Mariko Saito

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi request reprint Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons
    M Saito
    Department of Neurochemistry, The Nathan S Kline Institute for Psychiatric Research and New York University, Orangeburg 10962, USA
    Neurochem Res 24:1107-15. 1999
  2. ncbi request reprint Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Alcohol Clin Exp Res 31:665-74. 2007
  3. ncbi request reprint Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression
    Mariko Saito
    Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Res 30:1027-35. 2005
  4. ncbi request reprint Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons
    Mariko Saito
    Laboratory of Neurobehavior Genetics and the Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:1374-83. 2005
  5. ncbi request reprint Alcohol reduces GM1 ganglioside content in the serum of inbred mouse strains
    Mitsuo Saito
    Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 28:1107-13. 2004
  6. ncbi request reprint Ethanol alters lipid profiles and phosphorylation status of AMP-activated protein kinase in the neonatal mouse brain
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurochem 103:1208-18. 2007
  7. pmc Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brain
    Mariko Saito
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 34:1945-54. 2009
  8. pmc Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 35:651-9. 2010
  9. pmc Involvement of ceramide in ethanol-induced apoptotic neurodegeneration in the neonatal mouse brain
    Mariko Saito
    Division of Neurochemisty, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurochem 115:168-77. 2010
  10. pmc Lithium blocks ethanol-induced modulation of protein kinases in the developing brain
    Goutam Chakraborty
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Biochem Biophys Res Commun 367:597-602. 2008

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons
    M Saito
    Department of Neurochemistry, The Nathan S Kline Institute for Psychiatric Research and New York University, Orangeburg 10962, USA
    Neurochem Res 24:1107-15. 1999
    ..Data show native gangliosides and a synthetic derivative are potently neuroprotective in this model of ethanol toxicity, and potentially serve as useful probes to further unravel the mechanisms relevant to neuronal apoptosis...
  2. ncbi request reprint Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Alcohol Clin Exp Res 31:665-74. 2007
    ..In the present study, the effects of GM1 and LIGA20 on ethanol-induced apoptotic neurodegeneration were examined using an in vivo neonatal mouse model...
  3. ncbi request reprint Nicotine-induced sensitization in mice: changes in locomotor activity and mesencephalic gene expression
    Mariko Saito
    Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Res 30:1027-35. 2005
    ..Down-regulation of GABA-A receptors induced by repeated nicotine exposure may facilitate dopaminergic neuronal transmission and may contribute to increased locomotor activity...
  4. ncbi request reprint Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons
    Mariko Saito
    Laboratory of Neurobehavior Genetics and the Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:1374-83. 2005
    ..Ethanol treatment conditions that induced apoptosis in CGNs and SK-N-SH cells but not in Neuro2a cells were used for these experiments...
  5. ncbi request reprint Alcohol reduces GM1 ganglioside content in the serum of inbred mouse strains
    Mitsuo Saito
    Division of Analytical Psychopharmacology, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 28:1107-13. 2004
    ..Therefore, we analyzed serum gangliosides derived from inbred mouse strains with and without alcohol treatment...
  6. ncbi request reprint Ethanol alters lipid profiles and phosphorylation status of AMP-activated protein kinase in the neonatal mouse brain
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurochem 103:1208-18. 2007
    ..Our findings indicate that the ethanol-induced apoptotic neurodegeneration observed in mice during restricted developmental periods is accompanied by alterations in both the lipid content and the activity of AMPK in the brain...
  7. pmc Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brain
    Mariko Saito
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 34:1945-54. 2009
    ..These studies suggest that neurons in the early neonatal brain are involved in do novo fatty acid synthesis...
  8. pmc Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 35:651-9. 2010
    ..These results indicate that tau is phosphorylated by GSK-3beta and cleaved by caspase-3 during ethanol-induced neurodegeneration in the developing brain...
  9. pmc Involvement of ceramide in ethanol-induced apoptotic neurodegeneration in the neonatal mouse brain
    Mariko Saito
    Division of Neurochemisty, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurochem 115:168-77. 2010
    ..These results indicate that de novo ceramide synthesis has a vital role in ethanol-induced apoptotic neurodegeneration in the developing brain...
  10. pmc Lithium blocks ethanol-induced modulation of protein kinases in the developing brain
    Goutam Chakraborty
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Biochem Biophys Res Commun 367:597-602. 2008
    ..These results suggest that Akt, GSK-3beta, and AMPK are involved in ethanol-induced neurodegeneration and the neuroprotective effects of lithium by modulating both apoptotic and survival pathways...
  11. ncbi request reprint Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking
    Csaba Vadasz
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Genomics 90:690-702. 2007
    ..These data suggest for the first time that Grm7 is a risk factor for alcohol drinking and a new target in addiction therapy...
  12. pmc Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains
    Csaba Vadasz
    Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Res 32:1099-112. 2007
    ..12, while the MIM model for the B6.I strains confirmed the suggestive locus on chr. 12. Some of the QTLs for alcohol consumption are new, while others confirm previously reported QTLs for alcohol preference, and alcohol acceptance...
  13. ncbi request reprint Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol
    Mariko Saito
    Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol 32:223-41. 2004
    ....
  14. pmc Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain
    Mitsuo Saito
    Division of Analytical Psychopharmacology, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 121:649-61. 2012
    ..Subsequently, activated microglia accumulated GM2, indicating a close relationship between GM2 and ethanol-induced neurodegeneration...
  15. ncbi request reprint Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice
    Krisztina M Kovacs
    Laboratory of Neurobehavioral GeneticsNathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:730-8. 2005
    ..Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors...
  16. ncbi request reprint Ventral tegmental transcriptome response to intermittent nicotine treatment and withdrawal in BALB/cJ, C57BL/6ByJ, and quasi-congenic RQI mice
    Csaba Vadasz
    Laboratory of Neurobehavioral Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Res 32:457-80. 2007
    ..Our results suggest that while there are common regulatory mechanisms across inbred strains, even relatively small differences in genetic constitution can significantly affect transcriptome response to nicotine...
  17. pmc Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain
    Goutam Chakraborty
    Division of Neurochemisty, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Neurochem 121:806-17. 2012
    ..These results indicate that ethanol activates sphingosine kinase 2, leading to a transient increase in S1P, which may be involved in neuroapoptotic action of ethanol in the developing brain...
  18. ncbi request reprint Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuromolecular Med 3:95-104. 2003
    ..The NAA system, when present in the brain, appears to reflect a high degree of cellular integration, and therefore may be a unique metabolic construct of the intact vertebrate brain...
  19. pmc G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain
    Shivakumar Subbanna
    Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurobiol Dis 54:475-85. 2013
    ..Furthermore, these findings reveal a novel link between G9a and neurodegeneration in the developing brain exposed to postnatal ethanol and may have a role in fetal alcohol spectrum disorders...
  20. ncbi request reprint Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons
    Balapal S Basavarajappa
    New York State Psychiatric Institute, New York, NY 10032, USA
    Eur J Pharmacol 466:73-83. 2003
    ....
  21. ncbi request reprint Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide
    Kristen Ditaranto-Desimone
    Dementia Research Program, Nathan Kline Institute, Orangeburg, NY, USA
    Brain Res Bull 59:523-31. 2003
    ....
  22. doi request reprint mGluR7 genetics and alcohol: intersection yields clues for addiction
    Beatrix Gyetvai
    Laboratory of Neurobehavior Genetics, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Neurochem Res 36:1087-100. 2011
    ..which interact with substance use and the development of addiction. In conclusion, we suggest that mGluR7 is a significant new therapeutic target in addiction and related neurobehavioral disorders...
  23. ncbi request reprint Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol 29:39-49. 2003
    ..The strain-dependent variation in the expression of alternatively spliced genes can be a significant source of phenotypic variation of complex traits such as alcohol preference...
  24. ncbi request reprint Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons
    Neville Marks
    Division of Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road Orangeburg, NY 10962 USA
    Brain Res 1191:136-47. 2008
    ..Pretreatment with GM(1) whose turnover is compromised was protective and pointed to useful therapeutic applications by supplementing existing membrane stores prior to GSC dysfunction...
  25. pmc Local and regional network function in behaviorally relevant cortical circuits of adult mice following postnatal alcohol exposure
    Donald A Wilson
    Emotional Brain Institute, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Alcohol Clin Exp Res 35:1974-84. 2011
    ..The developmental stage of neonatal rodent brains that are at the peak of synaptogenesis is equivalent to the third trimester of human gestation...
  26. ncbi request reprint Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid
    Yasuji Matsuoka
    The Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 23:29-33. 2003
    ....
  27. ncbi request reprint Microarray analysis of gene expression in rat hippocampus after chronic ethanol treatment
    Mariko Saito
    Laboratory of Neurobehavioral Genetics, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 27:1221-9. 2002
    ..The results may reveal some of the pathways involved in ethanol-induced pathophysiological changes...
  28. ncbi request reprint Hematological abnormalities in a patient with a 22q11.2 deletion
    Mariko Saito
    Department of Pediatrics, Neonatology and Congenital Disorders, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Brain Dev 26:342-4. 2004
    ..2 deletion was suggested. Atypical features also included the lack of any cardiovascular defect, T cell deficit or palate anomaly, generally common with this deletion...
  29. ncbi request reprint Strain-specific pulmonary defense achieved after repeated airway immunizations with non-typeable haemophilus influenzae in a mouse model
    Jun Koyama
    Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Tohoku J Exp Med 211:63-74. 2007
    ..Our data may explain, in part, why patients with COPD experience recurrent NTHi infections...

Research Grants5

  1. Sphingolipids in Ethanol-Induced Neuronal Apoptosis
    Mariko Saito; Fiscal Year: 2007
    ..abstract_text> ..
  2. Sphingolipids in Ethanol-Induced Neuronal Apoptosis
    Mariko Saito; Fiscal Year: 2010
    ..These studies will reveal the functions of sphingolipids in ethanol-induced apoptosis in the developing brain, and will offer bases for future therapeutic strategies for FASD. ..