Aidong Yuan

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. pmc Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 32:8501-8. 2012
  2. pmc Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:1682-7. 2008
  3. pmc Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 29:11316-29. 2009
  4. ncbi request reprint Neurofilament transport in vivo minimally requires hetero-oligomer formation
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
    J Neurosci 23:9452-8. 2003
  5. ncbi request reprint Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 26:10006-19. 2006
  6. pmc Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density
    Mala V Rao
    Center for Dementia Research, Nathan Kline Institute, NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Cell Biol 159:279-90. 2002
  7. pmc The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate
    Mala V Rao
    Nathan Kline Institute, NYU School of Medicine, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    J Cell Biol 163:1021-31. 2003
  8. pmc The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons
    Mala V Rao
    Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York, United States of America
    PLoS ONE 6:e17087. 2011
  9. ncbi request reprint Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurosci Lett 393:264-8. 2006
  10. pmc The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network
    Mala V Rao
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York, United States of America
    PLoS ONE 7:e44320. 2012

Collaborators

Detail Information

Publications14

  1. pmc Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 32:8501-8. 2012
    ..Our findings provide a basis for its close relationship with neurofilaments in PNS diseases associated with neurofilament accumulation...
  2. pmc Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:1682-7. 2008
    ..These results suggest that tau is not essential for axonal transport and that transport rates in vivo are not significantly affected by substantial fluctuations in tau expression...
  3. pmc Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 29:11316-29. 2009
    ..These findings reconcile in vitro and in vivo axonal transport observations, showing that slowly transported NFs or subunit oligomers are precursors to a highly stable stationary cytoskeletal network that supports mature axons...
  4. ncbi request reprint Neurofilament transport in vivo minimally requires hetero-oligomer formation
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
    J Neurosci 23:9452-8. 2003
    ..They also show that NF-M can partner with intermediate filament proteins other than the NF-H and NF-L subunits in neurons to support slow transport and possibly other functions of neuronal intermediate filaments...
  5. ncbi request reprint Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 26:10006-19. 2006
    ....
  6. pmc Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density
    Mala V Rao
    Center for Dementia Research, Nathan Kline Institute, NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Cell Biol 159:279-90. 2002
    ....
  7. pmc The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate
    Mala V Rao
    Nathan Kline Institute, NYU School of Medicine, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    J Cell Biol 163:1021-31. 2003
    ....
  8. pmc The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons
    Mala V Rao
    Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York, United States of America
    PLoS ONE 6:e17087. 2011
    ..Based on observations that the Myo Va motor domain binds to intermediate filament (IF) proteins of several classes, Myo Va interactions with IFs may serve similar roles in organizing organelle topography in different cell types...
  9. ncbi request reprint Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurosci Lett 393:264-8. 2006
    ..Possible roles for tail domains as cross-bridges between a neurofilament and its neighbors or other cytoskeletal elements is discussed...
  10. pmc The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network
    Mala V Rao
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York, United States of America
    PLoS ONE 7:e44320. 2012
    ....
  11. pmc The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models
    Victor V Dyakin
    Center for Dementia Research, Nathan Kline Institute Orangeburg, New York 10962, USA
    Neuroimage 51:1098-105. 2010
    ..Our findings indicate that T2 is strongly influenced by myelination state and axonal volume, while neurofilament structure within the intra-axonal compartment has a lesser effect upon single compartment T2 estimates...
  12. pmc Global axonal transport rates are unaltered in htau mice in vivo
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA Department of Psychiatry, New York University School of Medicine, NY, USA
    J Alzheimers Dis 37:579-86. 2013
    ..These studies demonstrate that human tau overexpression, even when associated with a limited degree of tau pathology, does not necessarily impair general axonal transport function in vivo. ..
  13. pmc Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport
    Mala V Rao
    Nathan Kline Institute, New York University School of Medicine, Orangeburg, NY 10962, USA
    J Cell Biol 158:681-93. 2002
    ..Most surprisingly, at least in optic nerve axons, loss of the NF-H tail does not affect the rate of transport of neurofilament subunits...
  14. ncbi request reprint Slow axonal transport of the cytosolic chaperonin CCT with Hsc73 and actin in motor neurons
    Gregory J Bourke
    Department of Physiology and The Neuroscience Center, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Neurosci Res 68:29-35. 2002
    ..Our results are consistent with molecular chaperones having a post-translational role in maintaining the native form of actin during its slow transport to the axon terminal and ensuring its correct assembly into microfilaments...