Research Topics
Species | Robert M BilderSummaryAffiliation: Nathan Kline Institute Country: USA Publications
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Publications
Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorderRobert M Bilder
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Am J Psychiatry 159:1018-28. 2002....
Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorderMatthew J Hoptman
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
J Neuropsychiatry Clin Neurosci 18:509-15. 2006..The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate...- Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophreniaRobert M Bilder
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Biol Psychiatry 52:701-7. 2002.... - Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorderMatthew J Hoptman
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Psychiatry Res 140:133-45. 2005..Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects... - Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibilityKaren A Nolan
Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Am J Psychiatry 161:359-61. 2004..They hypothesized that the Val and Met alleles would be associated with deficits in imitation learning and reversal learning, respectively... - Diffusion tensor imaging reliably differentiates patients with schizophrenia from healthy volunteersBabak A Ardekani
Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Hum Brain Mapp 32:1-9. 2011..Patterns of water self-diffusion in the brain as estimated by DTI can be used in conjunction with automated pattern recognition algorithms to reliably distinguish between patients with schizophrenia and normal control subjects... - Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary studyMatthew J Hoptman
Division of Clinical Research and the Center for Advanced Brain Imaging, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
Biol Psychiatry 52:9-14. 2002..CONCLUSIONS: Inferior frontal white matter microstructure was associated with impulsivity and aggression in men with schizophrenia. These results implicate frontal lobe dysfunction in aggression and certain aspects of impulsivity... - Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE TrialRichard S E Keefe
Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
Arch Gen Psychiatry 64:633-47. 2007..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined... - Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorderDelbert G Robinson
Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Am J Psychiatry 161:473-9. 2004..e., sustained improvement in both symptoms and social/vocational functioning) when examined decades after an index admission. This study addressed recovery during the crucial early course of the illness... - Abnormal gyral complexity in first-episode schizophreniaKatherine L Narr
Laboratory of Neuro-Imaging, Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA 90095-1769, USA
Biol Psychiatry 55:859-67. 2004.... - White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging studyPhilip R Szeszko
The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 162:602-5. 2005..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset... - Neurocognitive profile in adolescents with early-onset schizophrenia: clinical correlatesJoseph P Rhinewine
Department of Psychiatry Research Zucker Hillside Hospital, Glen Oaks, New York 11004, USA
Biol Psychiatry 58:705-12. 2005..The overall pattern is similar to that observed in severely ill first-episode adult patients. The impairments across multiple neurocognitive domains suggest widespread brain dysfunction in EOS... 
Selective corticostriatal dysfunction in schizophrenia: examination of motor and cognitive skill learningKarin Foerde
Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA
Neuropsychology 22:100-9. 2008..In contrast, patients were not impaired at learning on the SRT relative to controls, suggesting that patients with schizophrenia may have dysfunction in a specific corticostriatal subcircuit...- Baseline neurocognitive deficits in the CATIE schizophrenia trialRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 31:2033-46. 2006..Multiple analyses suggested that a broad cognitive deficit characterizes this sample. These deficits are modestly related to negative symptoms and essentially independent of positive symptom severity... - DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophreniaPhilip R Szeszko
Feinstein Institute for Medical Research, Manhasset, NY, USA
Biol Psychol 79:103-10. 2008..Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology... - Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 33:976-84. 2008..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder... - Patterns of stress in schizophreniaJulia D Betensky
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Psychiatry Res 160:38-46. 2008.... - Investigation of unirhinal olfactory identification in antipsychotic-free patients experiencing a first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, North Shore Long Island Jewish Health System, Zucker Hillside Hospital, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Schizophr Res 67:219-25. 2004.... - Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, 75 59 263rd St, Glen Oaks, NY 11004, USA
Am J Psychiatry 160:2190-7. 2003..The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects... - Impairments in perceptual competency and maintenance on a visual delayed match-to-sample test in first-episode schizophreniaTodd Lencz
Department of Psychiatry, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
Arch Gen Psychiatry 60:238-43. 2003..It was hypothesized that patients in the first episode of schizophrenia would exhibit dissociable deficits in both WM domains... - Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorderDelbert G Robinson
Department of Psychiatry Research, Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Schizophr Res 57:209-19. 2002..Although extensively studied in multi-episode patients, little data exist on medication adherence by first-episode patients... - Neurocognitive assessment in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project schizophrenia trial: development, methodology, and rationaleRichard S E Keefe
Neurocognitive Assessment Unit, Duke University Medical Center, Durham, NC 27710, USA
Schizophr Bull 29:45-55. 2003.... - Lack of normal association between cerebellar volume and neuropsychological functions in first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
Am J Psychiatry 160:1884-7. 2003..Few studies, however, have examined the relationship between cerebellar size and neuropsychological functioning in schizophrenia. The authors' goal was to examine this relationship in patients and healthy comparison subjects... - Reversed cerebellar asymmetry in men with first-episode schizophreniaPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Biol Psychiatry 53:450-9. 2003.... - No evidence for phenotypic variation between probands in case-control versus family-based association studies of schizophreniaAnil K Malhotra
Hillside Hospital, Psychiatry Research, Glen Oaks, New York 11004, USA
Am J Med Genet 114:509-11. 2002.... - The effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophreniaElisabeth M Weiss
Department of Biological Psychiatry, Innsbruck University Clinics, Anichstrasse 35, 6020 Innsbruck University Clinics, Anichtrasse 35, 6020 Innsbruck, Austria
Psychopharmacology (Berl) 162:11-7. 2002..In this context it also addresses several methodological and conceptional issues that limited the comparison of these studies... - Neurocognitive correlates of response to treatment in formal thought disorder in patients with first-episode schizophreniaRita Z Goldstein
Brookhaven National Laboratory, Upton, New York 11973, USA
Neuropsychiatry Neuropsychol Behav Neurol 15:88-98. 2002..To examine the independent contribution of executive versus semantic function to improvement in formal thought disorder after initial stabilization in a first-episode sample... - Neuropsychological correlates of hippocampal volumes in patients experiencing a first episode of schizophreniaPhilip R Szeszko
Department of Psychiatry Research, Hillside Hospital, a division of North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Am J Psychiatry 159:217-26. 2002..This study investigated the neuropsychological correlates of hippocampal volume in 43 men and 32 women experiencing a first episode of schizophrenia... - Asymmetries of cortical thickness: effects of handedness, sex, and schizophreniaLiberty S Hamilton
Laboratory of Neuroimaging, Geffen School of Medicine at UCLA, Los Angeles, California 90095 7334, USA
Neuroreport 18:1427-31. 2007..Thus, dextrality relates to cortical thickness asymmetries, although schizophrenia may differentially affect asymmetry patterns across handedness... - Mapping the relationship between cortical convolution and intelligence: effects of genderEileen Luders
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, USA
Cereb Cortex 18:2019-26. 2008..This might lead to the development of sexually dimorphic information processing strategies and affect the relationship between intelligence and cortical convolution... - Phenomics: building scaffolds for biological hypotheses in the post-genomic eraRobert M Bilder
Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, California 90095, USA
Biol Psychiatry 63:439-40. 2008 - Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophreniaHandan Gunduz-Bruce
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Schizophr Res 94:281-7. 2007..Larger scale studies are needed to conclude a link between the two measures, yet it is possible that the negative association that was previously shown in other disorders may not apply to schizophrenia... - CSF sub-compartments in relation to plasma osmolality in healthy controls and in patients with first episode schizophreniaHandan Gunduz-Bruce
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Psychiatry Res 155:57-66. 2007..These results suggest that plasma osmolality is related to ventricle size in healthy volunteers and that this physiological link is impaired in patients with first episode schizophrenia... - Working memory effects on semantic processing: priming differences in pars orbitalisFred W Sabb
Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry, University of California, Los Angeles 760 Westwood Plaza, Los Angeles, CA 90095, USA
Neuroimage 37:311-22. 2007..fMRI signal changes in dorsolateral prefrontal cortex were negatively correlated with signal changes in pars orbitalis. The findings suggest that controlled semantic processing and working memory share neural system resources... - Asymmetries of cortical shape: Effects of handedness, sex and schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
Neuroimage 34:939-48. 2007.... - Increased stress and smaller anterior hippocampal volumePhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Neuroreport 17:1825-8. 2006..Our results may also have implications for neuropsychiatric disorders that have implicated stress and hippocampal abnormalities in their pathogenesis... - Regional specificity of hippocampal volume reductions in first-episode schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1769, USA
Neuroimage 21:1563-75. 2004..Targeting regional hippocampal abnormalities may help dissociate schizophrenia patients from other groups exhibiting global hippocampal volume changes, and better focus systems-level pathophysiological hypotheses... - Functional magnetic resonance imaging of source versus item memoryJin Fan
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
Neuroreport 14:2275-81. 2003..Hippocampal activation showed no difference between source and item retrieval. This pattern of results supports a model proposing a larger role for the frontal lobes in encoding and retrieval of source information... - Genetic linkage for schizophrenia?Jan Volavka
Am J Psychiatry 161:1134-5; author reply 1135-6. 2004 - Mapping cortical thickness and gray matter concentration in first episode schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1769, USA
Cereb Cortex 15:708-19. 2005..Cortical thickness and gray matter concentration mapping produce similar results, although the concentration metric may be influenced by diagnostic differences in extra-cortical cerebrospinal fluid and surface curvature/complexity... - Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophreniaClaudia I Rupp
Department of Psychiatry, Medical University Innsbruck, Austria
Schizophr Res 74:149-61. 2005..In this study, we examined the relationship between different olfactory functions and volumes of the hippocampus-amygdala complex (HAC) and the orbitofrontal brain region using magnetic resonance imaging (MRI)... - Adolescent immaturity in attention-related brain engagement to emotional facial expressionsChristopher S Monk
Section on Development and Affective Neuroscience and Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuroimage 20:420-8. 2003..These findings suggest that adults show greater modulation of activity in relevant brain structures based on attentional demands, whereas adolescents exhibit greater modulation based on emotional content... - Cortical thinning in cingulate and occipital cortices in first episode schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California, USA
Biol Psychiatry 58:32-40. 2005.... - White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging studyPhilip R Szeszko
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 62:782-90. 2005.... - Regional specificity of cerebrospinal fluid abnormalities in first episode schizophreniaKatherine L Narr
Laboratory of Neuroimaging, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Psychiatry Res 146:21-33. 2006..In contrast, sulcal and subarachnoid CSF increases may be manifest near or before the first episode but after brain development is complete, reflecting pronounced reductions in proximal brain tissue... - Cognitive development in schizophrenia: follow-back from the first episodeRobert M Bilder
Semel Institute for Neuroscience at UCLA, Los Angeles, CA, USA
J Clin Exp Neuropsychol 28:270-82. 2006..These observations may help advance concepts of premorbid cognitive ability in the schizophrenia syndrome and constrain models of pathophysiology... - Category fluency in first-episode schizophreniaTania Giovannetti
Moss Rehabilitation Research Institute, Philadelphia, Pennsylvania 19141, USA
J Int Neuropsychol Soc 9:384-93. 2003..e., semantic search/access, response monitoring) or global cognitive impairment... - Anterior cingulate grey-matter deficits and cannabis use in first-episode schizophreniaPhilip R Szeszko
Zucker Hillside Hospital, Psychiatry Research, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Br J Psychiatry 190:230-6. 2007..Despite the high prevalence of cannabis use in schizophrenia, few studies have examined the potential relationship between cannabis exposure and brain structural abnormalities in schizophrenia...