N Marks

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi Activation of caspase-3 and apoptosis in cerebellar granule cells
    N Marks
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry and Neurobiology, Orangeburg, New York 10962, USA
    J Neurosci Res 52:334-41. 1998
  2. ncbi Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons
    Neville Marks
    Division of Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road Orangeburg, NY 10962 USA
    Brain Res 1191:136-47. 2008
  3. ncbi Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
    Neville Marks
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Neurochem Int 52:184-215. 2008
  4. ncbi APP processing enzymes (secretases) as therapeutic targets: insights from the use of transgenics (Tgs) and transfected cells
    Neville Marks
    Division of Neurochemistry, New York University Medical Center, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Neurochem Res 28:1049-62. 2003
  5. doi BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis
    Neville Marks
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Res 35:181-210. 2010
  6. ncbi Recent advances on neuronal caspases in development and neurodegeneration
    N Marks
    Nathan S Kline Institute for Psychiatric Research, and New York University, Division of Neurochemistry, Orangeburg 10962, USA
    Neurochem Int 35:195-220. 1999
  7. ncbi Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons
    M Saito
    Department of Neurochemistry, The Nathan S Kline Institute for Psychiatric Research and New York University, Orangeburg 10962, USA
    Neurochem Res 24:1107-15. 1999
  8. ncbi Opposite effects of lithium on proximal and distal caspases of immature and mature primary neurons correlate with earlier paradoxical actions on viability
    N Marks
    Division of Neurochemistry, New York University Medical Center, USA
    Neurochem Res 26:1311-20. 2001
  9. ncbi Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuromolecular Med 3:95-104. 2003
  10. ncbi Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962, USA
    J Mol Neurosci 17:351-9. 2001

Collaborators

Detail Information

Publications11

  1. ncbi Activation of caspase-3 and apoptosis in cerebellar granule cells
    N Marks
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry and Neurobiology, Orangeburg, New York 10962, USA
    J Neurosci Res 52:334-41. 1998
    ..As such, gangliosides provide useful agents to further probe pathways relevant to neuronal death in culture...
  2. ncbi Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons
    Neville Marks
    Division of Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road Orangeburg, NY 10962 USA
    Brain Res 1191:136-47. 2008
    ..Pretreatment with GM(1) whose turnover is compromised was protective and pointed to useful therapeutic applications by supplementing existing membrane stores prior to GSC dysfunction...
  3. ncbi Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
    Neville Marks
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Neurochem Int 52:184-215. 2008
    ..This overview emphasizes the importance to develop new therapies targeting neurosecretases to treat a major neurological disorder that has vast economic and social implications...
  4. ncbi APP processing enzymes (secretases) as therapeutic targets: insights from the use of transgenics (Tgs) and transfected cells
    Neville Marks
    Division of Neurochemistry, New York University Medical Center, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Neurochem Res 28:1049-62. 2003
    ....
  5. doi BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis
    Neville Marks
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Res 35:181-210. 2010
    ..LRP11 (SorLA) is of particular importance since it decreases in sporadic AD whose etiology otherwise is unknown...
  6. ncbi Recent advances on neuronal caspases in development and neurodegeneration
    N Marks
    Nathan S Kline Institute for Psychiatric Research, and New York University, Division of Neurochemistry, Orangeburg 10962, USA
    Neurochem Int 35:195-220. 1999
    ..Identifying signaling pathways and related events paves the way to design useful therapeutic remedies to prevent neuronal loss in disease or aging...
  7. ncbi Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons
    M Saito
    Department of Neurochemistry, The Nathan S Kline Institute for Psychiatric Research and New York University, Orangeburg 10962, USA
    Neurochem Res 24:1107-15. 1999
    ..Data show native gangliosides and a synthetic derivative are potently neuroprotective in this model of ethanol toxicity, and potentially serve as useful probes to further unravel the mechanisms relevant to neuronal apoptosis...
  8. ncbi Opposite effects of lithium on proximal and distal caspases of immature and mature primary neurons correlate with earlier paradoxical actions on viability
    N Marks
    Division of Neurochemistry, New York University Medical Center, USA
    Neurochem Res 26:1311-20. 2001
    ....
  9. ncbi Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuromolecular Med 3:95-104. 2003
    ..The NAA system, when present in the brain, appears to reflect a high degree of cellular integration, and therefore may be a unique metabolic construct of the intact vertebrate brain...
  10. ncbi Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962, USA
    J Mol Neurosci 17:351-9. 2001
    ..The cellular separation of these hydrolytic enzyme activities, and the possible nature of the enzymes involved are discussed...
  11. ncbi Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide
    Kristen Ditaranto-Desimone
    Dementia Research Program, Nathan Kline Institute, Orangeburg, NY, USA
    Brain Res Bull 59:523-31. 2003
    ....