Affiliation: Nathan Kline Institute
Yuan A, Veeranna -, Sershen H, Basavarajappa B, Smiley J, Hashim A, et al
. Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors. Transl Psychiatry. 2018;8:167 pubmed publisher
..Our findings support an emerging view that central nervous system neurofilament subunits including NFL in the present report, serve distinctive, critical roles in synapses relevant to neuropsychiatric diseases. ..
Yuan A, Sasaki T, Rao M, Kumar A, Kanumuri V, Dunlop D, et al
. Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons. J Neurosci. 2009;29:11316-29 pubmed publisher
..These findings reconcile in vitro and in vivo axonal transport observations, showing that slowly transported NFs or subunit oligomers are precursors to a highly stable stationary cytoskeletal network that supports mature axons. ..
Yuan A, Nixon R. Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders. Brain Res Bull. 2016;126:334-346 pubmed publisher
Yuan A, Rao M, Kumar A, Julien J, Nixon R. Neurofilament transport in vivo minimally requires hetero-oligomer formation. J Neurosci. 2003;23:9452-8 pubmed
..They also show that NF-M can partner with intermediate filament proteins other than the NF-H and NF-L subunits in neurons to support slow transport and possibly other functions of neuronal intermediate filaments. ..
Yuan A, Rao M, Sasaki T, Chen Y, Kumar A, Veeranna -, et al
. Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J Neurosci. 2006;26:10006-19 pubmed
Yuan A, Kumar A, Peterhoff C, Duff K, Nixon R. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci. 2008;28:1682-7 pubmed publisher
..These results suggest that tau is not essential for axonal transport and that transport rates in vivo are not significantly affected by substantial fluctuations in tau expression. ..
Yuan A, Sasaki T, Kumar A, Peterhoff C, Rao M, LIEM R, et al
. Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons. J Neurosci. 2012;32:8501-8 pubmed publisher
..Our findings provide a basis for its close relationship with neurofilaments in PNS diseases associated with neurofilament accumulation. ..