R A Nixon
Affiliation: Nathan Kline Institute
Yuan A, Veeranna -, Sershen H, Basavarajappa B, Smiley J, Hashim A, et al
. Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors. Transl Psychiatry. 2018;8:167 pubmed publisher
..Our findings support an emerging view that central nervous system neurofilament subunits including NFL in the present report, serve distinctive, critical roles in synapses relevant to neuropsychiatric diseases. ..
Lee J, McBrayer M, Wolfe D, Haslett L, Kumar A, Sato Y, et al
. Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification. Cell Rep. 2015;12:1430-44 pubmed publisher
Nixon R, Yang D. Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiol Dis. 2011;43:38-45 pubmed publisher
..This article is part of a Special Issue entitled "Autophagy and protein degradation in neurological diseases." ..
Jiang Y, Rigoglioso A, Peterhoff C, Pawlik M, Sato Y, Bleiwas C, et al
. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiol Aging. 2016;39:90-8 pubmed publisher
Yuan A, Nixon R. Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders. Brain Res Bull. 2016;126:334-346 pubmed publisher
Nixon R. Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up. Am J Pathol. 2004;164:757-61 pubmed
..In this commentary, the common features of endosome dysfunction are reviewed. Emerging evidence that endosome dysfunction may lead to beta-amyloidogenic APP processing or neurodegeneration by several different means is discussed. ..
Colacurcio D, Nixon R. Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev. 2016;32:75-88 pubmed publisher
Colacurcio D, Pensalfini A, Jiang Y, Nixon R. Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease. Free Radic Biol Med. 2018;114:40-51 pubmed publisher
..Collectively, these studies underscore the growing value of investigating DS to probe the biological origins of AD as well as to understand and ameliorate the developmental disability of DS. ..