National Cancer Institute

Summary

Organization: National Cancer Institute
Country: USA

Top Publications

  1. doi Automatic nuclei segmentation and spatial FISH analysis for cancer detection
    Kaustav Nandy
    Optical Microscopy and Analysis Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6718-21. 2009
  2. ncbi Cloning technologies for protein expression and purification
    James L Hartley
    Protein Expression Laboratory, Research Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Curr Opin Biotechnol 17:359-66. 2006
  3. ncbi A high-throughput cell-based assay for inhibitors of ABCG2 activity
    Curtis J Henrich
    Basic Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Biomol Screen 11:176-83. 2006
  4. ncbi Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics
    Eugene V Barsov
    AIDS Vaccine Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, MD 21702, USA
    Immunol Lett 105:26-37. 2006
  5. ncbi From computational quantum chemistry to computational biology: experiments and computations are (full) partners
    Buyong Ma
    Basic Research Program, SAIC Frederick, Inc, Laboratory of Experimental and Computational Biology, NCI Frederick, Frederick, MD 21702, USA
    Phys Biol 1:P23-6. 2004
  6. ncbi Characterization and quantitation of membrane proteomes using multidimensional MS-based proteomic technologies
    Josip Blonder
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, National Cancer Institute, PO Box B, Frederick, MD 21702, USA
    Expert Rev Proteomics 1:153-63. 2004
  7. pmc A 1927 study supports a current genetic model for inheritance of human scalp hair-whorl orientation and hand-use preference traits
    Amar J S Klar
    Developmental Genetics Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Genetics 170:2027-30. 2005
  8. ncbi Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition
    Alla Gustchina
    Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    J Mol Biol 348:433-44. 2005
  9. pmc Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface
    Buyong Ma
    Basic Research Program, SAIC Frederick, Inc, Laboratory of Experimental and Computational Biology, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 102:3988-93. 2005
  10. ncbi PKCdelta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant
    Tanya Jelacic
    Basic Research Laboratory, Center for Cancer Research, Bldg 469, Rm 205, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Blood 105:1923-9. 2005

Scientific Experts

Detail Information

Publications62

  1. doi Automatic nuclei segmentation and spatial FISH analysis for cancer detection
    Kaustav Nandy
    Optical Microscopy and Analysis Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6718-21. 2009
    ..Results are encouraging and show that the method could evolve into a full fledged clinical application for cancer detection...
  2. ncbi Cloning technologies for protein expression and purification
    James L Hartley
    Protein Expression Laboratory, Research Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Curr Opin Biotechnol 17:359-66. 2006
    ..The construction of plasmids and viruses to overexpress proteins for their purification is often tedious. Alternatives to traditional methods that are faster, easier and more flexible are needed and are becoming available...
  3. ncbi A high-throughput cell-based assay for inhibitors of ABCG2 activity
    Curtis J Henrich
    Basic Research Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    J Biomol Screen 11:176-83. 2006
    ..2 microM) and, like FTC, restored sensitivity of resistant cells to mitoxantrone. Application of this assay to other libraries of synthetic compounds and natural products is expected to identify novel inhibitors of ABCG2 activity...
  4. ncbi Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics
    Eugene V Barsov
    AIDS Vaccine Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, MD 21702, USA
    Immunol Lett 105:26-37. 2006
    ..This approach provides a convenient, reproducible means for generating a stable, continuously renewable source of antigen-specific T lymphocytes for a variety of studies of T cell biology...
  5. ncbi From computational quantum chemistry to computational biology: experiments and computations are (full) partners
    Buyong Ma
    Basic Research Program, SAIC Frederick, Inc, Laboratory of Experimental and Computational Biology, NCI Frederick, Frederick, MD 21702, USA
    Phys Biol 1:P23-6. 2004
    ..For the perception to become reality, computation and experiment should be united as full partners in biological research...
  6. ncbi Characterization and quantitation of membrane proteomes using multidimensional MS-based proteomic technologies
    Josip Blonder
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, National Cancer Institute, PO Box B, Frederick, MD 21702, USA
    Expert Rev Proteomics 1:153-63. 2004
    ..Fortunately, rapid progress has increased the ability to characterize this critically important class of proteins on a scale analogous to that of aqueous soluble proteins...
  7. pmc A 1927 study supports a current genetic model for inheritance of human scalp hair-whorl orientation and hand-use preference traits
    Amar J S Klar
    Developmental Genetics Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Genetics 170:2027-30. 2005
    ....
  8. ncbi Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition
    Alla Gustchina
    Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    J Mol Biol 348:433-44. 2005
    ..Five disulfide bridges and a Zn-binding site confer stability to the protein, which may contribute to sensitization at lower levels of exposure than other allergens...
  9. pmc Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface
    Buyong Ma
    Basic Research Program, SAIC Frederick, Inc, Laboratory of Experimental and Computational Biology, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 102:3988-93. 2005
    ..Thus, they have significant implications toward our understanding of DNA binding by p53 as well as p53-mediated interactions with other proteins...
  10. ncbi PKCdelta plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant
    Tanya Jelacic
    Basic Research Laboratory, Center for Cancer Research, Bldg 469, Rm 205, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Blood 105:1923-9. 2005
    ..This is the first demonstration that PKCdelta has different functions in cells expressing normal versus oncogenic forms of a receptor...
  11. ncbi Modeling loop reorganization free energies of acetylcholinesterase: a comparison of explicit and implicit solvent models
    Mark A Olson
    Department of Cell Biology and Biochemistry, USAMRIID, Frederick, Maryland 21702, USA
    Proteins 57:645-50. 2004
    ..The simpler methods of ASP and the distance-dependent scaling of the dielectric constant both produced considerable distortions in the protein internal free-energy terms and are consequently unreliable...
  12. ncbi Proteomic patterns for early cancer detection
    Timothy D Veenstra
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick Inc, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Drug Discov Today 9:889-97. 2004
    ..This technology is capable of analyzing hundreds of clinical samples per day and has the potential to be a novel, highly sensitive diagnostic tool for the early detection of diseases, or as a predictor of response to therapy...
  13. ncbi The mutagenic effects of 7,12-dimethylbenz[a]anthacene, 3-methylcholanthrene and benzo[a]pyrene to the developing Syrian hamster fetus measured by an in vivo/in vitro mutation assay
    Paul J Donovan
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538, Room 205E, MD 21702 1201, USA
    Mutat Res 554:111-20. 2004
    ..The special effectiveness of DMBA as a transplacental mutagen may relate to its ability to cause increased cell division and fixation of DNA lesions as mutations...
  14. ncbi Infectious transmission and replication of human T-cell leukemia virus type 1
    David Derse
    Retrovirus Gene Expression Section, HIV Drug Resistance Program, NCI Frederick, Frederick, MD 21702 1201, USA
    Front Biosci 9:2495-9. 2004
    ..We are determining whether this block is conferred by the viral replication enzymes, results from the actions of cellular restriction factors, reflects the need for cell-cell contact, or is caused by a combination of these factors...
  15. pmc Retrotransposon suicide: formation of Ty1 circles and autointegration via a central DNA flap
    David J Garfinkel
    National Cancer Institute, P O Box B, Frederick, MD 21702 1201, USA
    J Virol 80:11920-34. 2006
    ..These results suggest that Ty1-specific mechanisms minimize copy number and raise the possibility that special DNA structures are a targeting determinant...
  16. ncbi Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma development
    Berton Zbar
    Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 1107, USA
    J Urol 177:461-5; discussion 465. 2007
    ..To better characterize this familial cancer we reviewed renal carcinoma families evaluated at the National Cancer Institute between 1990 and 2004 to identify distinctive features of these families...
  17. ncbi Trp/Met/Phe hot spots in protein-protein interactions: potential targets in drug design
    Buyong Ma
    Basic Research Program, SAIC Frederick, Inc, Center for Cancer Research Nanobiology Program, NCI Frederick, Frederick, MD 21702, USA
    Curr Top Med Chem 7:999-1005. 2007
    ..Thus, this may suggest that nature tends to avoid Ile conservation in protein-protein interaction to avoid amyloid formation. In this regards, Trp/Met/Phe as well as Ile may be targeted to modulate protein-protein interaction...
  18. pmc Artifacts of the 1.9x feline genome assembly derived from the feline-specific satellite sequence
    Joan U Pontius
    Laboratory of Genomic Diversity, Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Hered 100:S14-8. 2009
    ..The findings regarding the feline-specific sequence should be considered in the pending 8x assembly of the cat genome...
  19. pmc ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC
    Luke H Stockwin
    Developmental Therapeutics Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    BMC Cancer 9:63. 2009
    ..In this study, the mechanism of action of ARC was further investigated by comparing in vitro and in vivo activity with other anti-neoplastic purines...
  20. pmc Brain tumor susceptibility: the role of genetic factors and uses of mouse models to unravel risk
    Karlyne M Reilly
    Mouse Cancer Genetics Program, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Brain Pathol 19:121-31. 2009
    ..This review explores the difficulties in assessing risk factors in rare diseases such as brain tumors, and discusses how mouse models of cancer can aid in a better understanding of genetic risk factors for brain tumors...
  21. pmc An autosomal genetic linkage map of the domestic cat, Felis silvestris catus
    Marilyn Menotti-Raymond
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Genomics 93:305-13. 2009
    ..The improved linkage map will provide an added resource for the mapping of phenotypic variation in the domestic cat and the use of this species as a model system for biological research...
  22. pmc KIR-HLA intercourse in HIV disease
    Mary Carrington
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Trends Microbiol 16:620-7. 2008
    ..Here we concentrate on the interaction between the HLA-B and KIR3DL1/KIR3DS1 genes, describe the effects of these loci on HIV disease, and discuss questions that remain unresolved...
  23. pmc Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs
    Harinath Chakrapani
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Bioorg Med Chem 16:9764-71. 2008
    ..These properties may prove advantageous in the further development of this class of nitric oxide prodrugs as cancer therapeutic agents...
  24. pmc A crystallographic study of bright far-red fluorescent protein mKate reveals pH-induced cis-trans isomerization of the chromophore
    Sergei Pletnev
    Macromolecular Crystallography Laboratory, NCI, National Institutes of Health, Argonne, Illinois 60439, USA
    J Biol Chem 283:28980-7. 2008
    ..A group of residues consisting of Val(93), Arg(122), Glu(155), Arg(157), Asp(159), His(169), Ile(171), Asn(173), Val(192), Tyr(194), and Val(216), are most likely responsible for the observed monomeric state of the protein in solution...
  25. pmc CD45 immunoaffinity depletion of vesicles from Jurkat T cells demonstrates that exosomes contain CD45: no evidence for a distinct exosome/HIV-1 budding pathway
    Lori V Coren
    AIDS and Cancer Virus Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    Retrovirology 5:64. 2008
    ..The presence of CD45 on vesicles, including exosomes, and its absence on virions argues against a specialized budding pathway that is shared by both exosomes and HIV-1...
  26. doi Utility of separation science in metabolomic studies
    Haleem J Issaq
    Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    J Sep Sci 31:1936-47. 2008
    ..The application of each technique is discussed and its advantages and limitations are discussed with selective illustrative examples...
  27. doi A high-throughput system for segmenting nuclei using multiscale techniques
    Prabhakar R Gudla
    Image Analysis Laboratory, Advanced Technology Program, SAIC Frederick, NCI Frederick, Frederick, Maryland 21702, USA
    Cytometry A 73:451-66. 2008
    ..The algorithm allows complete automation and facilitates reproducible and unbiased spatial analysis of DNA sequences...
  28. pmc Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
    Sarah Palmer
    HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 105:3879-84. 2008
    ..These data suggest that low-level persistent viremia appears to arise from at least two cell compartments, one in which viral production decays over time and a second in which viral production remains stable for at least 7 years...
  29. ncbi Defensin participation in innate and adaptive immunity
    De Yang
    Basic Research Program, SAIC Frederick, Inc, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702 1201, USA
    Curr Pharm Des 13:3131-9. 2007
    ..Here we will briefly outline the classification, genes, expression, and structure of mammalian defensins and focus on their roles in innate and adaptive immune response of the host...
  30. ncbi Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data
    David G Covell
    National Cancer Institute Frederick, Developmental Therapeutics Program, Screening Technologies Branch, Laboratory of Computational Technologies, Frederick, MD 21702, USA
    Mol Cancer Ther 6:2261-70. 2007
    ..are in phase I, II, or III clinical trials and their structural analogues that have been screened in the National Cancer Institute (NCI) anticancer screening program...
  31. ncbi Introduction and overview. Perinatal carcinogenesis: growing a node for epidemiology, risk management, and animal studies
    Lucy M Anderson
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Toxicol Appl Pharmacol 199:85-90. 2004
    ....
  32. ncbi Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins
    Jeffrey D Lifson
    AIDS Vaccine Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    AIDS Res Hum Retroviruses 20:772-87. 2004
    ..With further optimization, AT-2-inactivated viral particles may be a useful class of immunogen in the development of a vaccine to prevent AIDS...
  33. pmc Identification of a key target sequence to block human immunodeficiency virus type 1 replication within the gag-pol transframe domain
    S Sei
    HIV Clinical Interface Laboratory, SAIC Frederick, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Virol 74:4621-33. 2000
    ....
  34. pmc Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment
    J D Lifson
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Virol 74:2584-93. 2000
    ..These findings may be particularly important in relation to prospects for control of primate lentiviruses in the settings of both prophylactic and therapeutic vaccination for prevention of AIDS...
  35. ncbi Molecular cloning of the guinea pig GRO gene and its rapid expression in the tissues of lipopolysaccharide-injected guinea pigs
    T Yoshimura
    Immunopathology Section, Laboratory of Immunobiology, Frederick, MD, USA
    Int Arch Allergy Immunol 119:101-11. 1999
    ..The functional orthologues in the rat and mouse are CINC/KC and MIP-2. The lack of IL-8 made these animals less useful to study the role of IL-8 and GRO...
  36. pmc Hybrid Ty1/HIV-1 elements used to detect inhibitors and monitor the activity of HIV-1 reverse transcriptase
    D V Nissley
    Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute Frederick Cancer Research and Development Center, ABL Basic Research Program, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 95:13905-10. 1998
    ..HART elements carrying NNRTI-resistant variants of HIV-1 RT can be used to identify compounds that are active against drug-resistant viruses...
  37. ncbi Pax-6, eyes absent, and Prox 1 in eye development
    S I Tomarev
    Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892 2730, USA
    Int J Dev Biol 41:835-42. 1997
    ..Mechanisms of eye formation and the generation of different types of eyes in the course of evolution are discussed...
  38. ncbi Promotion by Helicobacter hepaticus-induced hepatitis of hepatic tumors initiated by N-nitrosodimethylamine in male A/JCr mice
    B A Diwan
    Intramural Research Support Program, SAIC Frederick, Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Toxicol Pathol 25:597-605. 1997
    ..Thus, chronic H. hepaticus infection significantly stimulated cyclin D expression, accelerated the development of liver tumors, increased the multiplicity of such lesions, and enhanced the progression of benign to malignant tumors...
  39. pmc Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
    L Tessarollo
    Neural Development Group, ABL Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 94:14776-81. 1997
    ..The similarities in cardiac defects observed in the trkC and NT-3 null mutant mice indicate that the trkC receptor mediates most NT-3 effects on the cardiac neural crest...
  40. ncbi The potential role of NK cells in the separation of graft-versus-tumor effects from graft-versus-host disease after allogeneic bone marrow transplantation
    W J Murphy
    NCI FCRDC, SAIC Frederick Intramural Research Support Program, MD 21702 1201, USA
    Immunol Rev 157:167-76. 1997
    ..Thus, the use of activated NK cells after allogeneic BMT may provide GVT effects without inducing GVHD...
  41. ncbi Cationic liposome-mediated uptake of human immunodeficiency virus type 1 Tat protein into cells
    S E Fong
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0438, USA
    J Virol Methods 66:149-57. 1997
    ..The method may have applications for the analysis of other recombinant proteins that require uptake into intact cells for determination of functionality and presents a general technique for introducing exogenous proteins into cells...
  42. ncbi Methods and reagents. Degraded DNA and gel tornados
    P N Hengen
    National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702 1201, USA
    Trends Biochem Sci 22:138-9. 1997
    ..molbio.methds-reagnts, available on the Internet. This month's column discusses a case of inexplicable DNA degradation and tornados seen in agarose gels. For details on how to partake in the newsgroup, see the accompanying box...
  43. ncbi A common structural core in the internal ribosome entry sites of picornavirus, hepatitis C virus, and pestivirus
    S Y Le
    Laboratory of Mathematical Biology, National Cancer Institute, NIH, Frederick, MD 21702, USA
    Virus Genes 12:135-47. 1996
    ..The conserved structural motif from these divergent sequences that looks like the common core region of group 1 introns is probably a crucial element involved in the IRES-dependent translation...
  44. ncbi Methods and reagents. Eliminating banding artifacts from SDS-PAGE
    P N Hengen
    National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Trends Biochem Sci 21:191-3. 1996
    ..For details on how to partake in the newsgroup, see the accompanying box...
  45. ncbi Cycle sequencing through GC-rich regions
    P N Hengen
    National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702 1201, USA
    Trends Biochem Sci 21:33-4. 1996
    ..For details on how to partake in the newsgroup, see the accompanying box...
  46. ncbi Crystal structure analysis of recombinant human uteroglobin and molecular modeling of ligand binding
    N Pattabiraman
    Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, District of Columbia 20375 5341, USA
    Ann N Y Acad Sci 923:113-27. 2000
    ..Our results suggest that at least one of the physiological functions of UG is to bind to hydrophobic ligands, such as progesterone and retinol...
  47. pmc Evolution of mammalian genome organization inferred from comparative gene mapping
    W J Murphy
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Genome Biol 2:REVIEWS0005. 2001
    ....
  48. pmc Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway
    A Danilkovitch-Miagkova
    Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Fort Detrick, Frederick, MD 21702, USA
    Mol Cell Biol 21:5857-68. 2001
    ..Activation of beta-catenin by oncogenic RON and MET constitutes a new pathway, which might lead to cell transformation by these and other mutant growth factor RTKs...
  49. pmc Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes
    Sivasubramanian Baskar
    Basic Research Program, SAIC Frederick Inc, National Cancer Institute at Frederick, National Institutes of Health, Maryland, 21702, USA
    J Clin Invest 113:1498-510. 2004
    ..Such antigenic epitopes may serve as candidates for novel peptide-vaccine strategies, and as tools to selectively expand tumor antigen-specific T cells for adoptive immunotherapy and for monitoring T cell immunity in vaccinated patients...
  50. ncbi Virus entry: molecular mechanisms and biomedical applications
    Dimiter S Dimitrov
    Human Immunovirology and Computational Biology Group, Laboratory of Experimental and Computational Biology, Centre for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    Nat Rev Microbiol 2:109-22. 2004
    ....
  51. ncbi Virology. Weapons of mutational destruction
    Vineet N Kewalramani
    HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA
    Science 301:923-5. 2003
  52. ncbi Phosphatidylinositol 3'-kinase is required for growth of mast cells expressing the kit catalytic domain mutant
    R Shivakrupa
    Basic Research Laboratory, Center for Cancer Research, Building 567, Room 226, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Cancer Res 63:4412-9. 2003
    ..These findings may provide insight into designing strategies for treatment of mastocytosis and other diseases associated with mutations in the Kit catalytic domain...
  53. ncbi Strong population substructure is correlated with morphology and ecology in a migratory bat
    Cassandra M Miller-Butterworth
    Department of Zoology, University of Cape Town, Private Bag, Rondebosch, 7701, South Africa
    Nature 424:187-91. 2003
    ..There is therefore a close correlation of genetic and morphological differentiation in sympatric subspecific populations of this mammalian species...
  54. ncbi Nickel(II)-induced apoptosis in murine T cell hybridoma cells is associated with increased fas ligand expression
    Kyungtae Kim
    Cell Biology Laboratory, Graduate School of Biotechnology, Korea University, Seoul, 136 701, Korea
    Toxicol Appl Pharmacol 185:41-7. 2002
    ..Given that nickel(II) can directly generate ROS, exposure to nickel(II) may lead to apoptosis through a similar mechanism...
  55. ncbi Progress toward clinical application of the nitric oxide-releasing diazeniumdiolates
    Larry K Keefer
    Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Annu Rev Pharmacol Toxicol 43:585-607. 2003
    ....
  56. pmc PPAR and immune system--what do we know?
    Xia Zhang
    Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702 1201, USA
    Int Immunopharmacol 2:1029-44. 2002
    ..Deciphering the mechanism of action of PPAR-gamma and its ligands may lead to a new therapeutic regiment for treatment of diseases involving dysfunction of the immune system...
  57. pmc Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
    O M Zack Howard
    National Cancer Institute, Center for Cancer Research, Laboratory of Molecular Immunoregulation, Frederick, MD 21702, USA
    J Exp Med 196:781-91. 2002
    ..Therefore, the selection of a self-molecule as a target for an autoantibody response may be a consequence of the proinflammatory properties of the molecule itself...
  58. ncbi Methods for fractionation, separation and profiling of proteins and peptides
    Haleem J Issaq
    Analytical Chemistry Laboratory, SAIC Frederick NCI Frederick, Frederick, MD 21702, USA
    Electrophoresis 23:3048-61. 2002
    ....
  59. ncbi Study of diverse mechanisms of cell-mediated cytotoxicity in gene-targeted mice using flow cytometric cytotoxicity assay
    Anatoli Malyguine
    SAIC Frederick, Inc NCI at Frederick, P O Box B, Frederick, MD 21702 1201, USA
    Immunol Lett 83:55-9. 2002
    ....
  60. pmc Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses
    Sina Bavari
    Dept of Cell Biology and Biochemistry, U S Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702 5011, USA
    J Exp Med 195:593-602. 2002
    ....
  61. ncbi Transcription termination: primary intermediates and secondary adducts
    Mikhail Kashlev
    NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
    J Biol Chem 277:14501-8. 2002
    ..Thus, transcription elongation to a terminator site produces no termination intermediates that withstand dissociation in the time scale appropriate for biochemical studies...
  62. ncbi Methods and reagents. Is there any sense in antisense terminology?
    P N Hengen
    National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702 1201, USA
    Trends Biochem Sci 21:153-4. 1996
    ..methds-reagnts, available on the internet. This month's column reviews a recent debate held over the present sense and antisense terminology when referring to DNA. For details on how to partake in the newsgroup, see the accompanying box...