David Y Zhang

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Amplification of circularizable probes for the detection of target nucleic acids and proteins
    David Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York University, NY 10029, USA
    Clin Chim Acta 363:61-70. 2006
  2. ncbi request reprint Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract
    Fei Ye
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Nutr Cancer 57:100-10. 2007
  3. pmc Molecular Zipper: a fluorescent probe for real-time isothermal DNA amplification
    Jizu Yi
    Department of Pathology, Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, NY 10029, USA
    Nucleic Acids Res 34:e81. 2006
  4. ncbi request reprint Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis
    David Y Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    Cancer Res 63:4037-43. 2003
  5. ncbi request reprint Detection of target nucleic acids and proteins by amplification of circularizable probes
    David Y Zhang
    Molecular Pathology Laboratory, Mount Sinai School of Medicine, New York, NY 10021, USA
    Expert Rev Mol Diagn 3:237-48. 2003
  6. pmc Proteomics, pathway array and signaling network-based medicine in cancer
    David Y Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
    Cell Div 4:20. 2009
  7. ncbi request reprint The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cells
    Fei Ye
    Mount Sinai School of Medicine, New York, USA
    Nutr Cancer 61:530-7. 2009
  8. ncbi request reprint Anticancer activity of Scutellaria baicalensis and its potential mechanism
    Fei Ye
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, NY 10021, USA
    J Altern Complement Med 8:567-72. 2002
  9. ncbi request reprint Novel biodegradable HSAM nanoparticle for drug delivery
    Bin Liu
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncol Rep 15:957-61. 2006
  10. pmc Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer
    Xinyu Wu
    Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e77060. 2013

Research Grants

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Amplification of circularizable probes for the detection of target nucleic acids and proteins
    David Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York University, NY 10029, USA
    Clin Chim Acta 363:61-70. 2006
    ..Circularizable oligonucleotide probe (C-probe) is a unique molecule that offers significant advantages over conventional probes...
  2. ncbi request reprint Molecular mechanism of anti-prostate cancer activity of Scutellaria baicalensis extract
    Fei Ye
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Nutr Cancer 57:100-10. 2007
    ..Animal studies showed a 50% reduction in tumor volume after a 7-wk treatment period. This study demonstrated that S. baicalensis may be a novel anticancer agent for the treatment of prostate cancer...
  3. pmc Molecular Zipper: a fluorescent probe for real-time isothermal DNA amplification
    Jizu Yi
    Department of Pathology, Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, NY 10029, USA
    Nucleic Acids Res 34:e81. 2006
    ..985). These results indicate that molecular zipper can be applied to real-time monitoring and qualification of RAM reaction, implying an amenable method for automatic RAM-based diagnostic assays...
  4. ncbi request reprint Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis
    David Y Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    Cancer Res 63:4037-43. 2003
    ..Differences in biological effects of Scutellaria baicalensis compared with baicalein suggest the synergistic effects among components in Scutellaria baicalensis...
  5. ncbi request reprint Detection of target nucleic acids and proteins by amplification of circularizable probes
    David Y Zhang
    Molecular Pathology Laboratory, Mount Sinai School of Medicine, New York, NY 10021, USA
    Expert Rev Mol Diagn 3:237-48. 2003
    ..The applications of C-probe, rolling circle amplification, ramification mechanism, in situ detection, microarray, immunoassay, single nucleotide polymorphism and whole genome amplification are discussed...
  6. pmc Proteomics, pathway array and signaling network-based medicine in cancer
    David Y Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
    Cell Div 4:20. 2009
    ..As the use of signaling network-based cancer diagnosis, prognosis and treatment is anticipated in the near future, medical and scientific communities should be prepared to apply these techniques to further enhance personalized medicine...
  7. ncbi request reprint The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cells
    Fei Ye
    Mount Sinai School of Medicine, New York, USA
    Nutr Cancer 61:530-7. 2009
    ..baicalensis. These results indicate that S. baicalensis exerts a broad effect on cell signaling networks leading to a collective inhibition of cell proliferation...
  8. ncbi request reprint Anticancer activity of Scutellaria baicalensis and its potential mechanism
    Fei Ye
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, NY 10021, USA
    J Altern Complement Med 8:567-72. 2002
    ....
  9. ncbi request reprint Novel biodegradable HSAM nanoparticle for drug delivery
    Bin Liu
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncol Rep 15:957-61. 2006
    ..These results suggest that the HSAM nanoparticle is both biocompatible and biodegradable, making it a valuable vehicle for drug delivery in cancer treatment...
  10. pmc Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer
    Xinyu Wu
    Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e77060. 2013
    ..Our data strongly suggest that ACSL4 can serve as both a biomarker for, and mediator of, an aggressive breast cancer phenotype. ..
  11. pmc Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching
    Yirong Li
    Department of Pathology, New York University School of Medicine, New York Harbor Healthcare System, NY, USA
    Mol Cell Biol 32:2454-66. 2012
    ..Thus, we identified a novel mechanism for E2F factors in the regulation of cell cycle gene expression and cell cycle progression under the control of AR signaling...
  12. ncbi request reprint Quality evaluation of commercial extracts of Scutellaria baicalensis
    Fei Ye
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, USA
    Nutr Cancer 49:217-22. 2004
    ..Therefore, chemical analysis alone is inadequate for quality control, and biological assays must be included for botanical products to ensure chemical authenticity as well as pharmacological/biological potency and consistency...
  13. pmc Detection of Chlamydia trachomatis by isothermal ramification amplification method: a feasibility study
    Wandi Zhang
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York 10029, USA
    J Clin Microbiol 40:128-32. 2002
    ..trachomatis and presumably other sexually transmitted agents in cytological fluid and that the RAM assay can be an alternative to PCR and LCx because of its simplicity and isothermal amplification...
  14. pmc Use of ramification amplification assay for detection of Escherichia coli O157:H7 and other E. coli Shiga toxin-producing strains
    Fan Li
    Molecular Pathology Laboratory, Mount Sinai School of Medicine, Box 1122, One Gustave Levy Place, Box 1122, New York, NY 10029, USA
    J Clin Microbiol 43:6086-90. 2005
    ..coli isolates were undetected. The RAM results were 100% in concordance with those of PCR. Because of its simplicity and isothermal amplification, the RAM assay could be a useful method for detecting STEC in food and human specimens...
  15. doi request reprint Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway
    Dan Ning Hu
    Tissue Culture Center, Department of Pathology, New York Eye and Ear Infirmary, New York Medical College, New York, New York 10003, USA
    Invest Ophthalmol Vis Sci 52:3767-74. 2011
    ..Interleukin (IL)-6 is a proinflammatory cytokine. The authors studied the expression of IL-6 in cultured human uveal melanocytes (UMs) and their modulation by IL-1β and explored the relevant signal pathways...
  16. doi request reprint Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion
    Yi Peng
    Department of Pathology, New York University School of Medicine, New York, NY 10010, USA
    J Cell Mol Med 14:2780-9. 2010
    ..These findings strongly suggest that p44 plays a role in mediating the effects of hormones during tumorigenesis in breast...
  17. ncbi request reprint Detection of HPV DNA in cervical specimens collected in cytologic solution by ligation-dependent PCR
    Fugen Yarkin
    Department of Pathology, Mount Sinai School of Medicine, New York University, New York, New York, USA
    Acta Cytol 47:450-6. 2003
    ....
  18. pmc Fibrosis-dependent mechanisms of hepatocarcinogenesis
    David Y Zhang
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 56:769-75. 2012
    ..Clarifying fibrosis-dependent tumorigenic mechanisms will help rationalize antifibrotic therapies as a strategy to prevent and treat HCC...
  19. ncbi request reprint Intracranial tuberculoma in a liver transplant patient: first reported case and review of the literature
    Corey Henderson
    Division of Infectious Diseases, Mt Sinai Hospital, New York, NY, USA
    Am J Transplant 3:88-93. 2003
    ..A review of the literature reveals that the rare occurrence of intracranial tuberculoma should be considered in an orthotopic liver transplant (OLT) patient with central nervous system pathology...
  20. pmc Effect of Epstein-Barr virus sequence variation on performance of the Roche real-time LightCycler PCR assay
    Tao Feng
    J Clin Microbiol 46:2463-5. 2008

Research Grants1

  1. Anti-cancer activity of Scutellaria baicalensis
    David Zhang; Fiscal Year: 2003
    ....