Research Topics
| STEPHEN GINSBERGSummaryAffiliation: Nathan Kline Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's diseaseStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
J Neurochem 96:1401-8. 2006..A shift in 3Rtau to 4Rtau may precipitate a cascade of events in the selective vulnerability of neurons, ultimately leading to frank neurofibrillary tangle (NFT) formation in tauopathies including AD...
Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorderStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA
Pharmacol Biochem Behav 100:705-11. 2012....- Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's diseaseLatha Devi
Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
Mol Brain 3:34. 2010..In this study, we investigated a molecular mechanism by which sex and stress interactions may accelerate β-amyloidogenesis and contribute to sporadic AD... - Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's diseaseStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
J Chem Neuroanat 42:102-10. 2011..These findings provide further support that endosomal pathology accelerates endocytosis and endosome recycling, which may promote aberrant endosomal signaling and neurodegeneration throughout the progression of AD... - RNA amplification strategies for small sample populationsStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Department of Psychiatry and Physiology and Neuroscience, New York University School of Medicine, Orangeburg, NY 10962, USA
Methods 37:229-37. 2005..The present report illustrates practical usage of RNA amplification technologies within the context of regional, population cell, and single cell analyses in the brain... - Glutamatergic neurotransmission expression profiling in the mouse hippocampus after perforant-path transectionStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Am J Geriatr Psychiatry 13:1052-61. 2005..The goal is to determine cellular and molecular mechanisms that regulate regenerative and neurodegenerative responses within the adult mouse dentate gyrus after axotomy of the principal glutamatergic input, the perforant path (PP)... 
Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's diseaseStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, USA
J Neurochem 97:475-87. 2006..In contrast, there is a lack of regulation of p75(NTR) expression. Thus, trk defects may be a molecular marker for the transition from no cognitive impairment (NCI) to MCI, and from MCI to frank AD...- Single cell gene expression profiling in Alzheimer's diseaseStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
NeuroRx 3:302-18. 2006.... - Functional genomic methodologiesStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Prog Brain Res 158:15-40. 2006.... - Alterations in discrete glutamate receptor subunits in adult mouse dentate gyrus granule cells following perforant path transectionStephen D Ginsberg
Department of Psychiatry, Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Anal Bioanal Chem 397:3349-58. 2010.... - Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progressionStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, Orangeburg, NY 10962, USA
Biol Psychiatry 68:885-93. 2010.... - Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggressionStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, New York, NY, USA
Brain Struct Funct 216:347-56. 2011..Additional molecular and cellular characterization of COMT, TH, and other potential targets is warranted within this animal model of aggression... - Expression profile analysis within the human hippocampus: comparison of CA1 and CA3 pyramidal neuronsStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Department of Psychiatry, New York University School of Medicine, Orangeburg, New York 10962, USA
J Comp Neurol 487:107-18. 2005.... - Single-cell gene expression analysis: implications for neurodegenerative and neuropsychiatric disordersStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, USA
Neurochem Res 29:1053-64. 2004..This focused review illustrates the potential power of single-cell gene expression studies within the CNS in relation to neurodegenerative and neuropsychiatric disorders such as Alzheimer's disease (AD) and schizophrenia, respectively... - RNA amplification in brain tissuesStephen D Ginsberg
Neurochem Res 27:981-92. 2002.... - Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's diseaseStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University Langone Medical Center, Orangeburg, NY 10962, USA
J Alzheimers Dis 22:631-9. 2010.... - Combined histochemical staining, RNA amplification, regional, and single cell cDNA analysis within the hippocampusStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, NY, USA
Lab Invest 84:952-62. 2004.... - Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's diseaseStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
Neurobiol Dis 45:99-107. 2012..Thus, single population studies of specific neurons and intrinsic circuits will likely yield informative gene expression profile data that may be subthreshold and/or underrepresented in regional studies with an admixture of cell types... - Terminal continuation (TC) RNA amplification without second strand synthesisMelissa J Alldred
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, United States
J Neurosci Methods 177:381-5. 2009.... - In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome modelYuanxin Chen
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, United States
Neurobiol Aging 30:1453-65. 2009..These results establish the utility of quantitative MRI in vivo for identifying Alzheimer's disease-relevant cholinergic changes in animal models of DS and characterizing the selective vulnerability of cholinergic neuron subpopulations... - Amplification of RNA transcripts using terminal continuationShaoli Che
Center for Dementia Research, Nathan Kline Institute, New York University School of Medicine, Orangeburg, NY 10962, USA
Lab Invest 84:131-7. 2004..Following TC RNA amplification, a large proportion of genes can be assessed quantitatively as evidenced by bioanalysis and cDNA microarray analysis in mouse and human postmortem brain tissues... - Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's diseaseSeymour Levine
Center for Dementia Research, Nathan S Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Exp Mol Pathol 86:18-22. 2009..The occurrence of lymphomas in mouse DS models is of interest in relation to the increased incidence of malignant conditions in human DS... 
Different inflammatory reactions to vitamin D3 among the lateral, third and fourth ventricular choroid plexuses of the ratSeymour Levine
Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Exp Mol Pathol 85:117-21. 2008..These findings were compared to the scanty data from the literature on differences among the plexuses...- Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse modelJennifer H K Choi
Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
J Neurochem 110:1818-27. 2009..Therefore, multiple mechanisms contribute to the regulation towards diploid levels of APP metabolites in the Ts65Dn mouse brain... - Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibitionYing Jiang
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY 10962, USA
Proc Natl Acad Sci U S A 107:1630-5. 2010.... - Transcriptional profiling of small samples in the central nervous systemStephen D Ginsberg
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA
Methods Mol Biol 439:147-58. 2008.... - Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's diseaseElliott J Mufson
Department of Neurological Sciences, Rush Alzheimer s Disease Research Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Neurochem Res 27:1035-48. 2002..Thus, anterior NB neurons undergo selective alterations in gene expression in AD. These results may provide clues to the molecular pathogenesis of NB neuronal degeneration during AD... - Neuron-specific age-related decreases in dopamine receptor subtype mRNAsScott E Hemby
Department of Pharmacology and Psychiatry Behavioral Sciences, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA
J Comp Neurol 456:176-83. 2003..Furthermore, these results support the hypothesis that alterations in dopaminergic function may also be related to behavioral abnormalities, such as psychosis, that occur with aging... - Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortexScott E Hemby
Department of Pharmacology, Yerkes Regional Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, GA, USA
Arch Gen Psychiatry 59:631-40. 2002..Understanding the coordinated involvement of multiple genes in human disease provides insight into the molecular basis of the disease and offers new targets for pharmacotherapeutic intervention... - Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's diseaseScott E Counts
Department of Neurological Sciences, Rush University Medical Center, Chicago, Ill 60612, USA
Neurodegener Dis 5:228-31. 2008..Fibers containing galanin (GAL) enlarge and hyperinnervate cholinergic basal forebrain (CBF) nucleus basalis (NB) neurons in late-stage Alzheimer's disease (AD), yet the physiological consequences of this phenomenon are unclear... - RNA amplification of bromodeoxyuridine labeled newborn neurons in the monkey hippocampusScott E Counts
Department of Neurological Sciences, Alla and Solomon Jesmer Chair in Aging, Rush University Medical Center, 1735 W. Harrison Street, Suite 300, Chicago, IL, USA
J Neurosci Methods 144:197-201. 2005..The present study demonstrates for the first time that BrdU immunohistochemisty is compatable with gene array technology in the primate hippocampus to evaluate subclasses of genes in newborn neurons... - Expression profiling in the aging brain: a perspectiveJames E Galvin
Department of Neurology, Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63108, USA
Ageing Res Rev 4:529-47. 2005.... - Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's diseaseScott E Counts
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Ann Neurol 56:520-31. 2004..The selective reduction of cortical TrkA levels relative to p75(NTR) may have important consequences for cholinergic NB function during the transition from MCI to AD... - Expression profiling and pharmacotherapeutic development in the central nervous systemJames E Galvin
Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
Alzheimer Dis Assoc Disord 18:264-9. 2004..This is a difficult task that demands a multidisciplinary approach that is highlighted in this review within the context of neurodegenerative pathology... - Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunctionElliott J Mufson
Department of Neurological Sciences and Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Tech 2000, 2242 West Harrison St, Suite 200, Chicago, IL 60612, USA
J Chem Neuroanat 26:233-42. 2003..These observations indicate the complexity of the chemoanatomy of the human CBF and suggest that multiple factors play different roles in its dysfunction in aging and AD... - Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative diseaseElliott J Mufson
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Prog Brain Res 158:197-222. 2006..This chapter will review how regional and single cell gene array technologies have advanced our understanding of the genetics of human neurological disease... - Cholinotrophic molecular substrates of mild cognitive impairment in the elderlyElliott J Mufson
Department of Neurological Sciences, Rush University Medical School, Chicago, IL 60612, USA
Curr Alzheimer Res 4:340-50. 2007..These findings support the concept that from a neurotrophic pathobiologic perspective, MCI is already early AD... - Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer diseaseScott E Counts
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Arch Neurol 64:1771-6. 2007..Although alterations in these AChRs occur in the AD cortex, there is little information detailing whether defects in nAChR and mAChR gene expression occur in cholinergic NB neurons during disease progression... - An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brainSteven R King
Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030-3498, USA
J Neurosci 22:10613-20. 2002..These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain... - Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's diseaseScott E Counts
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Dement Geriatr Cogn Disord 21:205-14. 2006..These observations indicate that GAL hypertrophy within the anterior NB subfield is a late-stage AD response, which may play a role in regulating the cholinergic tone of remaining basocortical projection neurons... - Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neuronsStephen D Ginsberg
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA
J Neurotrauma 19:99-109. 2002..This transneuronal degeneration can be classified as sustained neuronal atrophy or transsynaptic apoptosis... - Galanin in Alzheimer diseaseScott E Counts
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, 2242 West Harrison Street, Chicago, IL 60612, USA
Mol Interv 3:137-56. 2003..Thus, GAL may also be neuroprotective for AD. Further elucidation of GAL activity in selectively vulnerable brain regions will help gauge the therapeutic potential of GALR ligands for the treatment of AD...
Research Grants
- Molecular Diagnosis Utilizing Cerebrospinal FluidSTEPHEN GINSBERG; Fiscal Year: 2003..abstract_text> ..
- Lesion Induced Synaptic PlasticitySTEPHEN GINSBERG; Fiscal Year: 2004....