Koon Sea Hui

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi request reprint A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
    Stanislav L Karsten
    Program in Neurogenetics, Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 51:549-60. 2006
  2. pmc Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis
    Guijie Ren
    Division of Neuroscience, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Mol Neurodegener 6:29. 2011
  3. ncbi request reprint Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration
    Koon Sea Hui
    Peptide Research Laboratory, Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 32:2062-71. 2007
  4. pmc A new type of neuron-specific aminopeptidase NAP-2 in rat brain synaptosomes
    Maria Hui
    Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Int 53:317-24. 2008
  5. ncbi request reprint A novel aminopeptidase with highest preference for lysine
    Maria Hui
    Peptide Research Laboratory, Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA
    Neurochem Res 31:95-102. 2006
  6. ncbi request reprint Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development
    Maria Hui
    Peptide Research Laboratory, Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Neurochem Res 28:855-60. 2003

Collaborators

  • R W Berry
  • Maria Hui
  • Stanislav L Karsten
  • Guijie Ren
  • Zhongcai Ma
  • Lili C Kudo
  • Lester I Binder
  • Tzu Kang Sang
  • Shreyasi Chatterjee
  • Harry V Vinters
  • Justine Pomakian
  • Jiankai Liu
  • Lauren T Gehman
  • Hyun S Oh
  • Soma Sengupta
  • George M Lawless
  • Daniel H Geschwind
  • Martina Wiedau-Pazos
  • Cordula Schulz
  • George R Jackson

Detail Information

Publications6

  1. ncbi request reprint A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration
    Stanislav L Karsten
    Program in Neurogenetics, Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 51:549-60. 2006
    ..Further investigation is warranted in defining the role of PSA and other genes identified here as potential therapeutic targets in tauopathy...
  2. pmc Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis
    Guijie Ren
    Division of Neuroscience, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Mol Neurodegener 6:29. 2011
    ..These results implicate SOD1 as a new target protein of PSA/NPEPPS and point to the possible neuroprotective role of PSA/NPEPPS in ALS...
  3. ncbi request reprint Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration
    Koon Sea Hui
    Peptide Research Laboratory, Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 32:2062-71. 2007
    ..Therefore, use of the puromycin-sensitive neuron-aminopeptidase NAP could provide neuroprotective mechanisms in AD and similar neurodegenerative diseases...
  4. pmc A new type of neuron-specific aminopeptidase NAP-2 in rat brain synaptosomes
    Maria Hui
    Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Int 53:317-24. 2008
    ..05microM. The data indicate that the enzyme is a new type of NAP found in rodent. Its possible function in neuron growth, neurodegeneration, and carcinomas is discussed...
  5. ncbi request reprint A novel aminopeptidase with highest preference for lysine
    Maria Hui
    Peptide Research Laboratory, Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA
    Neurochem Res 31:95-102. 2006
    ..However, metals could not restore KAP's activity after it was dialyzed against EGTA. Our data indicated that rat KAP did not resemble any aminopeptidases as well as the microbial lysine aminopeptidases...
  6. ncbi request reprint Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development
    Maria Hui
    Peptide Research Laboratory, Neurochemistry Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Neurochem Res 28:855-60. 2003
    ..Puromycin (1-5 microM) blocked neurite outgrowth and caused apoptosis by nonantibiotic effects. Our data suggest that the synaptosome-enriched NAP plays a role in neuron growth, differentiation, and information programming...