STEPHEN GINSBERG

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi request reprint Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurochem 96:1401-8. 2006
  2. pmc Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA
    Pharmacol Biochem Behav 100:705-11. 2012
  3. pmc Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease
    Latha Devi
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Mol Brain 3:34. 2010
  4. pmc Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    J Chem Neuroanat 42:102-10. 2011
  5. ncbi request reprint RNA amplification strategies for small sample populations
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Department of Psychiatry and Physiology and Neuroscience, New York University School of Medicine, Orangeburg, NY 10962, USA
    Methods 37:229-37. 2005
  6. ncbi request reprint Glutamatergic neurotransmission expression profiling in the mouse hippocampus after perforant-path transection
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Am J Geriatr Psychiatry 13:1052-61. 2005
  7. pdf Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, USA
    J Neurochem 97:475-87. 2006
  8. pmc Single cell gene expression profiling in Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    NeuroRx 3:302-18. 2006
  9. ncbi request reprint Functional genomic methodologies
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Prog Brain Res 158:15-40. 2006
  10. pmc Alterations in discrete glutamate receptor subunits in adult mouse dentate gyrus granule cells following perforant path transection
    Stephen D Ginsberg
    Department of Psychiatry, Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Anal Bioanal Chem 397:3349-58. 2010

Research Grants

  1. Molecular Diagnosis Utilizing Cerebrospinal Fluid
    STEPHEN GINSBERG; Fiscal Year: 2003
  2. Lesion Induced Synaptic Plasticity
    STEPHEN GINSBERG; Fiscal Year: 2004

Detail Information

Publications42

  1. ncbi request reprint Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurochem 96:1401-8. 2006
    ..A shift in 3Rtau to 4Rtau may precipitate a cascade of events in the selective vulnerability of neurons, ultimately leading to frank neurofibrillary tangle (NFT) formation in tauopathies including AD...
  2. pmc Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA
    Pharmacol Biochem Behav 100:705-11. 2012
    ....
  3. pmc Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease
    Latha Devi
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Mol Brain 3:34. 2010
    ..In this study, we investigated a molecular mechanism by which sex and stress interactions may accelerate β-amyloidogenesis and contribute to sporadic AD...
  4. pmc Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    J Chem Neuroanat 42:102-10. 2011
    ..These findings provide further support that endosomal pathology accelerates endocytosis and endosome recycling, which may promote aberrant endosomal signaling and neurodegeneration throughout the progression of AD...
  5. ncbi request reprint RNA amplification strategies for small sample populations
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Department of Psychiatry and Physiology and Neuroscience, New York University School of Medicine, Orangeburg, NY 10962, USA
    Methods 37:229-37. 2005
    ..The present report illustrates practical usage of RNA amplification technologies within the context of regional, population cell, and single cell analyses in the brain...
  6. ncbi request reprint Glutamatergic neurotransmission expression profiling in the mouse hippocampus after perforant-path transection
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Am J Geriatr Psychiatry 13:1052-61. 2005
    ..The goal is to determine cellular and molecular mechanisms that regulate regenerative and neurodegenerative responses within the adult mouse dentate gyrus after axotomy of the principal glutamatergic input, the perforant path (PP)...
  7. pdf Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, USA
    J Neurochem 97:475-87. 2006
    ..In contrast, there is a lack of regulation of p75(NTR) expression. Thus, trk defects may be a molecular marker for the transition from no cognitive impairment (NCI) to MCI, and from MCI to frank AD...
  8. pmc Single cell gene expression profiling in Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    NeuroRx 3:302-18. 2006
    ....
  9. ncbi request reprint Functional genomic methodologies
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Prog Brain Res 158:15-40. 2006
    ....
  10. pmc Alterations in discrete glutamate receptor subunits in adult mouse dentate gyrus granule cells following perforant path transection
    Stephen D Ginsberg
    Department of Psychiatry, Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Anal Bioanal Chem 397:3349-58. 2010
    ....
  11. pmc Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, Orangeburg, NY 10962, USA
    Biol Psychiatry 68:885-93. 2010
    ....
  12. pmc Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, New York, NY, USA
    Brain Struct Funct 216:347-56. 2011
    ..Additional molecular and cellular characterization of COMT, TH, and other potential targets is warranted within this animal model of aggression...
  13. ncbi request reprint Expression profile analysis within the human hippocampus: comparison of CA1 and CA3 pyramidal neurons
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Department of Psychiatry, New York University School of Medicine, Orangeburg, New York 10962, USA
    J Comp Neurol 487:107-18. 2005
    ....
  14. ncbi request reprint Single-cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disorders
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
    Neurochem Res 29:1053-64. 2004
    ..This focused review illustrates the potential power of single-cell gene expression studies within the CNS in relation to neurodegenerative and neuropsychiatric disorders such as Alzheimer's disease (AD) and schizophrenia, respectively...
  15. ncbi request reprint RNA amplification in brain tissues
    Stephen D Ginsberg
    Neurochem Res 27:981-92. 2002
    ....
  16. pmc Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, Orangeburg, NY 10962, USA
    J Alzheimers Dis 22:631-9. 2010
    ....
  17. ncbi request reprint Combined histochemical staining, RNA amplification, regional, and single cell cDNA analysis within the hippocampus
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, NY, USA
    Lab Invest 84:952-62. 2004
    ....
  18. pmc Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Neurobiol Dis 45:99-107. 2012
    ..Thus, single population studies of specific neurons and intrinsic circuits will likely yield informative gene expression profile data that may be subthreshold and/or underrepresented in regional studies with an admixture of cell types...
  19. pmc Terminal continuation (TC) RNA amplification without second strand synthesis
    Melissa J Alldred
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, United States
    J Neurosci Methods 177:381-5. 2009
    ....
  20. pmc In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model
    Yuanxin Chen
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, United States
    Neurobiol Aging 30:1453-65. 2009
    ..These results establish the utility of quantitative MRI in vivo for identifying Alzheimer's disease-relevant cholinergic changes in animal models of DS and characterizing the selective vulnerability of cholinergic neuron subpopulations...
  21. ncbi request reprint Amplification of RNA transcripts using terminal continuation
    Shaoli Che
    Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, NY 10962, USA
    Lab Invest 84:131-7. 2004
    ..Following TC RNA amplification, a large proportion of genes can be assessed quantitatively as evidenced by bioanalysis and cDNA microarray analysis in mouse and human postmortem brain tissues...
  22. pmc Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease
    Seymour Levine
    Center for Dementia Research, Nathan S Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Exp Mol Pathol 86:18-22. 2009
    ..The occurrence of lymphomas in mouse DS models is of interest in relation to the increased incidence of malignant conditions in human DS...
  23. doi request reprint Different inflammatory reactions to vitamin D3 among the lateral, third and fourth ventricular choroid plexuses of the rat
    Seymour Levine
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Exp Mol Pathol 85:117-21. 2008
    ..These findings were compared to the scanty data from the literature on differences among the plexuses...
  24. pmc Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model
    Jennifer H K Choi
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurochem 110:1818-27. 2009
    ..Therefore, multiple mechanisms contribute to the regulation towards diploid levels of APP metabolites in the Ts65Dn mouse brain...
  25. pmc Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
    Ying Jiang
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Proc Natl Acad Sci U S A 107:1630-5. 2010
    ....
  26. pmc Transcriptional profiling of small samples in the central nervous system
    Stephen D Ginsberg
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA
    Methods Mol Biol 439:147-58. 2008
    ....
  27. ncbi request reprint Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease
    Elliott J Mufson
    Department of Neurological Sciences, Rush Alzheimer s Disease Research Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Neurochem Res 27:1035-48. 2002
    ..Thus, anterior NB neurons undergo selective alterations in gene expression in AD. These results may provide clues to the molecular pathogenesis of NB neuronal degeneration during AD...
  28. ncbi request reprint Neuron-specific age-related decreases in dopamine receptor subtype mRNAs
    Scott E Hemby
    Department of Pharmacology and Psychiatry Behavioral Sciences, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Comp Neurol 456:176-83. 2003
    ..Furthermore, these results support the hypothesis that alterations in dopaminergic function may also be related to behavioral abnormalities, such as psychosis, that occur with aging...
  29. ncbi request reprint Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex
    Scott E Hemby
    Department of Pharmacology, Yerkes Regional Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, GA, USA
    Arch Gen Psychiatry 59:631-40. 2002
    ..We used single-cell gene expression technologies to assess coordinate changes in the expression of multiple genes, including neuronal signaling and synaptic-related markers in EC layer II stellate neurons...
  30. pmc Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Ill 60612, USA
    Neurodegener Dis 5:228-31. 2008
    ..Fibers containing galanin (GAL) enlarge and hyperinnervate cholinergic basal forebrain (CBF) nucleus basalis (NB) neurons in late-stage Alzheimer's disease (AD), yet the physiological consequences of this phenomenon are unclear...
  31. ncbi request reprint RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampus
    Scott E Counts
    Department of Neurological Sciences, Alla and Solomon Jesmer Chair in Aging, Rush University Medical Center, 1735 W Harrison Street, Suite 300, Chicago, IL, USA
    J Neurosci Methods 144:197-201. 2005
    ..The present study demonstrates for the first time that BrdU immunohistochemisty is compatable with gene array technology in the primate hippocampus to evaluate subclasses of genes in newborn neurons...
  32. ncbi request reprint Expression profiling in the aging brain: a perspective
    James E Galvin
    Department of Neurology, Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63108, USA
    Ageing Res Rev 4:529-47. 2005
    ....
  33. ncbi request reprint Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Ann Neurol 56:520-31. 2004
    ..The selective reduction of cortical TrkA levels relative to p75(NTR) may have important consequences for cholinergic NB function during the transition from MCI to AD...
  34. ncbi request reprint Expression profiling and pharmacotherapeutic development in the central nervous system
    James E Galvin
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 18:264-9. 2004
    ..This is a difficult task that demands a multidisciplinary approach that is highlighted in this review within the context of neurodegenerative pathology...
  35. ncbi request reprint Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction
    Elliott J Mufson
    Department of Neurological Sciences and Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Tech 2000, 2242 West Harrison St, Suite 200, Chicago, IL 60612, USA
    J Chem Neuroanat 26:233-42. 2003
    ..These observations indicate the complexity of the chemoanatomy of the human CBF and suggest that multiple factors play different roles in its dysfunction in aging and AD...
  36. ncbi request reprint Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease
    Elliott J Mufson
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Prog Brain Res 158:197-222. 2006
    ..This chapter will review how regional and single cell gene array technologies have advanced our understanding of the genetics of human neurological disease...
  37. ncbi request reprint Cholinotrophic molecular substrates of mild cognitive impairment in the elderly
    Elliott J Mufson
    Department of Neurological Sciences, Rush University Medical School, Chicago, IL 60612, USA
    Curr Alzheimer Res 4:340-50. 2007
    ..These findings support the concept that from a neurotrophic pathobiologic perspective, MCI is already early AD...
  38. ncbi request reprint Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 64:1771-6. 2007
    ..Although alterations in these AChRs occur in the AD cortex, there is little information detailing whether defects in nAChR and mAChR gene expression occur in cholinergic NB neurons during disease progression...
  39. ncbi request reprint An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain
    Steven R King
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurosci 22:10613-20. 2002
    ..These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain...
  40. ncbi request reprint Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease
    Scott E Counts
    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Dement Geriatr Cogn Disord 21:205-14. 2006
    ..These observations indicate that GAL hypertrophy within the anterior NB subfield is a late-stage AD response, which may play a role in regulating the cholinergic tone of remaining basocortical projection neurons...
  41. ncbi request reprint Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons
    Stephen D Ginsberg
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neurotrauma 19:99-109. 2002
    ..This transneuronal degeneration can be classified as sustained neuronal atrophy or transsynaptic apoptosis...
  42. ncbi request reprint Galanin in Alzheimer disease
    Scott E Counts
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, 2242 West Harrison Street, Chicago, IL 60612, USA
    Mol Interv 3:137-56. 2003
    ..Thus, GAL may also be neuroprotective for AD. Further elucidation of GAL activity in selectively vulnerable brain regions will help gauge the therapeutic potential of GALR ligands for the treatment of AD...

Research Grants5

  1. Molecular Diagnosis Utilizing Cerebrospinal Fluid
    STEPHEN GINSBERG; Fiscal Year: 2003
    ..abstract_text> ..
  2. Lesion Induced Synaptic Plasticity
    STEPHEN GINSBERG; Fiscal Year: 2004
    ....