Daniel Javitt

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi request reprint Is the glycine site half saturated or half unsaturated? Effects of glutamatergic drugs in schizophrenia patients
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, New York 10962, USA
    Curr Opin Psychiatry 19:151-7. 2006
  2. pmc Twenty-five years of glutamate in schizophrenia: are we there yet?
    Daniel C Javitt
    Department of Psychiatry, Nathan Kline Institute for Psychiatric Research and Columbia University College of Physicians and Surgeons, Orangeburg, NY, USA
    Schizophr Bull 38:911-3. 2012
  3. pmc Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia
    Daniel C Javitt
    Department of Psychiatry, Nathan Kline Institute for Psychiatric Research Columbia University College of Physicians and Surgeons, Orangeburg, NY 10962, USA
    Schizophr Bull 38:958-66. 2012
  4. doi request reprint Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Psychiatry Research, Orangeburg, NY, United States
    Schizophr Res 136:25-31. 2012
  5. ncbi request reprint Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia
    Glen M Doniger
    Cognitive Neurophysiology Laboratory, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 59:1011-20. 2002
  6. pmc Translating glutamate: from pathophysiology to treatment
    Daniel C Javitt
    Translational Schizophrenia Research Center, Nathan Kline Institute Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Sci Transl Med 3:102mr2. 2011
  7. ncbi request reprint Glutamatergic theories of schizophrenia
    Daniel C Javitt
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, New York 10962, USA
    Isr J Psychiatry Relat Sci 47:4-16. 2010
  8. ncbi request reprint Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
    Neuropsychopharmacology 29:300-7. 2004
  9. ncbi request reprint Glycine transport inhibitors and the treatment of schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Biol Psychiatry 63:6-8. 2008
  10. ncbi request reprint Glutamate as a therapeutic target in psychiatric disorders
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg, NY 10962, USA
    Mol Psychiatry 9:984-97, 979. 2004

Research Grants

  1. TREATMENT OF NEGATIVE SYMPTOMS AND COGNITIVE IMPAIRMENTS
    Daniel Javitt; Fiscal Year: 2003
  2. MECHANISMS OF COGNITIVE DYSFUNCTION IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2005
  3. Phencyclidine Abuse and Psychoses: Biomedical Mechanisms
    Daniel Javitt; Fiscal Year: 2005
  4. NEUROPHYSIOLOGICAL NMDA DYSFUNCTION IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2006
  5. EARLY CORTICAL PROCESSING IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2007
  6. D-Serine Treatment of Schizophrenia
    Daniel Javitt; Fiscal Year: 2007
  7. Phencyclidine Abuse & Psychosis: Biomedical Mechanisms
    Daniel Javitt; Fiscal Year: 2007
  8. EARLY CORTICAL PROCESSING IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2002
  9. PHENCYCLIDINE ABUSE AND PSYCHOSIS--BIOMEDICAL MECHANISMS
    Daniel Javitt; Fiscal Year: 2000
  10. High-Density ERP mapping & FMRI
    Daniel Javitt; Fiscal Year: 2002

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Is the glycine site half saturated or half unsaturated? Effects of glutamatergic drugs in schizophrenia patients
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, New York 10962, USA
    Curr Opin Psychiatry 19:151-7. 2006
    ..Compared with dopaminergic treatments, these treatments may show improved efficacy in the treatment of persistent negative symptoms...
  2. pmc Twenty-five years of glutamate in schizophrenia: are we there yet?
    Daniel C Javitt
    Department of Psychiatry, Nathan Kline Institute for Psychiatric Research and Columbia University College of Physicians and Surgeons, Orangeburg, NY, USA
    Schizophr Bull 38:911-3. 2012
    ....
  3. pmc Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia
    Daniel C Javitt
    Department of Psychiatry, Nathan Kline Institute for Psychiatric Research Columbia University College of Physicians and Surgeons, Orangeburg, NY 10962, USA
    Schizophr Bull 38:958-66. 2012
    ..Overall, these compounds have been found to induce significant beneficial effects on persistent symptoms, suggesting novel approaches for treatment and prevention of schizophrenia...
  4. doi request reprint Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Psychiatry Research, Orangeburg, NY, United States
    Schizophr Res 136:25-31. 2012
    ..Davunetide (AL-108, NAP) is an intranasally administered peptide currently being developed for treatment of Alzheimer's disease and related disorders. This study investigates effects of davunetide on cognition in schizophrenia...
  5. ncbi request reprint Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia
    Glen M Doniger
    Cognitive Neurophysiology Laboratory, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 59:1011-20. 2002
    ..This study assessed the neural integrity of perceptual closure processes in schizophrenia by examining N(cl) generation. Generation of the preceding positive (P1) and negative (N1) ERP components was also examined...
  6. pmc Translating glutamate: from pathophysiology to treatment
    Daniel C Javitt
    Translational Schizophrenia Research Center, Nathan Kline Institute Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Sci Transl Med 3:102mr2. 2011
    ..Here, we review a recent Institute of Medicine-sponsored meeting, highlighting advances in glutamatergic theories of neuropsychiatric illness as well as remaining barriers to treatment development...
  7. ncbi request reprint Glutamatergic theories of schizophrenia
    Daniel C Javitt
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, New York 10962, USA
    Isr J Psychiatry Relat Sci 47:4-16. 2010
    ..Overall, these findings suggest that glutamatergic theories may lead to new conceptualizations and treatment approaches that would not be possible based upon dopaminergic models alone...
  8. ncbi request reprint Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
    Neuropsychopharmacology 29:300-7. 2004
    ..These findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia...
  9. ncbi request reprint Glycine transport inhibitors and the treatment of schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Biol Psychiatry 63:6-8. 2008
  10. ncbi request reprint Glutamate as a therapeutic target in psychiatric disorders
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg, NY 10962, USA
    Mol Psychiatry 9:984-97, 979. 2004
    ..Other conditions for which glutamate modulators may prove effective include stroke, epilepsy, Alzheimer disease and PTSD...
  11. doi request reprint When doors of perception close: bottom-up models of disrupted cognition in schizophrenia
    Daniel C Javitt
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg, NY 10962, USA
    Annu Rev Clin Psychol 5:249-75. 2009
    ..In both auditory and visual systems, patterns of deficit are consistent with underlying impairment of brain N-methyl-d-aspartate receptor systems...
  12. ncbi request reprint Modulation of striatal dopamine release by glycine transport inhibitors
    Daniel C Javitt
    Department of Neurochemistry, Nathan S Kline Institute for Psychiatric Research NYU School of Medicine, Orangeburg, NY, USA
    Neuropsychopharmacology 30:649-56. 2005
    ..The present results are consistent with recent clinical studies showing significant effectiveness of glycine-site agonists and GTIs in reduction of persistent positive, as well as negative, symptoms in schizophrenia...
  13. ncbi request reprint Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Mol Psychiatry 10:275-87. 2005
    ....
  14. ncbi request reprint Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, NY 10962, USA
    Curr Opin Drug Discov Devel 12:468-78. 2009
    ..In addition, clinical trials have been conducted with sarcosine (N-methylglycine), a naturally occurring GTI. Issues related to clinical proof-of-concept studies with high-affinity GTIs in schizophrenia are discussed in this review...
  15. ncbi request reprint A naturalistic study of risperidone treatment outcome using prognosis-adjusted discharge rates in New York State inpatients
    Daniel C Javitt
    Nathan Kline Institite for Psychiatric Research New York University School of Medicine, Orangeburg 10962, USA
    J Clin Psychiatry 63:585-90. 2002
    ....
  16. ncbi request reprint Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 57:1131-7. 2000
    ..The AX-CPT is designed to assess prefrontal function, whereas mismatch negativity assesses functioning of the auditory sensory memory system...
  17. ncbi request reprint Associated deficits in mismatch negativity generation and tone matching in schizophrenia
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg, NY 10962, USA
    Clin Neurophysiol 111:1733-7. 2000
    ..Both deficits reflect impaired early cortical processing of auditory information. However, the relationship between deficits in MMN generation and tone matching performance in schizophrenia has not been established...
  18. ncbi request reprint Inhibition of striatal dopamine release by glycine and glycyldodecylamide
    D C Javitt
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Brain Res Bull 52:213-6. 2000
    ..Glycine and GDA significantly inhibit NMDA-induced striatal dopamine release, consistent with their ability to enhance local striatal inhibitory neurotransmission in vitro and to reverse PCP-induced hyperactivity in vivo...
  19. ncbi request reprint Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval
    D C Javitt
    Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg 10962, USA
    Electroencephalogr Clin Neurophysiol 108:143-53. 1998
    ..The pattern of deficit observed in schizophrenia differs from the pattern observed in other conditions associated with MMN dysfunction, including Alzheimer's disease, stroke, and alcohol intoxication...
  20. ncbi request reprint Schizophrenia-like deficits in auditory P1 and N1 refractoriness induced by the psychomimetic agent phencyclidine (PCP)
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, USA
    Clin Neurophysiol 111:833-6. 2000
    ..The present study investigates P1 and N1 refractoriness in the awake monkey in order to investigate underlying mechanisms...
  21. ncbi request reprint Effects of phencyclidine on prepulse inhibition of acoustic startle response in the macaque
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 156:165-8. 2001
    ..In rodents, phencyclidine (PCP) and other N-methyl-D-aspartate receptor (NMDAR) antagonists induce schizophrenia-like PPI deficits. Similar effects have recently been observed in a New World monkey species, Cebus apella...
  22. ncbi request reprint Management of negative symptoms of schizophrenia
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Curr Psychiatry Rep 3:413-7. 2001
    ..Whether or not these agents are effective in combination with clozapine remains an open question, and large scale multicenter clinical trials are ongoing...
  23. ncbi request reprint Adjunctive high-dose glycine in the treatment of schizophrenia
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Int J Neuropsychopharmacol 4:385-91. 2001
    ..Significant clinical effects were observed despite the fact that the majority of subjects were receiving atypical antipsychotics (clozapine or olanzapine). As in earlier studies, improvement persisted following glycine discontinuation...
  24. pmc Encoding vs. retention: differential effects of cue manipulation on working memory performance in schizophrenia
    Daniel C Javitt
    Program in Cognitive Neuroscience and Schizophrenia Nathan Kline Institute for Psychiatric Research, New York University School of Medicine 140 Old Orangeburg Road Orangeburg, NY 10962, United States
    Schizophr Res 91:159-68. 2007
    ..Roles of encoding vs. memory retention in working memory remain unresolved. The present study evaluated working memory performance in schizophrenia using an AX-type continuous performance test (AX-CPT) paradigm...
  25. ncbi request reprint A novel alanine-insensitive D-serine transporter in rat brain synaptosomal membranes
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Brain Res 941:146-9. 2002
    ..Inhibitors of the systems A, L and GLY were also ineffective. Saturation studies suggested a submillimolar K(m) for both D- and L-serine. These data suggest the presence of a novel serine transport system in rodent synaptosomes...
  26. ncbi request reprint Panmodal processing imprecision as a basis for dysfunction of transient memory storage systems in schizophrenia
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Schizophr Bull 25:763-75. 1999
    ..The severe deficits in processing precision, despite the relatively preserved maintenance of representation, may be relevant to pathophysiological models of schizophrenia...
  27. ncbi request reprint Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Audiol Neurootol 5:207-15. 2000
    ..Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia...
  28. ncbi request reprint The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents
    David I Leitman
    Program in Cognitive Neuroscience and Schizophrenia, Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Am J Psychiatry 164:474-82. 2007
    ..This study examined neural substrates of prosodic dysfunction in schizophrenia with voxelwise analysis of diffusion tensor magnetic resonance imaging (MRI)...
  29. ncbi request reprint Dysfunction of early-stage visual processing in schizophrenia: harmonic analysis
    Dongsoo Kim
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Schizophr Res 76:55-65. 2005
    ..Early sensory deficits may lead to impairments in subsequent stages of processing...
  30. pmc Impairments in generation of early-stage transient visual evoked potentials to magno- and parvocellular-selective stimuli in schizophrenia
    Isaac Schechter
    Nathan Kline Institute, Program in Cognitive Neuroscience and Schizophrenia, Orangeburg, NY 10962, USA
    Clin Neurophysiol 116:2204-15. 2005
    ..normal volunteers first to evaluate relative contributions of M and P systems to specific tVEP components in schizophrenia and, second, to evaluate integrity of early M and P processing in schizophrenia...
  31. doi request reprint Neurophysiological and neurochemical animal models of schizophrenia: focus on glutamate
    Stephan Bickel
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Behav Brain Res 204:352-62. 2009
    ..In addition, we emphasize the possible relevance of the amphetamine-challenge studies to positive symptoms and of EEG measures to cognitive deficits in schizophrenia...
  32. doi request reprint In support of Bleuler: objective evidence for increased affective ambivalence in schizophrenia based upon evocative testing
    Fabien Tremeau
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, United States
    Schizophr Res 107:223-31. 2009
    ..These characteristics have not received much attention in schizophrenia research...
  33. ncbi request reprint Sensory contributions to impaired prosodic processing in schizophrenia
    David I Leitman
    Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Biol Psychiatry 58:56-61. 2005
    ..Within the auditory domain, patients show difficulty in interpreting vocal emotional cues based on intonation (prosody). The relationship of these symptoms to deficits in basic sensory processing has not been previously evaluated...
  34. ncbi request reprint Multisensory visual-auditory object recognition in humans: a high-density electrical mapping study
    Sophie Molholm
    Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Cereb Cortex 14:452-65. 2004
    ..Multisensory inputs also modulated the visual 'selection-negativity', an attention dependent component of the evoked potential this is usually evoked when subjects selectively attend to a particular feature of a visual stimulus...
  35. ncbi request reprint Spatiotemporal dynamics of human object recognition processing: an integrated high-density electrical mapping and functional imaging study of "closure" processes
    Pejman Sehatpour
    The Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroimage 29:605-18. 2006
    ....
  36. ncbi request reprint Grabbing your ear: rapid auditory-somatosensory multisensory interactions in low-level sensory cortices are not constrained by stimulus alignment
    Micah M Murray
    The Cognitive Neurophysiology Lab, Nathan S Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Cereb Cortex 15:963-74. 2005
    ..Thus, multisensory interactions can occur across wide peripersonal spatial separations remarkably early in sensory processing and in cortical regions traditionally considered unisensory...
  37. pmc Sensory processing in schizophrenia: neither simple nor intact
    Daniel C Javitt
    Department of Psychiatry, New York University Langone School of Medicine, Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research NYU School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Bull 35:1059-64. 2009
    ..These studies also underscore the severe challenges that individuals with schizophrenia face when trying to decode the complex world around them...
  38. ncbi request reprint Subchronic continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release
    Andrea Balla
    Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY 10962, USA
    Neuropsychopharmacology 28:34-44. 2003
    ..Finally, these studies provide a model system in which to evaluate effects of potential psychotherapeutic agents...
  39. ncbi request reprint Characterization of interactions between phencyclidine and amphetamine in rodent prefrontal cortex and striatum: implications in NMDA/glycine-site-mediated dopaminergic dysregulation and dopamine transporter function
    Henry Sershen
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States
    Neurochem Int 52:119-29. 2008
    ..The present studies also demonstrate pharmacokinetic interaction between AMPH and PCP, which may be of both clinical and research relevance...
  40. ncbi request reprint Timing of pure tone and noise-evoked responses in macaque auditory cortex
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Neuroreport 16:933-7. 2005
    ..Dissociation of broadband noise and pure tone latencies may reflect the use of parallel anatomical routes into belt regions...
  41. doi request reprint Loss aversion in schizophrenia
    Fabien Tremeau
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, United States
    Schizophr Res 103:121-8. 2008
    ..Loss aversion is conceived as an affective interference in cognitive processes such as judgment and decision-making. Loss aversion in non-risky choices has not been studied in schizophrenia...
  42. doi request reprint GABA(B) receptors, schizophrenia and sleep dysfunction: a review of the relationship and its potential clinical and therapeutic implications
    Joshua Kantrowitz
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    CNS Drugs 23:681-91. 2009
    ..Further study is needed...
  43. pmc Magnocellular contributions to impaired motion processing in schizophrenia
    Dongsoo Kim
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Schizophr Res 82:1-8. 2006
    ..Further, this study supports and extends prior reports of impaired motion processing in schizophrenia, and indicates significant bottom-up contributions to higher-order cognitive impairments...
  44. ncbi request reprint Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions
    Daniel C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric, Research, New York University School of Medicine, Orangeburg, New York 10962, USA
    Int Rev Neurobiol 78:69-108. 2007
    ..Finally, genetic linkage and in vivo neurochemical studies in schizophrenia highlight potential etiological mechanisms giving rise to glutamatergic/NMDA dysfunction in schizophrenia...
  45. doi request reprint Sensory deficits and distributed hierarchical dysfunction in schizophrenia
    David I Leitman
    Schizophrenia Research Center, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Am J Psychiatry 167:818-27. 2010
    ..Here the authors examined the relationship between lower- and higher-level dysfunction within the auditory domain using the event-related brain potentials mismatch negativity (MMN) and P300...
  46. pmc High dose D-serine in the treatment of schizophrenia
    Joshua T Kantrowitz
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research New York University Langone School of Medicine, Orangeburg, NY, United States
    Schizophr Res 121:125-30. 2010
    ..We describe the first evaluation of the efficacy and safety of d-serine at doses >30 mg/kg/day; a 4-week, open-label trial of adjunctive D-serine (30, 60 or 120 mg/kg/day)...
  47. ncbi request reprint Decoding schizophrenia
    Daniel C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute, Orangeburg, N Y, USA
    Sci Am 290:48-55. 2004
  48. ncbi request reprint Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping study
    Sophie Molholm
    Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Brain Res Cogn Brain Res 14:115-28. 2002
    ..This RT facilitation could not be accounted for by probability summation, as evidenced by violation of the 'race' model, providing compelling evidence that auditory-visual neural interactions give rise to this RT effect...
  49. ncbi request reprint Visual backward-masking deficits in schizophrenia: relationship to visual pathway function and symptomatology
    Pamela D Butler
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Schizophr Res 59:199-209. 2003
    ....
  50. ncbi request reprint Theory of Mind (ToM) and counterfactuality deficits in schizophrenia: misperception or misinterpretation?
    David I Leitman
    Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Psychol Med 36:1075-83. 2006
    ..Sarcastic detection ability has not previously been studied in schizophrenia, although patients have been shown to have deficits in ability to decode emotional information from speech ('affective prosody')...
  51. doi request reprint GABAB/NMDA receptor interaction in the regulation of extracellular dopamine levels in rodent prefrontal cortex and striatum
    Andrea Balla
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuropharmacology 56:915-21. 2009
    ..Both sites, therefore, may represent appropriate targets for drug development in schizophrenia and substance abuse disorders...
  52. ncbi request reprint Functional anatomy and interaction of fast and slow visual pathways in macaque monkeys
    Chi Ming Chen
    Cognitive Neuroscience and Schizophrenia Program, Nathan S Kline Institute, Orangeburg, NY 10962, USA
    Cereb Cortex 17:1561-9. 2007
    ..These findings support a "Framing" Model of ventral stream visual processing in which rapidly conducted inputs, mediated by one or more accessory pathways, modulate the processing of more slowly conducted feedforward inputs...
  53. doi request reprint Magnocellular pathway impairment in schizophrenia: evidence from functional magnetic resonance imaging
    Antigona Martinez
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 28:7492-500. 2008
    ....
  54. pmc It's all in the cards: effect of stimulus manipulation on Wisconsin Card Sorting Test performance in schizophrenia
    Joshua T Kantrowitz
    Department of Life Sciences, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Psychiatry Res 168:198-204. 2009
    ..Furthermore, progressive improvement was seen following repeated RFST administration. These findings demonstrate that stimulus characteristics, as well as executive deficits, contribute to impaired WCST performance in schizophrenia...
  55. ncbi request reprint Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine
    Gary S Linn
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 192:27-38. 2007
    ..NMDA receptors in brain are modulated by the amino acid glycine (GLY), which reverses neurochemical and behavioral effects of PCP in rodents. The present study investigates GLY effects on PCP-induced behavior in primates...
  56. ncbi request reprint Multisensory convergence in auditory cortex, I. Cortical connections of the caudal superior temporal plane in macaque monkeys
    John F Smiley
    Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Comp Neurol 502:894-923. 2007
    ..The differential connections of CM compared with adjacent areas provide additional evidence for the functional specialization of the individual auditory belt areas...
  57. pmc Altered volume and hemispheric asymmetry of the superficial cortical layers in the schizophrenia planum temporale
    John F Smiley
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Eur J Neurosci 30:449-63. 2009
    ..In schizophrenia, the thinner upper layers of the caudal PT suggest disrupted corticocortical processing, possibly affecting the multisensory integration and phonetic processing of this region...
  58. pmc Neurophysiological biomarkers for drug development in schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Schizophrenia Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Nat Rev Drug Discov 7:68-83. 2008
    ..Moreover, many of these neurophysiological processes are phylogenetically conserved and can be modelled in preclinical studies, offering unique opportunities for use as translational biomarkers in schizophrenia drug discovery...
  59. doi request reprint Impaired visual object processing across an occipital-frontal-hippocampal brain network in schizophrenia: an integrated neuroimaging study
    Pejman Sehatpour
    Conte Center for Schizophrenia Research, Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Arch Gen Psychiatry 67:772-82. 2010
    ....
  60. pmc Seeing the world dimly: the impact of early visual deficits on visual experience in schizophrenia
    Joshua T Kantrowitz
    Department of Life Sciences, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY, USA
    Schizophr Bull 35:1085-94. 2009
    ..01). This study replicates and expands upon previous findings with visual illusions. Our results offer a unifying explanation for disparate studies and suggest that deficits in early sensory gain affect subsequent integrative processes...
  61. pmc What's in a face? Effects of stimulus duration and inversion on face processing in schizophrenia
    Pamela D Butler
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Schizophr Res 103:283-92. 2008
    ..Similar inversion effects for face part and spacing for both groups suggest that they are using the same holistic face processing mechanism...
  62. pmc Sensory contributions to impaired emotion processing in schizophrenia
    Pamela D Butler
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Schizophr Bull 35:1095-107. 2009
    ..These results provide evidence for a contribution of impaired early-stage visual processing in emotion recognition deficits in schizophrenia and suggest that a bottom-up approach to remediation may be effective...
  63. pmc Has an important test been overlooked? Closure flexibility in schizophrenia
    Pamela D Butler
    Schizophrenia Research Center, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, United States
    Schizophr Res 118:20-5. 2010
    ..In addition, the CFT is a brief, easy to administer alphabet-independent, paper-and-pencil test with established psychometric properties that may be useful as an index of the sustained visual attention construct in schizophrenia...
  64. pmc The leading sense: supramodal control of neurophysiological context by attention
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Neuron 64:419-30. 2009
    ..These findings outline a supramodal mechanism by which attention can control neurophysiological context, thus determining the representation of specific sensory content in primary sensory cortex...
  65. pmc Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 117:13-20. 2010
    ..These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed...
  66. ncbi request reprint Auditory-somatosensory multisensory processing in auditory association cortex: an fMRI study
    John J Foxe
    The Cognitive Neurophysiology Laboratory, Cognitive Neuroscience and Schizophrenia Program, New York City, New York 10016, USA
    J Neurophysiol 88:540-3. 2002
    ....
  67. pmc Preattentively grouped tones do not elicit MMN with respect to each other
    Walter Ritter
    Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Psychophysiology 43:423-30. 2006
    ..This implies that once acoustic input has been preattentively grouped, the MMN system is dedicated to detecting changes that occur within but not between preattentively grouped stimuli...
  68. ncbi request reprint Right hemisphere control of visuospatial attention: line-bisection judgments evaluated with high-density electrical mapping and source analysis
    John J Foxe
    The Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroimage 19:710-26. 2003
    ..Further, at 3% contrast, the line-bisection effect was equivalent to the effects seen at higher contrast levels, suggesting that parvocellular inputs are not necessary for successful performance of this task...
  69. ncbi request reprint Don't think of a white bear: an fMRI investigation of the effects of sequential instructional sets on cortical activity in a task-switching paradigm
    Glenn R Wylie
    Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Hum Brain Mapp 21:279-97. 2004
    ..Our data also revealed widespread activation of a frontoparietal network of areas, and we discuss how this network might be involved in mediating this competition...
  70. ncbi request reprint Changing plans: neural correlates of executive control in monkey and human frontal cortex
    Elisa C Dias
    Program in Cognitive Neurosciences and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Exp Brain Res 174:279-91. 2006
    ..We suggest that simultaneous activation of both types of subregions in conflict conditions may account the ubiquitous ACC activation observed with fMRI and ERP in those conditions...
  71. pmc Early-stage visual processing and cortical amplification deficits in schizophrenia
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 62:495-504. 2005
    ..Investigating magnocellular dysfunction in schizophrenia therefore permits evaluation of underlying etiologic hypotheses...
  72. pmc Reading impairment and visual processing deficits in schizophrenia
    Nadine Revheim
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 87:238-45. 2006
    ..Findings related to symptoms, functioning and recommendations for reading ability assessment are discussed...
  73. ncbi request reprint The neural circuitry of pre-attentive auditory change-detection: an fMRI study of pitch and duration mismatch negativity generators
    Sophie Molholm
    The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Cereb Cortex 15:545-51. 2005
    ..We also detail regions of the frontal and parietal cortices activated by change-detection processes. These regions also show feature dependence and we hypothesize that they reflect recruitment of attention-switching mechanisms...
  74. pmc A new dimension of sensory dysfunction: stereopsis deficits in schizophrenia
    Isaac Schechter
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Biol Psychiatry 60:1282-4. 2006
    ..Early visual processing has been shown to be especially impaired. This article investigates the integrity of binocular depth perception (stereopsis) in schizophrenia...
  75. ncbi request reprint MRI study of white matter diffusion anisotropy in schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuroreport 14:2025-9. 2003
    ..Regions showing reduced white matter fractional anisotropy are known to be abnormal in schizophrenia. The voxelwise method used in the current study can provide the basis for hypothesis-driven research...
  76. pmc Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Brain 130:417-30. 2007
    ....
  77. ncbi request reprint Glycine modulators in schizophrenia
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg 10962, USA
    Curr Opin Investig Drugs 3:1067-72. 2002
    ....
  78. ncbi request reprint Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys
    Gary S Linn
    The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 169:234-9. 2003
    ..g. phencyclidine (PCP)], whereas atypical antipsychotics (e.g. clozapine) reverse PPI deficits induced by DA agonists and NMDA antagonists. However, some discrepancies exist with some compounds and strains of rodents...
  79. pmc Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Neuroreport 16:1455-9. 2005
    ..Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia...
  80. ncbi request reprint Changing plans: a high density electrical mapping study of cortical control
    Elisa C Dias
    Cognitive Neurophysiology Laboratory, Program in Cognitive Neurosciences and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Cereb Cortex 13:701-15. 2003
    ..Similar patterns of activation were observed whether the changes in preparation were triggered by cue or target stimuli, though target-elicited potentials peaked earlier...
  81. pmc Visual white matter integrity in schizophrenia
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg NY, 10962, USA
    Am J Psychiatry 163:2011-3. 2006
    ..Patients with schizophrenia have visual-processing deficits. This study examines visual white matter integrity as a potential mechanism for these deficits...
  82. doi request reprint Anticipated, on-line and remembered positive experience in schizophrenia
    Fabien Tremeau
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Schizophr Res 122:199-205. 2010
    ..Moreover, the role of positive affect evaluations on motivation has rarely been studied in schizophrenia...
  83. pmc DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Neuroreport 15:2467-70. 2004
    ..These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks...
  84. ncbi request reprint Neurocognitive and symptom correlates of daily problem-solving skills in schizophrenia
    Nadine Revheim
    Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 83:237-45. 2006
    ..The findings suggest the ILS-PB has utility as a proxy measure for assessing real-world functioning in schizophrenia...
  85. doi request reprint A review of tolerability and abuse liability of gamma-hydroxybutyric acid for insomnia in patients with schizophrenia
    Joshua T Kantrowitz
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Clin Ther 31:1360-73. 2009
    ..A tolerability concern regarding use of GHB is its abuse potential. Given the high comorbidity of substance disorders and schizophrenia, a systematic assessment of the published literature is crucial...
  86. pmc Amygdalofrontal functional disconnectivity and aggression in schizophrenia
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Bull 36:1020-8. 2010
    ..Similar results were obtained for 2 other measures--Life History of Aggression and total arrests. These results suggest that amygdala/vPFC FC is compromised in schizophrenia and that this compromise is associated with aggression...
  87. ncbi request reprint Magnocellular and parvocellular contributions to backward masking dysfunction in schizophrenia
    Isaac Schechter
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 64:91-101. 2003
    ..Furthermore, deficits of letter identification, including those of P targets, may also reflect impairment of the M pathway given the priming function of the dorsal stream...
  88. ncbi request reprint Sensitive and simple gas chromatographic-mass spectrometric determination for amphetamine in microdialysate and ultrafiltrate samples
    Shan Xie
    Analytical Psychopharmacology Laboratory, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 805:27-31. 2004
    ..The within-day precision was from 1.7 to 5.1% and between-day precision was from 2.2 to 7.3%. The method has been used for the measurement of several thousand microdialysate and ultrafiltrate samples and proven reliable...
  89. doi request reprint Early sensory contributions to contextual encoding deficits in schizophrenia
    Elisa C Dias
    Center for Translational Schizophrenia Research, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 68:654-64. 2011
    ..Event-related potentials (ERP) provide an objective index of brain function and can be used to evaluate brain substrates underlying impaired cognition in schizophrenia...
  90. ncbi request reprint Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI
    A M Clare Kelly
    Department of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
    Eur J Neurosci 19:3105-12. 2004
    ....
  91. ncbi request reprint Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, Jerusalem, Israel
    Am J Psychiatry 159:480-2. 2002
    ..The authors investigated the clinical effects of D-cycloserine when added to treatment with conventional neuroleptics, olanzapine, or risperidone for treatment-resistant schizophrenia...
  92. ncbi request reprint Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis
    Uriel Heresco-Levy
    Ezrath Nashim Sarah Herzog Memorial Hospital, P O Box 35300, Givat Shaul, Jerusalem, Israel
    Schizophr Res 66:89-96. 2004
    ..Overall, the findings indicate that agents which potentiate NMDA transmission may be therapeutically beneficial in treatment of persistent symptoms of schizophrenia...
  93. ncbi request reprint High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia
    Uriel Heresco-Levy
    Ezrath Nashim Herzog Memorial Hospital, Department of Psychiatry, Hadassah Medical School Hebrew University, Jerusalem, Israel
    Biol Psychiatry 55:165-71. 2004
    ..In this study, we assessed whether high-dose glycine may also be therapeutically beneficial when added to olanzapine and risperidone treatment...
  94. ncbi request reprint Predicting success: patterns of cortical activation and deactivation prior to response inhibition
    Robert L Hester
    Trinity College, Dublin, Ireland
    J Cogn Neurosci 16:776-85. 2004
    ....
  95. ncbi request reprint Filling-in in schizophrenia: a high-density electrical mapping and source-analysis investigation of illusory contour processing
    John J Foxe
    Program in Cognitive Neuroscience, Department of Psychology, The City College of the City University of New York, North Academic Complex NAC 138th St and Convent Avenue, New York, NY 10031, USA
    Cereb Cortex 15:1914-27. 2005
    ....
  96. pmc Recent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia
    Robert W Buchanan
    Schizophr Bull 33:1120-30. 2007
    ..This article reviews the rationale for these 3 approaches and provides an update on the development of therapeutic agents, which act through one of these 3 mechanisms...
  97. pmc Perceptual organization by proximity and similarity in schizophrenia
    Daniel D Kurylo
    Psychology Department, Brooklyn College CUNY, 2900 Bedford Avenue, Brooklyn, NY 11210, USA
    Schizophr Res 95:205-14. 2007
    ..Although this study did not directly investigate the physiological correlates underlying perceptual impairments, these results are consistent with a theory of impaired lateral connections within visual cortical areas in schizophrenia...
  98. ncbi request reprint The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    Robert W Buchanan
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Am J Psychiatry 164:1593-602. 2007
    ..Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments...
  99. ncbi request reprint Impaired multisensory processing in schizophrenia: deficits in the visual enhancement of speech comprehension under noisy environmental conditions
    Lars A Ross
    Program in Cognitive Neuroscience, Department of Psychology, The City College of City University of New York, 138th St and Convent Avenue, New York, New York 10031, USA
    Schizophr Res 97:173-83. 2007
    ..Our objective was to determine to what extent they experience benefit from visual articulation and to detail under what listening conditions they might show the greatest impairments...
  100. ncbi request reprint Early visual processing deficits in dysbindin-associated schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Biol Psychiatry 63:484-9. 2008
    ..We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype...
  101. ncbi request reprint High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients
    Uriel Heresco-Levy
    Psychiatry and Research Department, Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Givat Shaul 91351, Jerusalem, Israel
    Schizophr Res 91:14-21. 2007
    ..4, p=0.03). These preliminary findings indirectly support previous observations on ketamine effects upon PPI in humans and suggest a dissociation of symptomatology and PPI changes as function of NMDAR modulation in schizophrenia...

Research Grants38

  1. TREATMENT OF NEGATIVE SYMPTOMS AND COGNITIVE IMPAIRMENTS
    Daniel Javitt; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d-cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  2. MECHANISMS OF COGNITIVE DYSFUNCTION IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2005
    ..This study will evaluate neurophysiological and neurochemical hypotheses concerning potential etiology of early sensory processing dysfunction in schizophrenia. ..
  3. Phencyclidine Abuse and Psychoses: Biomedical Mechanisms
    Daniel Javitt; Fiscal Year: 2005
    ....
  4. NEUROPHYSIOLOGICAL NMDA DYSFUNCTION IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2006
    ..The research will build upon studies currently supported by NIH research and career development awards to the candidate, and will permit the candidate to continue to devote >75 percent effort to research. ..
  5. EARLY CORTICAL PROCESSING IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2007
    ..Finally, this project will begin to evaluate the degree to which separate deficits in auditory and visual processing lead to impairments in higher order processes. ..
  6. D-Serine Treatment of Schizophrenia
    Daniel Javitt; Fiscal Year: 2007
    ..Together these projects will validate treatment targets for NMDA agonists in general and D-serine in particular and will encourage continued clinical development. ..
  7. Phencyclidine Abuse & Psychosis: Biomedical Mechanisms
    Daniel Javitt; Fiscal Year: 2007
    ....
  8. EARLY CORTICAL PROCESSING IN SCHIZOPHRENIA
    Daniel Javitt; Fiscal Year: 2002
    ..It is hypothesized that MMN dysfunction, along with other cognitive dysfunction, will serve as a marker for poor outcome and an objective index for investigating underlying intracortical mechanisms. ..
  9. PHENCYCLIDINE ABUSE AND PSYCHOSIS--BIOMEDICAL MECHANISMS
    Daniel Javitt; Fiscal Year: 2000
    ....
  10. High-Density ERP mapping & FMRI
    Daniel Javitt; Fiscal Year: 2002
    ..The equipment will also permit monitoring of background EEG during both human and animal studies. Software is requested for state-of-the-art ERP dipole mapping and ERP/MRI co-registration. ..
  11. Phencyclidine Abuse & Psychosis: Biomedical Mechanisms
    Daniel C Javitt; Fiscal Year: 2010
    ....