Patricia D Wilson

Summary

Affiliation: Mount Sinai School of Medicine
Country: USA

Publications

  1. ncbi request reprint Polycystic kidney disease: new understanding in the pathogenesis
    Patricia D Wilson
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, 1425 Madison Avenue, Box 1243, New York, NY 10029, USA
    Int J Biochem Cell Biol 36:1868-73. 2004
  2. ncbi request reprint Cystic disease of the kidney
    Patricia D Wilson
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Annu Rev Pathol 2:341-68. 2007
  3. ncbi request reprint Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia
    Samantha J Wilson
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochim Biophys Acta 1762:647-55. 2006
  4. ncbi request reprint Polycystin: new aspects of structure, function, and regulation
    P D Wilson
    Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Am Soc Nephrol 12:834-45. 2001
  5. ncbi request reprint Polycystic kidney disease
    Patricia D Wilson
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    N Engl J Med 350:151-64. 2004
  6. ncbi request reprint Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1
    M Albert Basson
    Division of Hematology Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 299:466-77. 2006
  7. ncbi request reprint Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Biochim Biophys Acta 1782:1-9. 2008
  8. doi request reprint Mechanoregulation of intracellular Ca2+ in human autosomal recessive polycystic kidney disease cyst-lining renal epithelial cells
    Rajeev Rohatgi
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1243, New York, New York 10029, USA
    Am J Physiol Renal Physiol 294:F890-9. 2008
  9. pmc Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells
    Sharon Israeli
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Cell Physiol 298:C831-46. 2010
  10. doi request reprint Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 76:54-62. 2009

Research Grants

  1. Novel Therapeutic Strategies for PKD
    Patricia Wilson; Fiscal Year: 2007

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Polycystic kidney disease: new understanding in the pathogenesis
    Patricia D Wilson
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, 1425 Madison Avenue, Box 1243, New York, NY 10029, USA
    Int J Biochem Cell Biol 36:1868-73. 2004
    ....
  2. ncbi request reprint Cystic disease of the kidney
    Patricia D Wilson
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Annu Rev Pathol 2:341-68. 2007
    ....
  3. ncbi request reprint Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia
    Samantha J Wilson
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochim Biophys Acta 1762:647-55. 2006
    ..These studies implicate HER2(neu/ErbB2) as an effector of apical EGFR complex mispolarization and that its inhibition should be considered a candidate for clinical therapy of ADPKD...
  4. ncbi request reprint Polycystin: new aspects of structure, function, and regulation
    P D Wilson
    Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    J Am Soc Nephrol 12:834-45. 2001
    ..Genetic evidence suggests that PKD1, PKD2, NPHP1, and tensin are in the same pathway...
  5. ncbi request reprint Polycystic kidney disease
    Patricia D Wilson
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    N Engl J Med 350:151-64. 2004
  6. ncbi request reprint Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1
    M Albert Basson
    Division of Hematology Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 299:466-77. 2006
    ..Epithelial cysts develop in Spry1-deficient kidneys that share several molecular characteristics with those observed in human disease, suggesting that Spry1 null mice may be useful animal models for cystic hyperplasia...
  7. ncbi request reprint Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Biochim Biophys Acta 1782:1-9. 2008
    ..These results suggest that PRKX can restore normal function to PKD1-deficient kidneys and have implications for the development of preventative therapy for ADPKD...
  8. doi request reprint Mechanoregulation of intracellular Ca2+ in human autosomal recessive polycystic kidney disease cyst-lining renal epithelial cells
    Rajeev Rohatgi
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1243, New York, New York 10029, USA
    Am J Physiol Renal Physiol 294:F890-9. 2008
    ..In summary, human ARPKD cells exhibit an exaggerated Gd(3+)-sensitive mechano-induced Ca(2+) response compared with controls; whether this represents dysregulated polycystin-2 activity in ARPKD cells remains to be explored...
  9. pmc Abnormalities in focal adhesion complex formation, regulation, and function in human autosomal recessive polycystic kidney disease epithelial cells
    Sharon Israeli
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Cell Physiol 298:C831-46. 2010
    ..Paxillin coimmunoprecipitation analyses suggested that fibrocystin-1 was a component of the normal focal adhesion complex and that actin and fibrocystin-1 were lost from ARPKD complexes...
  10. doi request reprint Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development
    Xiaohong Li
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 76:54-62. 2009
    ..These studies suggest that Polycystin-1 and Pin-1 may mediate the function of PRKX in kidney development...
  11. ncbi request reprint Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation
    L Geng
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, Box 1243, 1 Gustave L Levy Place, 10029, New York, NY 10029, USA
    Biochim Biophys Acta 1535:21-35. 2000
    ..Although inhibition of tyrosine phosphorylation by tyrphostin inhibits polycystin-1-FAK interactions, E-cadherin interactions are enhanced. High calcium treatment also increases polycystin-1-E-cadherin interactions...
  12. ncbi request reprint Disruption of polycystin-1 function interferes with branching morphogenesis of the ureteric bud in developing mouse kidneys
    Katalin Polgar
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Dev Biol 286:16-30. 2005
    ....
  13. ncbi request reprint Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney
    Xiaohong Li
    Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Soc Nephrol 16:3543-52. 2005
    ..These results suggest that PRKX stimulates epithelial branching morphogenesis by activating cell migration and support a role for this kinase in the regulation of nephrogenesis and of collecting system development in the fetal kidney...
  14. ncbi request reprint The exocyst localizes to the primary cilium in MDCK cells
    Katherine K Rogers
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochem Biophys Res Commun 319:138-43. 2004
    ..We further show that the exocyst is overexpressed in both cell lines and primary cell cultures of ADPKD origin, suggesting that the exocyst may be involved in the pathogenesis of ADPKD...
  15. pmc Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity
    Jingjing Zhang
    Renal Division, Department of Medicine, Room 522, Harvard Institute of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Hum Mol Genet 19:3306-19. 2010
    ..These findings demonstrate a novel function of FPC in centrosome duplication and mitotic spindle assembly during cell division. We propose that mitotic defects due to FPC dysfunction contribute to cystogenesis in ARPKD...
  16. doi request reprint PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, NY 10314, USA
    Dev Biol 356:475-85. 2011
    ..The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could contribute to the stimulating role of PRKX in angiogenesis...
  17. pmc PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis
    Xiaohong Li
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 99:9260-5. 2002
    ....
  18. ncbi request reprint The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development
    Isabelle Gross
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:41420-30. 2003
    ..In addition, sprouty1 was expressed in the ureteric tree and antisense-treated ureteric trees had cystic lumens. Therefore, sprouty1 represents a physiologically relevant target gene of WT1 during kidney development...
  19. pmc Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD
    Rama Nadella
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 21:1275-80. 2010
    ..AGS3 may play a receptor-independent role to regulate Galpha subunit function and control epithelial cell function in PKD...
  20. ncbi request reprint Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction
    M Albert Basson
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
    Dev Cell 8:229-39. 2005
    ..These results demonstrate the importance of negative feedback regulation of RTK signaling during kidney induction and suggest that failures in feedback control may underlie some human congenital kidney malformations...
  21. doi request reprint Mouse models of polycystic kidney disease
    Patricia D Wilson
    Mount Sinai School of Medicine, New York, USA
    Curr Top Dev Biol 84:311-50. 2008
    ..Appropriate genocopy models that faithfully recapitulate the phenotypic characteristics of the disease will be invaluable tools to analyze the effects of modifier genes and small molecule inhibitor therapies...
  22. ncbi request reprint The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area
    Shixuan Wang
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 15:592-602. 2004
    ..It is proposed that the pathogenesis of autosomal recessive polycystic kidney disease is linked to the dysfunction of primary cilia...
  23. doi request reprint Pathways of apoptosis in human autosomal recessive and autosomal dominant polycystic kidney diseases
    Beatrice Goilav
    Department of Pediatrics, Division of Pediatric Nephrology, Mount Sinai School of Medicine, New York, NY, USA
    Pediatr Nephrol 23:1473-82. 2008
    ..In conclusion, apoptosis in human ADPKD is an early event, occurring predominantly in normal-appearing tubules and small cysts, and is triggered by an extrinsic factor, but it occurs later in ARPKD...
  24. pmc c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation
    Justine Elliott
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    Am J Physiol Cell Physiol 301:C522-9. 2011
    ..This suggests that SKI-606 has dual effects on cystic epithelial cell proliferation and ECM adhesion and may have therapeutic potential for ADPKD patients...
  25. ncbi request reprint Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11
    J M Lasker
    Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 275:4118-26. 2000
    ..Considering their proximal tubular localization, these P450 enzymes may partake in pivotal renal functions, including the regulation of salt and water balance, and arterial blood pressure itself...
  26. pmc Apical plasma membrane mispolarization of NaK-ATPase in polycystic kidney disease epithelia is associated with aberrant expression of the beta2 isoform
    P D Wilson
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Pathol 156:253-68. 2000
    ..These results are consistent with a model in which the additional transcription and translation of the beta2 subunit of NaK-ATPase may result in the apical mislocalization of NaK-ATPase in ADPKD cystic epithelia...
  27. ncbi request reprint Microcyst formation and HIV-1 gene expression occur in multiple nephron segments in HIV-associated nephropathy
    M J Ross
    Division of Nephrology, Mount Sinai School of Medicine, New York, New York, USA
    J Am Soc Nephrol 12:2645-51. 2001
    ..These data support a direct role for HIV-1 infection of renal epithelial cells in the pathogenesis of microcyst formation in patients with HIVAN...
  28. ncbi request reprint Expression of the beta2-subunit and apical localization of Na+-K+-ATPase in metanephric kidney
    C R Burrow
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol 277:F391-403. 1999
    ....
  29. ncbi request reprint Cystic fibrosis transmembrane conductance regulator in the kidney: clues to its role?
    P D Wilson
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Nephrol 7:284-9. 1999
    ..Similar colocalization of WT-CFTR and Na-K-ATPase at the apical plasma membranes is found in collecting tubules during development when it is speculated to play a role in the initiation of opening of the tubule lumen...
  30. ncbi request reprint Identification of phosphorylation sites in the PKD1-encoded protein C-terminal domain
    H P Li
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biochem Biophys Res Commun 259:356-63. 1999
    ..In addition, we suggest that Y4237 might be phosphorylated by c-src in living cells...
  31. ncbi request reprint Cystic diseases of the kidney: role of adhesion molecules in normal and abnormal tubulogenesis
    P D Wilson
    Mount Sinai School of Medicine, New York, N Y, USA
    Exp Nephrol 7:114-24. 1999
    ..Further evidence of a critical role of cell-matrix interactions via focal adhesion complex formation is provided by the development of renal cystic disease in tensin knockout mice...
  32. ncbi request reprint The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia
    P D Wilson
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Lab Invest 79:1311-23. 1999
    ..These studies suggest that the PKD1-encoded protein is part of a large multiprotein complex in epithelial cells that functions in the regulation of extracellular matrix interactions with the plasma membrane and cell cytoskeleton...
  33. ncbi request reprint Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance
    Lorenzo Battini
    Division of Renal Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Am Soc Nephrol 17:3049-58. 2006
    ..Furthermore, these findings indicate that reduction of PC1 expression levels, rather than the loss of heterozygosity, may be sufficient to induce cystogenesis...
  34. ncbi request reprint Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease
    Michael J Ross
    Mount Sinai School of Medicine, Division of Nephrology, Box 1243, One Gustave L Levy Place, New York, NY 10029, USA
    J Am Soc Nephrol 17:996-1004. 2006
    ..These results suggest a novel role for FAT10 in epithelial apoptosis, which is an important component of the pathogenesis of many renal diseases...
  35. ncbi request reprint Expression of the urate transporter/channel is developmentally regulated in human kidneys
    D P Hyink
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol Renal Physiol 281:F875-86. 2001
    ..These data imply that different developmental factors regulate the initiation of cytoplasmic hUAT expression and subsequent insertion into human proximal tubule brush-border membranes...
  36. ncbi request reprint Stem cells and kidney injury
    Cecile Vigneau
    Mount Sinai School of Medicine, Department of Medicine, New York, New York 10029, USA
    Curr Opin Nephrol Hypertens 15:238-44. 2006
    ..Stem cells possess two characteristics, self-renewal and the capacity for multilineage differentiation. They are typically classified as derived from embryos or from the adult...
  37. ncbi request reprint Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells
    Rajeev Rohatgi
    Division of Renal Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Soc Nephrol 14:827-36. 2003
    ..Whether Na absorption is mediated by ENaC, perhaps of nonclassical subunit composition, or another amiloride-sensitive transporter remains to be determined...
  38. ncbi request reprint The genes and proteins associated with poly-cystic kidney diseases
    P D Wilson
    Department of Medicine, Mount Sinai School of Medicine, Box 1243, 1425 Madison Avenue, New York, NY 10029, USA
    Minerva Urol Nefrol 54:201-11. 2002
    ..It is suggested that the function of the polycystin complex is to act as a key developmental regulator of renal tubule morphogenesis...
  39. ncbi request reprint WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts
    S Hosono
    Brookdale Center for Developmental and Molecular Biology and Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Oncogene 18:417-27. 1999
    ....
  40. ncbi request reprint Polarity of alpha-galactosidase A uptake by renal tubule cells
    Aaron S Stern
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Kidney Int 61:S52-5. 2002
    ..Fabry disease is an attractive candidate for gene therapy, but uptake mechanisms of the enzyme must be understood for it to be used in treating patients with Fabry disease...
  41. ncbi request reprint Loss of chromosome 16 from renal epithelial cells in humans
    Jeffrey P Gardner
    Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103 2714, USA
    Hypertension 40:928-33. 2002
    ....
  42. ncbi request reprint Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5
    Francois Jouret
    Division of Nephrology and Laboratory of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 65:198-208. 2004
    ..However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown...

Research Grants1

  1. Novel Therapeutic Strategies for PKD
    Patricia Wilson; Fiscal Year: 2007
    ..abstract_text> ..