Research Topics
| R F SuckowSummaryAffiliation: Nathan Kline Institute Country: USA Publications
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Detail Information
Publications
Sensitive and selective liquid chromatographic assay of memantine in plasma with fluorescence detection after pre-column derivatizationR F Suckow
Analytical Psychopharmacology Laboratory, New York State Psychiatric Institute, NY 10032, USA
J Chromatogr B Biomed Sci Appl 729:217-24. 1999..The limit of quantitation was 3 ng/ml, and no major antidepressant, neuroleptic or their respective metabolites interfered with the quantitation of memantine. This method could also be applied to the quantitation of amantadine...- Determination of plasma ziprasidone using liquid chromatography with fluorescence detectionRaymond F Suckow
Analytical Psychopharmacology Laboratory, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
J Chromatogr B Analyt Technol Biomed Life Sci 799:201-8. 2004..The utility of the method is exemplified with the presentation of clinical data from patients receiving ziprasidone... - Separation methods for tricyclic antiviral drugsR F Suckow
Analytical Psychopharmacology Laboratory, New York State Psychiatric Institute, NY 10032, USA
J Chromatogr B Biomed Sci Appl 764:313-25. 2001..This review discusses the analytical methods used in the determination of amantadine, rimantadine, tromantadine and memantine and the pre-clinical and clinical application of these techniques... - Sex-related differences in nortriptyline-induced side-effects among depressed patientsN Pomara
The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Prog Neuropsychopharmacol Biol Psychiatry 25:1035-48. 2001..6. The results suggest the presence of sex-related differences in elevated supine HR response during the course of 6-week NT treatment. Depressed men may be more susceptible to NT-induced increases in supine HR than women... - Effects of ethanol and of alcohol dehydrogenase inhibitors on the reduction of N-acetylaspartate levels of brain in mice in vivo: a search for substances that may have therapeutic value in the treatment of Canavan diseaseM H Baslow
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Inherit Metab Dis 23:684-92. 2000..The importance of these findings in understanding the NAA intercompartmental cycle, and its role in Canavan disease, a genetic aspartoacylase deficiency disease, are discussed... - Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cellsM H Baslow
Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962, USA
J Mol Neurosci 17:351-9. 2001..The cellular separation of these hydrolytic enzyme activities, and the possible nature of the enzymes involved are discussed... - NMDA antagonist effects on striatal dopamine release: positron emission tomography studies in humansLawrence S Kegeles
Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
Synapse 43:19-29. 2002.... - Disposition of bupivacaine and its metabolites in the maternal, placental, and fetal compartments in ratsH O Morishima
Departments of Anesthesiology and Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Anesthesiology 93:1069-74. 2000..This study was designed to determine the disposition of bupivacaine and its metabolites in the maternal, placental, and fetal compartments, using multiple sampling time points in chronically prepared awake pregnant rats... - The apparent dependence of the diffusion coefficient of N-acetylaspartate upon magnetic field strength: evidence of an interaction with NMR methodologyDavid N Guilfoyle
Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
NMR Biomed 16:468-74. 2003..As a result, it has been demonstrated that the observed apparent magnetic field dependence of the ADC of NAA is a consequence of the NMR measurement and is apparently not a real effect on molecular diffusion... - Efficacy of the branched-chain amino acids in the treatment of tardive dyskinesia in menMary Ann Richardson
Division of Movement Disorders and Molecular Psychiatry, Nathan S Kine Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Am J Psychiatry 160:1117-24. 2003..The efficacy of the branched-chain amino acids in the treatment of tardive dyskinesia in men with psychiatric disorders was tested... - Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyteMorris H Baslow
Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neuromolecular Med 3:95-104. 2003..The NAA system, when present in the brain, appears to reflect a high degree of cellular integration, and therefore may be a unique metabolic construct of the intact vertebrate brain... - The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in Canavan disease-like ratsMorris H Baslow
Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962, USA
Neurochem Res 27:403-6. 2002..This is the first pharmacological investigation of the effect of drugs on the level of brain NAA in an animal model of CD, and the first report of a substance that can reduce the brain NAA level in this model... - Rapid and sensitive determination of nalmefene in human plasma by gas chromatography-mass spectrometryShan Xie
Analytical Psychopharmacology Laboratory, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
J Chromatogr B Analyt Technol Biomed Life Sci 773:143-9. 2002..5 ng/ml. The method described is highly specific and reproducible, and could also be applied for the determination of naltrexone and 6beta-naltrexol. Application of the method to actual human plasma samples is demonstrated... - Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humansPeter S Talbot
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
Synapse 55:164-75. 2005..These results suggest that (11)C-DASB in vivo binding is not affected by reductions in endogenous 5-HT... - Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depressionVictor L Serebruany
HeartDrug Research Laboratories, Johns Hopkins University, 7600 Osler Dr, Suite 307, Towson, MD 21204, USA
Am J Psychiatry 162:1165-70. 2005.... - Multidose risperidone treatment evaluated in a rodent model of tardive dyskinesiaXue Min Gao
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9070, USA
Neuropsychopharmacology 31:1864-8. 2006..If this animal model predicts TD risk in humans, the TD liability with low-dose risperidone is at a placebo level, whereas higher doses show haloperidol-like TD risk, as predicted from the acute motor effects... - Investigation of the phenylalanine hydroxylase gene and tardive dyskinesiaMary Ann Richardson
Movement Disorders and Molecular Psychiatry Division, Nathan Kline Institute for Psychiatric Research, New York State Office of Mental Health, Orangeburg, New York 10962, USA
Am J Med Genet B Neuropsychiatr Genet 141:195-7. 2006..Genetic screening of PAH in a group of 123 psychiatric patients revealed ten sequence polymorphisms and two mutations, but none appeared to be a significant risk factor for TD...