Jian Zhuge

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. doi request reprint Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Biol Toxicol 25:253-63. 2009
  2. doi request reprint A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biochem 314:105-12. 2008
  3. ncbi request reprint Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 41:1100-12. 2006
  4. pmc Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Biochem Biophys 466:177-85. 2007
  5. pmc Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 46:406-13. 2009
  6. ncbi request reprint Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 40:63-74. 2006
  7. pmc Ethanol induction of CYP2A5: permissive role for CYP2E1
    Yongke Lu
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Drug Metab Dispos 39:330-6. 2011
  8. doi request reprint Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008

Detail Information

Publications8

  1. doi request reprint Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Biol Toxicol 25:253-63. 2009
    ..The cytotoxicity mechanism of AICAR in E47 cells is suggested to include AMPK activation, p53 phosphorylation, p21 expression, overexpression of CYP2E1, and intracellular ROS accumulation...
  2. doi request reprint A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biochem 314:105-12. 2008
    ..Such interactions, e.g. induction of CYP2E1, decline in SAM and polyunsaturated fatty acid-induced lipid peroxidation, may contribute to alcohol-induced liver injury...
  3. ncbi request reprint Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 41:1100-12. 2006
    ..Potentiation of TGF-beta1-induced cell death by CYP2E1 may contribute to mechanisms of alcohol-induced liver disease...
  4. pmc Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Biochem Biophys 466:177-85. 2007
    ..This is due to elevated ROS production by CYP2E1 coupled to lower levels of hepatoprotective SAM and GSH. We speculate that such interactions e.g. induction of CYP2E1, decline in SAM and GSH may contribute to alcohol liver toxicity...
  5. pmc Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 46:406-13. 2009
    ..These results indicate that mitochondria are the critical targets of pyrazole plus LPS in mediating liver injury...
  6. ncbi request reprint Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 40:63-74. 2006
    ..Potentiation of serum deprivation-induced cell death by CYP2E1 may contribute to the sensitivity of the liver to alcohol-induced ischemia and growth factor deprivation...
  7. pmc Ethanol induction of CYP2A5: permissive role for CYP2E1
    Yongke Lu
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Drug Metab Dispos 39:330-6. 2011
    ..The possibility that induction of CYP2E1 is permissive for the induction of CYP2A5 may reflect a new contribution by CYP2E1 to the actions of ethanol...
  8. doi request reprint Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
    ....