Donald A Wilson

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. pmc Auditory stimulation dishabituates olfactory responses via noradrenergic cortical modulation
    Jonathan J Smith
    Department of Zoology, University of Oklahoma, Norman, 73019, USA
    Neural Plast 2009:754014. 2009
  2. doi request reprint Neurobiology of a simple memory
    Donald A Wilson
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurophysiol 100:2-7. 2008
  3. pmc Pattern separation and completion in olfaction
    Donald A Wilson
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, and Child and Adolescent Psychiatry, New York University School of Medicine, Orangeburg, New York 10962, USA
    Ann N Y Acad Sci 1170:306-12. 2009
  4. pmc Local and regional network function in behaviorally relevant cortical circuits of adult mice following postnatal alcohol exposure
    Donald A Wilson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Alcohol Clin Exp Res 35:1974-84. 2011
  5. pmc Olfaction as a model system for the neurobiology of mammalian short-term habituation
    Donald A Wilson
    Department of Zoology, Neurobehavioral Institute, University of Oklahoma, OK, USA
    Neurobiol Learn Mem 92:199-205. 2009
  6. pmc State-dependent functional connectivity of rat olfactory system assessed by fMRI
    D A Wilson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, USA
    Neurosci Lett 497:69-73. 2011
  7. pmc Developmental emergence of fear learning corresponds with changes in amygdala synaptic plasticity
    Jason V Thompson
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, OK 73019, USA
    Brain Res 1200:58-65. 2008
  8. pmc Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
    Dun Sheng Yang
    Nathan Kline Institute, Orangeburg, NY, USA
    Autophagy 7:788-9. 2011
  9. pmc Generalized vs. stimulus-specific learned fear differentially modifies stimulus encoding in primary sensory cortex of awake rats
    Chien Fu F Chen
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Neurophysiol 106:3136-44. 2011
  10. pmc Neurobehavioral consequences of cortical adaptation disruption during ontogeny
    Heather Bell
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, USA
    Neurosci Lett 445:47-52. 2008

Detail Information

Publications55

  1. pmc Auditory stimulation dishabituates olfactory responses via noradrenergic cortical modulation
    Jonathan J Smith
    Department of Zoology, University of Oklahoma, Norman, 73019, USA
    Neural Plast 2009:754014. 2009
    ..These results provide a cortical mechanism for a return of habituated sensory responses following a cross-modal alerting stimulus...
  2. doi request reprint Neurobiology of a simple memory
    Donald A Wilson
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurophysiol 100:2-7. 2008
    ..The differential locus of change underlying short- and long-term memory leads to predictable differences in their behavioral characteristics, such as specificity...
  3. pmc Pattern separation and completion in olfaction
    Donald A Wilson
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, and Child and Adolescent Psychiatry, New York University School of Medicine, Orangeburg, New York 10962, USA
    Ann N Y Acad Sci 1170:306-12. 2009
    ....
  4. pmc Local and regional network function in behaviorally relevant cortical circuits of adult mice following postnatal alcohol exposure
    Donald A Wilson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Alcohol Clin Exp Res 35:1974-84. 2011
    ..The developmental stage of neonatal rodent brains that are at the peak of synaptogenesis is equivalent to the third trimester of human gestation...
  5. pmc Olfaction as a model system for the neurobiology of mammalian short-term habituation
    Donald A Wilson
    Department of Zoology, Neurobehavioral Institute, University of Oklahoma, OK, USA
    Neurobiol Learn Mem 92:199-205. 2009
    ..Finally, evidence for, and a mechanisms of, dishabituation of the orienting reflex and cortical adaptation are described...
  6. pmc State-dependent functional connectivity of rat olfactory system assessed by fMRI
    D A Wilson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, USA
    Neurosci Lett 497:69-73. 2011
    ..This state-dependent shift in functional connectivity may be important for sleep-dependent odor memory consolidation...
  7. pmc Developmental emergence of fear learning corresponds with changes in amygdala synaptic plasticity
    Jason V Thompson
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, OK 73019, USA
    Brain Res 1200:58-65. 2008
    ..The results suggest that sensitive period deficits in fear conditioning may be related to impaired amygdala synaptic plasticity and the immature state of GABAergic inhibition and/or its modulation in the neonatal amygdala...
  8. pmc Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
    Dun Sheng Yang
    Nathan Kline Institute, Orangeburg, NY, USA
    Autophagy 7:788-9. 2011
    ..Our findings underscore the pathogenic significance of autophagic-lysosomal dysfunction in AD and demonstrate the value of reversing this dysfunction as an innovative therapeautic strategy for AD...
  9. pmc Generalized vs. stimulus-specific learned fear differentially modifies stimulus encoding in primary sensory cortex of awake rats
    Chien Fu F Chen
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Neurophysiol 106:3136-44. 2011
    ..Furthermore, changes in sensory processing are dependent on the nature of training and can predict the stimulus-controlled behavioral outcome of the training...
  10. pmc Neurobehavioral consequences of cortical adaptation disruption during ontogeny
    Heather Bell
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, USA
    Neurosci Lett 445:47-52. 2008
    ..Combined with previous work, these results suggest that sensory gating disruption during development can have both immediate and long-lasting effects on sensory-guided behavior...
  11. pmc Ontogeny of cortical synaptic depression underlying olfactory sensory gating in the rat
    Jason V Thompson
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Brain Res Dev Brain Res 158:107-10. 2005
    ....
  12. pmc Coordinate synaptic mechanisms contributing to olfactory cortical adaptation
    Aaron R Best
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 24:652-60. 2004
    ..Importantly, in line with the in vitro findings, both adaptation of odor responses in the beta (15-35 Hz) spectral range and the associated synaptic depression can also be blocked by intracortical infusion of CPPG in vivo...
  13. pmc Olfactory bulb mitral-tufted cell plasticity: odorant-specific tuning reflects previous odorant exposure
    Max L Fletcher
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 23:6946-55. 2003
    ....
  14. pmc Cortical metabotropic glutamate receptors contribute to habituation of a simple odor-evoked behavior
    Aaron R Best
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 25:2513-7. 2005
    ..Here we show that blockade of mGluRs within the olfactory cortex of awake, behaving rats diminishes habituation of a simple odor-induced behavior, strongly implicating a central mechanism for sensory gating in olfaction...
  15. pmc Acetylcholine and olfactory perceptual learning
    Donald A Wilson
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Learn Mem 11:28-34. 2004
    ..In this paper, data are reviewed that show the critical role of acetylcholine (Ach) in olfactory system function and plasticity, and cholinergic modulation of olfactory perceptual learning at both the behavioral and cortical level...
  16. pmc Separate encoding of identity and similarity of complex familiar odors in piriform cortex
    Mikiko Kadohisa
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Proc Natl Acad Sci U S A 103:15206-11. 2006
    ....
  17. pmc Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 31:15962-71. 2011
    ....
  18. pmc Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model
    Jose Morales-Corraliza
    Center for Dementia Research, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurobiol Aging 34:137-45. 2013
    ....
  19. pmc Single-unit activity in piriform cortex during slow-wave state is shaped by recent odor experience
    Donald A Wilson
    Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 30:1760-5. 2010
    ..The results demonstrate that piriform cortical activity during slow-wave state is shaped by recent odor experience, which could contribute to odor memory consolidation...
  20. pmc Olfactory perceptual stability and discrimination
    Dylan C Barnes
    Neurobehavioral Institute, Department of Zoology, University of Oklahoma, 730 Van Vleet Oval, Norman, Oklahoma 73019, USA
    Nat Neurosci 11:1378-80. 2008
    ..This piriform cortical ensemble activity predicts olfactory perception...
  21. pmc Spatial and temporal distribution of odorant-evoked activity in the piriform cortex
    Robert L Rennaker
    School of Aerospace and Mechanical Engineering, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 27:1534-42. 2007
    ..These results provide direct evidence for predictions stemming from anatomical- and theoretical-based models of piriform cortex...
  22. pmc High-frequency oscillations are not necessary for simple olfactory discriminations in young rats
    Max L Fletcher
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73072, USA
    J Neurosci 25:792-8. 2005
    ..The results suggest that high-frequency local field-potential oscillations do not reflect processes critical for simple odor discrimination...
  23. pmc Dual circuitry for odor-shock conditioning during infancy: corticosterone switches between fear and attraction via amygdala
    Stephanie Moriceau
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 26:6737-48. 2006
    ..Because maternal stimulation of pups modulates the pups' endogenous corticosterone, this suggests maternal care quality may alter sensitive-period duration...
  24. pmc Olfactory cortical adaptation facilitates detection of odors against background
    Mikiko Kadohisa
    Dept of Zoology, University of Oklahoma, Norman, OK 73019, USA
    J Neurophysiol 95:1888-96. 2006
    ..Thus the aPCX acts as a filter driven most strongly by changing stimuli, providing a potential mechanism for olfactory figure-ground separation and selective reading of olfactory bulb output...
  25. pmc Respiratory and sniffing behaviors throughout adulthood and aging in mice
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Behav Brain Res 223:99-106. 2011
    ..These results show that odor-orienting responses are minimally impacted throughout aging in mice, and suggest that the olfactomotor network is mostly spared of insults due to aging...
  26. pmc Smelling sounds: olfactory-auditory sensory convergence in the olfactory tubercle
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 30:3013-21. 2010
    ..Thus, the tubercle presents itself as a source for direct multimodal convergence within an early stage of odor processing and may serve as a seat for psychophysical interactions between smells and sounds...
  27. ncbi request reprint Olfactory perceptual learning: the critical role of memory in odor discrimination
    Donald A Wilson
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Neurosci Biobehav Rev 27:307-28. 2003
    ..g. fear conditioning, maze learning, and delayed-match-to-sample paradigms), but also play a critical, defining role in odor discrimination...
  28. ncbi request reprint Cortical contributions to olfaction: plasticity and perception
    Donald A Wilson
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Semin Cell Dev Biol 17:462-70. 2006
    ..Finally, the olfactory cortex serves as an important sensory gate, modulating information throughput based on recent experience and behavioral state...
  29. ncbi request reprint Odor perception is dynamic: consequences for interpretation of odor maps
    Donald A Wilson
    Department of Zoology, University of Oklahoma, Norman, OK, USA
    Chem Senses 30:i105-6. 2005
  30. pmc Sleep-like states modulate functional connectivity in the rat olfactory system
    Donald A Wilson
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    J Neurophysiol 104:3231-9. 2010
    ....
  31. pmc Experience modifies olfactory acuity: acetylcholine-dependent learning decreases behavioral generalization between similar odorants
    Max L Fletcher
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurosci 22:RC201. 2002
    ..These results could have important implications for mechanisms of olfactory perception and memory, as well as for correlating behavioral olfactory acuity with observed spatial representations of odorant features in the olfactory system...
  32. pmc Chronic anti-murine Aβ immunization preserves odor guided behaviors in an Alzheimer's β-amyloidosis model
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Behav Brain Res 237:96-102. 2013
    ..Further, these results provide mechanistic insights into olfactory dysfunction as a biomarker for AD by yielding evidence that focal reductions of Aβ may be sufficient to preserve olfaction...
  33. pmc Cortical processing of odor objects
    Donald A Wilson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuron 72:506-19. 2011
    ..Recent findings regarding the neural architecture, physiology, and plasticity of the olfactory cortex, principally the piriform cortex, will be described in the context of how this paleocortical structure creates odor objects...
  34. pmc Odor fear conditioning modifies piriform cortex local field potentials both during conditioning and during post-conditioning sleep
    Dylan C Barnes
    Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, United States of America
    PLoS ONE 6:e18130. 2011
    ....
  35. pmc Mechanisms of neural and behavioral dysfunction in Alzheimer's disease
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY 10962, USA
    Mol Neurobiol 43:163-79. 2011
    ....
  36. pmc Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Behav Brain Res 216:408-13. 2011
    ..These results suggest that the APP gene plays a role in affiliative behaviors and are discussed in relation to disorders characteristic of mutations in the APP gene and in affective dysfunction, including Alzheimer's disease...
  37. pmc Sniffing out the contributions of the olfactory tubercle to the sense of smell: hedonics, sensory integration, and more?
    Daniel W Wesson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurosci Biobehav Rev 35:655-68. 2011
    ..Together, the information within this review highlights an understudied yet potentially critical component in central odor processing...
  38. ncbi request reprint Rapid, experience-induced enhancement in odorant discrimination by anterior piriform cortex neurons
    Donald A Wilson
    Department of Zoology University of Oklahoma, Norman, Oklahoma 73019, USA
    J Neurophysiol 90:65-72. 2003
    ..These results suggest experience-dependent synthetic processing in aPCX and suggest an important role for perceptual learning in normal odor discrimination...
  39. pmc The role of metabotropic glutamate receptors and cortical adaptation in habituation of odor-guided behavior
    Carly A Yadon
    Department of Zoology, University of Oklahoma, Norman, 73019, USA
    Learn Mem 12:601-5. 2005
    ..Infusions into the brain outside of the piriform cortex were without effect. CPPG infusion into the piriform cortex also produced an enhancement of time spent investigating a conspecific, although this effect was not significant...
  40. pmc Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model
    Daniel W Wesson
    Emotional Brain Institute and Center for Dementia Research, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 30:505-14. 2010
    ..Furthermore, these results present the odor cross-habituation test as a powerful behavioral assay, which reflects Abeta deposition and thus may serve to monitor the efficacy of therapies aimed at reducing Abeta...
  41. pmc Slow-wave sleep-imposed replay modulates both strength and precision of memory
    Dylan C Barnes
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, Behavioral and Cognitive Neuroscience Program, City University of New York, New York, New York 10065, and Department of Child and Adolescent Psychiatry, New York University Langone Medical School, New York, New York 10016
    J Neurosci 34:5134-42. 2014
    ..These results suggest that SWS replay in the olfactory cortex enhances memory consolidation, and that memory precision is dependent on the fidelity of that replay. ..
  42. pmc Bidirectional plasticity of cortical pattern recognition and behavioral sensory acuity
    Julie Chapuis
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Nat Neurosci 15:155-61. 2012
    ..Thus pattern recognition, and the balance between pattern separation and completion, is highly malleable on the basis of task demands and occurs in concert with changes in perceptual performance...
  43. pmc Olfactory system modulation of hippocampal cell death
    Kenneth Pope
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Neurosci Lett 422:13-7. 2007
    ..Increased TUNEL-labeling was apparent within 24h in both structures, but was more extensive and prolonged in piriform cortex. The results suggest a trans-synaptic regulation of cell survival through at least two synapses...
  44. ncbi request reprint The fundamental role of memory in olfactory perception
    Donald A Wilson
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Trends Neurosci 26:243-7. 2003
    ..Moreover, we suggest that odor perception is wholly dependent on the integrity of this memory system and that its loss severely impairs normal perception...
  45. ncbi request reprint Trans-neuronal regulation of cortical apoptosis in the adult rat olfactory system
    Carol Ho Wing Leung
    Department of Zoology, University of Oklahoma, Norman, OK 73019, USA
    Brain Res 984:182-8. 2003
    ..Neither bulbectomy nor naris closure affected TUNEL labeling in layer III. Together, these results suggest that there is a population of superficial cells in piriform cortex whose survival is tightly regulated by sensory input...
  46. pmc Molecular biology of early olfactory memory
    Regina M Sullivan
    Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Learn Mem 10:1-4. 2003
  47. pmc Lateral entorhinal modulation of piriform cortical activity and fine odor discrimination
    Julie Chapuis
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 33:13449-59. 2013
    ..Furthermore, the results provide potential insight into how neuropathology in the entorhinal cortex could contribute to early olfactory deficits seen in Alzheimer's disease. ..
  48. pmc Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
    Dun Sheng Yang
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Brain 134:258-77. 2011
    ..Our findings support the pathogenic significance of autophagic-lysosomal dysfunction in Alzheimer's disease and indicate the potential value of restoring normal autophagy as an innovative therapeutic strategy for Alzheimer's disease...
  49. ncbi request reprint Cortical odor processing in health and disease
    Donald A Wilson
    Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, New York, USA Department of Child and Adolescent Psychiatry, New York University Langone School of Medicine, New York, USA Cognitive Neuroscience Program, City College, City University of New York, New York, USA Electronic address
    Prog Brain Res 208:275-305. 2014
    ..This olfactory deficit often occurs despite maintained functioning in other sensory systems. Does the unusual network of olfactory cortical structures contribute to this sensitivity? ..
  50. pmc Dynamics of Active Sensing and perceptual selection
    Charles E Schroeder
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, USA
    Curr Opin Neurobiol 20:172-6. 2010
    ..These observations outline the essentials of an Active Sensing paradigm, and argue for increased emphasis on the study of sensory processes as specific to the dynamic motor/attentional context in which inputs are acquired...
  51. pmc Cholinergic modulation of olfactory pattern separation
    Julie Chapuis
    Child and Adolescent Psychiatry, New York University Langone School of Medicine, USA
    Neurosci Lett 545:50-3. 2013
    ..Finally, acetylcholine effects are most robust during discrimination acquisition, with minimal effects during expression...
  52. ncbi request reprint Relative medial and dorsal cortex volume in relation to sex differences in spatial ecology of a snake population
    Eric D Roth
    Department of Zoology, University of Oklahoma, Norman, OK, USA
    Brain Behav Evol 67:103-10. 2006
    ..Similar to studies on mammals and birds, relative hippocampal or medial cortex volume was positively correlated with patterns of spatial use. We demonstrate volumetric sex differences within a reptilian putative hippocampal homologue...
  53. pmc The International Society for Developmental Psychobiology annual meeting symposium: Impact of early life experiences on brain and behavioral development
    Regina Sullivan
    Department of Zoology, University of Oklahoma, Norman, OK 73072, USA
    Dev Psychobiol 48:583-602. 2006
    ....
  54. pmc Interaction between δ opioid receptors and benzodiazepines in CO₂-induced respiratory responses in mice
    Anne H Borkowski
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Brain Res 1396:54-9. 2011
    ..This suggests an interplay between benzodiazepine receptors and δ-opioid receptors in regulating the respiratory effects of elevated CO₂, which might be related to CO₂ induced panic...
  55. pmc Distinct neural mechanisms mediate olfactory memory formation at different timescales
    Ann Marie McNamara
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    Learn Mem 15:117-25. 2008
    ....