Matthew Hoptman

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi request reprint Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study
    Matthew J Hoptman
    Division of Clinical Research and the Center for Advanced Brain Imaging, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Biol Psychiatry 52:9-14. 2002
  2. doi request reprint Neuroimaging correlates of aggression in schizophrenia: an update
    Matthew J Hoptman
    Schizophrenia Research Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, USA
    Curr Opin Psychiatry 24:100-6. 2011
  3. pmc Decreased interhemispheric coordination in schizophrenia: a resting state fMRI study
    Matthew J Hoptman
    Schizophrenia Research Division, Nathan Kline Institute, Orangeburg, NY, United States
    Schizophr Res 141:1-7. 2012
  4. pmc Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder
    Matthew J Hoptman
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Psychiatry Res 140:133-45. 2005
  5. pmc Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder
    Matthew J Hoptman
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Neuropsychiatry Clin Neurosci 18:509-15. 2006
  6. pmc Blood pressure and white matter integrity in geriatric depression
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, United States
    J Affect Disord 115:171-6. 2009
  7. pmc Amygdalofrontal functional disconnectivity and aggression in schizophrenia
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Bull 36:1020-8. 2010
  8. pmc DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Neuroreport 15:2467-70. 2004
  9. pmc Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 117:13-20. 2010
  10. pmc Structural neuroimaging research methods in geriatric depression
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Am J Geriatr Psychiatry 14:812-22. 2006

Research Grants

Detail Information

Publications23

  1. ncbi request reprint Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study
    Matthew J Hoptman
    Division of Clinical Research and the Center for Advanced Brain Imaging, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Biol Psychiatry 52:9-14. 2002
    ..Aggression and impulsivity may involve altered frontal white matter...
  2. doi request reprint Neuroimaging correlates of aggression in schizophrenia: an update
    Matthew J Hoptman
    Schizophrenia Research Division, Nathan S Kline Institute for Psychiatric Research, Orangeburg, USA
    Curr Opin Psychiatry 24:100-6. 2011
    ..As such it represents an important public health issue. This article reviews recent neuroimaging studies of aggression in schizophrenia, focusing on PET/single photon emission computed tomography and MRI methods...
  3. pmc Decreased interhemispheric coordination in schizophrenia: a resting state fMRI study
    Matthew J Hoptman
    Schizophrenia Research Division, Nathan Kline Institute, Orangeburg, NY, United States
    Schizophr Res 141:1-7. 2012
    ..VMHC in the postcentral gyrus extending into the precentral gyrus was correlated with PANSS Total scores. These results show substantial impairment of interhemispheric coordination in schizophrenia...
  4. pmc Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder
    Matthew J Hoptman
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Psychiatry Res 140:133-45. 2005
    ..Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects...
  5. pmc Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder
    Matthew J Hoptman
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Neuropsychiatry Clin Neurosci 18:509-15. 2006
    ..The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate...
  6. pmc Blood pressure and white matter integrity in geriatric depression
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, United States
    J Affect Disord 115:171-6. 2009
    ..This study examined whether and in which brain regions blood pressure is associated with compromised white matter integrity in elderly depressed patients...
  7. pmc Amygdalofrontal functional disconnectivity and aggression in schizophrenia
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Bull 36:1020-8. 2010
    ..Similar results were obtained for 2 other measures--Life History of Aggression and total arrests. These results suggest that amygdala/vPFC FC is compromised in schizophrenia and that this compromise is associated with aggression...
  8. pmc DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Neuroreport 15:2467-70. 2004
    ..These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks...
  9. pmc Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 117:13-20. 2010
    ..These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed...
  10. pmc Structural neuroimaging research methods in geriatric depression
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Am J Geriatr Psychiatry 14:812-22. 2006
    ..The authors argue that the available methods provide complementary information and that, when combined judiciously, can increase the knowledge gained from neuroimaging findings and conceptually advance the field of geriatric depression...
  11. ncbi request reprint The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents
    David I Leitman
    Program in Cognitive Neuroscience and Schizophrenia, Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Am J Psychiatry 164:474-82. 2007
    ..This study examined neural substrates of prosodic dysfunction in schizophrenia with voxelwise analysis of diffusion tensor magnetic resonance imaging (MRI)...
  12. ncbi request reprint Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder
    Robert M Bilder
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Am J Psychiatry 159:1018-28. 2002
    ....
  13. pmc Visual white matter integrity in schizophrenia
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg NY, 10962, USA
    Am J Psychiatry 163:2011-3. 2006
    ..Patients with schizophrenia have visual-processing deficits. This study examines visual white matter integrity as a potential mechanism for these deficits...
  14. ncbi request reprint MRI study of white matter diffusion anisotropy in schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuroreport 14:2025-9. 2003
    ..Regions showing reduced white matter fractional anisotropy are known to be abnormal in schizophrenia. The voxelwise method used in the current study can provide the basis for hypothesis-driven research...
  15. ncbi request reprint Quantitative comparison of algorithms for inter-subject registration of 3D volumetric brain MRI scans
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Neurosci Methods 142:67-76. 2005
    ..The spatial dispersion measure was found to be more sensitive when the landmarks were placed after image registration. The standard deviation measure was found sensitive to intensity normalization or the method of image interpolation...
  16. pmc Early-stage visual processing and cortical amplification deficits in schizophrenia
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 62:495-504. 2005
    ..Investigating magnocellular dysfunction in schizophrenia therefore permits evaluation of underlying etiologic hypotheses...
  17. doi request reprint A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia
    Matthew J Hoptman
    Division of Clinical Research, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, United States
    Schizophr Res 106:115-24. 2008
    ....
  18. ncbi request reprint Abnormal white matter integrity in healthy apolipoprotein E epsilon4 carriers
    Jay Nierenberg
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroreport 16:1369-72. 2005
    ..Diffusion tensor imaging may be sufficiently sensitive to detect preclinical brain changes related to Alzheimer's disease...
  19. ncbi request reprint Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia
    Robert M Bilder
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Biol Psychiatry 52:701-7. 2002
    ....
  20. pmc Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Neuroreport 16:1455-9. 2005
    ..Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia...
  21. doi request reprint Microstructural white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, New York, NY, USA
    Am J Psychiatry 165:238-44. 2008
    ..The authors used diffusion tensor imaging to test the hypothesis that depressed elders who fail to achieve remission have microstructural white matter abnormalities in cortico-striato-limbic networks implicated in geriatric depression...
  22. pmc White-matter integrity predicts stroop performance in patients with geriatric depression
    Christopher F Murphy
    Weill Medical College of Cornell University, Neill Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Biol Psychiatry 61:1007-10. 2007
    ..This study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders...
  23. pmc Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizophrenia
    Kelvin O Lim
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Am J Psychiatry 163:2008-10. 2006
    ..In each case, better performance on these tasks was associated with higher levels of fractional anisotropy in task-relevant regions...

Research Grants4

  1. Frontal White Matter and Impulsivity in Schizophrenia
    Matthew Hoptman; Fiscal Year: 2007
    ..A secondary aim will examine the relationship between FA and violence. Understanding the neural basis of impulsivity in schizophrenia would help identify at-risk patients and inform new treatment approaches. ..