Basalingappa Hungund

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi Ethanol, endocannabinoids, and the cannabinoidergic signaling system
    Basalingappa L Hungund
    New York State Psychiatric Institute and the Nathan Kline Institute, Orangeburg, New York 10962, USA
    Alcohol Clin Exp Res 26:565-74. 2002
  2. ncbi Distinct differences in the cannabinoid receptor binding in the brain of C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption
    B L Hungund
    New York State Psychiatric Institute at NKI, Orangeburg, NY 10962, USA
    J Neurosci Res 60:122-8. 2000
  3. ncbi Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors
    Basalingappa L Hungund
    New York State Psychiatric Institute, New York 10032, USA
    Ann N Y Acad Sci 1025:515-27. 2004
  4. ncbi Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims
    B L Hungund
    New York State Psychiatric Institute, New York, NY 10962, USA
    Mol Psychiatry 9:184-90. 2004
  5. ncbi Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens
    Basalingappa L Hungund
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, NY, USA
    J Neurochem 84:698-704. 2003
  6. ncbi The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
    Soren V Siegmund
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    FASEB J 21:2798-806. 2007
  7. ncbi Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol
    K Yaragudri Vinod
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, USA
    J Neurochem 104:233-43. 2008
  8. ncbi Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system
    K Yaragudri Vinod
    Department of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, NY, USA
    Neurochem Int 49:619-25. 2006
  9. ncbi Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice
    Balapal S Basavarajappa
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, USA
    Neuropharmacology 50:834-44. 2006
  10. ncbi Pharmacological manipulation of CB1 receptor function alters development of tolerance to alcohol
    Karen L Nowak
    New York State Psychiatric Institute, New York, NY, USA
    Alcohol Alcohol 41:24-32. 2006

Research Grants

  1. ENDOCANNABINOIDS AND VOLUNTARY ETHANOL CONSUMPTION
    Basalingappa Hungund; Fiscal Year: 2006
  2. CANNABINOIDERGIC CONTROL OF ALCOHOL RELATED BEHAVIORS
    Basalingappa Hungund; Fiscal Year: 2006

Collaborators

Detail Information

Publications21

  1. ncbi Ethanol, endocannabinoids, and the cannabinoidergic signaling system
    Basalingappa L Hungund
    New York State Psychiatric Institute and the Nathan Kline Institute, Orangeburg, New York 10962, USA
    Alcohol Clin Exp Res 26:565-74. 2002
    ....
  2. ncbi Distinct differences in the cannabinoid receptor binding in the brain of C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption
    B L Hungund
    New York State Psychiatric Institute at NKI, Orangeburg, NY 10962, USA
    J Neurosci Res 60:122-8. 2000
    ..These results suggest that CB1 receptor signal transduction may play an important role in controlling the voluntary EtOH consumption by these strains of mice...
  3. ncbi Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors
    Basalingappa L Hungund
    New York State Psychiatric Institute, New York 10032, USA
    Ann N Y Acad Sci 1025:515-27. 2004
    ..Ongoing investigations may lead to the development of potential therapeutic agents to modulate the endocannabinoid signaling system, which will be helpful for the treatment of alcoholism...
  4. ncbi Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims
    B L Hungund
    New York State Psychiatric Institute, New York, NY 10962, USA
    Mol Psychiatry 9:184-90. 2004
    ..The cannabinoidergic system may be a novel therapeutic target in the treatment of depression and/or suicidal behavior...
  5. ncbi Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol-induced dopamine release in the nucleus accumbens
    Basalingappa L Hungund
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, NY, USA
    J Neurochem 84:698-704. 2003
    ..These results strongly suggest that the CB1 receptor system plays an important role in regulating the positive reinforcing properties of alcohol...
  6. ncbi The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
    Soren V Siegmund
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    FASEB J 21:2798-806. 2007
    ..These findings suggest that 2-AG may act as an antifibrogenic mediator in the liver by inducing cell death in activated HSCs but not hepatocytes...
  7. ncbi Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol
    K Yaragudri Vinod
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, USA
    J Neurochem 104:233-43. 2008
    ..Treatment with drugs that decrease AEA tone might prove useful in reducing excessive ethanol consumption...
  8. ncbi Effect of chronic ethanol exposure and its withdrawal on the endocannabinoid system
    K Yaragudri Vinod
    Department of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, NY, USA
    Neurochem Int 49:619-25. 2006
    ..Taken together, the neuroadaptation in the EC system may have a potential role in development of tolerance and dependence to EtOH...
  9. ncbi Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice
    Balapal S Basavarajappa
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, USA
    Neuropharmacology 50:834-44. 2006
    ..Thus, the data suggest that FAAH may be indirectly related to ethanol intake and sensitivity and central endocannabinoidergic-mediated pathways may regulate ethanol consumption...
  10. ncbi Pharmacological manipulation of CB1 receptor function alters development of tolerance to alcohol
    Karen L Nowak
    New York State Psychiatric Institute, New York, NY, USA
    Alcohol Alcohol 41:24-32. 2006
    ..CONCLUSIONS: The data support a role for the endocannabinoid (EC) system in EtOH tolerance/dependence and suggest that drugs targeted against EC system could be therapeutically useful in treating alcohol-related disorders...
  11. ncbi Endocannabinoid lipids and mediated system: implications for alcoholism and neuropsychiatric disorders
    K Yaragudri Vinod
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, New York, USA
    Life Sci 77:1569-83. 2005
    ..This article presents a comprehensive overview of the currently available literature pertaining to the role of the EC system in alcoholism, schizophrenia, depression and/or suicide...
  12. ncbi 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Mol Neurosci 26:1-15. 2005
    ....
  13. ncbi The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in Canavan disease-like rats
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962, USA
    Neurochem Res 27:403-6. 2002
    ..This is the first pharmacological investigation of the effect of drugs on the level of brain NAA in an animal model of CD, and the first report of a substance that can reduce the brain NAA level in this model...
  14. ncbi Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons
    Balapal S Basavarajappa
    New York State Psychiatric Institute, New York, NY 10032, USA
    Eur J Pharmacol 466:73-83. 2003
    ....
  15. ncbi Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice
    K Yaragudri Vinod
    Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Synapse 62:574-81. 2008
    ..Innate differences in the CB(1) receptor function might be one of the contributing factors for higher ethanol drinking behavior. The antagonists of the CB(1) receptor may have therapeutic potential in the treatment of ethanol dependence...
  16. ncbi Role of the endocannabinoid system in the development of tolerance to alcohol
    Balapal S Basavarajappa
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol Alcohol 40:15-24. 2005
    ..Ongoing investigations may lead to a better understanding of the mechanisms underlying the development of tolerance to alcohol and to develop therapeutic strategies to treat alcoholism...
  17. ncbi Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims
    K Yaragudri Vinod
    Department of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Biol Psychiatry 57:480-6. 2005
    ..EC system may be a novel therapeutic target for the treatment of suicidal behavior...
  18. ncbi Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease
    Takahide Kaji
    Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Am J Pathol 165:795-805. 2004
    ....
  19. ncbi Cannabinoid-1 receptor: a novel target for the treatment of neuropsychiatric disorders
    K Yaragudri Vinod
    New York State Psychiatric Institute, Division of Analytical Psychopharmacology, New York, USA
    Expert Opin Ther Targets 10:203-10. 2006
    ....
  20. ncbi Role of the endocannabinoid system in depression and suicide
    K Yaragudri Vinod
    Division of Analytical Psychopharmacology, New York State Psychiatric Institute, NY 10032, USA
    Trends Pharmacol Sci 27:539-45. 2006
    ..Here, we provide a brief overview of the role of the EC system in alcoholism, depression and suicide, and discuss possible therapeutic interventions and directions for future research...
  21. ncbi Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice
    Mauro A M Carai
    C N R Institute of Neuroscience, Cagliari, Viale Armando Diaz 182, I 09126 Cagliari, Italy
    Br J Pharmacol 148:1043-50. 2006
    ....

Research Grants7

  1. ENDOCANNABINOIDS AND VOLUNTARY ETHANOL CONSUMPTION
    Basalingappa Hungund; Fiscal Year: 2006
    ..abstract_text> ..
  2. CANNABINOIDERGIC CONTROL OF ALCOHOL RELATED BEHAVIORS
    Basalingappa Hungund; Fiscal Year: 2006
    ..Studies with synthetic analogues of ANA or other agonists and antagonists will open up new avenues in alcohol research. ..