Research Topics
| Mary S WolffSummaryAffiliation: Mount Sinai School of Medicine Country: USA Publications
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Publications
Pharmacokinetic variability and modern epidemiology--the example of dichlorodiphenyltrichloroethane, body mass index, and birth cohortMary S Wolff
Division of Environmental and Occupational Medicine, Mt. Sinai School of Medicine, Box 1057, 1 Gustave L Levy Place, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 16:1925-30. 2007- Prenatal pesticide and PCB exposures and birth outcomesMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Pediatr Res 61:243-50. 2007..In summary, we found suggestive relationships between prenatal environmental biomarkers and birth outcomes in this population. Maternal susceptibility factors including PON1 and maternal weight contributed to the observed effects... 
Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girlsMary S Wolff
Mount Sinai School of Medicine, Division of Environmental Health Sciences, Department of Community and Preventive Medicine, New York, New York 10029, USA
Environ Health Perspect 115:116-21. 2007..S. children using exposure biomarkers in urine. However, little is known about their variation by race, age, sex, and geography, and no data exist for newly developed biomarkers...
Environmental exposures and puberty in inner-city girlsMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, Box 1057, 1 Gustav L Levy Place, New York, NY 10029, USA
Environ Res 107:393-400. 2008..Hormonally active environmental exposures are suspected to alter onset of puberty in girls, but research on this question has been very limited...
Prenatal phenol and phthalate exposures and birth outcomesMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 116:1092-7. 2008..Many phthalates and phenols are hormonally active and are suspected to alter the course of development...- Predictors of organochlorines in New York City pregnant women, 1998-2001Mary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, 1 Gustave Levy Pl, Box 1057, New York, NY 10029 6574, USA
Environ Res 97:170-7. 2005..In multivariate models, levels of OCs increased with age; DDE was higher in women not born in the US or Puerto Rico; PCB were higher in women who bought fresh fish and lower in those with higher body mass indices... - Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girlsMary S Wolff
Mount Sinai School of Medicine, New York, NY 10029, USA
Environ Health Perspect 118:1039-46. 2010..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins... - Improving organochlorine biomarker models for cancer researchMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Cancer Epidemiol Biomarkers Prev 14:2224-36. 2005..e., PCB) or long discontinued (i.e., DDE)... - Exposures among pregnant women near the World Trade Center site on 11 September 2001Mary S Wolff
Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 113:739-48. 2005..This report indicates intense bystander exposure after the WTC collapse and provides information about nonoccupational exposures among a vulnerable population of pregnant women... - Endocrine disruptors: challenges for environmental research in the 21st centuryMary S Wolff
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann N Y Acad Sci 1076:228-38. 2006..This article discusses the toxicology, human exposure, and potential health effects of EDs that are likely to be important in the 21st century... - Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohortStephanie M Engel
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Am J Epidemiol 165:1397-404. 2007..The authors uncovered additional evidence that prenatal levels of organophosphate pesticide metabolites are associated with anomalies in primitive reflexes, which are a critical marker of neurologic integrity... - Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohortStephanie M Engel
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, United States
Neurotoxicology 30:522-8. 2009..This is the first study to report an association between prenatal phthalate exposure and neurological effects in humans or animals, and as such requires replication... - Characteristics of pubertal development in a multi-ethnic population of nine-year-old girlsJulie A Britton
Division of Environmental Health Science, Mount Sinai School of Medicine, New York, NY 10029, USA
Ann Epidemiol 14:179-87. 2004..Early age at menarche increases future disease risk. Secular decline in age at menarche has been attributed to body size characteristics, diet, and energy expenditure. Risk factors for puberty have been less frequently explored... - Associations between phthalate metabolite urinary concentrations and body size measures in New York City childrenSusan L Teitelbaum
Mount Sinai School of Medicine, Department of Preventive Medicine, One Gustave L Levy Place, Box 1057, NY 10029, USA
Environ Res 112:186-93. 2012..To examine prospectively associations between urinary phthalate metabolite concentrations and body size measures in children... - Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohortGertrud S Berkowitz
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Environ Health Perspect 111:79-84. 2003..These data underscore the need to assess the potentially adverse effects of pesticide exposure on fetuses and infants and the importance of finding alternative methods for pest management to reduce pesticide exposures... - In utero pesticide exposure, maternal paraoxonase activity, and head circumferenceGertrud S Berkowitz
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, Box 1172, One Gustave L Levy Place, New York, NY 10029 6574, USA
Environ Health Perspect 112:388-91. 2004..Because small head size has been found to be predictive of subsequent cognitive ability, these data suggest that chlorpyrifos may have a detrimental effect on fetal neurodevelopment among mothers who exhibit low PON1 activity... - Xenobiotic phenols in early pregnancy amniotic fluidStephanie M Engel
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1043, New York, NY 10029, USA
Reprod Toxicol 21:110-2. 2006..e. enterolactone>daidzein>genistein>>BPA. Amniotic fluid is a source of fetal exposure to polar xenobiotics that come from the mother... - Analysis of environmental biomarkers in urine using an electrochemical detectorZhisong Liu
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Chromatogr B Analyt Technol Biomed Life Sci 819:155-9. 2005..As a pilot study to demonstrate the method's utility, we determined urinary enterolactone, daidzein, genistein and BPA in samples from nine children and 24 adults... - Temporal variability in urinary concentrations of perchlorate, nitrate, thiocyanate and iodide among childrenNancy Mervish
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
J Expo Sci Environ Epidemiol 22:212-8. 2012..Surrogate analysis show that single-spot urine samples reliably categorize participant's exposure providing support for the use of a single sample as an exposure measure in epidemiological studies that use relative ranking of exposure... - Endocrine disruptors and childhood social impairmentAmir Miodovnik
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Neurotoxicology 32:261-7. 2011..These results extend our previous finding of atypical neonatal and early childhood behaviors in relation to prenatal phthalate exposure... - Comparison of polyfluoroalkyl compound concentrations in maternal serum and amniotic fluid: a pilot studyCheryl R Stein
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, United States
Reprod Toxicol 34:312-6. 2012..5 ng/mL whereas PFOS was rarely detected in amniotic fluid until the serum concentration was about 5.5 ng/mL. No PFCs were detected in urine... - Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhoodStephanie M Engel
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
Environ Health Perspect 119:1182-8. 2011..Prenatal exposure to organophosphate pesticides has been shown to negatively affect child neurobehavioral development. Paraoxonase 1 (PON1) is a key enzyme in the metabolism of organophosphates... - Organochlorine pesticide exposure in essential tremor: a case-control study using biological and occupational exposure assessmentsElan D Louis
Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Neurotoxicology 27:579-86. 2006..Our data suggest that these tremor-producing chemicals are not of major etiological importance in our patients with ET... - Effect of socioeconomic status on exposures to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) among pregnant African-American womenLuisa N Borrell
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Arch Environ Health 59:250-5. 2004..Neither income nor education was associated with concentrations of DDE. The authors concluded that maternal socioeconomic indicators may influence the effects of exposure to PCBs among African-American pregnant women... - Prenatal phthalate exposure is associated with childhood behavior and executive functioningStephanie M Engel
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 118:565-71. 2010..Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment... - Integrated pest management in an urban community: a successful partnership for preventionBarbara L Brenner
Department of Community and Preventive Medicine, Mount Sinai Medical Center, New York, New York 10029 6547, USA
Environ Health Perspect 111:1649-53. 2003..These findings demonstrate that individually tailored IPM can be successful and cost-effective in an urban community... - Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspringAmir Miodovnik
Department of Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, PO Box 1057, New York, NY 10029, USA
Psychiatr Genet 22:115-22. 2012..We investigated maternal functional polymorphisms of CYP17, CYP19, and CYP1B1, which control three major enzymatic steps in sex steroid biosynthesis and metabolism, in relation to childhood behaviors... - Psychological trauma associated with the World Trade Center attacks and its effect on pregnancy outcomeStephanie Mulherin Engel
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Paediatr Perinat Epidemiol 19:334-41. 2005..Long-term follow-up of infants exposed to extreme trauma in utero is needed to evaluate the persistence of these effects... - Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysisMatthew R Lamb
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 114:779-85. 2006..Although limited by sample size, our results suggest that prenatal exposure to PCBs may affect growth, especially in girls, and that ortho-substitution is an important determinant of its effect on growth... - Dietary and physical activity behaviors of New York City children from different ethnic minority subgroupsNita Vangeepuram
Department of Preventive Medicine and Pediatrics, Division of General Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
Acad Pediatr 12:481-8. 2012..To examine racial/ethnic differences in diet and physical activity behaviors in ethnic minority New York City children... - Associations between neighborhood resources and physical activity in inner-city minority childrenMaida P Galvez
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10023, USA
Acad Pediatr 13:20-6. 2013..We describe how availability of physical activity resources varies by individual and block characteristics and then examine its associations with physical activity levels of Latino and black children in East Harlem, New York City... - Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohortsLawrence S Engel
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 67:5545-52. 2007..The results from these three cohorts suggest that concentrations of certain PCBs in blood are associated with increased risk of NHL... - Differential effects of the organochlorine pesticide DDT and its metabolite p,p'-DDE on p-glycoprotein activity and expressionArsalan Shabbir
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Toxicol Appl Pharmacol 203:91-8. 2005..These results suggest that DDT, but not p,p'-DDE, induces an endoplasmic reticulum stress response... - Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York CityYin Leng Lee
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Genet 89:417-23. 2010..In summary, a minimal set of 35 AIMs is sufficient to detect population stratification and estimate the proportion of individual genetic admixture; however, the utility of these markers remains questionable... - Prospective study of blood and tibia lead in women undergoing surgical menopauseGertrud S Berkowitz
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA
Environ Health Perspect 112:1673-8. 2004..These findings do not point to substantial mobilization of lead from cortical bone during menopause... - Environmental risk factors for breast cancer among African-American womenMary S Wolff
Department of Community and Preventative Medicine, Mount Sinai School of Medicine, New York, New York, USA
Cancer 97:289-310. 2003..Breast cancer studies should be expanded to examine combinations of chemicals as well as competing or complementary exposures such as endogenous hormones, dietary intake, and behavioral factors... - Air pollution and activity during transportation by car, subway, and walkingAlfredo Morabia
Center for the Biology of Natural Systems, Queens College, Queens, New York, USA
Am J Prev Med 37:72-7. 2009..5 microns or smaller (PM(2.5)) and concomitant physical activity energy expenditure (PAEE) for transportation by car, subway, or walking... - Measures of obesity associated with asthma diagnosis in ethnic minority childrenNita Vangeepuram
Department of Preventive Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1512, New York, NY 10029, USA
J Obes 2011:517417. 2011..63 (95% CI 1.12-2.39), 1.50 (95% CI 1.02-2.21), and 1.56 (95% CI 1.04-2.34), resp.). Conclusions. This study found a significant association between increased body size and asthma diagnosis, regardless of the measurement examined... - Comparison of polychlorinated biphenyl levels across studies of human neurodevelopmentMatthew P Longnecker
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 111:65-70. 2003..S. studies or recent Dutch, German, and northern Québec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies... - The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancerMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
Breast Cancer Res Treat 74:235-54. 2002.... - Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in bloodMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:686-97. 2002..These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women... - Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adductsMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:677-85. 2002..These data indicate that PAH-DNA adduct formation may influence breast cancer development, although the association does not appear to be dose dependent and may have a threshold effect... - Organochlorine chemicals and children's healthMary S Wolff
J Pediatr 140:10-3. 2002 - Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health StudyFrancine Laden
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 11:1560-5. 2002..99-7.82). The majority of studies have concluded that exposure to PCBs is unlikely to be a major cause of breast cancer, but these findings indicate that further studies of genetically susceptible populations are warranted... - The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancerFred F Kadlubar
Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA
Cancer Epidemiol Biomarkers Prev 12:327-31. 2003..In heterozygotes, 56% had reached puberty. CYP1B1, CYP3A4, and CYP3A5 rapid variants were more common in African-American than in Hispanic or Caucasian girls... - Correspondence re: Schoen et al., Lack of association between adipose tissue distribution, and insulin-like growth factor-I and insulin-like growth factor binding protein-3 in men and women. Cancer Epidemiol. Biomark. Prev., 11: 581-586, 2002Julie A Britton
Cancer Epidemiol Biomarkers Prev 12:586; author reply 586-7. 2003 - TCDD and puberty in girlsMary S Wolff
Environ Health Perspect 113:A17; author reply A18. 2005 - Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studiesRichard A Fenske
Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
Environ Health Perspect 113:1455-62. 2005..Saliva measurements of pesticides, if feasible, would overcome the limitations of urinary metabolite-based exposure analysis. Global positioning system technology appears promising in the delineation of children's time-location patterns... - DDT serum concentration and menstruation among young Chinese womenAimin Chen
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA
Environ Res 99:397-402. 2005..The study largely suggests no association between DDE and DDT concentrations and menstrual cycle characteristics in young Chinese women, though the weak-to-no correlation of DDE with menstrual cycle length merits further study... - Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysisMarilie D Gammon
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Arch Environ Health 59:640-9. 2004..These data provide only modest support for an association between PAH-DNA adducts and breast cancer development... - Waf-1 (p21) and p53 polymorphisms in breast cancerChanna Keshava
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
Cancer Epidemiol Biomarkers Prev 11:127-30. 2002..Consistent with the finding that p53(1-2-1) is a risk factor for Caucasian women was the observation of a strong interaction between race and p53 (P < 0.01)... - Dietary flavonoid intake and breast cancer risk among women on Long IslandBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Am J Epidemiol 165:514-23. 2007..These results suggest that US women can consume sufficient levels of flavonoids to benefit from their potential chemopreventive effects... - Construction of a flavonoid database for assessing intake in a population-based sample of women on Long Island, New YorkBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Nutr Cancer 56:57-66. 2006..Each class of flavonoids and lignans exhibited a wide range of intake levels. This database is useful to quantify flavonoid and lignan intake for other observational studies conducted in the United States that utilize the Block FFQ... - The World Trade Center disaster and intrauterine growth restrictionGertrud S Berkowitz
JAMA 290:595-6. 2003 - In utero p,p'-DDE exposure and infant neurodevelopment: a perinatal cohort in MexicoLuisa Torres Sanchez
Instituto Nacional de Salud Publica, Morelos, Mexico
Environ Health Perspect 115:435-9. 2007..Evidence suggests that p,p'-dichlorodiphenyldichloroethene (DDE) affects neurodevelopment in infants, although a critical exposure window has not yet been identified... - DDT and DDE exposure in mothers and time to pregnancy in daughtersBarbara A Cohn
Child Health and Development Studies, Center for Research on Women s and Children s Health, Public Health Institute, 1683 Shattuck Avenue, Suite B, Berkeley, CA 94709, USA
Lancet 361:2205-6. 2003..The decreased fecundability associated with prenatal p,p'-DDT remains unexplained. We speculate that the antiandrogenic activity of p,p'-DDE may mitigate harmful androgen effects on the ovary during gestation or early life... - DDT and breast cancer in young women: new data on the significance of age at exposureBarbara A Cohn
Child Health and Development Studies, Center for Research on Women s and Children s Health, Public Health Institute, Berkeley, California 94709, USA
Environ Health Perspect 115:1406-14. 2007..Previous studies of DDT and breast cancer assessed exposure later in life when the breast may not have been vulnerable, after most DDT had been eliminated, and after DDT had been banned... - Dietary flavonoid intake and breast cancer survival among women on Long IslandBrian N Fink
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 16:2285-92. 2007..However, the effects of flavonoids on survival are not known. In a population-based cohort of breast cancer patients, we investigated whether dietary flavonoid intake before diagnosis is associated with subsequent survival... - HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analysesRobert C Millikan
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 89:309-12. 2005..The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer... - Assessing phytochemical intake in a group of Mexican womenMarcia V Galvan Portillo
Mexico s National Institute of Public Health, Cuernavaca, Morelos, Mexico
Salud Publica Mex 49:126-31. 2007..Identify the content of selected phytochemicals (PHYs) in Mexican foods and evaluate the reliability of a food frequency questionnaire (FFQ) in assessing PHYs intake among Mexican women...
Research Grants
- Inner City Toxicants, Child Growth and DevelopmentMary Wolff; Fiscal Year: 2007..The Center will support two new investigators in children's environmental research. ..