Francis A Cucinotta

Summary

Affiliation: NASA Ames Research Center
Country: USA

Publications

  1. doi request reprint Nuclear interactions in heavy ion transport and event-based risk models
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston, TX 77058, USA
    Radiat Prot Dosimetry 143:384-90. 2011
  2. pmc Increased Artemis levels confer radioresistance to both high and low LET radiation exposures
    Deepa M Sridharan
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Radiat Oncol 7:96. 2012
  3. doi request reprint Radiation carcinogenesis risk assessments for never-smokers
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, 2101 NASA Parkway, Houston, TX 77058, USA
    Health Phys 103:643-51. 2012
  4. ncbi request reprint Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings
    Francis A Cucinotta
    National Aeronautics and Space Administration, Lyndon B Johnson Space Centre, Houston, TX 77058, USA
    Lancet Oncol 7:431-5. 2006
  5. ncbi request reprint Description of light ion production cross sections and fluxes on the Mars surface using the QMSFRG model
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston, TX, USA
    Radiat Environ Biophys 46:101-6. 2007
  6. doi request reprint Non-targeted effects and the dose response for heavy ion tumor induction
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Space Radiation Program, 2101 NASA Parkway, Mail Code SK, Houston, TX 77058, USA
    Mutat Res 687:49-53. 2010
  7. ncbi request reprint Updates to astronaut radiation limits: radiation risks for never-smokers
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston Texas 77058, USA
    Radiat Res 176:102-14. 2011
  8. doi request reprint Biochemical kinetics model of DSB repair and induction of gamma-H2AX foci by non-homologous end joining
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 169:214-22. 2008
  9. doi request reprint Physical and biological organ dosimetry analysis for international space station astronauts
    Francis A Cucinotta
    NASA, Space Radiation Program, Lyndon B Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 170:127-38. 2008
  10. ncbi request reprint Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions
    Honglu Wu
    National Space Biomedical Research Institute, Baylor College of Medicine, NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 160:418-24. 2003

Collaborators

Detail Information

Publications66

  1. doi request reprint Nuclear interactions in heavy ion transport and event-based risk models
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston, TX 77058, USA
    Radiat Prot Dosimetry 143:384-90. 2011
    ..A new computer model, which was developed for the description of biophysical events from heavy ion beams at the NASA Space Radiation Laboratory (NSRL), called the GCR Event Risk-Based Model (GERMcode) is described...
  2. pmc Increased Artemis levels confer radioresistance to both high and low LET radiation exposures
    Deepa M Sridharan
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Radiat Oncol 7:96. 2012
    ....
  3. doi request reprint Radiation carcinogenesis risk assessments for never-smokers
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, 2101 NASA Parkway, Houston, TX 77058, USA
    Health Phys 103:643-51. 2012
    ....
  4. ncbi request reprint Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings
    Francis A Cucinotta
    National Aeronautics and Space Administration, Lyndon B Johnson Space Centre, Houston, TX 77058, USA
    Lancet Oncol 7:431-5. 2006
    ..In recent years, worldwide efforts have focussed on an increased understanding of the oncogenic potential of galactic cosmic rays. A review of the new results in this specialty will be presented here...
  5. ncbi request reprint Description of light ion production cross sections and fluxes on the Mars surface using the QMSFRG model
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston, TX, USA
    Radiat Environ Biophys 46:101-6. 2007
    ..Finally, we consider sensitivity assessments of the impact of the Martian atmospheric composition on particle fluxes at the surface...
  6. doi request reprint Non-targeted effects and the dose response for heavy ion tumor induction
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Space Radiation Program, 2101 NASA Parkway, Mail Code SK, Houston, TX 77058, USA
    Mutat Res 687:49-53. 2010
    ..Our analysis provides important in vivo support for the deviation from linear dose responses at low doses for high LET radiation, which are best explained by a NTE model...
  7. ncbi request reprint Updates to astronaut radiation limits: radiation risks for never-smokers
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston Texas 77058, USA
    Radiat Res 176:102-14. 2011
    ..Our analysis illustrates that gaining knowledge to improve transfer models, which entail knowledge of cancer initiation and promotion effects, could significantly reduce uncertainties in risk projections...
  8. doi request reprint Biochemical kinetics model of DSB repair and induction of gamma-H2AX foci by non-homologous end joining
    Francis A Cucinotta
    NASA, Lyndon B Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 169:214-22. 2008
    ..Predictions are made for the behaviors of NHEJ components at low doses and dose rates, and a steady state is found at dose rates of 0.1 Gy/h or lower...
  9. doi request reprint Physical and biological organ dosimetry analysis for international space station astronauts
    Francis A Cucinotta
    NASA, Space Radiation Program, Lyndon B Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 170:127-38. 2008
    ..Finally, effective dose estimates for all previous NASA missions are summarized...
  10. ncbi request reprint Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions
    Honglu Wu
    National Space Biomedical Research Institute, Baylor College of Medicine, NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 160:418-24. 2003
    ..After 0.7 Gy of iron ions, most complex aberrations were found to involve three or four chromosomes, which is a likely indication of the maximum number of chromosome domains traversed by a single iron-ion track...
  11. ncbi request reprint Radiation dosimetry and biophysical models of space radiation effects
    Francis A Cucinotta
    NASA Lyndon B Johnson Space Center, Houston, TX, USA
    Gravit Space Biol Bull 16:11-8. 2003
    ....
  12. ncbi request reprint A temporal forecast of radiation environments for future space exploration missions
    Myung Hee Y Kim
    Wyle Laboratories, Wyle HAC 37A, 1290 Hercules Dr, Houston, TX 77058, USA
    Radiat Environ Biophys 46:95-100. 2007
    ..Results will guide the design of protection systems for astronauts during future space exploration missions...
  13. pmc Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways
    Minli Wang
    USRA Division of Life Sciences, Houston, TX 77058, USA
    Nucleic Acids Res 41:933-42. 2013
    ..In summary, we suggest that Smad2 and Smad7 contribute to IR-induced DSB signaling in an ATM or TGFβR1-dependent manner, respectively...
  14. ncbi request reprint Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition
    Minli Wang
    USRA, Division of Life Sciences, Houston, TX 77058, USA
    J Radiat Res 53:51-7. 2012
    ....
  15. doi request reprint Putative binding modes of Ku70-SAP domain with double strand DNA: a molecular modeling study
    Shaowen Hu
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    J Mol Model 18:2163-74. 2012
    ..The calculation also reveals the sequence specified binding preference which may relate to the observed pause sites when Ku translocates along DNA and the perplex binding of Ku with circular DNA...
  16. ncbi request reprint Biological effectiveness of accelerated particles for the induction of chromosome damage measured in metaphase and interphase human lymphocytes
    Kerry George
    Wyle Laboratories, 1290 Hercules Drive, Houston, Texas 77058, USA
    Radiat Res 160:425-35. 2003
    ....
  17. doi request reprint Dose response of gamma rays and iron nuclei for induction of chromosomal aberrations in normal and repair-deficient cell lines
    Kerry A George
    Wyle, Houston, Texas 77058, USA
    Radiat Res 171:752-63. 2009
    ..The differences found between AT and NBS cells at lower doses suggest important questions about the applicability of observations of radiation sensitivity at high doses to low-dose exposures...
  18. doi request reprint Computational studies on full-length Ku70 with DNA duplexes: base interactions and a helical path
    Shaowen Hu
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    J Mol Model 18:1935-49. 2012
    ....
  19. doi request reprint AT cells are not radiosensitive for simple chromosomal exchanges at low dose
    Megumi Hada
    USRA Division of Life Sciences, Houston, TX 77058, USA
    Mutat Res 716:76-83. 2011
    ..5Gy or below. These results were confirmed using siRNA knockdown of ATM. The present study provides evidence that the increased radiation sensitivity of AT cells for chromosomal exchanges found at high dose does not occur at low dose...
  20. doi request reprint Analysis of flow cytometry DNA damage response protein activation kinetics after exposure to x rays and high-energy iron nuclei
    Lori J Chappell
    U S R A, Division of Space Life Science Division, Houston, Texas 77058, USA
    Radiat Res 174:691-702. 2010
    ..05 Gy). These results show that mathematical models can be applied to flow cytometry data to identify important and subtle differences after exposure to various qualities of low-dose radiation...
  21. ncbi request reprint Solar particle events observed at Mars: dosimetry measurements and model calculations
    Timothy F Cleghorn
    NASA Johnson Space Center, Houston, TX 77058 3696, USA
    Adv Space Res 33:2215-8. 2004
    ..The dose rates at Martian orbit are calculated, both for the galactic and solar components of the ionizing particle radiation environment. The dose rates due to galactic cosmic rays (GCR) agree well with the HZETRN model calculations...
  22. ncbi request reprint Chromatin loops are responsible for higher counts of small DNA fragments induced by high-LET radiation, while chromosomal domains do not affect the fragment sizes
    Artem L Ponomarev
    USRA, Houston, Texas, USA
    Int J Radiat Biol 82:293-305. 2006
    ..To apply a polymer model of DNA damage induced by high-LET (linear energy transfer) radiation and determine the influence of chromosomal domains and loops on fragment length distribution...
  23. doi request reprint Association of inter- and intrachromosomal exchanges with the distribution of low- and high-LET radiation-induced breaks in chromosomes
    Megumi Hada
    NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 176:25-37. 2011
    ..In general, breakpoint distributions depend on whether a chromosome fragment joins with another fragment in the same chromosome or with a fragment from a different chromosome...
  24. ncbi request reprint Visualization of particle flux in the human body on the surface of Mars
    Premkumar B Saganti
    Lockheed Martin Space Operations, NASA JSC, Houston, TX 77058, USA
    J Radiat Res 43:S119-24. 2002
    ....
  25. doi request reprint 3D visualisation of the stochastic patterns of the radial dose in nano-volumes by a Monte Carlo simulation of HZE ion track structure
    Ianik Plante
    NASA Johnson Space Center, 2101 NASA Parkway, Houston, TX 77058, USA
    Radiat Prot Dosimetry 143:156-61. 2011
    ....
  26. ncbi request reprint Modelling and calculations of the response of tissue equivalent proportional counter to charged particles
    H Nikjoo
    USRA, NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Prot Dosimetry 126:512-8. 2007
    ..3-100 MeV, is presented. The distributions show the clustering properties of protons of different energies in a 100 nm by 100 nm cylinder...
  27. doi request reprint Prediction of frequency and exposure level of solar particle events
    Myung Hee Y Kim
    Universities Space Research Association, Division of Space Life Sciences, 2101 NASA Parkway, SK SRPE B37, Houston, TX 77058, USA
    Health Phys 97:68-81. 2009
    ..These results will be useful in implementing probabilistic risk assessment approaches at NASA and guidelines for protection systems for astronauts on future space exploration missions...
  28. doi request reprint Description of transport codes for space radiation shielding
    Myung Hee Y Kim
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    Health Phys 103:621-39. 2012
    ..This paper reviews current transport codes and analyzes their accuracy through comparison to laboratory and spaceflight data. This paper also introduces a probabilistic risk assessment approach for the evaluation of radiation shielding...
  29. doi request reprint The analysis of the densely populated patterns of radiation-induced foci by a stochastic, Monte Carlo model of DNA double-strand breaks induction by heavy ions
    Artem L Ponomarev
    Universities Space Research Association USRA, Houston, TX, USA
    Int J Radiat Biol 86:507-15. 2010
    ..To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns...
  30. doi request reprint mBAND analysis for high- and low-LET radiation-induced chromosome aberrations: a review
    Megumi Hada
    NASA Johnson Space Center, Houston, TX 77058, USA Universities Space Research Association, Houston, TX 77058, USA
    Mutat Res 711:187-92. 2011
    ..Chromosome analysis with mBAND technique allows detection of both inter- and intrachromosomal exchanges, and also distribution of the breakpoints of aberrations...
  31. doi request reprint Modeling the acute health effects of astronauts from exposure to large solar particle events
    Shaowen Hu
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    Health Phys 96:465-76. 2009
    ..Uncertainties in the calculation due to limited data on relative biological effectiveness and dose-rate modifying factors for protons and secondary radiation, and the identification of sensitive sites in critical organs are discussed...
  32. doi request reprint Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci
    Artem L Ponomarev
    The Universities Space Research Association, Division of Space Life Sciences, Houston, Texas, USA
    Int J Radiat Biol 84:916-29. 2008
    ....
  33. ncbi request reprint Analysis of unrejoined chromosomal breakage in human fibroblast cells exposed to low- and high-LET radiation
    Honglu Wu
    Wyle Laboratories, Houston, Texas, USA
    J Radiat Res 43:S181-5. 2002
    ..Results showed that the frequency of unrejoined chromosome breaks was higher after high-LET radiation, and the ratio of unrejoined to misrejoined chromosome breaks increased steadily with LET up a peak value at 440 keV/microm...
  34. ncbi request reprint Computational model of chromosome aberration yield induced by high- and low-LET radiation exposures
    Artem L Ponomarev
    Life Sciences, Universities Space Research Association, Houston, Texas 77058, USA
    Radiat Res 177:727-37. 2012
    ..Additionally, the model was used to scale chromosomal exchanges in two or three chromosomes that were obtained from whole-chromosome FISH painting analysis techniques to whole-genome equivalent values...
  35. ncbi request reprint Subtraction of background damage in PFGE experiments on DNA fragment-size distributions
    Artem L Ponomarev
    NASA Johnson Space Center, Mail Code SK, build 37, Room 119, Houston, TX 77058, USA
    Radiat Environ Biophys 46:155-60. 2007
    ..The formalism systematically gives better results than naïve bin-by-bin subtraction in all these artificial data sets...
  36. ncbi request reprint Analysis of complex-type chromosome exchanges in astronauts' lymphocytes after space flight as a biomarker of high-LET exposure
    Kerry George
    Wyle Life Sciences, Houston, TX, USA
    J Radiat Res 43:S129-32. 2002
    ..It appears that the use of complex-type exchanges as biomarker of radiation quality in vivo after low-dose chronic exposure in mixed radiation fields is hampered by statistical uncertainties...
  37. ncbi request reprint Model of the initiation of signal transduction by ligands in a cell culture: simulation of molecules near a plane membrane comprising receptors
    Ianik Plante
    NASA Johnson Space Center, Houston, Texas 77058, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 84:051920. 2011
    ..These simulations will be of great importance to model interactions at low doses where stochastic effects induced by a small number of molecules or interactions come into play...
  38. doi request reprint A biomathematical model of lymphopoiesis following severe radiation accidents--potential use for dose assessment
    Shaowen Hu
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    Health Phys 102:425-36. 2012
    ..The physiological assumptions underlying the model are also discussed, which may provide a putative mechanism for some biodosimetric tools that use the peripheral blood cell counts as markers of radiation impairment...
  39. doi request reprint A cell kinetic model of granulopoiesis under radiation exposure: extension from rodents to canines and humans
    Shaowen Hu
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    Radiat Prot Dosimetry 143:207-13. 2011
    ..The suppression of granulocytes' level of a space traveller under chronic stress of low-dose irradiation as well as the granulopoietic response when encountering a historically large solar particle event is also discussed...
  40. doi request reprint Characterization of the radiation-damaged precursor cells in bone marrow based on modeling of the peripheral blood granulocytes response
    Shaowen Hu
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    Health Phys 101:67-78. 2011
    ....
  41. doi request reprint Energy deposition and relative frequency of hits of cylindrical nanovolume in medium irradiated by ions: Monte Carlo simulation of tracks structure
    Ianik Plante
    NASA Johnson Space Center, 2101 NASA Parkway, Houston, TX 77058, USA
    Radiat Environ Biophys 49:5-13. 2010
    ..Our Monte Carlo simulations are consistent with the experimental data both in the core and in the penumbra of the beam, and are shown to provide a better description of the experimental data than deterministic codes...
  42. doi request reprint Modelling the way Ku binds DNA
    Shaowen Hu
    Universities Space Research Association, Division of Space Life Sciences, Houston, TX 77058, USA
    Radiat Prot Dosimetry 143:196-201. 2011
    ....
  43. doi request reprint Binding selectivity of RecA to a single stranded DNA, a computational approach
    Claudio Carra
    Universities Space Research Association, 2101 NASA Parkway, Houston, TX 77058, USA
    J Mol Model 17:133-50. 2011
    ..The study revealed how the binding affinity of EcRecA is significantly higher toward dT₉ rather than dA₉, as expected from the experimental results...
  44. ncbi request reprint Advances in space radiation shielding codes
    John W Wilson
    NASA Langley Research Center, Hampton, VA 23681, USA
    J Radiat Res 43:S87-91. 2002
    ..A single ray trace in such geometry requires 14 milliseconds and limits application of Monte Carlo methods to such engineering models. A potential means of improving the Monte Carlo efficiency in coupling to spacecraft geometry is given...
  45. ncbi request reprint Binding sites of the E. Coli DNA recombinase protein to the ssDNA: a computational study
    Claudio Carra
    Universities Space Research Association Houston TX 77058, USA
    J Biomol Struct Dyn 27:407-28. 2010
    ..This is consistent with the complete loss of the enzyme activity for any mutation on that point...
  46. ncbi request reprint Implementation of Gy-Eq for deterministic effects limitation in shield design
    John W Wilson
    NASA Langley Research Center, Hampton, VA 23681, USA
    J Radiat Res 43:S103-6. 2002
    ..In the present report we will suggest a complete definition of neutron RBE consistent with the NCRP recommendations and evaluate attenuation properties of deterministic effects (Gy-Eq) in comparison with other dosimetric quantities...
  47. ncbi request reprint A robust procedure for removing background damage in assays of radiation-induced DNA fragment distributions
    Artem L Ponomarev
    NASA Johnson Space Center, Houston, Texas, 77058
    Radiat Res 166:908-16. 2006
    ..We give a generalized formalism based on stochastic processes for the subtraction of the background damage in PFGE experiments for any LET and apply it to two sets of PFGE data for iron ions...
  48. ncbi request reprint A procedure for benchmarking laboratory exposures with 1 A GeV iron ions
    John W Wilson
    NASA Langley Research Center, Hampton, VA 23681 2199, USA
    Adv Space Res 35:185-93. 2005
    ..The benchmark quantities will be dose, track averaged LET, dose averaged LET, fraction of iron ion remaining, and fragment energy spectra after 23 g/cm2 of polymethyl metachrylate...
  49. doi request reprint Accurate prediction of the binding free energy and analysis of the mechanism of the interaction of replication protein A (RPA) with ssDNA
    Claudio Carra
    Universities Space Research Association, Houston, TX 77058, USA
    J Mol Model 18:2761-83. 2012
    ..The agreement with experiment is optimal and a strong change in the binding free energy can be considered as the dominant factor in the loss for the binding affinity resulting from mutation...
  50. doi request reprint Modularized Smad-regulated TGFβ signaling pathway
    Yongfeng Li
    USRA, Division of Space Life Sciences, Houston, TX 77058, United States
    Math Biosci 240:187-200. 2012
    ..Meanwhile the excitability, a common feature observed in the biological systems, in the TGFβ signaling pathway is discussed and supported as well by numerical simulation, indicating the robustness of the model...
  51. ncbi request reprint Ionizing radiation enhances esophageal epithelial cell migration and invasion through a paracrine mechanism involving stromal-derived hepatocyte growth factor
    Zarana S Patel
    Division of Space Life Sciences, Universities Space Research Association, Houston, Texas 77058, USA
    Radiat Res 177:200-8. 2012
    ....
  52. pmc From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation
    Jerry W Shay
    University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Res 71:6926-9. 2011
    ..The workshop examined preclinical models, epidemiology, molecular markers, "omics" technology, radiobiology issues, and lung stem cells that relate to the development of lung cancer...
  53. ncbi request reprint Model predictions and visualization of the particle flux on the surface of Mars
    Francis A Cucinotta
    NASA Johnson Space Center, Houston, TX 77058, USA
    J Radiat Res 43:S35-9. 2002
    ..001 to 0.01 particle-hits/cell/year...
  54. ncbi request reprint mBAND analysis of chromosomal aberrations in human epithelial cells exposed to low- and high-LET radiation
    Megumi Hada
    Universities Space Research Association, Houston, Texas 77085, USA
    Radiat Res 168:98-105. 2007
    ..In contrast, iron ions induced a significant fraction of inversions that involved complex rearrangements of both inter- and intrachromosome exchanges...
  55. doi request reprint Smad7 foci are present in micronuclei induced by heavy particle radiation
    Minli Wang
    Universities Space Research Association, Division of Space Life Sciences, 3600 Bay Area Boulevard, Houston, TX, USA
    Mutat Res 756:108-14. 2013
    ..Our data suggest a unique role of Smad7 in IR-induced MN formation, which may associate with DNA repair, apoptosis and genomic instability. ..
  56. doi request reprint Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects
    Kerry A George
    Technology and Engineering Group, Wyle Science, Houston, Texas 77058, USA
    Radiat Res 180:25-33. 2013
    ..Our results are consistent with model expectations within the limitation of experimental error, and provide the most extensive data that have been reported on the radiation quality dependences of chromosomal aberrations. ..
  57. doi request reprint Modeling non-homologous end joining
    Yongfeng Li
    USRA, Division of Space Life Sciences, Houston, TX 77058, United States
    J Theor Biol 283:122-35. 2011
    ....
  58. ncbi request reprint Chromosome aberrations induced by high-LET radiations
    Tetsuya Kawata
    Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Biol Sci Space 18:216-23. 2004
    ..Published data on the cytogenetic effects of in vitro exposures of high-LET radiation is reviewed, along with biodosimetry results from astronauts after short or long space missions...
  59. ncbi request reprint Radiation-induced chromosome aberrations in ataxia telangiectasia cells: high frequency of deletions and misrejoining detected by fluorescence in situ hybridization
    Tetsuya Kawata
    Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Radiat Res 159:597-603. 2003
    ..These results indicate that both repair deficiency and misrepair may be involved in the hyper-radiosensitivity of AT cells...
  60. ncbi request reprint Caffeine sensitizes nondividing human fibroblasts to x rays by inducing a high frequency of misrepair
    Tetsuya Kawata
    Department of Radiology, Graduate School of Medicine, Chiba, Japan
    Radiat Res 164:509-13. 2005
    ..Since most DNA repair in nongrowing G0 cells is believed to result from nonhomologous end joining (NHEJ), caffeine may influence the fidelity of the NHEJ pathway in irradiated G0 cells...
  61. pmc Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains
    Sylvain V Costes
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Comput Biol 3:e155. 2007
    ..These data suggest that DNA damage-induced foci are restricted to certain regions of the nucleus of human epithelial cells. It is possible that DNA lesions are collected in these nuclear sub-domains for more efficient repair...
  62. doi request reprint Heavy ion carcinogenesis and human space exploration
    Marco Durante
    Biophysics group at GSI, Planckstrasse 1, 64291 Darmstadt, Germany
    Nat Rev Cancer 8:465-72. 2008
    ..Here, we describe how research in cancer radiobiology can support human missions to Mars and other planets...
  63. ncbi request reprint Induction and quantification of gamma-H2AX foci following low and high LET-irradiation
    Emma L Leatherbarrow
    DNA Damage Group, Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire, UK
    Int J Radiat Biol 82:111-8. 2006
    ....
  64. ncbi request reprint The response of tissue-equivalent proportional counters to heavy ions
    Hooshang Nikjoo
    MRC Radiation and Genome Stability Unit, Harwell, OX11 0RD, United Kingdom
    Radiat Res 157:435-45. 2002
    ..It is shown that the anomalous response observed at large event sizes in the experiment is due to an enhanced entry of secondary electrons from the wall into the gas cavity...
  65. ncbi request reprint Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions
    Tetsuya Kawata
    Department of Radiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Radiat Res 43:S169-73. 2002
    ..The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks...
  66. ncbi request reprint A complete dielectric response model for liquid water: a solution of the Bethe ridge problem
    Dimitris Emfietzoglou
    Medical Physics Laboratory, University of Ioannina Medical School, 451 10 Ioannina, Greece
    Radiat Res 164:202-11. 2005
    ..Thus the present model helps extend the ICRU electron stopping power database for liquid water down to about two orders of magnitude with a comparable level of uncertainty...