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| Daniel JavittSummaryAffiliation: Nathan Kline Institute Country: USA Publications
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Is the glycine site half saturated or half unsaturated? Effects of glutamatergic drugs in schizophrenia patientsDaniel C Javitt
Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, New York 10962, USA
Curr Opin Psychiatry 19:151-7. 2006..Compared with dopaminergic treatments, these treatments may show improved efficacy in the treatment of persistent negative symptoms...
Twenty-five years of glutamate in schizophrenia: are we there yet?Daniel C Javitt
Department of Psychiatry, Nathan Kline Institute for Psychiatric Research and Columbia University College of Physicians and Surgeons, Orangeburg, NY, USA
Schizophr Bull 38:911-3. 2012....- Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophreniaDaniel C Javitt
Department of Psychiatry, Nathan Kline Institute for Psychiatric Research Columbia University College of Physicians and Surgeons, Orangeburg, NY 10962, USA
Schizophr Bull 38:958-66. 2012..Overall, these compounds have been found to induce significant beneficial effects on persistent symptoms, suggesting novel approaches for treatment and prevention of schizophrenia... 
Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophreniaDaniel C Javitt
Nathan Kline Institute for Psychiatry Research, Orangeburg, NY, United States
Schizophr Res 136:25-31. 2012..Davunetide (AL-108, NAP) is an intranasally administered peptide currently being developed for treatment of Alzheimer's disease and related disorders. This study investigates effects of davunetide on cognition in schizophrenia...- Impaired visual object recognition and dorsal/ventral stream interaction in schizophreniaGlen M Doniger
Cognitive Neurophysiology Laboratory, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Arch Gen Psychiatry 59:1011-20. 2002..This study assessed the neural integrity of perceptual closure processes in schizophrenia by examining N(cl) generation. Generation of the preceding positive (P1) and negative (N1) ERP components was also examined... - Translating glutamate: from pathophysiology to treatmentDaniel C Javitt
Translational Schizophrenia Research Center, Nathan Kline Institute Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Sci Transl Med 3:102mr2. 2011..Here, we review a recent Institute of Medicine-sponsored meeting, highlighting advances in glutamatergic theories of neuropsychiatric illness as well as remaining barriers to treatment development... - Glutamatergic theories of schizophreniaDaniel C Javitt
Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, New York 10962, USA
Isr J Psychiatry Relat Sci 47:4-16. 2010..Overall, these findings suggest that glutamatergic theories may lead to new conceptualizations and treatment approaches that would not be possible based upon dopaminergic models alone... - Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonistsDaniel C Javitt
Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
Neuropsychopharmacology 29:300-7. 2004..These findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia... - Glycine transport inhibitors and the treatment of schizophreniaDaniel C Javitt
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Biol Psychiatry 63:6-8. 2008 - Glutamate as a therapeutic target in psychiatric disordersD C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg, NY 10962, USA
Mol Psychiatry 9:984-97, 979. 2004..Other conditions for which glutamate modulators may prove effective include stroke, epilepsy, Alzheimer disease and PTSD... - When doors of perception close: bottom-up models of disrupted cognition in schizophreniaDaniel C Javitt
Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg, NY 10962, USA
Annu Rev Clin Psychol 5:249-75. 2009..In both auditory and visual systems, patterns of deficit are consistent with underlying impairment of brain N-methyl-d-aspartate receptor systems... - Modulation of striatal dopamine release by glycine transport inhibitorsDaniel C Javitt
Department of Neurochemistry, Nathan S Kline Institute for Psychiatric Research NYU School of Medicine, Orangeburg, NY, USA
Neuropsychopharmacology 30:649-56. 2005..The present results are consistent with recent clinical studies showing significant effectiveness of glycine-site agonists and GTIs in reduction of persistent positive, as well as negative, symptoms in schizophrenia... - Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of actionD C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Mol Psychiatry 10:275-87. 2005.... - Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modificationDaniel C Javitt
Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, NY 10962, USA
Curr Opin Drug Discov Devel 12:468-78. 2009..In addition, clinical trials have been conducted with sarcosine (N-methylglycine), a naturally occurring GTI. Issues related to clinical proof-of-concept studies with high-affinity GTIs in schizophrenia are discussed in this review... - A naturalistic study of risperidone treatment outcome using prognosis-adjusted discharge rates in New York State inpatientsDaniel C Javitt
Nathan Kline Institite for Psychiatric Research New York University School of Medicine, Orangeburg 10962, USA
J Clin Psychiatry 63:585-90. 2002.... - Deficits in auditory and visual context-dependent processing in schizophrenia: defining the patternD C Javitt
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Arch Gen Psychiatry 57:1131-7. 2000..The AX-CPT is designed to assess prefrontal function, whereas mismatch negativity assesses functioning of the auditory sensory memory system... - Associated deficits in mismatch negativity generation and tone matching in schizophreniaD C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg, NY 10962, USA
Clin Neurophysiol 111:1733-7. 2000..Both deficits reflect impaired early cortical processing of auditory information. However, the relationship between deficits in MMN generation and tone matching performance in schizophrenia has not been established... - Inhibition of striatal dopamine release by glycine and glycyldodecylamideD C Javitt
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Brain Res Bull 52:213-6. 2000..Glycine and GDA significantly inhibit NMDA-induced striatal dopamine release, consistent with their ability to enhance local striatal inhibitory neurotransmission in vitro and to reverse PCP-induced hyperactivity in vivo... - Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant intervalD C Javitt
Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg 10962, USA
Electroencephalogr Clin Neurophysiol 108:143-53. 1998..The pattern of deficit observed in schizophrenia differs from the pattern observed in other conditions associated with MMN dysfunction, including Alzheimer's disease, stroke, and alcohol intoxication... - Schizophrenia-like deficits in auditory P1 and N1 refractoriness induced by the psychomimetic agent phencyclidine (PCP)D C Javitt
Program in Cognitive Neuroscience and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, USA
Clin Neurophysiol 111:833-6. 2000..The present study investigates P1 and N1 refractoriness in the awake monkey in order to investigate underlying mechanisms... - Effects of phencyclidine on prepulse inhibition of acoustic startle response in the macaqueD C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute, Orangeburg, NY 10962, USA
Psychopharmacology (Berl) 156:165-8. 2001..In rodents, phencyclidine (PCP) and other N-methyl-D-aspartate receptor (NMDAR) antagonists induce schizophrenia-like PPI deficits. Similar effects have recently been observed in a New World monkey species, Cebus apella... - Management of negative symptoms of schizophreniaD C Javitt
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Curr Psychiatry Rep 3:413-7. 2001..Whether or not these agents are effective in combination with clozapine remains an open question, and large scale multicenter clinical trials are ongoing... - Adjunctive high-dose glycine in the treatment of schizophreniaD C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Int J Neuropsychopharmacol 4:385-91. 2001..Significant clinical effects were observed despite the fact that the majority of subjects were receiving atypical antipsychotics (clozapine or olanzapine). As in earlier studies, improvement persisted following glycine discontinuation... - Encoding vs. retention: differential effects of cue manipulation on working memory performance in schizophreniaDaniel C Javitt
Program in Cognitive Neuroscience and Schizophrenia Nathan Kline Institute for Psychiatric Research, New York University School of Medicine 140 Old Orangeburg Road Orangeburg, NY 10962, United States
Schizophr Res 91:159-68. 2007..Roles of encoding vs. memory retention in working memory remain unresolved. The present study evaluated working memory performance in schizophrenia using an AX-type continuous performance test (AX-CPT) paradigm... - A novel alanine-insensitive D-serine transporter in rat brain synaptosomal membranesDaniel C Javitt
Nathan Kline Institute for Psychiatric Research NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Brain Res 941:146-9. 2002..Inhibitors of the systems A, L and GLY were also ineffective. Saturation studies suggested a submillimolar K(m) for both D- and L-serine. These data suggest the presence of a novel serine transport system in rodent synaptosomes... - Panmodal processing imprecision as a basis for dysfunction of transient memory storage systems in schizophreniaD C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Schizophr Bull 25:763-75. 1999..The severe deficits in processing precision, despite the relatively preserved maintenance of representation, may be relevant to pathophysiological models of schizophrenia... - Intracortical mechanisms of mismatch negativity dysfunction in schizophreniaD C Javitt
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Audiol Neurootol 5:207-15. 2000..Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia... - The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedentsDavid I Leitman
Program in Cognitive Neuroscience and Schizophrenia, Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Am J Psychiatry 164:474-82. 2007..This study examined neural substrates of prosodic dysfunction in schizophrenia with voxelwise analysis of diffusion tensor magnetic resonance imaging (MRI)... - Dysfunction of early-stage visual processing in schizophrenia: harmonic analysisDongsoo Kim
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Schizophr Res 76:55-65. 2005..Early sensory deficits may lead to impairments in subsequent stages of processing... - Impairments in generation of early-stage transient visual evoked potentials to magno- and parvocellular-selective stimuli in schizophreniaIsaac Schechter
Nathan Kline Institute, Program in Cognitive Neuroscience and Schizophrenia, Orangeburg, NY 10962, USA
Clin Neurophysiol 116:2204-15. 2005..Further, between-group differences in visual acuity may influence VEP results, even for subjects with 'normal' vision (20/32 or better)... - Neurophysiological and neurochemical animal models of schizophrenia: focus on glutamateStephan Bickel
Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Behav Brain Res 204:352-62. 2009..In addition, we emphasize the possible relevance of the amphetamine-challenge studies to positive symptoms and of EEG measures to cognitive deficits in schizophrenia... - In support of Bleuler: objective evidence for increased affective ambivalence in schizophrenia based upon evocative testingFabien Tremeau
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, United States
Schizophr Res 107:223-31. 2009..These characteristics have not received much attention in schizophrenia research... - Sensory contributions to impaired prosodic processing in schizophreniaDavid I Leitman
Program in Cognitive Neuroscience and Schizophrenia, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Biol Psychiatry 58:56-61. 2005..The separate loading of auditory and visual affective recognition measures suggests that within-modality factors may be more significant than cross-modality factors in the etiology of affect recognition deficits in schizophrenia... - Multisensory visual-auditory object recognition in humans: a high-density electrical mapping studySophie Molholm
Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Cereb Cortex 14:452-65. 2004..Multisensory inputs also modulated the visual 'selection-negativity', an attention dependent component of the evoked potential this is usually evoked when subjects selectively attend to a particular feature of a visual stimulus... - Spatiotemporal dynamics of human object recognition processing: an integrated high-density electrical mapping and functional imaging study of "closure" processesPejman Sehatpour
The Cognitive Neurophysiology Laboratory, Nathan S. Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neuroimage 29:605-18. 2006.... - Grabbing your ear: rapid auditory-somatosensory multisensory interactions in low-level sensory cortices are not constrained by stimulus alignmentMicah M Murray
The Cognitive Neurophysiology Lab, Nathan S. Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Cereb Cortex 15:963-74. 2005..Thus, multisensory interactions can occur across wide peripersonal spatial separations remarkably early in sensory processing and in cortical regions traditionally considered unisensory... - Sensory processing in schizophrenia: neither simple nor intactDaniel C Javitt
Department of Psychiatry, New York University Langone School of Medicine, Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Bull 35:1059-64. 2009..These studies also underscore the severe challenges that individuals with schizophrenia face when trying to decode the complex world around them... - Subchronic continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine releaseAndrea Balla
Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY 10962, USA
Neuropsychopharmacology 28:34-44. 2003..Finally, these studies provide a model system in which to evaluate effects of potential psychotherapeutic agents... - Characterization of interactions between phencyclidine and amphetamine in rodent prefrontal cortex and striatum: implications in NMDA/glycine-site-mediated dopaminergic dysregulation and dopamine transporter functionHenry Sershen
Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States
Neurochem Int 52:119-29. 2008..The present studies also demonstrate pharmacokinetic interaction between AMPH and PCP, which may be of both clinical and research relevance... - Timing of pure tone and noise-evoked responses in macaque auditory cortexPeter Lakatos
Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York 10962, USA
Neuroreport 16:933-7. 2005..Dissociation of broadband noise and pure tone latencies may reflect the use of parallel anatomical routes into belt regions... - Loss aversion in schizophreniaFabien Tremeau
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, United States
Schizophr Res 103:121-8. 2008..Loss aversion is conceived as an affective interference in cognitive processes such as judgment and decision-making. Loss aversion in non-risky choices has not been studied in schizophrenia... - GABA(B) receptors, schizophrenia and sleep dysfunction: a review of the relationship and its potential clinical and therapeutic implicationsJoshua Kantrowitz
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
CNS Drugs 23:681-91. 2009..Further study is needed... - Magnocellular contributions to impaired motion processing in schizophreniaDongsoo Kim
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
Schizophr Res 82:1-8. 2006..Further, this study supports and extends prior reports of impaired motion processing in schizophrenia, and indicates significant bottom-up contributions to higher-order cognitive impairments... - Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactionsDaniel C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric, Research, New York University School of Medicine, Orangeburg, New York 10962, USA
Int Rev Neurobiol 78:69-108. 2007..Finally, genetic linkage and in vivo neurochemical studies in schizophrenia highlight potential etiological mechanisms giving rise to glutamatergic/NMDA dysfunction in schizophrenia... - Sensory deficits and distributed hierarchical dysfunction in schizophreniaDavid I Leitman
Schizophrenia Research Center, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Am J Psychiatry 167:818-27. 2010..Here the authors examined the relationship between lower- and higher-level dysfunction within the auditory domain using the event-related brain potentials mismatch negativity (MMN) and P300... - High dose D-serine in the treatment of schizophreniaJoshua T Kantrowitz
Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, NY, United States
Schizophr Res 121:125-30. 2010..We describe the first evaluation of the efficacy and safety of d-serine at doses >30 mg/kg/day; a 4-week, open-label trial of adjunctive D-serine (30, 60 or 120 mg/kg/day)... - Decoding schizophreniaDaniel C Javitt
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute, Orangeburg, N.Y, USA
Sci Am 290:48-55. 2004 - Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping studySophie Molholm
Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Brain Res Cogn Brain Res 14:115-28. 2002..This RT facilitation could not be accounted for by probability summation, as evidenced by violation of the 'race' model, providing compelling evidence that auditory-visual neural interactions give rise to this RT effect... - Visual backward-masking deficits in schizophrenia: relationship to visual pathway function and symptomatologyPamela D Butler
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Schizophr Res 59:199-209. 2003.... - Theory of Mind (ToM) and counterfactuality deficits in schizophrenia: misperception or misinterpretation?David I Leitman
Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Psychol Med 36:1075-83. 2006..Sarcastic detection ability has not previously been studied in schizophrenia, although patients have been shown to have deficits in ability to decode emotional information from speech ('affective prosody')... - GABAB/NMDA receptor interaction in the regulation of extracellular dopamine levels in rodent prefrontal cortex and striatumAndrea Balla
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neuropharmacology 56:915-21. 2009..Both sites, therefore, may represent appropriate targets for drug development in schizophrenia and substance abuse disorders... - Functional anatomy and interaction of fast and slow visual pathways in macaque monkeysChi Ming Chen
Cognitive Neuroscience and Schizophrenia Program, Nathan S Kline Institute, Orangeburg, NY 10962, USA
Cereb Cortex 17:1561-9. 2007..These findings support a "Framing" Model of ventral stream visual processing in which rapidly conducted inputs, mediated by one or more accessory pathways, modulate the processing of more slowly conducted feedforward inputs... - Magnocellular pathway impairment in schizophrenia: evidence from functional magnetic resonance imagingAntigona Martinez
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Neurosci 28:7492-500. 2008.... - It's all in the cards: effect of stimulus manipulation on Wisconsin Card Sorting Test performance in schizophreniaJoshua T Kantrowitz
Department of Life Sciences, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Psychiatry Res 168:198-204. 2009..Furthermore, progressive improvement was seen following repeated RFST administration. These findings demonstrate that stimulus characteristics, as well as executive deficits, contribute to impaired WCST performance in schizophrenia... - Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidineGary S Linn
Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Psychopharmacology (Berl) 192:27-38. 2007..NMDA receptors in brain are modulated by the amino acid glycine (GLY), which reverses neurochemical and behavioral effects of PCP in rodents. The present study investigates GLY effects on PCP-induced behavior in primates... - Multisensory convergence in auditory cortex, I. Cortical connections of the caudal superior temporal plane in macaque monkeysJohn F Smiley
Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
J Comp Neurol 502:894-923. 2007..The differential connections of CM compared with adjacent areas provide additional evidence for the functional specialization of the individual auditory belt areas... - Altered volume and hemispheric asymmetry of the superficial cortical layers in the schizophrenia planum temporaleJohn F Smiley
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Eur J Neurosci 30:449-63. 2009..In schizophrenia, the thinner upper layers of the caudal PT suggest disrupted corticocortical processing, possibly affecting the multisensory integration and phonetic processing of this region... - Neurophysiological biomarkers for drug development in schizophreniaDaniel C Javitt
Nathan Kline Institute for Schizophrenia Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
Nat Rev Drug Discov 7:68-83. 2008..Moreover, many of these neurophysiological processes are phylogenetically conserved and can be modelled in preclinical studies, offering unique opportunities for use as translational biomarkers in schizophrenia drug discovery... - Impaired visual object processing across an occipital-frontal-hippocampal brain network in schizophrenia: an integrated neuroimaging studyPejman Sehatpour
Conte Center for Schizophrenia Research, Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Arch Gen Psychiatry 67:772-82. 2010.... - Seeing the world dimly: the impact of early visual deficits on visual experience in schizophreniaJoshua T Kantrowitz
Department of Life Sciences, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY, USA
Schizophr Bull 35:1085-94. 2009..01). This study replicates and expands upon previous findings with visual illusions. Our results offer a unifying explanation for disparate studies and suggest that deficits in early sensory gain affect subsequent integrative processes... - What's in a face? Effects of stimulus duration and inversion on face processing in schizophreniaPamela D Butler
Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
Schizophr Res 103:283-92. 2008..Similar inversion effects for face part and spacing for both groups suggest that they are using the same holistic face processing mechanism... - Sensory contributions to impaired emotion processing in schizophreniaPamela D Butler
Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Schizophr Bull 35:1095-107. 2009..These results provide evidence for a contribution of impaired early-stage visual processing in emotion recognition deficits in schizophrenia and suggest that a bottom-up approach to remediation may be effective... - Has an important test been overlooked? Closure flexibility in schizophreniaPamela D Butler
Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
Schizophr Res 118:20-5. 2010..In addition, the CFT is a brief, easy to administer alphabet-independent, paper-and-pencil test with established psychometric properties that may be useful as an index of the sustained visual attention construct in schizophrenia... - The leading sense: supramodal control of neurophysiological context by attentionPeter Lakatos
Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York 10962, USA
Neuron 64:419-30. 2009..These findings outline a supramodal mechanism by which attention can control neurophysiological context, thus determining the representation of specific sensory content in primary sensory cortex... - Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI studyMatthew J Hoptman
Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Res 117:13-20. 2010..These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed... - Auditory-somatosensory multisensory processing in auditory association cortex: an fMRI studyJohn J Foxe
The Cognitive Neurophysiology Laboratory, Cognitive Neuroscience and Schizophrenia Program, New York City, New York 10016, USA
J Neurophysiol 88:540-3. 2002.... - Preattentively grouped tones do not elicit MMN with respect to each otherWalter Ritter
Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
Psychophysiology 43:423-30. 2006..This implies that once acoustic input has been preattentively grouped, the MMN system is dedicated to detecting changes that occur within but not between preattentively grouped stimuli... - Right hemisphere control of visuospatial attention: line-bisection judgments evaluated with high-density electrical mapping and source analysisJohn J Foxe
The Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Neuroimage 19:710-26. 2003..Further, at 3% contrast, the line-bisection effect was equivalent to the effects seen at higher contrast levels, suggesting that parvocellular inputs are not necessary for successful performance of this task... - Don't think of a white bear: an fMRI investigation of the effects of sequential instructional sets on cortical activity in a task-switching paradigmGlenn R Wylie
Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Hum Brain Mapp 21:279-97. 2004..Our data also revealed widespread activation of a frontoparietal network of areas, and we discuss how this network might be involved in mediating this competition... - Changing plans: neural correlates of executive control in monkey and human frontal cortexElisa C Dias
Program in Cognitive Neurosciences and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Exp Brain Res 174:279-91. 2006..We suggest that simultaneous activation of both types of subregions in conflict conditions may account the ubiquitous ACC activation observed with fMRI and ERP in those conditions... - Early-stage visual processing and cortical amplification deficits in schizophreniaPamela D Butler
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Arch Gen Psychiatry 62:495-504. 2005..Investigating magnocellular dysfunction in schizophrenia therefore permits evaluation of underlying etiologic hypotheses... - Reading impairment and visual processing deficits in schizophreniaNadine Revheim
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Res 87:238-45. 2006..Findings related to symptoms, functioning and recommendations for reading ability assessment are discussed... - The neural circuitry of pre-attentive auditory change-detection: an fMRI study of pitch and duration mismatch negativity generatorsSophie Molholm
The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Cereb Cortex 15:545-51. 2005..We also detail regions of the frontal and parietal cortices activated by change-detection processes. These regions also show feature dependence and we hypothesize that they reflect recruitment of attention-switching mechanisms... - A new dimension of sensory dysfunction: stereopsis deficits in schizophreniaIsaac Schechter
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Biol Psychiatry 60:1282-4. 2006..Early visual processing has been shown to be especially impaired. This article investigates the integrity of binocular depth perception (stereopsis) in schizophrenia... - MRI study of white matter diffusion anisotropy in schizophreniaBabak A Ardekani
Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Neuroreport 14:2025-9. 2003..Regions showing reduced white matter fractional anisotropy are known to be abnormal in schizophrenia. The voxelwise method used in the current study can provide the basis for hypothesis-driven research... - Subcortical visual dysfunction in schizophrenia drives secondary cortical impairmentsPamela D Butler
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Brain 130:417-30. 2007.... - Glycine modulators in schizophreniaDaniel C Javitt
Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg 10962, USA
Curr Opin Investig Drugs 3:1067-72. 2002.... - Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeysGary S Linn
The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Psychopharmacology (Berl) 169:234-9. 2003..g. phencyclidine (PCP)], whereas atypical antipsychotics (e.g. clozapine) reverse PPI deficits induced by DA agonists and NMDA antagonists. However, some discrepancies exist with some compounds and strains of rodents... - Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophreniaBabak A Ardekani
Center for Advanced Brain Imaging, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA
Neuroreport 16:1455-9. 2005..Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia... - Changing plans: a high density electrical mapping study of cortical controlElisa C Dias
Cognitive Neurophysiology Laboratory, Program in Cognitive Neurosciences and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Cereb Cortex 13:701-15. 2003..Similar patterns of activation were observed whether the changes in preparation were triggered by cue or target stimuli, though target-elicited potentials peaked earlier... - Visual white matter integrity in schizophreniaPamela D Butler
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg NY, 10962, USA
Am J Psychiatry 163:2011-3. 2006..Patients with schizophrenia have visual-processing deficits. This study examines visual white matter integrity as a potential mechanism for these deficits... - Anticipated, on-line and remembered positive experience in schizophreniaFabien Tremeau
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Schizophr Res 122:199-205. 2010..Moreover, the role of positive affect evaluations on motivation has rarely been studied in schizophrenia... - DTI and impulsivity in schizophrenia: a first voxelwise correlational analysisMatthew J Hoptman
Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
Neuroreport 15:2467-70. 2004..These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks... - Neurocognitive and symptom correlates of daily problem-solving skills in schizophreniaNadine Revheim
Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Res 83:237-45. 2006..The findings suggest the ILS-PB has utility as a proxy measure for assessing real-world functioning in schizophrenia... - A review of tolerability and abuse liability of gamma-hydroxybutyric acid for insomnia in patients with schizophreniaJoshua T Kantrowitz
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Clin Ther 31:1360-73. 2009..A tolerability concern regarding use of GHB is its abuse potential. Given the high comorbidity of substance disorders and schizophrenia, a systematic assessment of the published literature is crucial... - Amygdalofrontal functional disconnectivity and aggression in schizophreniaMatthew J Hoptman
Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Bull 36:1020-8. 2010..Similar results were obtained for 2 other measures--Life History of Aggression and total arrests. These results suggest that amygdala/vPFC FC is compromised in schizophrenia and that this compromise is associated with aggression... - Magnocellular and parvocellular contributions to backward masking dysfunction in schizophreniaIsaac Schechter
Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Schizophr Res 64:91-101. 2003..Furthermore, deficits of letter identification, including those of P targets, may also reflect impairment of the M pathway given the priming function of the dorsal stream... - Sensitive and simple gas chromatographic-mass spectrometric determination for amphetamine in microdialysate and ultrafiltrate samplesShan Xie
Analytical Psychopharmacology Laboratory, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
J Chromatogr B Analyt Technol Biomed Life Sci 805:27-31. 2004..The within-day precision was from 1.7 to 5.1% and between-day precision was from 2.2 to 7.3%. The method has been used for the measurement of several thousand microdialysate and ultrafiltrate samples and proven reliable... - Early sensory contributions to contextual encoding deficits in schizophreniaElisa C Dias
Center for Translational Schizophrenia Research, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Arch Gen Psychiatry 68:654-64. 2011..Event-related potentials (ERP) provide an objective index of brain function and can be used to evaluate brain substrates underlying impaired cognition in schizophrenia... - Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRIA M Clare Kelly
Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Eur J Neurosci 19:3105-12. 2004.... - Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophreniaUriel Heresco-Levy
Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
Am J Psychiatry 159:480-2. 2002..The authors investigated the clinical effects of D-cycloserine when added to treatment with conventional neuroleptics, olanzapine, or risperidone for treatment-resistant schizophrenia... - Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysisUriel Heresco-Levy
Ezrath Nashim Sarah Herzog Memorial Hospital, P O Box 35300, Givat Shaul, Jerusalem, Israel
Schizophr Res 66:89-96. 2004..Overall, the findings indicate that agents which potentiate NMDA transmission may be therapeutically beneficial in treatment of persistent symptoms of schizophrenia... - High-dose glycine added to olanzapine and risperidone for the treatment of schizophreniaUriel Heresco-Levy
Ezrath Nashim-Herzog Memorial Hospital, Department of Psychiatry, Hadassah Medical School-Hebrew University, Jerusalem, Israel
Biol Psychiatry 55:165-71. 2004.... - Predicting success: patterns of cortical activation and deactivation prior to response inhibitionRobert L Hester
Trinity College, Dublin, Ireland
J Cogn Neurosci 16:776-85. 2004.... - Filling-in in schizophrenia: a high-density electrical mapping and source-analysis investigation of illusory contour processingJohn J Foxe
Program in Cognitive Neuroscience, Department of Psychology, The City College of the City University of New York, North Academic Complex (NAC) 138th St. and Convent Avenue, New York, NY 10031, USA
Cereb Cortex 15:1914-27. 2005.... - Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophreniaRobert W Buchanan
Schizophr Bull 33:1120-30. 2007..This article reviews the rationale for these 3 approaches and provides an update on the development of therapeutic agents, which act through one of these 3 mechanisms... - Perceptual organization by proximity and similarity in schizophreniaDaniel D Kurylo
Psychology Department, Brooklyn College CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
Schizophr Res 95:205-14. 2007..Although this study did not directly investigate the physiological correlates underlying perceptual impairments, these results are consistent with a theory of impaired lateral connections within visual cortical areas in schizophrenia... - The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairmentsRobert W Buchanan
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Am J Psychiatry 164:1593-602. 2007..Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments... - Impaired multisensory processing in schizophrenia: deficits in the visual enhancement of speech comprehension under noisy environmental conditionsLars A Ross
Program in Cognitive Neuroscience, Department of Psychology, The City College of City University of New York, 138th St and Convent Avenue, New York, New York 10031, USA
Schizophr Res 97:173-83. 2007..Our objective was to determine to what extent they experience benefit from visual articulation and to detail under what listening conditions they might show the greatest impairments... - Early visual processing deficits in dysbindin-associated schizophreniaGary Donohoe
Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
Biol Psychiatry 63:484-9. 2008..We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype... - High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patientsUriel Heresco-Levy
Psychiatry and Research Department, Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Givat Shaul 91351, Jerusalem, Israel
Schizophr Res 91:14-21. 2007..4, p=0.03). These preliminary findings indirectly support previous observations on ketamine effects upon PPI in humans and suggest a dissociation of symptomatology and PPI changes as function of NMDAR modulation in schizophrenia...
Research Grants
- TREATMENT OF NEGATIVE SYMPTOMS AND COGNITIVE IMPAIRMENTSDaniel Javitt; Fiscal Year: 2003..The study will provide new information on the efficacy of d-cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
- MECHANISMS OF COGNITIVE DYSFUNCTION IN SCHIZOPHRENIADaniel Javitt; Fiscal Year: 2005..This study will evaluate neurophysiological and neurochemical hypotheses concerning potential etiology of early sensory processing dysfunction in schizophrenia. ..
- Phencyclidine Abuse and Psychoses: Biomedical MechanismsDaniel Javitt; Fiscal Year: 2005....
- NEUROPHYSIOLOGICAL NMDA DYSFUNCTION IN SCHIZOPHRENIADaniel Javitt; Fiscal Year: 2006..The research will build upon studies currently supported by NIH research and career development awards to the candidate, and will permit the candidate to continue to devote >75 percent effort to research. ..
- EARLY CORTICAL PROCESSING IN SCHIZOPHRENIADaniel Javitt; Fiscal Year: 2007..Finally, this project will begin to evaluate the degree to which separate deficits in auditory and visual processing lead to impairments in higher order processes. ..
- D-Serine Treatment of SchizophreniaDaniel Javitt; Fiscal Year: 2007..Together these projects will validate treatment targets for NMDA agonists in general and D-serine in particular and will encourage continued clinical development. ..
- Phencyclidine Abuse & Psychosis: Biomedical MechanismsDaniel Javitt; Fiscal Year: 2007....
- EARLY CORTICAL PROCESSING IN SCHIZOPHRENIADaniel Javitt; Fiscal Year: 2002..It is hypothesized that MMN dysfunction, along with other cognitive dysfunction, will serve as a marker for poor outcome and an objective index for investigating underlying intracortical mechanisms. ..
- PHENCYCLIDINE ABUSE AND PSYCHOSIS--BIOMEDICAL MECHANISMSDaniel Javitt; Fiscal Year: 2000....
- High-Density ERP mapping & FMRIDaniel Javitt; Fiscal Year: 2002..The equipment will also permit monitoring of background EEG during both human and animal studies. Software is requested for state-of-the-art ERP dipole mapping and ERP/MRI co-registration. ..
- Phencyclidine Abuse & Psychosis: Biomedical MechanismsDaniel C Javitt; Fiscal Year: 2010....