J M Mullin

Summary

Country: USA

Publications

  1. ncbi Protein kinase C activation increases transepithelial transport of biologically active insulin
    J M Mullin
    The Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 58:1641-5. 1998
  2. ncbi Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis
    A P Soler
    The Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    Eur J Cell Biol 78:56-66. 1999
  3. ncbi The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha
    H Clarke
    Lankenau Medical Research Institute, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Exp Cell Res 261:239-49. 2000
  4. ncbi Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets
    H Clarke
    Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    J Cell Sci 113:3187-96. 2000
  5. ncbi Regulation of protein kinase C-delta and -epsilon isoforms by phorbol ester treatment of LLC-PK1 renal epithelia
    H Clarke
    Lankenau Medical Research Center, Wynnewood, Pennsylvania, USA
    Kidney Int 58:1004-15. 2000
  6. ncbi Effects of apical vs. basolateral palytoxin on LLC-PK1 renal epithelia
    J M Mullin
    Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096
    Am J Physiol 260:C1201-11. 1991
  7. ncbi Increased tight junctional permeability is associated with the development of colon cancer
    A P Soler
    The Lankenau Medical Research Center, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Carcinogenesis 20:1425-31. 1999
  8. ncbi Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers
    J M Mullin
    Lankenau Medical Research Center, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Ann N Y Acad Sci 915:231-6. 2000
  9. ncbi Omeprazole induces gastric permeability to digoxin
    M Gabello
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Dig Dis Sci 55:1255-63. 2010
  10. ncbi Plasma concentrations of soluble tumor necrosis factor receptor I and tumor necrosis factor during cardiopulmonary bypass
    C W Marano
    Lankenau Institute for Medical Research, Department of Surgery, Lankenau Hospital, Wynnewood, Pennsylvania 19096, USA
    Ann Thorac Surg 70:1313-8. 2000

Collaborators

  • A P Soler
  • H Clarke
  • D M Klurfeld
  • C W Marano
  • M Gabello
  • L A Garulacan
  • M C Valenzano
  • P Zurbach
  • M Barr
  • N Ginanni
  • S M Goldman
  • K V Laughlin
  • G A Reichard
  • C Trace
  • F P Sutter
  • L Igidbashian

Detail Information

Publications12

  1. ncbi Protein kinase C activation increases transepithelial transport of biologically active insulin
    J M Mullin
    The Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096, USA
    Cancer Res 58:1641-5. 1998
    ..The dramatically enhanced permeability of macromolecules across epithelial cell layers undergoing protein kinase C activation may play a significant role in epithelial cancer, immunology, and drug delivery...
  2. ncbi Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis
    A P Soler
    The Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    Eur J Cell Biol 78:56-66. 1999
    ..These data demonstrate that NF-kappaB activation is required for the maintenance of the barrier function of an epithelium undergoing TNF-induced apoptosis...
  3. ncbi The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha
    H Clarke
    Lankenau Medical Research Institute, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Exp Cell Res 261:239-49. 2000
    ..Due to its transient effect on tight junction permeability, bryostatin 1 offers a novel pharmacological tool to investigate junctional physiology...
  4. ncbi Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets
    H Clarke
    Lankenau Medical Research Center, Wynnewood, PA 19096, USA
    J Cell Sci 113:3187-96. 2000
    ....
  5. ncbi Regulation of protein kinase C-delta and -epsilon isoforms by phorbol ester treatment of LLC-PK1 renal epithelia
    H Clarke
    Lankenau Medical Research Center, Wynnewood, Pennsylvania, USA
    Kidney Int 58:1004-15. 2000
    ..Protein kinase C (PKC) has been observed to play a role in both processes. This study examines the subcellular distribution and down-regulation of PKC-delta and PKC-epsilon isoforms in phorbol ester-treated LLC-PK1 epithelia...
  6. ncbi Effects of apical vs. basolateral palytoxin on LLC-PK1 renal epithelia
    J M Mullin
    Lankenau Medical Research Center, Wynnewood, Pennsylvania 19096
    Am J Physiol 260:C1201-11. 1991
    ..It also adds to a growing literature suggesting the existence of Na(+)-K(+)-ATPase in the apical cell surface of epithelia under certain conditions...
  7. ncbi Increased tight junctional permeability is associated with the development of colon cancer
    A P Soler
    The Lankenau Medical Research Center, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Carcinogenesis 20:1425-31. 1999
    ..These results showed that increased TJ permeability of the colon epithelium and consequently a decrease in epithelial barrier function precede the development of colon tumors...
  8. ncbi Increased tight junction permeability can result from protein kinase C activation/translocation and act as a tumor promotional event in epithelial cancers
    J M Mullin
    Lankenau Medical Research Center, 100 Lancaster Avenue, Wynnewood, Pennsylvania 19096, USA
    Ann N Y Acad Sci 915:231-6. 2000
    ..Tight junctional leakiness is therefore a promotional event that would be unique to epithelial cancers...
  9. ncbi Omeprazole induces gastric permeability to digoxin
    M Gabello
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Dig Dis Sci 55:1255-63. 2010
    ....
  10. ncbi Plasma concentrations of soluble tumor necrosis factor receptor I and tumor necrosis factor during cardiopulmonary bypass
    C W Marano
    Lankenau Institute for Medical Research, Department of Surgery, Lankenau Hospital, Wynnewood, Pennsylvania 19096, USA
    Ann Thorac Surg 70:1313-8. 2000
    ..Despite their postulated roles as modulators of TNF bioavailability, soluble TNF receptors have not been characterized in patients undergoing this procedure and is the focus of this study...
  11. ncbi Phorbol ester treatment increases paracellular permeability across IEC-18 gastrointestinal epithelium in vitro
    C W Marano
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    Dig Dis Sci 46:1490-9. 2001
    ....
  12. ncbi Esomeprazole induces upper gastrointestinal tract transmucosal permeability increase
    J M Mullin
    The Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    Aliment Pharmacol Ther 28:1317-25. 2008
    ..In a previous work, we observed that a transmucosal, upper gastrointestinal (GI) leak exists in Barrett's oesophagus (BO) patients. PPI medications are commonly used by Barrett's patients...