N Pomara

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. pmc Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder
    Nunzio Pomara
    Nathan Kline Institute, Orangeburg, NY, USA
    Am J Psychiatry 169:523-30. 2012
  2. ncbi request reprint Sex-related elevation in cortisol during chronic treatment with alprazolam associated with enhanced cognitive performance
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute, Orangeburg, NY, 10962, USA
    Psychopharmacology (Berl) 182:414-9. 2005
  3. ncbi request reprint Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary report
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, USA
    Am J Geriatr Psychiatry 13:914-7. 2005
  4. ncbi request reprint Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administration
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd Bldg 35, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 185:487-94. 2006
  5. ncbi request reprint Elevation in plasma Abeta42 in geriatric depression: a pilot study
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Neurochem Res 31:341-9. 2006
  6. ncbi request reprint The effect of mifepristone (RU 486) on plasma cortisol in Alzheimer's disease
    Nunzio Pomara
    Geriatric Psychiatry Division, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA
    Neurochem Res 31:585-8. 2006
  7. ncbi request reprint Memantine treatment of cognitive symptoms in mild to moderate Alzheimer disease: secondary analyses from a placebo-controlled randomized trial
    Nunzio Pomara
    Nathan S Kline Institute and New York University School of Medicine, Orangeburg, NY 10962, USA
    Alzheimer Dis Assoc Disord 21:60-4. 2007
  8. doi request reprint Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderly
    Nunzio Pomara
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Am J Geriatr Psychiatry 16:116-24. 2008
  9. doi request reprint The apolipoprotein E epsilon4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 201:125-35. 2008
  10. doi request reprint Retrograde facilitation of verbal memory by trihexyphenidyl in healthy elderly with and without the APOE epsilon4 allele
    Nunzio Pomara
    The Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Eur Neuropsychopharmacol 20:467-72. 2010

Detail Information

Publications32

  1. pmc Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder
    Nunzio Pomara
    Nathan Kline Institute, Orangeburg, NY, USA
    Am J Psychiatry 169:523-30. 2012
    ..The authors assessed whether major depression was associated with CSF levels of amyloid beta, tau protein, and F2-isoprostanes in elderly individuals with major depressive disorder and age-matched nondepressed comparison subjects...
  2. ncbi request reprint Sex-related elevation in cortisol during chronic treatment with alprazolam associated with enhanced cognitive performance
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute, Orangeburg, NY, 10962, USA
    Psychopharmacology (Berl) 182:414-9. 2005
    ..In this study, we examined sex-related differences in this population...
  3. ncbi request reprint Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary report
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, USA
    Am J Geriatr Psychiatry 13:914-7. 2005
    ..Longitudinal changes in plasma beta amyloid protein 1-42 and 1-40 (Abeta42 and Abeta40) levels and possible relationships with cognitive decline and apolipoprotein (APOE) genotype were studied in healthy elderly individuals...
  4. ncbi request reprint Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administration
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd Bldg 35, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 185:487-94. 2006
    ....
  5. ncbi request reprint Elevation in plasma Abeta42 in geriatric depression: a pilot study
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Neurochem Res 31:341-9. 2006
    ....
  6. ncbi request reprint The effect of mifepristone (RU 486) on plasma cortisol in Alzheimer's disease
    Nunzio Pomara
    Geriatric Psychiatry Division, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA
    Neurochem Res 31:585-8. 2006
    ..However, further studies with age-matched controls should be done to determine possible AD related changes in this response...
  7. ncbi request reprint Memantine treatment of cognitive symptoms in mild to moderate Alzheimer disease: secondary analyses from a placebo-controlled randomized trial
    Nunzio Pomara
    Nathan S Kline Institute and New York University School of Medicine, Orangeburg, NY 10962, USA
    Alzheimer Dis Assoc Disord 21:60-4. 2007
    ....
  8. doi request reprint Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderly
    Nunzio Pomara
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Am J Geriatr Psychiatry 16:116-24. 2008
    ....
  9. doi request reprint The apolipoprotein E epsilon4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 201:125-35. 2008
    ..Lorazepam and other benzodiazepines are widely prescribed in individuals with HIV-1 infection who are at increased risk for cognitive impairment...
  10. doi request reprint Retrograde facilitation of verbal memory by trihexyphenidyl in healthy elderly with and without the APOE epsilon4 allele
    Nunzio Pomara
    The Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Eur Neuropsychopharmacol 20:467-72. 2010
    ..Our findings demonstrated that RF induced by trihexyphenidyl was related to anterograde amnestic effects of the drug and resulted in part from drug-induced reduction of retroactive interference...
  11. doi request reprint TOMM40 poly-T variants and cerebrospinal fluid amyloid beta levels in the elderly
    Nunzio Pomara
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Bldg 35, Orangeburg, NY 10962, USA
    Neurochem Res 36:1124-8. 2011
    ..APOE ε4 carriers showed significant reductions in Aβ 1-42 levels compared to non-ε4 carriers, but no differences were detected across TOMM40 variants. Neither Aβ 1-40 nor tau levels were affected by APOE or TOMM40...
  12. ncbi request reprint Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 62:209-16. 2005
    ..The apolipoprotein E (APOE) epsilon4 allele has been implicated as a significant risk factor in the development of late-onset Alzheimer disease, but the evidence of cognitive sequelae in healthy individuals has been mixed...
  13. ncbi request reprint Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly
    Nunzio Pomara
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 29:2311-5. 2004
    ..Plasma GABA concentration does not appear to be a useful marker of susceptibility to benzodiazepine-induced cognitive toxicity in the elderly. Other approaches to estimating central GABA activity should be pursued...
  14. ncbi request reprint Cortisol response to diazepam: its relationship to age, dose, duration of treatment, and presence of generalized anxiety disorder
    Nunzio Pomara
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Building 35, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 178:1-8. 2005
    ..However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relationship to age, anxiety, duration of treatment, and dose are not well understood...
  15. ncbi request reprint Sex-related differences in nortriptyline-induced side-effects among depressed patients
    N Pomara
    The Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:1035-48. 2001
    ..6. The results suggest the presence of sex-related differences in elevated supine HR response during the course of 6-week NT treatment. Depressed men may be more susceptible to NT-induced increases in supine HR than women...
  16. ncbi request reprint Mifepristone (RU 486) for Alzheimer's disease
    Nunzio Pomara
    Department of Psychiatry, New York University School of Medicine, USA
    Neurology 58:1436. 2002
  17. ncbi request reprint Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele
    N Pomara
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Neurochem Res 23:1563-6. 1998
    ..Subjects without the epsilon 4 allele showed a significant positive correlation between A beta 40 and A beta 42 levels. There was also a significant correlation between plasma A beta 40 and apoE levels in all subjects...
  18. ncbi request reprint Does increased platelet release of Abeta peptide contribute to brain abnormalities in individuals with depression?
    Nunzio Pomara
    Department of Psychiatry, New York University School of Medicine, USA
    Med Hypotheses 60:640-3. 2003
    ..If true, our hypothesis would imply that platelet inhibitors may have a role in preventing or delaying the neuronal consequences of disorders characterized by activated platelets...
  19. ncbi request reprint Therapeutic implications of HPA axis abnormalities in Alzheimer's disease: review and update
    Nunzio Pomara
    Psychaiatric Division, Nathan S Kline Institute, Dept of Psychology, New York University School of Medicine, Orangeburg, NY 10962, USA
    Psychopharmacol Bull 37:120-34. 2003
    ..Given the burden of this disease, we feel it timely to encourage controlled trials of antiglucocorticoid agents in the treatment of mild cognitive impairment and Alzheimers disease...
  20. ncbi request reprint Interdose elevation in plasma cortisol during chronic treatment with alprazolam but not lorazepam in the elderly
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuropsychopharmacology 29:605-11. 2004
    ..If confirmed, this effect may contribute to an increased risk for drug escalation and dependence during chronic alprazolam treatment...
  21. ncbi request reprint Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot study
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Neuropsychopharmacology 29:403-9. 2004
    ..A larger study is warranted to confirm these preliminary findings...
  22. ncbi request reprint Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Neurochem Res 29:1391-8. 2004
    ..The epsilon4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance...
  23. ncbi request reprint Abnormal white matter integrity in healthy apolipoprotein E epsilon4 carriers
    Jay Nierenberg
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroreport 16:1369-72. 2005
    ..Diffusion tensor imaging may be sufficiently sensitive to detect preclinical brain changes related to Alzheimer's disease...
  24. ncbi request reprint Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis study
    E Shearman
    Nathan Kline Institute, Orangeburg, NY 10962, USA
    Brain Res Bull 69:204-13. 2006
    ....
  25. ncbi request reprint White matter abnormalities in HIV-1 infection: a diffusion tensor imaging study
    N Pomara
    Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Psychiatry Res 106:15-24. 2001
    ..DTI may be more sensitive than conventional MRI methods for detecting subtle white matter disruptions in HIV-1 disease...
  26. pmc Brain neurotoxic amyloid-beta peptides: their potential role in the pathophysiology of depression and as molecular therapeutic targets
    Nunzio Pomara
    The Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Br J Pharmacol 161:768-70. 2010
    ..describe results suggesting that a new neurobiological mechanism with treatment implications should be considered for the development of depression in humans, namely, elevations in potentially neurotoxic brain amyloid-ß peptides...
  27. ncbi request reprint Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study
    Kelvin O Lim
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Biol Psychiatry 51:890-5. 2002
    ..Thus, we sought to examine the effects of cocaine dependence on frontal WM integrity...
  28. ncbi request reprint Possible therapeutic implication of Abeta disturbances in depression
    Nunzio Pomara
    Int J Geriatr Psychiatry 22:931-2; author reply 930. 2007
  29. ncbi request reprint Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial
    Elaine R Peskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 14:704-15. 2006
    ..The objective of this study was to compare the efficacy and safety of the moderate-affinity, uncompetitive N-methyl-d-aspartate receptor antagonist, memantine, versus placebo in patients with mild to moderate Alzheimer disease (AD)...
  30. pmc Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI
    Clifford R Jack
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurobiol Aging 29:1285-95. 2008
    ..000). Results of this study support the feasibility of using MRI as an outcome measure of disease progression in multi center therapeutic trials for MCI...
  31. ncbi request reprint Ginkgo and memory
    P Murali Doraiswamy
    JAMA 289:547; author reply 547-8. 2003
  32. ncbi request reprint Pathophysiology of Alzheimer's disease
    Bruno P Imbimbo
    Research and Development Department, Chiesi Farmaceutici, Parma, Italy
    Neuroimaging Clin N Am 15:727-53, ix. 2005
    ..Progress is needed in understanding the mechanisms that link beta-amyloid accumulation and neuronal death. The next 5 years will be crucial in this respect...

Research Grants9

  1. LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGED
    Nunzio Pomara; Fiscal Year: 2005
    ..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..
  2. Plasma and CSF Abeta peptides in late-onset major depression
    Nunzio Pomara; Fiscal Year: 2007
    ..If these hypotheses are confirmed, then the determination of plasma A/?42 might become an easily obtainable marker to identify those individuals with late-onset LLMD who may have prodromal AD. ..
  3. Plasma and CSF Abeta peptides in late-onset major depression
    Nunzio Pomara; Fiscal Year: 2010
    ..If these hypotheses are confirmed, then the determination of plasma A/?42 might become an easily obtainable marker to identify those individuals with late-onset LLMD who may have prodromal AD. ..