MONE contact ZAIDI

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Special stem cells for bone
    Mone Zaidi
    The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Stem Cell 10:233-4. 2012
  2. ncbi request reprint Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss
    Mone Zaidi
    The Mount Sinai Bone Program, Box 1055, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Curr Osteoporos Rep 7:118-26. 2009
  3. ncbi request reprint New insights: elevated follicle-stimulating hormone and bone loss during the menopausal transition
    Mone Zaidi
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Rheumatol Rep 11:191-5. 2009
  4. doi request reprint Paradigm shift in the pathophysiology of postmenopausal and thyrotoxic osteoporosis
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 76:474-83. 2009
  5. ncbi request reprint Thyroid-stimulating hormone, thyroid hormones, and bone loss
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Osteoporos Rep 7:47-52. 2009
  6. ncbi request reprint Skeletal remodeling in health and disease
    Mone Zaidi
    The Mount Sinai Bone Program, Department of Medicine, Box 1055, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Med 13:791-801. 2007
  7. pmc ACTH protects against glucocorticoid-induced osteonecrosis of bone
    Mone Zaidi
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:8782-7. 2010
  8. doi request reprint New horizons in skeletal physiology and pathophysiology
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocr Pract 16:874-81. 2010
  9. ncbi request reprint Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS
    Mone Zaidi
    Departments of Medicine and Geriatrics, Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1055, New York, NY 10029, USA
    Bone 30:655-63. 2002
  10. ncbi request reprint Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics
    Mone Zaidi
    Department of Medicine, Geriatrics and Physiology and The Mount Sinai Bone Program, Bronx VA Geriatrics Research Education and Clinical Center, New York, New York, USA
    J Bone Miner Res 18:599-609. 2003

Research Grants

  1. TSH and Bone
    Mone Zaidi; Fiscal Year: 2009
  2. Role of FSH in Osreoclast Formation and Function
    Mone Zaidi; Fiscal Year: 2010
  3. The Role of NFATc1 and Calcineurin in Bone Remodeling
    Mone Zaidi; Fiscal Year: 2007
  4. Calcium in the regulation of osteoclast formation
    Mone Zaidi; Fiscal Year: 2007
  5. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
  6. Calcium in the regulation of osteoclast formation
    Mone Zaidi; Fiscal Year: 2007
  7. TSH and Bone
    MONE contact ZAIDI; Fiscal Year: 2010
  8. Role of FSH in Osreoclast Formation and Function
    Mone Zaidi; Fiscal Year: 2009
  9. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
  10. Skeletal Development and Remodeling in Health, Disease and Aging
    Mone Zaidi; Fiscal Year: 2005

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Special stem cells for bone
    Mone Zaidi
    The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Stem Cell 10:233-4. 2012
    ..In this issue of Cell Stem Cell, Park et al. (2012) report that an MSC-like, osteolineage-directed Mx1+ population generates new osteoblasts at sites of bone damage, suggesting its potential for skeletal repair and regeneration...
  2. ncbi request reprint Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss
    Mone Zaidi
    The Mount Sinai Bone Program, Box 1055, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Curr Osteoporos Rep 7:118-26. 2009
    ....
  3. ncbi request reprint New insights: elevated follicle-stimulating hormone and bone loss during the menopausal transition
    Mone Zaidi
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Rheumatol Rep 11:191-5. 2009
    ..Potential therapeutic implications include the development of antagonists to circulating FSH and its osteoclastic receptor...
  4. doi request reprint Paradigm shift in the pathophysiology of postmenopausal and thyrotoxic osteoporosis
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 76:474-83. 2009
    ..New therapeutic targets thus emerge from these studies. Mt Sinai J Med 76:474-483, 2009. (c) 2009 Mount Sinai School of Medicine...
  5. ncbi request reprint Thyroid-stimulating hormone, thyroid hormones, and bone loss
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Osteoporos Rep 7:47-52. 2009
    ..TSH and its receptor could become valuable drug targets in treating bone loss...
  6. ncbi request reprint Skeletal remodeling in health and disease
    Mone Zaidi
    The Mount Sinai Bone Program, Department of Medicine, Box 1055, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Med 13:791-801. 2007
    ..It also highlights molecular aberrations that cause bone cells to become dysfunctional, as well as therapeutic options and opportunities to counteract skeletal loss...
  7. pmc ACTH protects against glucocorticoid-induced osteonecrosis of bone
    Mone Zaidi
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:8782-7. 2010
    ..We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy...
  8. doi request reprint New horizons in skeletal physiology and pathophysiology
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocr Pract 16:874-81. 2010
    ..To review new discoveries that revisit our current thinking on the genesis of osteoporosis using hypogonadal and thyrotoxic bone loss as examples...
  9. ncbi request reprint Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS
    Mone Zaidi
    Departments of Medicine and Geriatrics, Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1055, New York, NY 10029, USA
    Bone 30:655-63. 2002
    ....
  10. ncbi request reprint Osteoclastogenesis, bone resorption, and osteoclast-based therapeutics
    Mone Zaidi
    Department of Medicine, Geriatrics and Physiology and The Mount Sinai Bone Program, Bronx VA Geriatrics Research Education and Clinical Center, New York, New York, USA
    J Bone Miner Res 18:599-609. 2003
    ..The main outstanding issues, basic and translational, will be considered in relation to the osteoclast as a target for antiresorptive therapies...
  11. ncbi request reprint TSH is a negative regulator of skeletal remodeling
    Etsuko Abe
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 115:151-62. 2003
    ..These studies define a role for TSH as a single molecular switch in the independent control of both bone formation and resorption...
  12. pmc TNFalpha mediates the skeletal effects of thyroid-stimulating hormone
    Hidenori Hase
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:12849-54. 2006
    ..The results suggest that TNFalpha is the critical cytokine mediating the downstream antiresorptive effects of TSH on the skeleton...
  13. ncbi request reprint Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption
    Li Sun
    Mount Sinai Bone Program and Department of Medicine and Geriatrics, Mount Sinai School of Medicine, and Division of Endocrinology and Geriatric Research Education and Clinical Center GRECC, Veterans Affairs Medical Center, New York, New York 10029, USA
    FASEB J 17:369-75. 2003
    ..These findings establish a critical role for CD38 in osteoclast formation and bone resorption. We speculate that CD38 functions as a cellular NAD+ "sensor," particularly during periods of active motility and secretion...
  14. ncbi request reprint FSH directly regulates bone mass
    Li Sun
    Mount Sinai Bone Program, Department of Medicine and Department of Orthopedics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 125:247-60. 2006
    ..Osteoclasts and their precursors possess G(i2alpha)-coupled FSHRs that activate MEK/Erk, NF-kappaB, and Akt to result in enhanced osteoclast formation and function. We suggest that high circulating FSH causes hypogonadal bone loss...
  15. pmc Calcineurin regulates bone formation by the osteoblast
    Li Sun
    Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 102:17130-5. 2005
    ..Together, the gain- and loss-of-function experiments indicate that calcineurin regulates bone formation through an effect on osteoblast differentiation...
  16. ncbi request reprint TSH and bone loss
    Li Sun
    Department of Medicine, Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1068:309-18. 2006
    ..The evidence that low TSH levels predispose to osteoporosis in hyperthyroidism is discussed in view of the emerging role of pituitary hormones in bone biology...
  17. pmc Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth
    Rebecca A Mosig
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hum Mol Genet 16:1113-23. 2007
    ..Thus, Mmp2-/- mice provide a valuable biological resource for studying the pathophysiological mechanisms underlying the human disease and defining the in vivo physiological role of MMP-2...
  18. pmc Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss
    Li Sun
    The Mount Sinai Bone Program and The Thyroid Research Unit at the Bronx Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:4289-94. 2008
    ..In contrast, loss of function of a mutant TSHR (Pro --> Leu at 556) in congenital hypothyroid mice activates osteoclast differentiation, confirming once again our premise that TSHRs have a critical role in regulating bone remodeling...
  19. pmc Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
    Xue Bin Wu
    Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1055, New York, New York 10029, USA
    J Clin Invest 112:924-34. 2003
    ..Thus, the overproduction of noggin during biological aging may result in impaired osteoblast formation and function and hence, net bone loss...
  20. ncbi request reprint Cellular and molecular consequences of calcineurin A alpha gene deletion
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:216-26. 2007
    ..We speculate that the so-called "calcineurin inhibitors" may interact with molecules other than calcineurin. The clinical relevance of these observations is explored...
  21. pmc Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice
    Firas M Kara
    New York University School of Medicine, New York, NY, USA
    Arthritis Rheum 62:534-41. 2010
    ....
  22. ncbi request reprint Bone loss in thyroid disease: role of low TSH and high thyroid hormone
    Etsuko Abe
    Mount Sinai Bone Program and The Thyroid Research Unit at the James Peter s Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:383-91. 2007
    ..We can now provide results that not thyroid hormones but also TSH itself has an equally important role to play in bone remodeling...
  23. ncbi request reprint A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor
    Li Sun
    Mount Sinai Bone Program, Department of Medicine, and Bronx Veterans Affairs Geriatrics Research Education and Clinical Center GRECC, New York, New York 10029, USA
    FASEB J 16:302-14. 2002
    ..Finally, ryanodine inhibited Ca2+ signaling, indicating the downstream activation of ryanodine receptors by cADPr. We conclude that intracellularly expressed CD38 might link cellular NAD+ production to cytosolic Ca2+ signaling...
  24. pmc Physiological loading of joints prevents cartilage degradation through CITED2
    Daniel J Leong
    Leni and Peter W May Department of Orthopedics, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    FASEB J 25:182-91. 2011
    ..Together, these studies identify a novel regulatory pathway involving CITED2 and p38δ, which may be critical for the maintenance of articular cartilage integrity under normal physical activity levels...
  25. doi request reprint The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling
    Rauf Latif
    Thyroid Research Unit, Mount Sinai School of Medicine and the James J Peters VA Medical Center, New York, NY 10468, USA
    Endocrinol Metab Clin North Am 38:319-41, viii. 2009
    ..Knowledge of the structure/function relationship of the TSHR is beginning to provide a greater understanding of thyroid physiology and thyroid autoimmunity...
  26. ncbi request reprint Molecular cloning, expression, and function of osteoclastic calcineurin Aalpha
    Li Sun
    Mount Sinai Bone Program and Division of Endocrinology, Mount Sinai School of Medicine, New York, 10029, USA
    Am J Physiol Renal Physiol 284:F575-83. 2003
    ....
  27. ncbi request reprint Molecular regulation of mechanotransduction
    Jameel Iqbal
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 328:751-5. 2005
    ....
  28. pmc Calcitonin and bone formation: a knockout full of surprises
    Mone Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 110:1769-71. 2002
  29. pmc Further evidence for direct pro-resorptive actions of FSH
    Li Sun
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 394:6-11. 2010
    ..On the basis of accumulating evidence, we reaffirm that FSH contributes to the rapid peri-menopausal and early post-menopausal bone loss, which might thus be amenable to FSH blockade...
  30. pmc Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation
    Jameel Iqbal
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:14925-30. 2006
    ..Ascorbic acid may prevent FSH-induced hypogonadal bone loss by modulating the catabolic actions of TNFalpha...
  31. ncbi request reprint Evidence that calcineurin is required for the genesis of bone-resorbing osteoclasts
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 292:F285-91. 2007
    ..Together, the gain- and loss-of-function experiments establish that calcineurin Aalpha is necessary for osteoclast formation from its precursor and that this occurs via an NFATc1-dependent mechanism...
  32. doi request reprint Nandrolone slows hindlimb bone loss in a rat model of bone loss due to denervation
    Christopher P Cardozo
    James J Peters VA Medical Center, Bronx, NY, USA
    Ann N Y Acad Sci 1192:303-6. 2010
    ..This study offers a potential novel pharmacological strategy for use of nandrolone to reduce bone loss in severe disuse- and denervation-related bone loss, such as that which occurs after spinal cord injury...
  33. doi request reprint Commentary-FSH and bone 2010: evolving evidence
    Jameel Iqbal
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, USA
    Eur J Endocrinol 163:173-6. 2010
    ..strengthen the view for a primary role of FSH signaling in the regulation of bone mass and bone remodeling in humans by demonstrating that an 'activating' polymorphism AA rs6166 causes low bone mass and high bone turnover...
  34. ncbi request reprint Calcium sensing and cell signaling processes in the local regulation of osteoclastic bone resorption
    Mone Zaidi
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Rev Camb Philos Soc 79:79-100. 2004
    ....
  35. ncbi request reprint Progression of efficacy with ibandronate: a paradigm for the development of new bisphosphonates
    Mone Zaidi
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1117:273-82. 2007
    ..The ibandronate story should serve as an important future paradigm for bisphosphonate development...
  36. doi request reprint Role of the pituitary-bone axis in skeletal pathophysiology
    Aliza Imam
    The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York, USA
    Curr Opin Endocrinol Diabetes Obes 16:423-9. 2009
    ..We propose a paradigm shift in endocrine physiology, which is that these hormones act by design on bone directly, also now considered an endocrine organ...
  37. doi request reprint Oxytocin deficiency impairs maternal skeletal remodeling
    Xuan Liu
    Mount Sinai School of Medicine, NY, USA
    Biochem Biophys Res Commun 388:161-6. 2009
    ..We suggest that OT facilitates intergenerational transfer of calcium ions from a pregnant mother to the pups...
  38. ncbi request reprint Structure and functional regulation of the CD38 promoter
    Li Sun
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, NY, USA
    Biochem Biophys Res Commun 341:804-9. 2006
    ....
  39. doi request reprint Prostaglandin E2 modulates components of the Wnt signaling system in bone and prostate cancer cells
    Xin Hua Liu
    Department of Medicine, Division of Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 394:715-20. 2010
    ..These data demonstrate that there are dose-dependent effects of PGE(2) on Wnt activation in osteoblast-lineage cells and Wnt-inhibitor expression in PCa cells which may have clinical implications in the management...
  40. ncbi request reprint Osteoporosis: trends and intervention
    Angela M Inzerillo
    Mount Sinai Bone Program, Department of Medicine, Division of Endocrinology, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA
    Mt Sinai J Med 69:220-31. 2002
    ..Various therapeutic approaches now in use, and some promising experimental trials, will be discussed...
  41. ncbi request reprint Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor
    Baljit S Moonga
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, New York 10029, USA
    Am J Physiol Renal Physiol 282:F921-32. 2002
    ..It is likely therefore that the surface RyR-2 not only gates Ca(2+) influx but also functions as a sensor for extracellular divalent cations...
  42. ncbi request reprint Selective upregulation of the ADP-ribosyl cyclases CD38 and CD157 by TNF but not by RANK-L reveals differences in downstream signaling
    Jameel Iqbal
    Department of Endocrinology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 291:F557-66. 2006
    ....
  43. ncbi request reprint Bisphosphonates induce inflammation and rupture of atherosclerotic plaques in apolipoprotein-E null mice
    Mona Shimshi
    Department of Medicine, The Mount Sinai Bone Program, The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 07936 1080, USA
    Biochem Biophys Res Commun 328:790-3. 2005
    ..Our finding of plaque inflammation and rupture in bisphosphonate-treated Apo-E-/- mice may provide the first animal model for studies aimed at characterizing mechanisms of plaque rupture in animal models...
  44. ncbi request reprint Disorders associated with acute rapid and severe bone loss
    Solomon Epstein
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Bone Miner Res 18:2083-94. 2003
    ..However, more severe forms of bone loss that result from an osteoblastic defect and reduced bone formation may benefit potentially more from newer anabolic agents, such as recombinant human parathyroid hormone (rhPTH)...
  45. ncbi request reprint Calcitonin: physiological actions and clinical applications
    Angela M Inzerillo
    Mount Sinai Bone Program, Departments of Medicine and Geriatrics, Mount Sinai School of Medicine, and Bronx Veteran s Affairs, New York, NY, USA
    J Pediatr Endocrinol Metab 17:931-40. 2004
    ....
  46. ncbi request reprint Proresorptive actions of FSH and bone loss
    Mone Zaidi
    Mount Sinai Bone Program, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann N Y Acad Sci 1116:376-82. 2007
    ..Potential therapeutic implications include the development of antagonists to both circulating FSH and its osteoclastic receptor...
  47. ncbi request reprint Regulation of FSH receptor promoter activation in the osteoclast
    Samir Zaidi
    Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave L Levy Place, NY 10029, USA
    Biochem Biophys Res Commun 361:910-5. 2007
    ..We surmise that the FSHR expression is regulated distinctly in the osteoclast, and differently from other cells, such as the ovarian follicular and Leydig cells...
  48. ncbi request reprint Induction of a program gene expression during osteoblast differentiation with strontium ranelate
    Ling Ling Zhu
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 355:307-11. 2007
    ..The increased osteoblastic differentiation is the likely basis underlying the therapeutic bone-forming actions of strontium ranelate...
  49. ncbi request reprint CD38 is required for priming by TNF-alpha: a mechanism for extracellular coordination of cell fate
    Jameel Iqbal
    Mount Sinai Bone Program, Mount Sinai School of Medicine, Box 1055, 1 Gustave Levy Place, New York, NY 10029, USA
    Am J Physiol Renal Physiol 292:F1283-90. 2007
    ..Since CD38 is an ectoenzyme, we suggest that the modulation of extracellular NAD(+) metabolism likely serves as a unique mechanism to coordinate the fate of cells within a local environment...
  50. ncbi request reprint Extracellular NAD+ metabolism modulates osteoclastogenesis
    Jameel Iqbal
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 349:533-9. 2006
    ..As CD38 is the major NAD+ -degrading enzyme present in the bone marrow, these results suggest that CD38-mediated inhibition of osteoclastogenesis is related to its NADase activity, not its ADPribosyl cyclase activity...
  51. ncbi request reprint The second conference on skeletal medicine and biology: special features
    Mone Zaidi
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York NY 10029, USA
    Ann N Y Acad Sci 1117:xiii-xix. 2007
  52. ncbi request reprint Modeling of serum C-telopeptide levels with daily and monthly oral ibandronate in humans
    Mone Zaidi
    Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1055, New York, NY 10029, USA
    Ann N Y Acad Sci 1068:560-3. 2006
    ....
  53. ncbi request reprint Skeletal morphofunctional considerations and the pituitary-thyroid axis
    Jameel Iqbal
    Mount Sinai Bone Program and Department of Medicine, Mount Sinai School of Medicine, New York 10029, USA
    Front Biosci (Schol Ed) 1:92-107. 2009
    ..The current review describes these molecular mechanisms in relation to the way thyroid hormones, and the pituitary hormone thyrotropin (TSH), regulate skeletal morphogenesis and remodeling...
  54. ncbi request reprint Restoration of bone mass in hpg mouse by preoptic area grafting
    Gopalan Rajendren
    Department of Medicine, The Mount Sinai Bone Program, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Ann N Y Acad Sci 1068:341-7. 2006
    ..This establishes that the low bone mass that occurs in old hpg mice can be fully and rapidly ameliorated by preoptic area grafting...
  55. ncbi request reprint Functional grouping of osteoclast genes revealed through microarray analysis
    Guozhe Yang
    Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 366:352-9. 2008
    ..We discuss herein the relevance of these functional gene clusters and their modulation to biological processes underlying the formation, function, and fate of osteoclasts...
  56. ncbi request reprint Neural surveillance of skeletal homeostasis
    Mone Zaidi
    Department of Medicine and The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cell Metab 1:219-21. 2005
    ..2005)...
  57. doi request reprint The crossover of bisphosphonates to cancer therapy
    Merry Sun
    The Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1211:107-12. 2010
    ..This review explores bisphosphonates' current clinical utility and potential as a crossover cancer therapy...
  58. ncbi request reprint Calcitonin: the other thyroid hormone
    Angela M Inzerillo
    Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, and Bronx Veteran s Affairs Geriatric Research Education and Clinical Center GRECC, New York, New York 10029, USA
    Thyroid 12:791-8. 2002
    ..This review surveys the cellular and molecular basis of these physiologic and clinical actions...
  59. pmc Identification of CITED2 as a negative regulator of fracture healing
    Jonathan Y Lee
    Leni and Peter W May Department of Orthopaedics, Mount Sinai School of Medicine, NY, USA
    Biochem Biophys Res Commun 387:641-5. 2009
    ..Taken together, the studies suggest that CITED2 is a critical upstream regulator of fracture healing. The suppression of CITED2 early after fracture may allow an optimal initiation of the healing response...
  60. ncbi request reprint Cinacalcet hydrochloride (Amgen)
    Jameel Iqbal
    Mount Sinai Bone Program, Division of Endocrinology, Mount Sinai School of Medicine, New York, NY 10029, USA
    IDrugs 6:587-92. 2003
    ..Cinacalcet hydrochloride was developed in an effort to improve on the poor pharmacokinetics and metabolism of tecalcet hydrochloride...
  61. pmc TNF-induced MAP kinase activation oscillates in time
    Jameel Iqbal
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, P O Box 1055, New York, NY 10029, USA
    Biochem Biophys Res Commun 371:906-11. 2008
    ..In view of the discovery that multiple phosphorylation pathways display dynamic oscillations, time-resolved, instead of static, measurements of kinase phosphorylation should become the experimental norm...
  62. ncbi request reprint Low TSH triggers bone loss: fact or fiction?
    Mone Zaidi
    Thyroid 16:1075-6. 2006
  63. ncbi request reprint Osteoclast signalling pathways
    Harry C Blair
    Department of Pathology, University of Pittsburgh, Veterans Affairs Health System, Pittsburgh, PA 15261, USA
    Biochem Biophys Res Commun 328:728-38. 2005
    ....
  64. ncbi request reprint Osteoclastic differentiation and function regulated by old and new pathways
    Harry C Blair
    Department of Pathology, University of Pittsburgh and Veterans Affairs Health System, Pittsburgh, PA 15261, USA
    Rev Endocr Metab Disord 7:23-32. 2006
    ..Recent findings suggest that there is a network of cytoplasmic adapters, including Gab-2 and BCAR1, which are modified by multiple signalling mechanisms and which serve to integrate the signalling pathways...
  65. pmc Mechanisms balancing skeletal matrix synthesis and degradation
    Harry C Blair
    Department of Pathology, University of Pittsburgh and Veteran s Affairs Health System, Pittsburgh, Pennsylvania, USA
    Biochem J 364:329-41. 2002
    ..Secondary modulation of mineral secretion and bone degradation are mediated by humoral signals, including parathyroid hormone and vitamin D, as well as the cytokines that also regulate the underlying cell differentiation...
  66. ncbi request reprint The second conference on skeletal medicine and biology: overview and some comments
    Mone Zaidi
    Ann N Y Acad Sci 1116:xi-xiii. 2007
  67. ncbi request reprint NO-dependent osteoclast motility: reliance on cGMP-dependent protein kinase I and VASP
    Beatrice B Yaroslavskiy
    Department of Pathology, University of Pittsburgh and Veteran s Affairs Medical Center, Pittsburgh, PA 15243, USA
    J Cell Sci 118:5479-87. 2005
    ..VASP knockdown also altered distribution of alphavbeta3 at the attachment site. We conclude that PKG I and VASP are essential for reorganization of attachment and cytoplasmic proteins in motility induced by NO or by cGMP...
  68. ncbi request reprint Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA study
    John A Eisman
    Garvan Institute of Medical Research, St Vincent s Campus and University of New South Wales, Sydney, Australia
    J Rheumatol 35:488-97. 2008
    ..We report the effects on lumbar spine and proximal femur bone mineral density (BMD) and bone resorption markers over 2 years...
  69. ncbi request reprint Molecules, mechanisms, and momentum in bone and cartilage research
    Mone Zaidi
    Biochem Biophys Res Commun 328:647-50. 2005
  70. pmc Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta
    Gopa Biswas
    Dept of Animal Biology, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 161:507-19. 2003
    ..The results provide new insights into the role of Cn as a critical link between Ca2+ signaling and NFkappaB/Rel activation...
  71. ncbi request reprint Similarities and contrasts in ryanodine receptor localization and function in osteoclasts and striated muscle cells
    Christopher L H Huang
    Physiological Laboratory, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 1116:255-70. 2007
    ..Such a mechanism could interact with other osteoclast processes transferring Ca(2+) between cytosol, intracellular stores and extracellular space and be integrated with systemic processes regulating Ca(2+) homeostasis...

Research Grants24

  1. TSH and Bone
    Mone Zaidi; Fiscal Year: 2009
    ..This proposal examines the molecular mechanism through which TSH acts directly on the skeleton. ..
  2. Role of FSH in Osreoclast Formation and Function
    Mone Zaidi; Fiscal Year: 2010
    ....
  3. The Role of NFATc1 and Calcineurin in Bone Remodeling
    Mone Zaidi; Fiscal Year: 2007
    ....
  4. Calcium in the regulation of osteoclast formation
    Mone Zaidi; Fiscal Year: 2007
    ..Finally, we will determine whether CD38 over-expression in transgenic mice results in an osteopetrotic phenotype and dysfunctional osteoclasts...
  5. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
    ....
  6. Calcium in the regulation of osteoclast formation
    Mone Zaidi; Fiscal Year: 2007
    ..abstract_text> ..
  7. TSH and Bone
    MONE contact ZAIDI; Fiscal Year: 2010
    ..This proposal examines the molecular mechanism through which TSH acts directly on the skeleton. ..
  8. Role of FSH in Osreoclast Formation and Function
    Mone Zaidi; Fiscal Year: 2009
    ....
  9. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
  10. Skeletal Development and Remodeling in Health, Disease and Aging
    Mone Zaidi; Fiscal Year: 2005
    ..A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned. ..
  11. TSH and Bone
    MONE contact ZAIDI; Fiscal Year: 2010
    ..We showed that decrements in the pituitary hormone TSH accompany the high thyroid hormone levels, both of which contribute to the bone loss. This proposal examines the molecular mechanism through which TSH acts directly on the skeleton. ..