Research Topics
Species | Jean Pierre LindenmayerSummaryAffiliation: Nathan Kline Institute Country: USA Publications
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Detail Information
Publications
Improving social cognition in schizophrenia: a pilot intervention combining computerized social cognition training with cognitive remediationJean Pierre Lindenmayer
To whom correspondence should be addressed Psychopharmacology Research Department, Manhattan Psychiatric Center, 600 E 125 St, Ward s Island, NY 10035, US tel 646 672 6171, fax 646 672 6276, E mail
Schizophr Bull 39:507-17. 2013..05). Conclusions: Combined CR with emotion perception remediation produced greater improvements in emotion recognition, emotion discrimination, social functioning, and neurocognition compared with CR alone in chronic schizophrenia...
Relationship between metabolic syndrome and cognition in patients with schizophreniaJean Pierre Lindenmayer
Manhattan Psychiatric Center, Wards Island, NY, United States
Schizophr Res 142:171-6. 2012..We hypothesized that patients with MetS would be associated with more impaired cognitive performance...
The efficacy and tolerability of once-daily extended release quetiapine fumarate in hospitalized patients with acute schizophrenia: a 6-week randomized, double-blind, placebo-controlled studyJean Pierre Lindenmayer
Manhattan Psychiatric Center Nathan Kline Institute for Psychiatric Research, New York University, New York, NY, USA
Psychopharmacol Bull 41:11-35. 2008..This study aimed to demonstrate efficacy of once-daily extended release quetiapine fumarate (quetiapine XR) versus placebo in patients with acute schizophrenia...
Ziprasidone's effect on metabolic markers in patients with diabetes and chronic schizophreniaJean Pierre Lindenmayer
Department of Psychiatry, New York University School of Medicine, New York, NY, USA
Clin Schizophr Relat Psychoses 5:185-92. 2012....
Paliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysisIbrahim Turkoz
Johnson and Johnson Pharmaceutical Research and Development, LLC, Titusville, New Jersey, USA
BMC Psychiatry 11:21. 2011..To compare the efficacy and tolerability of paliperidone extended-release (ER) with risperidone immediate-release using propensity score methodology...
Item response analysis of the Positive and Negative Syndrome ScaleDarcy A Santor
School of Psychology, University of Ottawa, Ottawa, Canada, and The Provincial Centre of Excellence for Child and Youth Mental Health, Ottawa, Ontario, Canada
BMC Psychiatry 7:66. 2007....
Minimal injection site pain and high patient satisfaction during treatment with long-acting risperidoneJean Pierre Lindenmayer
New York University Medical Center, New York, USA
Int Clin Psychopharmacol 20:213-21. 2005..30; endpoint = 7.70; P<0.0001 versus baseline). These findings may positively affect patient and clinician attitudes towards long-term therapy with long-acting injectable risperidone...
Galantamine augmentation of long-acting injectable risperidone for cognitive impairments in chronic schizophreniaJean Pierre Lindenmayer
New York University School of Medicine, 530 1st Ave New York, NY 10016, USA
Schizophr Res 125:267-77. 2011..Given these mixed results we examined whether galantamine compared to adjunctive placebo may improve cognitive functions in patients treated concomitantly with a long acting atypical antipsychotic...
Long-term safety and tolerability of long-acting injectable risperidone in patients with schizophrenia or schizoaffective disorderJean Pierre Lindenmayer
Manhattan Psychiatric Center, New York University of Medicine, New York, NY, USA
Eur Neuropsychopharmacol 17:138-44. 2007..It is concluded that treatment with long-acting injectable risperidone for 1 year or longer appeared to be safe and well tolerated in patients with schizophrenia or schizoaffective disorder...
A randomized controlled trial of cognitive remediation among inpatients with persistent mental illnessJean Pierre Lindenmayer
Manhattan Psychiatric Center, 600 East 125th St, Wards Island, NY 10035, USA
Psychiatr Serv 59:241-7. 2008..This study evaluated the feasibility and efficacy of a cognitive remediation program in improving cognitive and work functioning for intermediate- to long-stay psychiatric inpatients...
Dimensions of psychosis in patients with bipolar mania as measured by the positive and negative syndrome scaleJean Pierre Lindenmayer
Manhattan Psychiatric Center, New York University of Medicine, New York, NY, USA
Psychopathology 41:264-70. 2008....
Medication nonadherence and treatment outcome in patients with schizophrenia or schizoaffective disorder with suboptimal prior responseJean Pierre Lindenmayer
New York University School of Medicine, New York, N Y 10035, USA
J Clin Psychiatry 70:990-6. 2009..To examine the impact of medication nonadherence on treatment outcome in schizophrenia and potential risk factors for nonadherence...
A randomized, double-blind, parallel-group, fixed-dose, clinical trial of quetiapine at 600 versus 1200 mg/d for patients with treatment-resistant schizophrenia or schizoaffective disorderJean Pierre Lindenmayer
Manhattan Psychiatric Center, Psychopharmacology Research Program, New York, NY, USA
J Clin Psychopharmacol 31:160-8. 2011..In conclusion, quetiapine at 1200 mg/d, although reasonably tolerated, did not confer any advantages over quetiapine at 600 mg/d among patients who had failed to demonstrate an adequate response to a prospective 4-week trial of 600 mg/d...
Pharmacological treatment strategies for schizophreniaJ P Lindenmayer
Psychopharmacology Research Unit, Manhattan Psychiatric Center, Wards Island, NY 10035, USA
Expert Rev Neurother 4:705-23. 2004..Finally, the results of recent meta-analyses comparing the effects of atypical versus typical compounds will be critically reviewed and remaining gaps in the current pharmacotherapy of schizophrenia will be explored...
Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychoticsJean Pierre Lindenmayer
Nathan Kline Institute fo Psychiatric Research, New York, NY 10035, USA
Am J Psychiatry 160:290-6. 2003....
Treatment refractory schizophreniaJ P Lindenmayer
Psychopharmacology Research Unit, Manhattan Psychiatric Center Nathan Kline Institute for Psychiatric Research, New York, NY 10035, USA
Psychiatr Q 71:373-84. 2000..We review studies with augmentation strategies which remain difficult to interpret given the open label and uncontrolled nature of most of these studies...
An excitement subscale of the Positive and Negative Syndrome ScaleJean Pierre Lindenmayer
Department of Psychiatry, New York University School of Medicine, and Manhattan Psychiatric Center, Wards Island Complex, New York, NY, USA
Schizophr Res 68:331-7. 2004....
Olanzapine for schizophrenia refractory to typical and atypical antipsychotics: an open-label, prospective trialJ P Lindenmayer
Psychopharmacology Research Unit, Manhattan Psychiatric Unit, Manhattan Psychiatric Center, Wards Island, New York 10035, USA
J Clin Psychopharmacol 21:448-53. 2001..However, a trial with olanzapine can be recommended in these patients before moving to augmentation strategies, given the lack of proven alternatives and the observation that 16.7% of patients reached the response criteria...
Effects of atypical antipsychotics on the syndromal profile in treatment-resistant schizophreniaJean Pierre Lindenmayer
Nathan Kline Institute, Orangeburg, N Y, USA
J Clin Psychiatry 65:551-6. 2004..We are exploring whether this expanded clinical efficacy can also be seen in patients with treatment-resistant schizophrenia...
The InterSePT scale for suicidal thinking reliability and validityJ P Lindenmayer
New York University School of Medicine, New York, NY, USA
Schizophr Res 63:161-70. 2003..We report the psychometric characteristics of this new scale based on two studies...
Olanzapine in refractory schizophrenia after failure of typical or atypical antipsychotic treatment: an open-label switch studyJean Pierre Lindenmayer
Psychopharmacology Research Unit, Manhattan Psychiatric Center, Wards Island, NY 10035, USA
J Clin Psychiatry 63:931-5. 2002....
Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorderJan Volavka
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10982, USA
Am J Psychiatry 159:255-62. 2002....
Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorderRobert M Bilder
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Am J Psychiatry 159:1018-28. 2002....
Overt aggression and psychotic symptoms in patients with schizophrenia treated with clozapine, olanzapine, risperidone, or haloperidolJan Volavka
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10982, USA
J Clin Psychopharmacol 24:225-8. 2004..Clozapine appears to have superior antiaggresive effects in treatment-resistant patients; this superiority develops after the patient has been exposed to an adequate dose regimen...
Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophreniaRobert M Bilder
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Biol Psychiatry 52:701-7. 2002....
Effects of olanzapine and risperidone on glucose metabolism and insulin sensitivity in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized 5-month studyRobert C Smith
Department of Psychiatry, NYU Medical School, Hewlett, NY 11557, USA
J Clin Psychiatry 70:1501-13. 2009..Randomized prospective studies of metabolic effects during treatment with these drugs may provide results that are more informative...
Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorderKaren A Nolan
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
J Psychiatr Res 39:109-15. 2005..These findings in chronic, treatment resistant inpatients support the view that positive symptoms may lead to aggression...
Prolactin levels in schizophrenia and schizoaffective disorder patients treated with clozapine, olanzapine, risperidone, or haloperidolJan Volavka
Nathan Kline Institute, Orangeburg, NY 10982, USA
J Clin Psychiatry 65:57-61. 2004....
Antipsychotic-induced weight gain and therapeutic response: a differential associationPal Czobor
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Clin Psychopharmacol 22:244-51. 2002..These findings suggest that patients who are likely to have the maximal benefits of olanzapine or clozapine treatment for symptom alleviation are at the highest risk of a clinically significant increase in weight gain...
COMT158 polymorphism and hostilityJan Volavka
Nathan Kline Institute, Orangeburg, New York 10982, USA
Am J Med Genet B Neuropsychiatr Genet 127:28-9. 2004..The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample...
Effects of olanzapine and risperidone on lipid metabolism in chronic schizophrenic patients with long-term antipsychotic treatment: a randomized five month studyRobert C Smith
Department of Psychiatry, New York University Medical School, Hewlett, NY 11557, USA
Schizophr Res 120:204-9. 2010..We present results of a randomized prospective study of lipid metabolism and metabolic syndrome in chronic schizophrenic patients using both fasting and post-prandial lipid measures...
Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorderMatthew J Hoptman
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Psychiatry Res 140:133-45. 2005..Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects...
Outcome evaluation of a structured educational wellness program in patients with severe mental illnessJean Pierre Lindenmayer
Manhattan Psychiatric Center, Department of Psychiatry, New York University School of Medicine, Manhattan, New York, New York, USA
J Clin Psychiatry 70:1385-96. 2009....
A randomized controlled trial of olanzapine versus haloperidol in the treatment of primary negative symptoms and neurocognitive deficits in schizophreniaJean Pierre Lindenmayer
Manhattan Psychiatric Center, Psychopharmacology Research Unit, New York, NY 10035, USA
J Clin Psychiatry 68:368-79. 2007....
Safety and efficacy of long-acting risperidone in schizophrenia: a 12-week, multicenter, open-label study in stable patients switched from typical and atypical oral antipsychoticsJean Pierre Lindenmayer
Manhattan Psychiatric Center, New York University School of Medicine, New York, NY 10035, USA
J Clin Psychiatry 65:1084-9. 2004..The safety and efficacy of the first long-acting injectable atypical antipsychotic, risperidone, were assessed in stable patients with schizophrenia switched from oral antipsychotic medications...
Dosing of quetiapine in schizophrenia: how clinical practice differs from registration studiesLeslie Citrome
Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
J Clin Psychiatry 66:1512-6. 2005..The purpose of this article is to review the past and present dosing patterns of quetiapine for the treatment of schizophrenia...
A cognitive, behaviorally based program for patients with persistent mental illness and a history of aggression, crime, or both: structure and correlates of completers of the programKathy Yates
New York University School of Medicine and Manhattan Psychiatric Center, Ward s Island Complex, NY 10035, USA
J Am Acad Psychiatry Law 33:214-22. 2005..In comparison with the 91 who did not complete the program, those who did were less cognitively impaired and less impulsive. We present a new, intensive treatment program and define the predictors of successful completion of the program...
Long-acting injectable risperidone: efficacy and safety of the first long-acting atypical antipsychoticJohn M Kane
The Zucker Hillside Hospital, New York, NY 11004, USA
Am J Psychiatry 160:1125-32. 2003..CONCLUSIONS: Long-acting injectable risperidone was efficacious and well tolerated and provides both clinicians and patients with a new mode of treatment that can improve the outcome of long-term therapy...
Cognitive and symptomatic predictors of functional disability in schizophreniaSyed Shamsi
Department of Psychiatry, Division of Psychiatry Research, Glen Oaks, NY 11004, United States
Schizophr Res 126:257-64. 2011..Few studies have assessed the relationship between functional outcomes and the MATRICS consensus cognition battery (MCCB), which will be central to future clinical trials of cognitive enhancing agents...
Cognitive and antismoking effects of varenicline in patients with schizophrenia or schizoaffective disorderRobert C Smith
Department of Psychiatry, New York University Medical School, NY 11557 0316, United States
Schizophr Res 110:149-55. 2009..We present the first prospective quantitative data on the effects of varenicline on cognitive function, cigarette smoking, and psychopathology in a small sample of schizophrenic patients...
Pimozide augmentation of clozapine inpatients with schizophrenia and schizoaffective disorder unresponsive to clozapine monotherapyJoseph I Friedman
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Neuropsychopharmacology 36:1289-95. 2011..However, given the lack of evidence to guide clinicians and patients when clozapine does not work well, more controlled trials of innovative strategies are warranted...
Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorderMatthew J Hoptman
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
J Neuropsychiatry Clin Neurosci 18:509-15. 2006..The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate...
Modafinil as an adjunctive treatment of sedation, negative symptoms, and cognition in schizophrenia: a critical reviewCarlos Saavedra-Velez
Department of Psychiatry, New York University Medical Center, New York, NY, USA
J Clin Psychiatry 70:104-12. 2009....
Use of non-parametric item response theory to develop a shortened version of the Positive and Negative Syndrome Scale (PANSS)Anzalee Khan
Fordham University, Department of Psychometrics, Bronx, NY, USA
BMC Psychiatry 11:178. 2011....
Clozapine, risperidone, olanzapine, and conventional antipsychotic drug effects on glucose, lipids, and leptin in schizophrenic patientsRobert C Smith
Department of Psychiatry, New York University Medical School, Hewlett, NY 11557, USA
Int J Neuropsychopharmacol 8:183-94. 2005....
Normal pressure hydrocephalus presenting as Othello syndrome: case presentation and review of the literatureAnna Yusim
Department of Psychiatry, New York University Medical Center, New York, NY 10128, USA
Am J Psychiatry 165:1119-25. 2008
Neuroleptic malignant syndrome in children and adolescents on atypical antipsychotic medication: a reviewRachel Neuhut
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
J Child Adolesc Psychopharmacol 19:415-22. 2009..The purpose of this report is to examine the published cases of NMS in children and adolescents receiving atypical antipsychotic medication and review early warning symptoms, risk factors, and treatment in this population...
Measuring efficacy of polypharmacy in schizophrenic inpatientsJean-Pierre Lindenmayer
J Clin Psychiatry 65:1148; author reply 1148. 2004
Antipsychotic-induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophreniaDaniel E Casey
J Clin Psychiatry 65:4-18; quiz 19-20. 2004
Course of patients with histories of aggression and crime after discharge from a cognitive-behavioral programMichael Kunz
Huntington Department of Veterans Affairs Medical Center, West Virginia, USA
Psychiatr Serv 55:654-9. 2004..The predictors of poor outcome may be used to develop a follow-up treatment program that focuses more resources on patients who are at the highest risk...
Awareness of disorder and suicide risk in the treatment of schizophrenia: results of the international suicide prevention trialMarc Bourgeois
Psychopathology Research Laboratory, University of Bordeaux, 3 ter, Place de la Victoire, 33076 Bordeaux, France
Am J Psychiatry 161:1494-6. 2004..The complex interactions and mediation effects of these clinical variables require careful monitoring...
The international suicide prevention trial (interSePT): rationale and design of a trial comparing the relative ability of clozapine and olanzapine to reduce suicidal behavior in schizophrenia and schizoaffective patientsLarry Alphs
Schizophr Bull 30:577-86. 2004..Because of the complexity of the design issues, a steering committee, suicide monitoring board, and publication committee were established to assist with their management...
Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatmentVincenzo De Luca
Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ont, Canada M5T 1R8
Pharmacol Res 51:381-4. 2005..Our results suggest that the novel polymorphism may not play a major role in antipsychotic response...
The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophreniaDaniel J Muller
Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R30, Toronto, Ont M5T 1R8, Canada
Neurosci Lett 379:81-9. 2005..Weight changes do not seem to be associated with polymorphism of the SNAP-25 gene, however, replication in independent samples is warranted...
Efficacy of clozapine, olanzapine, risperidone, and haloperidol in schizophrenia and schizoaffective disorder assessed with nurses observation scale for inpatient evaluationJan Volavka
Schizophr Res 76:127-9. 2005
Suggestive association between the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) and clinical improvement with antipsychotics in schizophreniaDaniel J Muller
Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Eur Neuropsychopharmacol 15:525-31. 2005..8 to 7%. Our results further suggest that this effect is only attributable to Caucasians when compared to African-Americans. Moreover, our findings point to the role of intracellular mechanisms in antipsychotic response...
Clozapine augmentation with aripiprazole for negative symptomsLaura A Clarke
J Clin Psychiatry 67:675-6. 2006
Tolerability of high-dose aripiprazole in treatment-refractory schizophrenic patientsAndrya M Crossman
J Clin Psychiatry 67:1158-9. 2006
Improved long-term outcome with long-acting risperidone treatment of chronic schizophrenia with prior partial responseJean-Pierre Lindenmayer
McLean Hospital
J Psychiatr Pract 12:55-7. 2006
Standard and higher dose of olanzapine in patients with schizophrenia or schizoaffective disorder: a randomized, double-blind, fixed-dose studyBruce J Kinon
Eli Lilly and Company, Lilly Corporate Center, Drop Code 4133, Indianapolis, IN 46285, USA
J Clin Psychopharmacol 28:392-400. 2008....
Efficacy of molindone in treatment-refractory agitated schizophrenia: three case reportsMichael Ciranni
J Clin Psychiatry 69:1018-9. 2008
