D C Javitt

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi request reprint Impaired precision, but normal retention, of auditory sensory ("echoic") memory information in schizophrenia
    D C Javitt
    Department of Psychiatry, Albert Einstein College of Medicine Bronx Psychiatric Center, USA
    J Abnorm Psychol 106:315-24. 1997
  2. ncbi request reprint Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10692, USA
    Psychopharmacology (Berl) 129:96-8. 1997
  3. ncbi request reprint Inhibition of striatal dopamine release by glycine and glycyldodecylamide
    D C Javitt
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Brain Res Bull 52:213-6. 2000
  4. ncbi request reprint Schizophrenia-like deficits in auditory P1 and N1 refractoriness induced by the psychomimetic agent phencyclidine (PCP)
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, USA
    Clin Neurophysiol 111:833-6. 2000
  5. ncbi request reprint Multisensory auditory-somatosensory interactions in early cortical processing revealed by high-density electrical mapping
    J J Foxe
    Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, 10962, Orangeburg, NY, USA
    Brain Res Cogn Brain Res 10:77-83. 2000
  6. ncbi request reprint Visual perceptual learning in human object recognition areas: a repetition priming study using high-density electrical mapping
    G M Doniger
    Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroimage 13:305-13. 2001
  7. ncbi request reprint Visuo-spatial neural response interactions in early cortical processing during a simple reaction time task: a high-density electrical mapping study
    M M Murray
    Cognitive Neuroscience and Schizophrenia Program, Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuropsychologia 39:828-44. 2001
  8. ncbi request reprint Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 57:1131-7. 2000
  9. ncbi request reprint Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Audiol Neurootol 5:207-15. 2000
  10. ncbi request reprint Auditory sensory dysfunction in schizophrenia: imprecision or distractibility?
    E F Rabinowicz
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 57:1149-55. 2000

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Impaired precision, but normal retention, of auditory sensory ("echoic") memory information in schizophrenia
    D C Javitt
    Department of Psychiatry, Albert Einstein College of Medicine Bronx Psychiatric Center, USA
    J Abnorm Psychol 106:315-24. 1997
    ..These findings demonstrate that schizophrenic may be in the sensitivity of the system rather than the duration for which memory traces were retained...
  2. ncbi request reprint Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10692, USA
    Psychopharmacology (Berl) 129:96-8. 1997
    ....
  3. ncbi request reprint Inhibition of striatal dopamine release by glycine and glycyldodecylamide
    D C Javitt
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Brain Res Bull 52:213-6. 2000
    ..Glycine and GDA significantly inhibit NMDA-induced striatal dopamine release, consistent with their ability to enhance local striatal inhibitory neurotransmission in vitro and to reverse PCP-induced hyperactivity in vivo...
  4. ncbi request reprint Schizophrenia-like deficits in auditory P1 and N1 refractoriness induced by the psychomimetic agent phencyclidine (PCP)
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, The Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, USA
    Clin Neurophysiol 111:833-6. 2000
    ..The present study investigates P1 and N1 refractoriness in the awake monkey in order to investigate underlying mechanisms...
  5. ncbi request reprint Multisensory auditory-somatosensory interactions in early cortical processing revealed by high-density electrical mapping
    J J Foxe
    Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, 10962, Orangeburg, NY, USA
    Brain Res Cogn Brain Res 10:77-83. 2000
    ..Both the topography and timing of these interactions are consistent with multisensory integration early in the cortical processing hierarchy, in brain regions traditionally held to be unisensory...
  6. ncbi request reprint Visual perceptual learning in human object recognition areas: a repetition priming study using high-density electrical mapping
    G M Doniger
    Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroimage 13:305-13. 2001
    ..That the earliest priming-related activity occurs over LO complex, suggests that the sensory trace itself may reside in these object recognition areas...
  7. ncbi request reprint Visuo-spatial neural response interactions in early cortical processing during a simple reaction time task: a high-density electrical mapping study
    M M Murray
    Cognitive Neuroscience and Schizophrenia Program, Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuropsychologia 39:828-44. 2001
    ..Interaction effects place an upper limit on the time required for neuronal ensembles to combine inputs from different quadrants of visual space ( approximately 72 ms for unilateral and approximately 82 ms for bilateral conditions)...
  8. ncbi request reprint Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 57:1131-7. 2000
    ..The AX-CPT is designed to assess prefrontal function, whereas mismatch negativity assesses functioning of the auditory sensory memory system...
  9. ncbi request reprint Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Audiol Neurootol 5:207-15. 2000
    ..Deficits in MMN generation may also be seen following focal cortical damage, especially to the dorsolateral prefrontal cortex. MMN thus provides a useful tool for investigating mechanisms underlying brain dysfunction in schizophrenia...
  10. ncbi request reprint Auditory sensory dysfunction in schizophrenia: imprecision or distractibility?
    E F Rabinowicz
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 57:1149-55. 2000
    ..The present study evaluates susceptibility of schizophrenic subjects to same-modality distraction to determine whether patients fit a "bitemporal" or "prefrontal" model of sensory dysfunction...
  11. ncbi request reprint Continuous phencyclidine treatment induces schizophrenia-like hyperreactivity of striatal dopamine release
    A Balla
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuropsychopharmacology 25:157-64. 2001
    ..These findings support the concept that NMDA receptor dysfunction may contribute to dopaminergic dysfunction in schizophrenia...
  12. ncbi request reprint Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Mol Psychiatry 10:275-87. 2005
    ....
  13. pmc Expectancy-related modulations of neural oscillations in continuous performance tasks
    S Bickel
    Center for Schizophrenia Research, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuroimage 62:1867-76. 2012
    ..These results provide a basis for investigating the differential neural underpinnings of oscillatory cognitive control deficits observed in various patient populations...
  14. ncbi request reprint Adjunctive high-dose glycine in the treatment of schizophrenia
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Int J Neuropsychopharmacol 4:385-91. 2001
    ..Significant clinical effects were observed despite the fact that the majority of subjects were receiving atypical antipsychotics (clozapine or olanzapine). As in earlier studies, improvement persisted following glycine discontinuation...
  15. ncbi request reprint Early visual processing deficits in schizophrenia: impaired P1 generation revealed by high-density electrical mapping
    J J Foxe
    Cognitive Neurophysiology Laboratory, Cognitive Neuroscience and Schizophrenia Program, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroreport 12:3815-20. 2001
    ..These results imply that the cognitive impairment seen in schizophrenia is not just due to deficits in higher order aspects of cognition but also encompasses significant deficits in early sensory processing...
  16. ncbi request reprint Associated deficits in mismatch negativity generation and tone matching in schizophrenia
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg, NY 10962, USA
    Clin Neurophysiol 111:1733-7. 2000
    ..Both deficits reflect impaired early cortical processing of auditory information. However, the relationship between deficits in MMN generation and tone matching performance in schizophrenia has not been established...
  17. ncbi request reprint Attention-dependent suppression of distracter visual input can be cross-modally cued as indexed by anticipatory parieto-occipital alpha-band oscillations
    K M Fu
    Cognitive Neurophysiology Laboratory, Nathan Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Brain Res Cogn Brain Res 12:145-52. 2001
    ..Taken together, the results of this series of studies suggest that these parietal regions are capable of integrating sensory cues from multiple sensory modalities in order to program the subsequent deployment of visual attention...
  18. ncbi request reprint Effects of phencyclidine on prepulse inhibition of acoustic startle response in the macaque
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Psychopharmacology (Berl) 156:165-8. 2001
    ..In rodents, phencyclidine (PCP) and other N-methyl-D-aspartate receptor (NMDAR) antagonists induce schizophrenia-like PPI deficits. Similar effects have recently been observed in a New World monkey species, Cebus apella...
  19. ncbi request reprint Panmodal processing imprecision as a basis for dysfunction of transient memory storage systems in schizophrenia
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Schizophr Bull 25:763-75. 1999
    ..The severe deficits in processing precision, despite the relatively preserved maintenance of representation, may be relevant to pathophysiological models of schizophrenia...
  20. ncbi request reprint Phencyclidine (PCP)-induced deficits of prepulse inhibition in monkeys
    G S Linn
    The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuroreport 12:117-20. 2001
    ..The ability of PCP to induce schizophrenia-like deficits in PPI suggests that PPI in nonhuman primates may provide an important animal model for the development of novel anti-schizophrenia medications...
  21. ncbi request reprint Glutamate as a therapeutic target in psychiatric disorders
    D C Javitt
    Program in Cognitive Neuroscience and Schizophrenia, Nathan Kline Institute for Psychiatric Research New York University School of Medicine, Orangeburg, NY 10962, USA
    Mol Psychiatry 9:984-97, 979. 2004
    ..Other conditions for which glutamate modulators may prove effective include stroke, epilepsy, Alzheimer disease and PTSD...
  22. ncbi request reprint Nitric oxide synthase interneurons in the monkey cerebral cortex are subsets of the somatostatin, neuropeptide Y, and calbindin cells
    J F Smiley
    The Program in Cognitive Neurology and Schizophrenia, Nathan Kline Institute, Bldng 39, 140 Old Orangeburg Rd, Orangeburg, NY, USA
    Brain Res 863:205-12. 2000
    ..Nevertheless, neuropeptide Y-immunoreactivity provides a useful marker for LNOS cells, because it is very dense in these cells and only light in the interneurons that lack nNOS...
  23. ncbi request reprint Somatosensory input to auditory association cortex in the macaque monkey
    C E Schroeder
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg 10962, New York, New York 10003, USA
    J Neurophysiol 85:1322-7. 2001
    ..No somatosensory responses were observed in A1. These findings suggest a potential neural substrate for multisensory integration at an early stage of auditory cortical processing...
  24. ncbi request reprint Phencyclidine-induced dysregulation of dopamine response to amphetamine in prefrontal cortex and striatum
    A Balla
    Nathan S. Kline Institute, Orangeburg, NY 10962, USA
    Neurochem Res 26:1001-6. 2001
    ....
  25. ncbi request reprint Impaired sensory processing as a basis for object-recognition deficits in schizophrenia
    G M Doniger
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Am J Psychiatry 158:1818-26. 2001
    ..Furthermore, this work suggests that deficits in perceptual closure may contribute to the muted world experience of patients with the persistent negative symptoms of schizophrenia...
  26. ncbi request reprint Management of negative symptoms of schizophrenia
    D C Javitt
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Curr Psychiatry Rep 3:413-7. 2001
    ..Whether or not these agents are effective in combination with clozapine remains an open question, and large scale multicenter clinical trials are ongoing...
  27. pmc Visual form perception: a comparison of individuals at high risk for psychosis, recent onset schizophrenia and chronic schizophrenia
    D Kimhy
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Schizophr Res 97:25-34. 2007
    ..These deficits are discussed in the context of the putative neurobiological underpinnings of visual deficits and the developmental pathophysiology of psychosis in schizophrenia...
  28. ncbi request reprint Jumping the gun: is effective preparation contingent upon anticipatory activation in task-relevant neural circuitry?
    G R Wylie
    The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Cereb Cortex 16:394-404. 2006
    ..In contrast, subjects showed considerable behavioral costs when switching to the motion task, evincing a lack of effective preparation, borne out by the fact that motion circuits were silent during the preparatory period...
  29. ncbi request reprint Chronic high-dose glycine nutrition: effects on rat brain cell morphology
    S Shoham
    Research Department, Ezrath Nashim-Herzog Memorial Hospital, Jerusalem, Israel
    Biol Psychiatry 49:876-85. 2001
    ..A reduction in density of class B, N-type Ca(2+) channels in specific brain regions may represent one general adaptation to long-term, high-dose glycine treatment...
  30. ncbi request reprint The role of response requirements in task switching: dissolving the residue
    G R Wylie
    The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroreport 15:1079-87. 2004
    ..These data call into question models of executive control that interpret switch costs as reflecting the time taken by neural processes to switch the system from a readiness to perform one task to a readiness to perform another...
  31. ncbi request reprint Cognitive control processes during an anticipated switch of task
    G R Wylie
    The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, New York 10962, USA
    Eur J Neurosci 17:667-72. 2003
    ....
  32. ncbi request reprint Objects are highlighted by spatial attention
    A Martinez
    Dept of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Cogn Neurosci 18:298-310. 2006
    ..We conclude that object-selective attention shares a common neural mechanism with spatial attention that entails the facilitation of sensory processing of stimuli within the boundaries of an attended object...
  33. ncbi request reprint Task switching: a high-density electrical mapping study
    G R Wylie
    The Cognitive Neurophysiology Laboratory, Program in Cognitive Neuroscience and Schizophrenia, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroimage 20:2322-42. 2003
    ..Our findings are difficult to account for with models that posit a strong role for frontal cortical regions in "reconfiguring" the system during switches of task...