Research Topics
Genomes and GenesSpecies | David Y ZhangSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Amplification of circularizable probes for the detection of target nucleic acids and proteinsDavid Zhang
Department of Pathology, Mount Sinai School of Medicine, New York University, NY 10029, USA
Clin Chim Acta 363:61-70. 2006..Circularizable oligonucleotide probe (C-probe) is a unique molecule that offers significant advantages over conventional probes...- Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extractFei Ye
Department of Pathology, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
Nutr Cancer 57:100-10. 2007..Animal studies showed a 50% reduction in tumor volume after a 7-wk treatment period. This study demonstrated that S. baicalensis may be a novel anticancer agent for the treatment of prostate cancer... 
Proteomics, pathway array and signaling network-based medicine in cancerDavid Y Zhang
Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
Cell Div 4:20. 2009..As the use of signaling network-based cancer diagnosis, prognosis and treatment is anticipated in the near future, medical and scientific communities should be prepared to apply these techniques to further enhance personalized medicine...- Detection of target nucleic acids and proteins by amplification of circularizable probesDavid Y Zhang
Molecular Pathology Laboratory, Mount Sinai School of Medicine, New York, NY 10021, USA
Expert Rev Mol Diagn 3:237-48. 2003..The applications of C-probe, rolling circle amplification, ramification mechanism, in situ detection, microarray, immunoassay, single nucleotide polymorphism and whole genome amplification are discussed... - Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensisDavid Y Zhang
Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
Cancer Res 63:4037-43. 2003..Differences in biological effects of Scutellaria baicalensis compared with baicalein suggest the synergistic effects among components in Scutellaria baicalensis... 
The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cellsFei Ye
Mount Sinai School of Medicine, New York, USA
Nutr Cancer 61:530-7. 2009..baicalensis. These results indicate that S. baicalensis exerts a broad effect on cell signaling networks leading to a collective inhibition of cell proliferation...- Anticancer activity of Scutellaria baicalensis and its potential mechanismFei Ye
Department of Pathology, Mount Sinai School of Medicine, New York University, New York, NY 10021, USA
J Altern Complement Med 8:567-72. 2002..This study supports the notion of using Scutellaria baicalensis as a novel anticancer agent to treat various cancers... - Novel biodegradable HSAM nanoparticle for drug deliveryBin Liu
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
Oncol Rep 15:957-61. 2006..These results suggest that the HSAM nanoparticle is both biocompatible and biodegradable, making it a valuable vehicle for drug delivery in cancer treatment... - Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switchingYirong Li
Department of Pathology, New York University School of Medicine, New York Harbor Healthcare System, NY, USA
Mol Cell Biol 32:2454-66. 2012..Thus, we identified a novel mechanism for E2F factors in the regulation of cell cycle gene expression and cell cycle progression under the control of AR signaling... 
Molecular Zipper: a fluorescent probe for real-time isothermal DNA amplificationJizu Yi
Department of Pathology, Mount Sinai School of Medicine, New York University, One Gustave L. Levy Place, New York, NY 10029, USA
Nucleic Acids Res 34:e81. 2006..985). These results indicate that molecular zipper can be applied to real-time monitoring and qualification of RAM reaction, implying an amenable method for automatic RAM-based diagnostic assays...- Quality evaluation of commercial extracts of Scutellaria baicalensisFei Ye
Department of Pathology, Mount Sinai School of Medicine, New York University, New York, USA
Nutr Cancer 49:217-22. 2004..Therefore, chemical analysis alone is inadequate for quality control, and biological assays must be included for botanical products to ensure chemical authenticity as well as pharmacological/biological potency and consistency... - Use of ramification amplification assay for detection of Escherichia coli O157:H7 and other E. coli Shiga toxin-producing strainsFan Li
Molecular Pathology Laboratory, Mount Sinai School of Medicine, Box 1122, One Gustave Levy Place, Box 1122, New York, NY 10029, USA
J Clin Microbiol 43:6086-90. 2005..coli isolates were undetected. The RAM results were 100% in concordance with those of PCR. Because of its simplicity and isothermal amplification, the RAM assay could be a useful method for detecting STEC in food and human specimens... - Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathwayDan Ning Hu
Tissue Culture Center, Department of Pathology, New York Eye and Ear Infirmary, New York Medical College, New York, New York 10003, USA
Invest Ophthalmol Vis Sci 52:3767-74. 2011..Interleukin (IL)-6 is a proinflammatory cytokine. The authors studied the expression of IL-6 in cultured human uveal melanocytes (UMs) and their modulation by IL-1β and explored the relevant signal pathways... - Detection of Chlamydia trachomatis by isothermal ramification amplification method: a feasibility studyWandi Zhang
Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
J Clin Microbiol 40:128-32. 2002..trachomatis and presumably other sexually transmitted agents in cytological fluid and that the RAM assay can be an alternative to PCR and LCx because of its simplicity and isothermal amplification... - Detection of HPV DNA in cervical specimens collected in cytologic solution by ligation-dependent PCRFugen Yarkin
Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York, USA
Acta Cytol 47:450-6. 2003.... - Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasionYi Peng
Department of Pathology, New York University School of Medicine, New York, NY 10010, USA
J Cell Mol Med 14:2780-9. 2010..These findings strongly suggest that p44 plays a role in mediating the effects of hormones during tumorigenesis in breast... - Fibrosis-dependent mechanisms of hepatocarcinogenesisDavid Y Zhang
Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
Hepatology 56:769-75. 2012..Clarifying fibrosis-dependent tumorigenic mechanisms will help rationalize antifibrotic therapies as a strategy to prevent and treat HCC... - Intracranial tuberculoma in a liver transplant patient: first reported case and review of the literatureCorey Henderson
Division of Infectious Diseases, Mt Sinai Hospital, New York, NY, USA
Am J Transplant 3:88-93. 2003..A review of the literature reveals that the rare occurrence of intracranial tuberculoma should be considered in an orthotopic liver transplant (OLT) patient with central nervous system pathology... - Effect of Epstein-Barr virus sequence variation on performance of the Roche real-time LightCycler PCR assayTao Feng
J Clin Microbiol 46:2463-5. 2008
Research Grants
- Anti-cancer activity of Scutellaria baicalensisDavid Zhang; Fiscal Year: 2003....