that HS transiently lowers HuR by proteolysis linked to K182 ubiquitination and that HuR reduction enhances cell survival following HS...
  6. pmc miR-375 inhibits differentiation of neurites by lowering HuD levels
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Mol Cell Biol 30:4197-210. 2010
    ..Our findings indicate that miR-375 modulates neuronal HuD expression and function, in turn affecting dendrite abundance...
  7. pmc RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
    Stefanie Galban
    LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Cell Biol 28:93-107. 2008
    ..Conversely, HIF-1alpha expression and translation in response to CoCl(2) were markedly elevated after HuR overexpression. We propose that HuR and PTB jointly upregulate HIF-1alpha translation in response to CoCl(2)...
  8. pmc MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90
    Yuki Kuwano
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21228, USA
    Mol Cell Biol 28:4562-75. 2008
    ..Collectively, MKP-1 upregulation by oxidative stress is potently influenced by increased mRNA stability and translation, mediated at least in part by the RNA-BPs HuR and NF90...
  9. pmc Translational control of TOP2A influences doxorubicin efficacy
    Subramanya Srikantan
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, Baltimore, Maryland 21224, USA
    Mol Cell Biol 31:3790-801. 2011
    ..In sum, HuR enhances TOP2A translation by competing with miR-548c-3p; their combined actions control TOP2A expression levels and determine the effectiveness of doxorubicin...
  10. pmc Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs
    Rudolf Pullmann
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21228, USA
    Mol Cell Biol 27:6265-78. 2007
    ..Together, our findings underscore the notion that TTR-RBP expression is controlled, at least in part, at the posttranscriptional level through a complex circuitry of self- and cross-regulatory RNP interactions...
  11. pmc Nuclear HuR accumulation through phosphorylation by Cdk1
    Hyeon Ho Kim
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Genes Dev 22:1804-15. 2008
    ..Our findings suggest that Cdk1 phosphorylates HuR during G2, thereby helping to retain it in the nucleus in association with 14-3-3 and hindering its post-transcriptional function and anti-apoptotic influence...
  12. pmc MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence
    Bernard S Marasa
    Laboratory of Cellular and Molecular Biology, NIA IRP, NIH, Baltimore, MD 21224, USA
    Aging (Albany NY) 2:333-43. 2010
    ..These data suggest that miR-519 can suppress tumor growth by triggering senescence and that miR-519 elicits these actions by repressing HuR expression...
  13. pmc Phosphorylation of HuR by Chk2 regulates SIRT1 expression
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 25:543-57. 2007
    ..Our findings demonstrate that HuR regulates SIRT1 expression, underscore functional links between the two stress-response proteins, and implicate Chk2 in these processes...
  14. pmc Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs
    Bernard S Marasa
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Sci Signal 2:ra69. 2009
    ..Thus, multiple microRNAs acting on a single target, the MKK4 mRNA, collectively influence MKK4 abundance during replicative senescence...
  15. pmc hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies
    Eun Kyung Lee
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, US National Institutes of Health, Baltimore, Maryland, USA
    Nat Struct Mol Biol 17:732-9. 2010
    ..Our findings indicate that FMRP represses translation by recruiting APP mRNA to processing bodies, whereas hnRNP C promotes APP translation by displacing FMRP, thereby relieving the translational block...
  16. pmc Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation
    Kiyoshi Masuda
    Laboratory of Molecular Biology and Immunology, Baltimore, MD, USA
    EMBO J 30:1040-53. 2011
    ..We propose that the release of HuR-bound mRNAs via an IR-Chk2-HuR regulatory axis improves cell outcome following IR...
  17. ncbi request reprint Posttranscriptional orchestration of an anti-apoptotic program by HuR
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 6:1288-92. 2007
    ....
  18. pmc Competitive regulation of nucleolin expression by HuR and miR-494
    Kumiko Tominaga
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Mol Cell Biol 31:4219-31. 2011
    ..Our collective findings indicate that nucleolin expression is positively regulated by HuR and negatively regulated via competition with miR-494...
  19. pmc NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif
    Yuki Kuwano
    RNA Regulation Section, Laboratory of Cellular and Molecular Biology and Bioinformatics Unit, Research Resources Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Nucleic Acids Res 38:225-38. 2010
    ..In summary, we have identified an AU-rich RNA motif present in NF90 target mRNAs and have obtained evidence that NF90 represses the translation of this subset of mRNAs...
  20. pmc RNA-binding protein AUF1 represses Dicer expression
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, NIH, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Nucleic Acids Res 40:11531-44. 2012
    ..In summary, AUF1 suppresses miRNA production by reducing Dicer production...
  21. pmc p16(INK4a) translation suppressed by miR-24
    Ashish Lal
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1864. 2008
    ..Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence...
  22. pmc LincRNA-p21 suppresses target mRNA translation
    Je Hyun Yoon
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 47:648-55. 2012
    ..We propose that HuR controls translation of a subset of target mRNAs by influencing lincRNA-p21 levels. Our findings uncover a role for lincRNA as a posttranscriptional inhibitor of translation...
  23. pmc miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression
    Eun Kyung Lee
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, Baltimore, Maryland 21224, USA
    Mol Cell Biol 31:626-38. 2011
    ..Our findings reveal that miR-130 reduces adipogenesis by repressing PPARγ biosynthesis and suggest that perturbations in this regulation is linked to human obesity...
  24. doi request reprint Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA
    Biol Chem 389:243-55. 2008
    ....
  25. pmc Paradoxical microRNAs: individual gene repressors, global translation enhancers
    Subramanya Srikantan
    Laboratory of Molecular Biology and Immunology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Cell Cycle 10:751-9. 2011
    ..We discuss possible scenarios through which Dicer/Drosha/microRNAs could enhance translation...
  26. ncbi request reprint Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1
    Rudolf Pullmann
    Laboratory of Cellular and Molecular Biology, NIA IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 281:23456-63. 2006
    ..Our results illustrate the functional consequences of ribonucleoprotein associations involving a polymorphic RNA sequence and uncover a novel mechanism of action for non-coding RNA polymorphisms...
  27. pmc NF90 coordinately represses the senescence-associated secretory phenotype
    Kumiko Tominaga-Yamanaka
    Laboratory of Genetics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Aging (Albany NY) 4:695-708. 2012
    ..Our findings indicate that NF90 contributes to maintaining low levels of SASP factors in non-senescent cells, while NF90 reduction in senescent cells allows SASP factor expression to rise...
  28. ncbi request reprint Posttranscriptional derepression of GADD45alpha by genotoxic stress
    Ashish Lal
    Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Mol Cell 22:117-28. 2006
    ..We propose that the posttranscriptional derepression of GADD45alpha critically contributes to its potent upregulation after DNA damage...
  29. ncbi request reprint Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss
    Steven C Cunningham
    Department of Oncology, Sidney Kimmel Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 66:5560-4. 2006
    ....
  30. pmc Senescence-associated lncRNAs: senescence-associated long noncoding RNAs
    Kotb Abdelmohsen
    Laboratory of Genetics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Aging Cell 12:890-900. 2013
    ..Our results reveal that the expression of known and novel lncRNAs changes with senescence and suggests that SAL-RNAs play direct regulatory roles in this important cellular process. ..
  31. pmc RNA-binding protein nucleolin in disease
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    RNA Biol 9:799-808. 2012
    ..Here, we review the RNA-binding activities of nucleolin, its influence on gene expression patterns, and its impact upon diseases. We also discuss the rising interest in targeting nucleolin therapeutically...
  32. doi request reprint Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes
    Emmette R Hutchison
    Laboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, Maryland, 21224, USA
    Glia 61:1018-28. 2013
    ..Further understanding of the role of miR-181 in inflammatory events and CNS injury could lead to novel approaches for the treatment of CNS disorders with an inflammatory component...
  33. pmc Regulation of senescence by microRNA biogenesis factors
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, Baltimore, MD 21224, USA
    Ageing Res Rev 11:491-500. 2012
    ..We discuss how miRNA biogenesis proteins promote or inhibit senescence, and thus influence the senescent phenotype that affects normal tissue function and pathology...
  34. pmc The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif
    Faoud T Ishmael
    Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Immunol 186:1189-98. 2011
    ..These results indicate that cytoplasmic GR interacts with a subset of mRNA through specific sequences and can regulate turnover rates, suggesting a novel posttranscriptional role for GR as an RNA-binding protein...
  35. pmc microRNA expression patterns reveal differential expression of target genes with age
    Nicole Noren Hooten
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    PLoS ONE 5:e10724. 2010
    ..Taken together, these findings demonstrate that changes in miRNA expression occur with human aging and suggest that miRNAs and their predicted targets have the potential to be diagnostic indicators of age or age-related diseases...
  36. pmc RNA-binding proteins implicated in the hypoxic response
    Kiyoshi Masuda
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Cell Mol Med 13:2759-69. 2009
    ..We discuss the efficient regulation of hypoxic gene expression by RBPs and the mounting interest in targeting hypoxia-regulatory RBPs in diseases with aberrant hypoxic responses...
  37. doi request reprint Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination
    Je Hyun Yoon
    Laboratory of Genetics, National Institute on Aging Intramural Research Program, NIH, Baltimore, Maryland 21224, USA
    Nat Commun 4:2939. 2013
    ..These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination. ..
  38. pmc Posttranscriptional regulation of cancer traits by HuR
    Kotb Abdelmohsen
    LCMB, NIA IRP, NIH, Baltimore, MD 21224, USA
    Wiley Interdiscip Rev RNA 1:214-29. 2010
    ..We propose that HuR exerts a tumorigenic function by enabling these cancer phenotypes. We discuss evidence that links HuR to several specific cancers and suggests its potential usefulness in cancer diagnosis, prognosis, and therapy...
  39. pmc Posttranscriptional gene regulation by long noncoding RNA
    Je Hyun Yoon
    Laboratory of Genetics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Mol Biol 425:3723-30. 2013
    ..In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now...
  40. pmc Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation
    Shaoming Song
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 339:905-13. 2011
    ..These results demonstrate a critical effect of PDTC on mTOR complex 1 function and provide evidence that PDTC can reverse IL-6-related signaling via induction of DDIT4...
  41. pmc MicroRegulators come of age in senescence
    Myriam Gorospe
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Trends Genet 27:233-41. 2011
    ..We discuss evidence that dysregulation of miRNA-governed senescence programs underlies age-associated diseases, including cancer...
  42. pmc Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction
    Evi M Mercken
    Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Aging (Albany NY) 5:692-703. 2013
    ..Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. ..
  43. ncbi request reprint Theoretical proposal: allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers
    Steven C Cunningham
    Department of Oncology, The Sidney Kimmel Cancer Research Center at Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cell Cycle 5:1090-3. 2006
    ..Consideration of gene dosage changes specifically affecting members of positive feedback loops may permit integration of the aneuploidy process into a conventional model of clonal selection in tumorigenesis...
  44. pmc Posttranscriptional regulation of insulin family ligands and receptors
    Amaresh C Panda
    Laboratory of Genetics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Int J Mol Sci 14:19202-29. 2013
    ..Due to the pathological impacts of insulin system, we also discussed the possibilities of discovering new potential regulators which will improve understanding of insulin system and associated diseases. ..
  45. pmc SRT1720 improves survival and healthspan of obese mice
    Robin K Minor
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Sci Rep 1:70. 2011
    ....
  46. pmc Modulation of Cancer Traits by Tumor Suppressor microRNAs
    Ioannis Grammatikakis
    Laboratory of Genetics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Int J Mol Sci 14:1822-42. 2013
    ..In this review, we focus specifically on TS-miRNAs and their effects on well-established cancer traits. We also discuss the rising interest in TS-miRNAs in cancer therapy...