M H Baslow

Summary

Affiliation: Nathan Kline Institute
Country: USA

Publications

  1. ncbi request reprint Functions of N-acetylaspartate and N-acetylaspartylglutamate in brain: evidence of a role in maintenance of higher brain integrative activities of information processing and cognition
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York 10962 USA
    Adv Exp Med Biol 576:95-112; discussion 361-3. 2006
  2. doi request reprint Canavan disease, a rare early-onset human spongiform leukodystrophy: insights into its genesis and possible clinical interventions
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Biochimie 95:946-56. 2013
  3. doi request reprint Stimulation-induced decreases in the diffusion of extra-vascular water in the human visual cortex: a window in time and space on mechanisms of brain water transport and economy
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Mol Neurosci 47:639-48. 2012
  4. doi request reprint Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain's "operating system": how NAA metabolism supports meaningful intercellular frequency-encoded communications
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Amino Acids 39:1139-45. 2010
  5. ncbi request reprint 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Mol Neurosci 26:1-15. 2005
  6. ncbi request reprint NAAG peptidase as a therapeutic target: Potential for regulating the link between glucose metabolism and cognition
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962, USA
    Drug News Perspect 19:145-50. 2006
  7. ncbi request reprint Using proton magnetic resonance imaging and spectroscopy to understand brain "activation"
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Brain Lang 102:153-64. 2007
  8. ncbi request reprint Dynamic relationship between neurostimulation and N-acetylaspartate metabolism in the human visual cortex: evidence that NAA functions as a molecular water pump during visual stimulation
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Mol Neurosci 32:235-45. 2007
  9. doi request reprint The astrocyte surface NAAG receptor and NAAG peptidase signaling complex as a therapeutic target
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Centre for Neurochemistry, Orangeburg, New York 10962, USA
    Drug News Perspect 21:251-7. 2008
  10. doi request reprint A novel key-lock mechanism for inactivating amino acid neurotransmitters during transit across extracellular space
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Amino Acids 38:51-5. 2010

Detail Information

Publications24

  1. ncbi request reprint Functions of N-acetylaspartate and N-acetylaspartylglutamate in brain: evidence of a role in maintenance of higher brain integrative activities of information processing and cognition
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York 10962 USA
    Adv Exp Med Biol 576:95-112; discussion 361-3. 2006
  2. doi request reprint Canavan disease, a rare early-onset human spongiform leukodystrophy: insights into its genesis and possible clinical interventions
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Biochimie 95:946-56. 2013
    ..In this article we also evaluate current hypotheses, and discuss possible clinical interventions that may be of value in treatment of CD...
  3. doi request reprint Stimulation-induced decreases in the diffusion of extra-vascular water in the human visual cortex: a window in time and space on mechanisms of brain water transport and economy
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Mol Neurosci 47:639-48. 2012
    ..The nature of these processes including possible roles of the putative glucose water import and N-acetylaspartate water export molecular water pumps in brain function are discussed...
  4. doi request reprint Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain's "operating system": how NAA metabolism supports meaningful intercellular frequency-encoded communications
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Amino Acids 39:1139-45. 2010
    ..Evidence in support of this hypothesis is provided by the outcomes of two human inborn errors in NAA metabolism...
  5. ncbi request reprint 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Mol Neurosci 26:1-15. 2005
    ....
  6. ncbi request reprint NAAG peptidase as a therapeutic target: Potential for regulating the link between glucose metabolism and cognition
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962, USA
    Drug News Perspect 19:145-50. 2006
    ..We also consider their probable site and mode of action and speculate upon their therapeutic potential...
  7. ncbi request reprint Using proton magnetic resonance imaging and spectroscopy to understand brain "activation"
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Brain Lang 102:153-64. 2007
    ..Finally, evidence is presented that the neuropeptide, N-acetylaspartylglutamate, is a neuronal astrocyte-vascular feedback signal that regulates activation induced focal hyperemic responses...
  8. ncbi request reprint Dynamic relationship between neurostimulation and N-acetylaspartate metabolism in the human visual cortex: evidence that NAA functions as a molecular water pump during visual stimulation
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Mol Neurosci 32:235-45. 2007
    ....
  9. doi request reprint The astrocyte surface NAAG receptor and NAAG peptidase signaling complex as a therapeutic target
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Centre for Neurochemistry, Orangeburg, New York 10962, USA
    Drug News Perspect 21:251-7. 2008
    ..These substances appear to have potential for treating schizophrenia and other cognitive neuropathies by interfering with a homeostatic NAAG activated neuron-astrocyte-vascular energy supply system...
  10. doi request reprint A novel key-lock mechanism for inactivating amino acid neurotransmitters during transit across extracellular space
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Amino Acids 38:51-5. 2010
    ....
  11. ncbi request reprint Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    J Mol Neurosci 21:185-90. 2003
    ..94 lbs per square inch) of hydrostatic pressure to brain ECF, on the brain cell side of brain-barrier epithelial membranes, resulting from the continuous synthesis and efflux of NAA, is considered to be responsible for the syndrome...
  12. ncbi request reprint Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuromolecular Med 3:95-104. 2003
    ..The NAA system, when present in the brain, appears to reflect a high degree of cellular integration, and therefore may be a unique metabolic construct of the intact vertebrate brain...
  13. ncbi request reprint The existence of molecular water pumps in the nervous system: a review of the evidence
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962, USA
    Neurochem Int 34:77-90. 1999
    ..In this article, evidence of the presence of MWP's in the nervous system, and how they might relate to aspects of both normal and abnormal brain function is reviewed...
  14. ncbi request reprint Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    J Neurochem 75:453-9. 2000
    ....
  15. ncbi request reprint Canavan's spongiform leukodystrophy: a clinical anatomy of a genetic metabolic CNS disease
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962, USA
    J Mol Neurosci 15:61-9. 2000
    ..In addition, present efforts to counter the results of the genetic defects in this disease are also considered...
  16. ncbi request reprint Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurochem Int 40:295-300. 2002
    ....
  17. ncbi request reprint Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962, USA
    J Mol Neurosci 17:351-9. 2001
    ..The cellular separation of these hydrolytic enzyme activities, and the possible nature of the enzymes involved are discussed...
  18. ncbi request reprint The effects of lithium chloride and other substances on levels of brain N-acetyl-L-aspartic acid in Canavan disease-like rats
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962, USA
    Neurochem Res 27:403-6. 2002
    ..This is the first pharmacological investigation of the effect of drugs on the level of brain NAA in an animal model of CD, and the first report of a substance that can reduce the brain NAA level in this model...
  19. ncbi request reprint Effect of N-acetylaspartic acid on the diffusion coefficient of water: a proton magnetic resonance phantom method for measurement of osmolyte-obligated water
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Anal Biochem 311:133-8. 2002
    ..Based on these results, apparent K(NAA) varies inversely with field strength, and with a computed field strength factor of 2.55mmol water/unit Tesla, K(NAA) in the absence of any applied magnetic field strength would be 32...
  20. ncbi request reprint N-acetylaspartate in the vertebrate brain: metabolism and function
    Morris H Baslow
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Neurochem Res 28:941-53. 2003
    ....
  21. doi request reprint Are astrocytes the missing link between lack of brain aspartoacylase activity and the spongiform leukodystrophy in Canavan disease?
    Morris H Baslow
    Center for Neurochemistry, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neurochem Res 34:1523-34. 2009
    ..It also offers new perspectives on the cause of the leukodystrophy in CD, and on possible treatment strategies for this inherited metabolic disease...
  22. ncbi request reprint The apparent dependence of the diffusion coefficient of N-acetylaspartate upon magnetic field strength: evidence of an interaction with NMR methodology
    David N Guilfoyle
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    NMR Biomed 16:468-74. 2003
    ..As a result, it has been demonstrated that the observed apparent magnetic field dependence of the ADC of NAA is a consequence of the NMR measurement and is apparently not a real effect on molecular diffusion...
  23. ncbi request reprint Effects of ethanol and of alcohol dehydrogenase inhibitors on the reduction of N-acetylaspartate levels of brain in mice in vivo: a search for substances that may have therapeutic value in the treatment of Canavan disease
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Inherit Metab Dis 23:684-92. 2000
    ..The importance of these findings in understanding the NAA intercompartmental cycle, and its role in Canavan disease, a genetic aspartoacylase deficiency disease, are discussed...
  24. ncbi request reprint Canavan disease. Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms
    M H Baslow
    Nathan S Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962, USA
    J Mol Neurosci 9:109-25. 1997
    ....