Research Topics
| Mariko SaitoSummaryAffiliation: Nathan Kline Institute Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neuronsM Saito
Department of Neurochemistry, The Nathan S Kline Institute for Psychiatric Research and New York University, Orangeburg 10962, USA
Neurochem Res 24:1107-15. 1999..Data show native gangliosides and a synthetic derivative are potently neuroprotective in this model of ethanol toxicity, and potentially serve as useful probes to further unravel the mechanisms relevant to neuronal apoptosis...- Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brainMariko Saito
Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
Alcohol Clin Exp Res 31:665-74. 2007..In the present study, the effects of GM1 and LIGA20 on ethanol-induced apoptotic neurodegeneration were examined using an in vivo neonatal mouse model... - Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expressionMariko Saito
Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neurochem Res 30:1027-35. 2005..Down-regulation of GABA-A receptors induced by repeated nicotine exposure may facilitate dopaminergic neuronal transmission and may contribute to increased locomotor activity... - Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neuronsMariko Saito
Laboratory of Neurobehavior Genetics and the Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Alcohol Clin Exp Res 29:1374-83. 2005..Ethanol treatment conditions that induced apoptosis in CGNs and SK-N-SH cells but not in Neuro2a cells were used for these experiments... - Alcohol reduces GM1 ganglioside content in the serum of inbred mouse strainsMitsuo Saito
Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Alcohol Clin Exp Res 28:1107-13. 2004..Therefore, we analyzed serum gangliosides derived from inbred mouse strains with and without alcohol treatment... - Ethanol alters lipid profiles and phosphorylation status of AMP-activated protein kinase in the neonatal mouse brainMariko Saito
Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Neurochem 103:1208-18. 2007..Our findings indicate that the ethanol-induced apoptotic neurodegeneration observed in mice during restricted developmental periods is accompanied by alterations in both the lipid content and the activity of AMPK in the brain... 
Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brainMariko Saito
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neurochem Res 34:1945-54. 2009..These studies suggest that neurons in the early neonatal brain are involved in do novo fatty acid synthesis...- Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brainMariko Saito
Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neurochem Res 35:651-9. 2010..These results indicate that tau is phosphorylated by GSK-3beta and cleaved by caspase-3 during ethanol-induced neurodegeneration in the developing brain... - Involvement of ceramide in ethanol-induced apoptotic neurodegeneration in the neonatal mouse brainMariko Saito
Division of Neurochemisty, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Neurochem 115:168-77. 2010..These results indicate that de novo ceramide synthesis has a vital role in ethanol-induced apoptotic neurodegeneration in the developing brain... - Lithium blocks ethanol-induced modulation of protein kinases in the developing brainGoutam Chakraborty
Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Biochem Biophys Res Commun 367:597-602. 2008..These results suggest that Akt, GSK-3beta, and AMPK are involved in ethanol-induced neurodegeneration and the neuroprotective effects of lithium by modulating both apoptotic and survival pathways... - Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinkingCsaba Vadasz
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Genomics 90:690-702. 2007..These data suggest for the first time that Grm7 is a risk factor for alcohol drinking and a new target in addiction therapy... - Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strainsCsaba Vadasz
Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neurochem Res 32:1099-112. 2007..12, while the MIM model for the B6.I strains confirmed the suggestive locus on chr. 12. Some of the QTLs for alcohol consumption are new, while others confirm previously reported QTLs for alcohol preference, and alcohol acceptance... - Mouse striatal transcriptome analysis: effects of oral self-administration of alcoholMariko Saito
Laboratory of Neurobehavioral Genetics, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Alcohol 32:223-41. 2004.... - Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brainMitsuo Saito
Division of Analytical Psychopharmacology, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
J Neurochem 121:649-61. 2012..Subsequently, activated microglia accumulated GM2, indicating a close relationship between GM2 and ethanol-induced neurodegeneration... - Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out miceKrisztina M Kovacs
Laboratory of Neurobehavioral GeneticsNathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Alcohol Clin Exp Res 29:730-8. 2005..Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors... - Ventral tegmental transcriptome response to intermittent nicotine treatment and withdrawal in BALB/cJ, C57BL/6ByJ, and quasi-congenic RQI miceCsaba Vadasz
Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neurochem Res 32:457-80. 2007..Our results suggest that while there are common regulatory mechanisms across inbred strains, even relatively small differences in genetic constitution can significantly affect transcriptome response to nicotine... - Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brainGoutam Chakraborty
Division of Neurochemisty, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
J Neurochem 121:806-17. 2012..These results indicate that ethanol activates sphingosine kinase 2, leading to a transient increase in S1P, which may be involved in neuroapoptotic action of ethanol in the developing brain... - Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyteMorris H Baslow
Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neuromolecular Med 3:95-104. 2003..The NAA system, when present in the brain, appears to reflect a high degree of cellular integration, and therefore may be a unique metabolic construct of the intact vertebrate brain... - Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neuronsBalapal S Basavarajappa
New York State Psychiatric Institute, New York, NY 10032, USA
Eur J Pharmacol 466:73-83. 2003.... - Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding miceMariko Saito
Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Alcohol 29:39-49. 2003..The strain-dependent variation in the expression of alternatively spliced genes can be a significant source of phenotypic variation of complex traits such as alcohol preference... 
mGluR7 genetics and alcohol: intersection yields clues for addictionBeatrix Gyetvai
Laboratory of Neurobehavior Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Neurochem Res 36:1087-100. 2011..which interact with substance use and the development of addiction. In conclusion, we suggest that mGluR7 is a significant new therapeutic target in addiction and related neurobehavioral disorders...- Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramideKristen Ditaranto-Desimone
Dementia Research Program, Nathan Kline Institute, Orangeburg, NY, USA
Brain Res Bull 59:523-31. 2003.... - Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neuronsNeville Marks
Division of Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road Orangeburg, NY 10962 USA
Brain Res 1191:136-47. 2008..Pretreatment with GM(1) whose turnover is compromised was protective and pointed to useful therapeutic applications by supplementing existing membrane stores prior to GSC dysfunction... - Local and regional network function in behaviorally relevant cortical circuits of adult mice following postnatal alcohol exposureDonald A Wilson
Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Alcohol Clin Exp Res 35:1974-84. 2011..The developmental stage of neonatal rodent brains that are at the peak of synaptogenesis is equivalent to the third trimester of human gestation... - Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloidYasuji Matsuoka
The Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
J Neurosci 23:29-33. 2003.... - Microarray analysis of gene expression in rat hippocampus after chronic ethanol treatmentMariko Saito
Laboratory of Neurobehavioral Genetics, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neurochem Res 27:1221-9. 2002..The results may reveal some of the pathways involved in ethanol-induced pathophysiological changes... - Strain-specific pulmonary defense achieved after repeated airway immunizations with non-typeable haemophilus influenzae in a mouse modelJun Koyama
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
Tohoku J Exp Med 211:63-74. 2007..Our data may explain, in part, why patients with COPD experience recurrent NTHi infections... - Hematological abnormalities in a patient with a 22q11.2 deletionMariko Saito
Department of Pediatrics, Neonatology and Congenital Disorders, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Brain Dev 26:342-4. 2004..2 deletion was suggested. Atypical features also included the lack of any cardiovascular defect, T cell deficit or palate anomaly, generally common with this deletion...
Research Grants
- Sphingolipids in Ethanol-Induced Neuronal ApoptosisMariko Saito; Fiscal Year: 2007..abstract_text> ..
- Sphingolipids in Ethanol-Induced Neuronal ApoptosisMariko Saito; Fiscal Year: 2010..These studies will reveal the functions of sphingolipids in ethanol-induced apoptosis in the developing brain, and will offer bases for future therapeutic strategies for FASD. ..