Research Topics
Species | N PomaraSummaryAffiliation: Nathan Kline Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorderNunzio Pomara
Nathan Kline Institute, Orangeburg, NY, USA
Am J Psychiatry 169:523-30. 2012..The authors assessed whether major depression was associated with CSF levels of amyloid beta, tau protein, and F2-isoprostanes in elderly individuals with major depressive disorder and age-matched nondepressed comparison subjects...- Sex-related elevation in cortisol during chronic treatment with alprazolam associated with enhanced cognitive performanceNunzio Pomara
Geriatric Psychiatry Program, Nathan S Kline Institute, Orangeburg, NY, 10962, USA
Psychopharmacology (Berl) 182:414-9. 2005..In this study, we examined sex-related differences in this population... - Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary reportNunzio Pomara
Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, USA
Am J Geriatr Psychiatry 13:914-7. 2005..Longitudinal changes in plasma beta amyloid protein 1-42 and 1-40 (Abeta42 and Abeta40) levels and possible relationships with cognitive decline and apolipoprotein (APOE) genotype were studied in healthy elderly individuals... - Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administrationNunzio Pomara
Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd Bldg 35, Orangeburg, NY 10962, USA
Psychopharmacology (Berl) 185:487-94. 2006.... - Elevation in plasma Abeta42 in geriatric depression: a pilot studyNunzio Pomara
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Neurochem Res 31:341-9. 2006.... - The effect of mifepristone (RU 486) on plasma cortisol in Alzheimer's diseaseNunzio Pomara
Geriatric Psychiatry Division, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA
Neurochem Res 31:585-8. 2006..However, further studies with age-matched controls should be done to determine possible AD related changes in this response... - Memantine treatment of cognitive symptoms in mild to moderate Alzheimer disease: secondary analyses from a placebo-controlled randomized trialNunzio Pomara
Nathan S Kline Institute and New York University School of Medicine, Orangeburg, NY 10962, USA
Alzheimer Dis Assoc Disord 21:60-4. 2007.... - Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderlyNunzio Pomara
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Am J Geriatr Psychiatry 16:116-24. 2008.... - The apolipoprotein E epsilon4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challengeNunzio Pomara
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Psychopharmacology (Berl) 201:125-35. 2008..Lorazepam and other benzodiazepines are widely prescribed in individuals with HIV-1 infection who are at increased risk for cognitive impairment... - Retrograde facilitation of verbal memory by trihexyphenidyl in healthy elderly with and without the APOE epsilon4 alleleNunzio Pomara
The Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
Eur Neuropsychopharmacol 20:467-72. 2010..Our findings demonstrated that RF induced by trihexyphenidyl was related to anterograde amnestic effects of the drug and resulted in part from drug-induced reduction of retroactive interference... - TOMM40 poly-T variants and cerebrospinal fluid amyloid beta levels in the elderlyNunzio Pomara
Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA
Neurochem Res 36:1124-8. 2011..APOE ε4 carriers showed significant reductions in Aβ 1-42 levels compared to non-ε4 carriers, but no differences were detected across TOMM40 variants. Neither Aβ 1-40 nor tau levels were affected by APOE or TOMM40... - Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adultsNunzio Pomara
Geriatric Psychiatry Program, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Arch Gen Psychiatry 62:209-16. 2005..The apolipoprotein E (APOE) epsilon4 allele has been implicated as a significant risk factor in the development of late-onset Alzheimer disease, but the evidence of cognitive sequelae in healthy individuals has been mixed... - Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderlyNunzio Pomara
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neurochem Res 29:2311-5. 2004..Plasma GABA concentration does not appear to be a useful marker of susceptibility to benzodiazepine-induced cognitive toxicity in the elderly. Other approaches to estimating central GABA activity should be pursued... - Cortisol response to diazepam: its relationship to age, dose, duration of treatment, and presence of generalized anxiety disorderNunzio Pomara
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Building 35, Orangeburg, NY 10962, USA
Psychopharmacology (Berl) 178:1-8. 2005..However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relationship to age, anxiety, duration of treatment, and dose are not well understood... - Sex-related differences in nortriptyline-induced side-effects among depressed patientsN Pomara
The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Prog Neuropsychopharmacol Biol Psychiatry 25:1035-48. 2001..6. The results suggest the presence of sex-related differences in elevated supine HR response during the course of 6-week NT treatment. Depressed men may be more susceptible to NT-induced increases in supine HR than women... - Mifepristone (RU 486) for Alzheimer's diseaseNunzio Pomara
Department of Psychiatry, New York University School of Medicine, USA
Neurology 58:1436. 2002 - Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 alleleN Pomara
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Neurochem Res 23:1563-6. 1998..Subjects without the epsilon 4 allele showed a significant positive correlation between A beta 40 and A beta 42 levels. There was also a significant correlation between plasma A beta 40 and apoE levels in all subjects... - Does increased platelet release of Abeta peptide contribute to brain abnormalities in individuals with depression?Nunzio Pomara
Department of Psychiatry, New York University School of Medicine, USA
Med Hypotheses 60:640-3. 2003..If true, our hypothesis would imply that platelet inhibitors may have a role in preventing or delaying the neuronal consequences of disorders characterized by activated platelets... - Therapeutic implications of HPA axis abnormalities in Alzheimer's disease: review and updateNunzio Pomara
Psychaiatric Division, Nathan S Kline Institute, Dept of Psychology, New York University School of Medicine, Orangeburg, NY 10962, USA
Psychopharmacol Bull 37:120-34. 2003..Given the burden of this disease, we feel it timely to encourage controlled trials of antiglucocorticoid agents in the treatment of mild cognitive impairment and Alzheimers disease... - Interdose elevation in plasma cortisol during chronic treatment with alprazolam but not lorazepam in the elderlyNunzio Pomara
Geriatric Psychiatry Program, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neuropsychopharmacology 29:605-11. 2004..If confirmed, this effect may contribute to an increased risk for drug escalation and dependence during chronic alprazolam treatment... - Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot studyNunzio Pomara
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Neuropsychopharmacology 29:403-9. 2004..A larger study is warranted to confirm these preliminary findings... - Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotypeNunzio Pomara
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Neurochem Res 29:1391-8. 2004..The epsilon4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance... - Abnormal white matter integrity in healthy apolipoprotein E epsilon4 carriersJay Nierenberg
Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neuroreport 16:1369-72. 2005..Diffusion tensor imaging may be sufficiently sensitive to detect preclinical brain changes related to Alzheimer's disease... - Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis studyE Shearman
Nathan Kline Institute, Orangeburg, NY 10962, USA
Brain Res Bull 69:204-13. 2006.... - White matter abnormalities in HIV-1 infection: a diffusion tensor imaging studyN Pomara
Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Psychiatry Res 106:15-24. 2001..DTI may be more sensitive than conventional MRI methods for detecting subtle white matter disruptions in HIV-1 disease... - Brain neurotoxic amyloid-beta peptides: their potential role in the pathophysiology of depression and as molecular therapeutic targetsNunzio Pomara
The Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Br J Pharmacol 161:768-70. 2010..describe results suggesting that a new neurobiological mechanism with treatment implications should be considered for the development of depression in humans, namely, elevations in potentially neurotoxic brain amyloid-ß peptides... - Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging studyKelvin O Lim
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA
Biol Psychiatry 51:890-5. 2002..CONCLUSIONS: These findings were consistent with the hypothesis that cocaine dependence involves alterations in orbitofrontal connectivity, which may be involved in the decision-making deficits seen in this disorder... - Possible therapeutic implication of Abeta disturbances in depressionNunzio Pomara
Int J Geriatr Psychiatry 22:931-2; author reply 930. 2007 - Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trialElaine R Peskind
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
Am J Geriatr Psychiatry 14:704-15. 2006..The objective of this study was to compare the efficacy and safety of the moderate-affinity, uncompetitive N-methyl-d-aspartate receptor antagonist, memantine, versus placebo in patients with mild to moderate Alzheimer disease (AD)... - Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCIClifford R Jack
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Neurobiol Aging 29:1285-95. 2008..000). Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI... - Ginkgo and memoryP Murali Doraiswamy
JAMA 289:547; author reply 547-8. 2003 - Pathophysiology of Alzheimer's diseaseBruno P Imbimbo
Research and Development Department, Chiesi Farmaceutici, Parma, Italy
Neuroimaging Clin N Am 15:727-53, ix. 2005..Progress is needed in understanding the mechanisms that link beta-amyloid accumulation and neuronal death. The next 5 years will be crucial in this respect...
Research Grants
- LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGEDNunzio Pomara; Fiscal Year: 2005..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..
- Plasma and CSF Abeta peptides in late-onset major depressionNunzio Pomara; Fiscal Year: 2007..If these hypotheses are confirmed, then the determination of plasma A/?42 might become an easily obtainable marker to identify those individuals with late-onset LLMD who may have prodromal AD. ..
- Plasma and CSF Abeta peptides in late-onset major depressionNunzio Pomara; Fiscal Year: 2010..If these hypotheses are confirmed, then the determination of plasma A/?42 might become an easily obtainable marker to identify those individuals with late-onset LLMD who may have prodromal AD. ..