Zhong Zhao

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis
    Zhong Zhao
    Neuroinflammation Research Laboratories, Department of Psychiatry, USA
    BMC Neurosci 7:29. 2006
  2. ncbi Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
  3. ncbi Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    FASEB J 18:902-4. 2004
  4. ncbi Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
  5. ncbi Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:3393-402. 2007
  6. ncbi Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Pl, New York, NY 10029, USA
    FASEB J 20:2313-20. 2006
  7. ncbi Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York, NY 10468, USA
    Schizophr Res 84:1-14. 2006
  8. ncbi Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    Weiping Qin
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:50970-7. 2003
  9. ncbi Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications
    Giulio Maria Pasinetti
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Interdiscip Top Gerontol 35:159-75. 2007
  10. ncbi Expression of tau reduces secretion of Abeta without altering the amyloid precursor protein content in CHOsw cells
    Zhong Zhao
    Neuroinflammation Research Laboratories, Department of Psychiatry of the Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    FEBS Lett 579:2119-24. 2005

Detail Information

Publications13

  1. ncbi A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis
    Zhong Zhao
    Neuroinflammation Research Laboratories, Department of Psychiatry, USA
    BMC Neurosci 7:29. 2006
    ..The cause of neuronal death in amyotrophic lateral sclerosis (ALS) is uncertain but mitochondrial dysfunction may play an important role. Ketones promote mitochondrial energy production and membrane stabilization...
  2. ncbi Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
    FASEB J 19:2081-2. 2005
    ....
  3. ncbi Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
    Lap Ho
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    FASEB J 18:902-4. 2004
    ....
  4. ncbi Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..The study provides a potentially novel pharmacological strategy for AD prevention and/or treatment...
  5. ncbi Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:3393-402. 2007
    ..These preclinical studies suggest that certain antihypertensive drugs may have AD-modifying activity and may protect against progressive Abeta-related memory deficits in subjects with AD or in those at high risk of developing AD...
  6. ncbi Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Pl, New York, NY 10029, USA
    FASEB J 20:2313-20. 2006
    ....
  7. ncbi Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction
    Zhong Zhao
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York, NY 10468, USA
    Schizophr Res 84:1-14. 2006
    ..Our studies suggest that aberrant IR function may be important in the pathophysiology of schizophrenia...
  8. ncbi Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    Weiping Qin
    Neuroinflammation Research Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:50970-7. 2003
    ....
  9. ncbi Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications
    Giulio Maria Pasinetti
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Interdiscip Top Gerontol 35:159-75. 2007
    ....
  10. ncbi Expression of tau reduces secretion of Abeta without altering the amyloid precursor protein content in CHOsw cells
    Zhong Zhao
    Neuroinflammation Research Laboratories, Department of Psychiatry of the Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA
    FEBS Lett 579:2119-24. 2005
    ..This was accompanied by a reduction in the gamma-secretase and an increase in the insulin degrading enzyme activities. Our results suggest that tau may play an inhibitory role in the amyloidogenic activity of APP...
  11. ncbi Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    Zhongmin Xiang
    Neuroinflammation Research Laboratories, Department of Psychiatry, and Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Gene Expr 10:271-8. 2002
    ..Collectively these data suggest that COX-2 influences APP processing and promotes amyloidosis in the brain...
  12. ncbi Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis
    Zhong Zhao
    James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Int J Med Sci 5:92-9. 2008
    ....
  13. ncbi Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease
    Zhong Zhao
    Neuroinflammation Research Laboratories, The Mount Sinai School of Medicine, New York, NY 10029, United States
    Neurobiol Aging 28:824-30. 2007
    ....