Dun Sheng Yang

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. pmc Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease
    Dun Sheng Yang
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Rd, Bldg 39, Orangeburg, NY 10962, USA
    Am J Pathol 173:665-81. 2008
  2. pmc Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
    Dun Sheng Yang
    Nathan Kline Institute, Orangeburg, NY, USA
    Autophagy 7:788-9. 2011
  3. pmc Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
    Dun Sheng Yang
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Brain 134:258-77. 2011
  4. pmc Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
    - Veeranna
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States Department of Psychiatry, New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 32:2016-29. 2011
  5. ncbi request reprint Neurodegenerative lysosomal disorders: a continuum from development to late age
    Ralph A Nixon
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
    Autophagy 4:590-9. 2008
  6. pmc Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain
    Mitsuo Saito
    Division of Analytical Psychopharmacology, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 121:649-61. 2012
  7. pmc Autophagy failure in Alzheimer's disease--locating the primary defect
    Ralph A Nixon
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurobiol Dis 43:38-45. 2011
  8. pmc Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression
    Mala V Rao
    Center for Dementia Research, Nathan S Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:12241-54. 2008
  9. doi request reprint Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases
    Dun Sheng Yang
    Center for Dementia Research, Nathan S Kline Institute, Orangeburg, New York, USA
    Methods Enzymol 453:111-44. 2009
  10. ncbi request reprint Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
    Dun Sheng Yang
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 277:28135-42. 2002

Detail Information

Publications10

  1. pmc Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease
    Dun Sheng Yang
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Rd, Bldg 39, Orangeburg, NY 10962, USA
    Am J Pathol 173:665-81. 2008
    ..Our findings establish apoptosis as a mode of neuronal cell death in aging PS/APP mice and identify the cross talk between autophagy and apoptosis, which influences neuronal survival in AD-related neurodegeneration...
  2. pmc Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
    Dun Sheng Yang
    Nathan Kline Institute, Orangeburg, NY, USA
    Autophagy 7:788-9. 2011
    ..Our findings underscore the pathogenic significance of autophagic-lysosomal dysfunction in AD and demonstrate the value of reversing this dysfunction as an innovative therapeautic strategy for AD...
  3. pmc Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
    Dun Sheng Yang
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Brain 134:258-77. 2011
    ..Our findings support the pathogenic significance of autophagic-lysosomal dysfunction in Alzheimer's disease and indicate the potential value of restoring normal autophagy as an innovative therapeutic strategy for Alzheimer's disease...
  4. pmc Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments
    - Veeranna
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States Department of Psychiatry, New York University School of Medicine, New York, NY 10016, United States
    Neurobiol Aging 32:2016-29. 2011
    ..Declining PP2A activity, therefore, can account for rising neurofilament phosphorylation in maturing brain, potentially compounding similar changes associated with adult-onset neurodegenerative diseases...
  5. ncbi request reprint Neurodegenerative lysosomal disorders: a continuum from development to late age
    Ralph A Nixon
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
    Autophagy 4:590-9. 2008
    ..We highlight Alzheimer's disease as a disease within this group and discuss how each of the genes and other risk factors promoting this disease contribute to progressive lysosomal dysfunction and neuronal cell death...
  6. pmc Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain
    Mitsuo Saito
    Division of Analytical Psychopharmacology, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 121:649-61. 2012
    ..Subsequently, activated microglia accumulated GM2, indicating a close relationship between GM2 and ethanol-induced neurodegeneration...
  7. pmc Autophagy failure in Alzheimer's disease--locating the primary defect
    Ralph A Nixon
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurobiol Dis 43:38-45. 2011
    ..This article is part of a Special Issue entitled "Autophagy and protein degradation in neurological diseases."..
  8. pmc Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression
    Mala V Rao
    Center for Dementia Research, Nathan S Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:12241-54. 2008
    ..CAST mimetics may, therefore, be neuroprotective in AD...
  9. doi request reprint Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases
    Dun Sheng Yang
    Center for Dementia Research, Nathan S Kline Institute, Orangeburg, New York, USA
    Methods Enzymol 453:111-44. 2009
    ....
  10. ncbi request reprint Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
    Dun Sheng Yang
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 277:28135-42. 2002
    ....